Management Of Hereditary Colorectal Cancer

Author : Jose G. Guillem,Garrett Friedman
Publisher : Springer Nature
Page : 213 pages
File Size : 49,6 Mb
Release : 2020-04-02
Category : Medical
ISBN : 9783030262341

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Management of Hereditary Colorectal Cancer by Jose G. Guillem,Garrett Friedman Pdf

This book provides a comprehensive review of the clinical management of hereditary colorectal cancer. The text focuses on six distinct patient groups: patients with early age-of-onset colorectal cancer and adenomas, patients with hamartomatous colorectal polyps, patients afflicted with familial adenomatous polyposis (FAP), patients with attenuated familial adenomatous polyposis (AFAP), patients with MYH associated polyposis (MAP), and patients afflicted with lynch syndrome (LS). Each chapter illustrates how clinicians utilize current technologies in genetic testing, pathological review, and endoscopic, surgical, and chemotherapeutic/immunotherapeutic approaches to manage these patient groups. Topics such as the timing of genetic testing, endoscopic screening and surveillance, prophylactic surgical options and chemo-preventive interventions are also discussed in concise yet precise detail. Written by experts in their fields, Management of Hereditary Colorectal Cancer: A Multidisciplinary Approach is a valuable and timely resource for gastroenterologists, surgeons, genetic counselors, medical oncologists, psychologists, and any health caregivers involved with the management of patients and families afflicted with a hereditary form of colorectal cancer.

Author : Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen
Publisher : Springer Science & Business Media
Page : 630 pages
File Size : 54,7 Mb
Release : 2010-09-10
Category : Medical
ISBN : 144196603X

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Hereditary Colorectal Cancer by Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen Pdf

Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.

Author : Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen
Publisher : Springer Science & Business Media
Page : 630 pages
File Size : 46,8 Mb
Release : 2010-09-10
Category : Medical
ISBN : 144196603X

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Hereditary Colorectal Cancer by Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen Pdf

Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.

Author : Laura Valle,Stephen B. Gruber,Gabriel Capellá
Publisher : Springer
Page : 505 pages
File Size : 48,5 Mb
Release : 2018-05-04
Category : Medical
ISBN : 9783319742595

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Hereditary Colorectal Cancer by Laura Valle,Stephen B. Gruber,Gabriel Capellá Pdf

This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

Author : John D. Potter,Noralane M. Lindor
Publisher : Springer
Page : 309 pages
File Size : 50,6 Mb
Release : 2008-12-08
Category : Medical
ISBN : 0387095675

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Genetics of Colorectal Cancer by John D. Potter,Noralane M. Lindor Pdf

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Author : Éanna Ryan,Desmond Winter
Publisher : Cambridge Scholars Publishing
Page : 525 pages
File Size : 43,5 Mb
Release : 2022-10-17
Category : Medical
ISBN : 9781527587359

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Hereditary and Familial Colorectal Cancer by Éanna Ryan,Desmond Winter Pdf

This book describes the historical context of colorectal cancer predisposition syndromes and the latest knowledge relating to each of the known hereditary colorectal cancer predisposition syndromes. There is a particular focus on the management of each of these syndromes in turn, including medical and surgical management, cancer surveillance, and screening recommendations. It also explores the workings of specialised hereditary and familial cancer clinics from the perspectives of the various clinicians involved in the running of the service. Multidisciplinary management, universal tumour screening, risk estimation, the obtaining and use of genetic information, and appropriate high-risk population screening and surveillance are also discussed, as are future developments and how these may relate to this exciting and evolving field.

Author : Fred H. Menko
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 49,8 Mb
Release : 1993-07-31
Category : Medical
ISBN : 0792321006

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Genetics of Colorectal Cancer for Clinical Practice by Fred H. Menko Pdf

Colorectal cancer is a collective term for a heterogeneous group of diseases. In a large proportion of cases, the condition is attributable to genetic predisposition. Those directly involved in the treatment of patients with cancer of the large bowel are confronted to an increasing degree with the genetic aspects of the disease. In familial and hereditary forms of the disorder periodic screening of the close relatives of the patients can in principle prevent disease and death from colorectal cancer. Presymptomatic diagnosis by means of DNA technology is now possible in many cases of familial adenomatous polyposis. Genetic diagnosis will be increasingly important for the identification of high-risk groups. This book summarizes those aspects of the genetics of colorectal cancer that are important for clinical pracice. It has been stated that clinicians can contribute to the goal of reducing mortality from cancer by asking each patient about his or her family history of cancer. The aim of this book is to provide a guideline for the management of those situations in which the family history of colorectal cancer is found to be positive.

