Magic Bullets Miracle Drugs And Microbiologists

Author : William C. Summers
Publisher : John Wiley & Sons
Page : 151 pages
File Size : 53,5 Mb
Release : 2024-05-08
Category : Science
ISBN : 9781683674795

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Magic Bullets, Miracle Drugs, and Microbiologists by William C. Summers Pdf

Magic Bullets, Miracle Drugs, and Microbiologists Magic Bullets, Miracle Drugs, and Microbiologists: A History of the Microbiome and Metagenomics by William C. Summers is an enlightening journey through the fascinating world of microbiology, exploring its history, challenges, and the revolutionary concept of the microbiome. Summers draws from his unique perspective as both a practicing microbiologist and a historian of science, influenced by early microbiological literature and his own extensive career, presenting how our understanding of microbes evolved from concepts of simple germs to complex, essential elements of life. Summers skillfully ties together key players and eras in the microbial sciences into a concise narrative, from early microscopic observations to the revolutionary developments in genetic analysis and metagenomics, highlighting our ever-evolving understanding of the diverse microbial world. Magic Bullets, Miracle Drugs, and Microbiologists is a compelling read for anyone interested in the profound impact of microorganisms on our world. “Bill Summers artfully explains how, over the past century, scientists have synthesized new disciplines and embraced evolving technologies to develop new concepts about how germs behave in microbial communities and what their relationship is to the environment, human health, and epidemic diseases. Skillfully written in engaging prose, this book will be valuable to microbiologists, epidemiologists, medical historians, and geneticists seeking to better understand the historic roots of twenty-first century microbiology.” — Powel H Kazanjian, University of Michigan Medical School and Author of Frederick Novy and the Development of Bacteriology in Medicine

Author : Sebastian G. B. Amyes
Publisher : CRC Press
Page : 272 pages
File Size : 51,9 Mb
Release : 2001-09-13
Category : Medical
ISBN : 9780203303009

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Magic Bullets, Lost Horizons by Sebastian G. B. Amyes Pdf

From the day that Paul Ehrlich hailed his newly discovered treatment for syphilis as the magic bullet, antibiotics have transformed medical practice. They are considered one of the miracle drugs of the 20th century. However, the massive and increasing misuse of these agents is More...causing a problem of resistance that may prove to be one of the greatest threats to health in the 21st century. Magic Bullets, Lost Horizons aims to put some of the media sensationalism into perspective. It examines not only the development of modern antibiotics but also the obstacles faced during application of the drugs and their expected efficacy in the future.

Author : Finn Sandberg
Publisher : Unknown
Page : 128 pages
File Size : 46,9 Mb
Release : 2001
Category : Electronic
ISBN : OCLC:1099334164

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Magic Bullets, Lost Horizons by Finn Sandberg Pdf

An in-depth account of the way antibiotics have transformed medical practice, how certain diseases are developing an increased resistance to available treatments, and how these cases are sensationalized in the media.

Author : Daniel V. Lim
Publisher : Kendall Hunt
Page : 838 pages
File Size : 44,9 Mb
Release : 2003
Category : Science
ISBN : 0787292036

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Microbiology by Daniel V. Lim Pdf

Author : Anonim
Publisher : Academic Press
Page : 4358 pages
File Size : 55,8 Mb
Release : 2009-01-14
Category : Science
ISBN : 9780123739445

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Encyclopedia of Microbiology by Anonim Pdf

Available as an exclusive product with a limited print run, Encyclopedia of Microbiology, 3e, is a comprehensive survey of microbiology, edited by world-class researchers. Each article is written by an expert in that specific domain and includes a glossary, list of abbreviations, defining statement, introduction, further reading and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields. 16 separate areas of microbiology covered for breadth and depth of content Extensive use of figures, tables, and color illustrations and photographs Language is accessible for undergraduates, depth appropriate for scientists Links to original journal articles via Crossref 30% NEW articles and 4-color throughout – NEW!

Author : Azeez, P.A.,Raj, P.P. Nikhil,Mohanraj, R.
Publisher : IGI Global
Page : 320 pages
File Size : 52,8 Mb
Release : 2023-09-25
Category : Medical
ISBN : 9781799894162

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Ecological and Evolutionary Perspectives on Infections and Morbidity by Azeez, P.A.,Raj, P.P. Nikhil,Mohanraj, R. Pdf

The management of infectious diseases demands a deeper understanding of the ecological and socio-economic drivers and needs a holistic and systematic system-thinking approach. Issues such as the ecological and social features of the source of the disease-causing organisms, the landscape, and how such organisms invade larger distribution ranges need to be sufficiently understood. The remedial measures must be handled from the perspectives of ecology, evolution, epidemiology, socioeconomics, forestry practices, and agriculture from the viewpoint of systems thinking and complex interactions. It is a paradigm shift from the current reductionist disease management. Ecological and Evolutionary Perspectives on Infections and Morbidity addresses human diseases from a holistic perspective by looking at morbidity from an ecological viewpoint and highlights the need for a wider perspective in healthcare that focuses on more than managing diseases and relieving the individual patients from suffering. Covering a range of topics such as antiviral research and human health, this reference work is ideal for healthcare professionals, academicians, policymakers, practitioners, scholars, researchers, instructors, and students.

