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Author : Dolph O. Adams
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 51,8 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781475714456
Author : Khalid Hussain Bhat
Publisher : BoD – Books on Demand
Page : 134 pages
File Size : 50,5 Mb
Release : 2020-03-25
Category : Medical
ISBN : 9781789846447
Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.
Author : Stephen W. Russell,Siamon Gordon
Publisher : Springer Science & Business Media
Page : 301 pages
File Size : 48,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642773778
The amazing world of the mononuclear phagocytes keeps expanding at a truly awesome pace. As a result, maintaining currency with the latest developments and controversies that pertain to this cell type is increasingly difficult. The aspects covered in this volume have been selected to provide an overview of subject areas that either have recently become much better understood or hold the promise of new levels of understanding as they are developed in the future. The scope of topics ranges from how these cells develop, through the means that are used to regulate them, to the roles that they have in different tissues and in a variety of infectious diseases.
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Philip Conaghan,Chris Denton,Helen Foster,John Isaacs
Publisher : Oxford University Press
Page : 1553 pages
File Size : 53,7 Mb
Release : 2013-10
Category : Medical
ISBN : 9780199642489
A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
Author : Claire E. Lewis,James O'Donnell McGee
Publisher : Oxford University Press, USA
Page : 462 pages
File Size : 45,9 Mb
Release : 1992
Category : Macrophages
ISBN : UOM:39015025285472
Historically, the study of immunology has focused to a large extent on the central role of antigen recognition and antibody structure and function in the response of the host to infection. In the last two decades, however, scientists have been turning their attention to the involvement of various cell types in host defense. This volume provides a collection of absorbing reviews written by expert scientists on this developing topic. A broad range of material is included relating to the molecular and cell biology of the macrophage and its host defence activity in human disease. The important role that these cells play in hemopoiesis and the functioning of the nervous system is also discussed. Advanced students and researchers in immunology, cell biology, and medicine will find The Macrophage a valuable source of current research into this emerging field.
Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 50,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : David S. Nelson
Publisher : Academic Press
Page : 652 pages
File Size : 46,7 Mb
Release : 2014-06-28
Category : Nature
ISBN : 9781483274775
Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.
Author : Tamás Röszer
Publisher : Springer Nature
Page : 224 pages
File Size : 55,5 Mb
Release : 2020-08-03
Category : Medical
ISBN : 9783030504809
Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.
Author : E. Raz
Publisher : Springer Science & Business Media
Page : 202 pages
File Size : 42,9 Mb
Release : 2001
Category : Medical
ISBN : 3540677496
This volume is a product of a collaborative effort and attempts to provide a wide and up-to-date coverage of information regarding the biology and on the potential application of immunostimulatory DNA. ISS hold great promise for influencing the immune response and the authors anticipate that the high efficacy and low toxicity observed in animal models will translate into success in a variety of human clinical applications.
Author : Charles Dudley Mills,Laurel L Lenz,Klaus Ley
Publisher : Frontiers Media SA
Page : 281 pages
File Size : 50,9 Mb
Release : 2015-03-23
Category : Immunologic diseases
ISBN : 9782889194995
Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.
Author : Gloria H. Heppner,Amy M. Fulton
Publisher : CRC Press
Page : 224 pages
File Size : 49,6 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000012972
First Published in 1988, this book offers a full, comprehensive guide into the relationship between macrophages and Cancer. Carefully compiled and filled with a vast repertoire of notes and references this book serves as a useful reference for Students of Medicine, Oncology and other practitioners in their respective fields.
Author : Malgorzata Kloc
Publisher : Springer
Page : 376 pages
File Size : 50,9 Mb
Release : 2017-04-26
Category : Medical
ISBN : 9783319540900
This volume gives a state-of-the-art overview on macrophage functions in various invertebrate and vertebrate systems and diseases. It also covers various aspects of macrophage development and formation, behavior and response to nano- and biomaterials, the latter of which have become very important components of modern medicine. Macrophages are evolutionarily conserved phagocytotic cells. In recent years macrophages have emerged as one of the most versatile cells of immune system, which, depending on the milieu and circumstance, participate in development or inhibition of cancer, regeneration, wound healing, inflammation, organ rejection and interaction between mother and a fetus. This book will be of particular interest to researchers working in immunology, cancer research, developmental biology, or related fields.
Author : Bruce Spiegelman
Publisher : Springer
Page : 108 pages
File Size : 55,5 Mb
Release : 2018-03-07
Category : Science
ISBN : 9783319727905
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Author : Robert D. Stout,Jill Suttles
Publisher : Unknown
Page : 189 pages
File Size : 53,9 Mb
Release : 1995-01-01
Category : Cell interaction
ISBN : 3540594892
Describes the progress that has been made in the understanding of how macrophages are activated to display inflammatory and effector function, beginning with a definition of what is meant by macrophage activation, and progressing through the LPS plus IFN(gamma) model for macrophage activation to the unraveling of how T cells may interact with, and activate effector function in, antigen presenting macrophages. Annotation copyright by Book News, Inc., Portland, OR