Author : Hideyuki Ishida,Keiji Koda
Publisher : Springer
Page : 144 pages
File Size : 50,5 Mb
Release : 2018-12-31
Category : Medical
ISBN : 9789811330506

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Recent Advances in the Treatment of Colorectal Cancer by Hideyuki Ishida,Keiji Koda Pdf

This book examines the latest indications and techniques for various endoscopic and surgical colorectal cancer treatments, discussing not only on the standard lymph node dissection technique, but also on laparoscopic and robotic surgery. It particularly focuses on the treatment of rectal cancer, with chapters on radiation therapy and sphincter preservation, which is analyzed from Asian perspectives that differ from those of Western treatment. Further, it presents the results of combining chemotherapy and oral drugs, as well as the treatment of hereditary cancer using next-generation sequencing for genetic diagnosis. Edited by surgeons who have pioneered the research and treatment of colorectal cancer, Recent Advances in the Treatment of Colorectal Cancer presents extensive information for clinicians such as endoscopic surgeons, colorectal surgeons, as well as oncologists and researchers specializing in this field. Providing a foundation for new ideas, it enables advanced surgeons to further develop their skills and offers thought-provoking, instructive and informative reading for residents, students and medical staff.

Author : Joji Utsunomiya,Henry T. Lynch
Publisher : Springer Science & Business Media
Page : 564 pages
File Size : 53,9 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9784431683377

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Hereditary Colorectal Cancer by Joji Utsunomiya,Henry T. Lynch Pdf

Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.

Author : Nereo Segnan,Julietta Patnick,Lawrence von Karsa
Publisher : Unknown
Page : 452 pages
File Size : 45,9 Mb
Release : 2010
Category : Colon (Anatomy)
ISBN : UCSD:31822036616274

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European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis by Nereo Segnan,Julietta Patnick,Lawrence von Karsa Pdf

Recoge: 1. Introduction -- 2. Organisation -- Guiding principles for organising a colorectal cancer screening programme -- 3. Evaluation and interpretation of screening outcomes -- 4. Faecal occult blood testing -- 5. Quality assurance in endoscopy in colorectal cancer screening and diagnosis -- 6. Professional requirements and training -- 7. Quality assurance in pathology in colorectal cancer screening and diagnosis -- 8. Management of lesions detected in colorectal cancer screening -- 9. Colonoscopic surveillance following adenoma removal --10. Communication -- Appendices.

Author : C. Richard Boland, MD
Publisher : AuthorHouse
Page : 330 pages
File Size : 42,7 Mb
Release : 2015-08-30
Category : Biography & Autobiography
ISBN : 9781504928670

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Cancer Family by C. Richard Boland, MD Pdf

It is 1946, and a young man stares out his third-story apartment window. He has returned from the war with metastatic cancer and assumes he will die, leaving his wife and infant daughter behind. Instead, he lives another twenty-four years, raising a family of four children, before he succumbs to a second colon cancer. His son, the author, recognizes that there is a hereditary cancer syndrome in the family and resolves to solve the problem as a medical researcher. Eventually, hereditary colorectal cancer is recognized as a medical entity, and multiple genes responsible for this hereditary condition are isolated. However, the mutation responsible in the author’s family escaped detection. In 2001, his laboratory identifies the mutation responsible for the problem and develops a specific test for the family. This permits the mutation carriers to obtain life-saving care, altering the natural history of the disease for his family and others.

Author : Joseph Anderson, MD,Charles Kahi, MD
Publisher : Springer Science & Business Media
Page : 205 pages
File Size : 52,5 Mb
Release : 2011-04-23
Category : Medical
ISBN : 9781607613985

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Colorectal Cancer Screening by Joseph Anderson, MD,Charles Kahi, MD Pdf

Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines. Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer.

Author : Matjaž Vogelsang
Publisher : Springer
Page : 0 pages
File Size : 43,6 Mb
Release : 2013-05-25
Category : Medical
ISBN : 9400765967

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DNA Alterations in Lynch Syndrome by Matjaž Vogelsang Pdf

Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.

Author : Anonim
Publisher : Unknown
Page : 599 pages
File Size : 42,6 Mb
Release : 1990
Category : Electronic
ISBN : OCLC:320716113

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Hereditary Colorectal Cancer by Anonim Pdf

Author : Jindong Chen
Publisher : BoD – Books on Demand
Page : 130 pages
File Size : 43,6 Mb
Release : 2018-05-16
Category : Medical
ISBN : 9781789231007

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Colorectal Cancer by Jindong Chen Pdf

With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.