Author : Donald R. Kirsch,Ogi Ogas
Publisher : Simon and Schuster
Page : 328 pages
File Size : 55,8 Mb
Release : 2016-12-13
Category : Science
ISBN : 9781628727197

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The Drug Hunters by Donald R. Kirsch,Ogi Ogas Pdf

The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

Author : Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publisher : Academic Press
Page : 434 pages
File Size : 49,9 Mb
Release : 2020-05-15
Category : Medical
ISBN : 9780128184813

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Drug Discovery Targeting Drug-Resistant Bacteria by Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta Pdf

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Author : Bernard Dixon
Publisher : Unknown
Page : 264 pages
File Size : 43,9 Mb
Release : 1978
Category : Chemotherapy
ISBN : UOM:39015003221630

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Beyond the Magic Bullet by Bernard Dixon Pdf

Author : Parija
Publisher : Elsevier India
Page : 688 pages
File Size : 55,7 Mb
Release : 2009
Category : Microbiology
ISBN : 8131221636

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Textbook of Microbiology & Immunology by Parija Pdf

This book provides an up-to-date information on microbial diseases which is an emerging health problem world over.This book presents a comprehensive coverage of basic and clinical microbiology, including immunology, bacteriology, virology, and mycology, in a clear and succinct manner.The text includes morphological features and identification of each organism along with the pathogenesis of diseases, clinical manifestations, diagnostic laboratory tests, treatment, and prevention and control of resulting infections along with most recent advances in the field. About the Author : - Subhash Chandra Parija, MD, PhD, DSc, FRCPath, is Director-Professor and Head, Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER), Pondicherry, India. Professor Parija, author of more than 200 research publications and 5 textbooks, is the recipient of more than 20 National and International Awards including the most prestigious Dr BC Roy National Award of the Medical Council of India for his immense contribution in the field of Medical Microbiology.

Author : Jian Li,Roger L. Nation,Keith S. Kaye
Publisher : Springer
Page : 366 pages
File Size : 44,6 Mb
Release : 2019-07-30
Category : Science
ISBN : 9783030163730

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Polymyxin Antibiotics: From Laboratory Bench to Bedside by Jian Li,Roger L. Nation,Keith S. Kaye Pdf

This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’.

Author : Lorenzo Servitje
Publisher : State University of New York Press
Page : 419 pages
File Size : 51,6 Mb
Release : 2021-02-01
Category : Literary Criticism
ISBN : 9781438481692

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Medicine Is War by Lorenzo Servitje Pdf

Medicine is most often understood through the metaphor of war. We encounter phrases such as "the war against the coronavirus," "the front lines of the Ebola crisis," "a new weapon against antibiotic resistance," or "the immune system fights cancer" without considering their assumptions, implications, and history. But there is nothing natural about this language. It does not have to be, nor has it always been, the way to understand the relationship between humans and disease. Medicine Is War shows how this "martial metaphor" was popularized throughout the nineteenth century. Drawing on the works of Mary Shelley, Charles Kingsley, Bram Stoker, Arthur Conan Doyle, and Joseph Conrad, Lorenzo Servitje examines how literary form reflected, reinforced, and critiqued the convergence of militarism and medicine in Victorian culture. He considers how, in migrating from military medicine to the civilian sphere, this metaphor responded to the developments and dangers of modernity: urbanization, industrialization, government intervention, imperial contact, crime, changing gender relations, and the relationship between the one and the many. While cultural and literary scholars have attributed the metaphor to late nineteenth-century germ theory or immunology, this book offers a new, more expansive history stretching from the metaphor's roots in early nineteenth-century militarism to its consolidation during the rise of early twentieth-century pharmacology. In so doing, Servitje establishes literature's pivotal role in shaping what war has made thinkable and actionable under medicine's increasing jurisdiction in our lives. Medicine Is War reveals how, in our own moment, the metaphor remains conducive to harming as much as healing, to control as much as empowerment.

Author : William Jackson Payne,Dean R. Brown
Publisher : Unknown
Page : 260 pages
File Size : 44,9 Mb
Release : 1968
Category : Microbiology
ISBN : MINN:31951000123213Q

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Microbiology by William Jackson Payne,Dean R. Brown Pdf

Author : Lois N. Magner
Publisher : CRC Press
Page : 456 pages
File Size : 52,6 Mb
Release : 2002-08-13
Category : Science
ISBN : 9780824743604

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A History of the Life Sciences, Revised and Expanded by Lois N. Magner Pdf

A clear and concise survey of the major themes and theories embedded in the history of life science, this book covers the development and significance of scientific methodologies, the relationship between science and society, and the diverse ideologies and current paradigms affecting the evolution and progression of biological studies. The author discusses cell theory, embryology, physiology, microbiology, evolution, genetics, and molecular biology; the Human Genome Project; and genomics and proteomics. Covering the philosophies of ancient civilizations to modern advances in genomics and molecular biology, the book is a unique and comprehensive resource.

Author : Christiane Nockels Fabbri
Publisher : Bloomsbury Publishing USA
Page : 173 pages
File Size : 49,6 Mb
Release : 2016-11-28
Category : Medical
ISBN : 9798216087403

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From Anesthesia to X-Rays by Christiane Nockels Fabbri Pdf

Easy to read and to use, this A-to-Z mini-encyclopedia covers the most important medical innovations of the last 200 years. Medical innovation is an extremely important topic—and one to which relatively little study has been devoted. This volume is designed to introduce readers to the history and development of key advances in the science and practice of medicine. It explores issues in medical history and provides perspective on contemporary scientific research and innovation. It also provides a backdrop against which to evaluate current headlines, such as the discoveries of live samples of smallpox virus in an unused storage room at the National Institutes of Health (NIH) and incidents of bubonic plague in China and Colorado. Although the entries in this single-volume resource describe how each innovation works, this is not intended as a technical text. Instead, the focus is on the context in which each innovation was developed and on its lasting importance in the field of medicine. Through these fascinating accounts, readers will be able to trace the evolution and legacy of key innovations and to see how other sectors of society—such as industry and the military—have affected and been affected by advances in the field of medicine.