Macrophage Biology And Activation

Author : Khalid Hussain Bhat
Publisher : BoD – Books on Demand
Page : 134 pages
File Size : 40,6 Mb
Release : 2020-03-25
Category : Medical
ISBN : 9781789846447

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Macrophage Activation by Khalid Hussain Bhat Pdf

Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.

Author : Stephen W. Russell
Publisher : Springer Verlag
Page : 299 pages
File Size : 55,9 Mb
Release : 1992-01-01
Category : Macrophages
ISBN : 0387552936

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Macrophage Biology and Activation by Stephen W. Russell Pdf

Author : Dolph O. Adams
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 44,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781475714456

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Macrophage Activation by Dolph O. Adams Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 41,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Subhra K. Biswas,Alberto Mantovani
Publisher : Springer
Page : 603 pages
File Size : 53,5 Mb
Release : 2014-11-12
Category : Medical
ISBN : 9781493913114

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Macrophages: Biology and Role in the Pathology of Diseases by Subhra K. Biswas,Alberto Mantovani Pdf

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.

Author : Tamás Röszer
Publisher : Springer Nature
Page : 224 pages
File Size : 42,8 Mb
Release : 2020-08-03
Category : Medical
ISBN : 9783030504809

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The M2 Macrophage by Tamás Röszer Pdf

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.

Author : Malgorzata Kloc
Publisher : Springer
Page : 376 pages
File Size : 52,9 Mb
Release : 2017-04-26
Category : Medical
ISBN : 9783319540900

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Macrophages by Malgorzata Kloc Pdf

This volume gives a state-of-the-art overview on macrophage functions in various invertebrate and vertebrate systems and diseases. It also covers various aspects of macrophage development and formation, behavior and response to nano- and biomaterials, the latter of which have become very important components of modern medicine. Macrophages are evolutionarily conserved phagocytotic cells. In recent years macrophages have emerged as one of the most versatile cells of immune system, which, depending on the milieu and circumstance, participate in development or inhibition of cancer, regeneration, wound healing, inflammation, organ rejection and interaction between mother and a fetus. This book will be of particular interest to researchers working in immunology, cancer research, developmental biology, or related fields.

Author : David Selwyn Nelson
Publisher : Unknown
Page : 664 pages
File Size : 49,8 Mb
Release : 1976
Category : Medical
ISBN : UOM:39015000889496

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Immunobiology of the Macrophage by David Selwyn Nelson Pdf

Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book's contributors-immunologists of diverse scientific and geographic backgrounds-have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making an ...

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 53,8 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Sigurd J. Normann
Publisher : Springer Science & Business Media
Page : 814 pages
File Size : 50,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468443943

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Macrophages and Natural Killer Cells by Sigurd J. Normann Pdf

This book is the outcome of a meeting held in Davos, Switzerland, February 7-12, 1982 focused primarily on mononuclear phagocytes and on natural killer (NK) cells. This IX International RES Congress was attended by 489 scientists from 31 countries and there were 340 scientific presentations in oral or poster session. The essential purpose of the Congress was to bring together scientists representing various aspects of mononuclear phagocyte biology to review and examine cri~ically the effects and mechanisms of macrophage growth control as well as the participatio~ of these cells in the afferent and efferent limbs of the immune response. Additional topics included the production and distribution of mono nuclear phagocytes; the intrinsic and extrinsic regulation of these cells; and the origin, nature, function and regulation of NK cells. The ultimate goal of the Congress was to enhance communication between scientists in various countries and disciplines so that new research directives could be defined with which to explore basic aspects of macrophage and NK cell participation in the control of cancer and infection.

Author : Claire E. Lewis,James O'Donnell McGee
Publisher : Oxford University Press, USA
Page : 462 pages
File Size : 53,5 Mb
Release : 1992
Category : Macrophages
ISBN : UOM:39015025285472

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The Macrophage by Claire E. Lewis,James O'Donnell McGee Pdf

Historically, the study of immunology has focused to a large extent on the central role of antigen recognition and antibody structure and function in the response of the host to infection. In the last two decades, however, scientists have been turning their attention to the involvement of various cell types in host defense. This volume provides a collection of absorbing reviews written by expert scientists on this developing topic. A broad range of material is included relating to the molecular and cell biology of the macrophage and its host defence activity in human disease. The important role that these cells play in hemopoiesis and the functioning of the nervous system is also discussed. Advanced students and researchers in immunology, cell biology, and medicine will find The Macrophage a valuable source of current research into this emerging field.

Author : International Union of Reticuloendothelial Societies. International Congress,Sherwood M. Reichard,Mizu Kojima
Publisher : Alan R. Liss
Page : 1012 pages
File Size : 47,9 Mb
Release : 1985
Category : Nature
ISBN : UOM:39015010658667

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Macrophage Biology by International Union of Reticuloendothelial Societies. International Congress,Sherwood M. Reichard,Mizu Kojima Pdf

Author : Gabriel Lopez-Berestein,Jim Klostergaard
Publisher : CRC Press
Page : 264 pages
File Size : 49,7 Mb
Release : 1992-12-07
Category : Medical
ISBN : 0849347068

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Mononuclear Phagocytes in Cell Biology by Gabriel Lopez-Berestein,Jim Klostergaard Pdf

Mononuclear Phagocytes in Cell Biology provides a state-of-the-art review of the biological, biochemical, and molecular processes involved in macrophage activation. The book focuses on the role of macrophage "signals" in health and disease, which are discussed with particular attention to the physiological role of macrophages in homeostasis. The role played by macrophages in bone metabolism and the role of cytokines in diseases affecting the macrophage (e.g., HIV and leishmaniasis) are covered as well. The book also exploits the potential of macrophage "mimicry" as a therapeutic tool. Mononuclear Phagocytes in Cell Biology is a practical reference for cell biologists, medical microbiologists, molecular biologists, immunologists, hematologists, immunogeneticists, immunopharmacologists, and other basic and clinical researchers interested in macrophage development, biology, and differentiation.

Author : Robert D. Stout,Jill Suttles
Publisher : Unknown
Page : 189 pages
File Size : 46,8 Mb
Release : 1995-01-01
Category : Cell interaction
ISBN : 3540594892

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T-cell Signaling of Macrophage Activation by Robert D. Stout,Jill Suttles Pdf

Describes the progress that has been made in the understanding of how macrophages are activated to display inflammatory and effector function, beginning with a definition of what is meant by macrophage activation, and progressing through the LPS plus IFN(gamma) model for macrophage activation to the unraveling of how T cells may interact with, and activate effector function in, antigen presenting macrophages. Annotation copyright by Book News, Inc., Portland, OR

Author : Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
Publisher : Springer Science & Business Media
Page : 1693 pages
File Size : 55,5 Mb
Release : 2009-02-27
Category : Medical
ISBN : 9781402090639

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Handbook on Immunosenescence by Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec Pdf

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.