Management Of Peritoneal Metastases Cytoreductive Surgery Hipec And Beyond

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Management of Peritoneal Metastases- Cytoreductive Surgery, HIPEC and Beyond

Aditi Bhatt
Management of Peritoneal Metastases Cytoreductive Surgery HIPEC and Beyond Book PDF

Author : Aditi Bhatt
Publisher : Springer
Page : 580 pages
File Size : 48,6 Mb
Release : 2018-04-02
Category : Medical
ISBN : 9789811070532

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Management of Peritoneal Metastases- Cytoreductive Surgery, HIPEC and Beyond by Aditi Bhatt Pdf

The widespread acceptance among the oncology community at large of cytoreductive surgery and HIPEC as a potentially curative treatment for peritoneal metastases has paved the way for innovative new therapies that could benefit a larger proportion of patients. Much has been and continues to be published on this subject. This book provides comprehensive reviews on the various aspects of managing peritoneal metastases. The authors highlight essential practical issues that surgical oncologists encounter in their day-to-day practice, and try to before provide evidence based answers to address them. All chapters were written and/or reviewed by leading experts in this field.

Management of Peritoneal Surface Malignancies. (Cytoreductive Surgery, HIPEC, PIPAC, and Beyond)

Amine Souadka,Naoual Bakrin
Management of Peritoneal Surface Malignancies Cytoreductive Surgery HIPEC PIPAC and Beyond Book PDF

Author : Amine Souadka,Naoual Bakrin
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 40,9 Mb
Release : 2024-04-05
Category : Medical
ISBN : 9782832546703

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Management of Peritoneal Surface Malignancies. (Cytoreductive Surgery, HIPEC, PIPAC, and Beyond) by Amine Souadka,Naoual Bakrin Pdf

Peritoneal surface malignancies (PSM) include a heterogeneous group of primary tumors, like peritoneal mesothelioma, and peritoneal metastases from various origins such as ovarian, gastric, colorectal, or appendicular cancers. Their pathophysiology is complex and still not fully elucidated. Historically, due to their dismal prognosis, peritoneal surface malignancies were considered a terminal condition and treated as such in palliative intent.. Surgery has become pivotal in the treatment of PSM and the development of specific techniques of cytoreductive surgery (peritonectomies, “en-bloc” resection) open up a new era of curative intent treatments.

Peritoneal Surface Malignancies

Emel Canbay,Yutaka Yonemura
Peritoneal Surface Malignancies Book PDF

Author : Emel Canbay,Yutaka Yonemura
Publisher : Springer
Page : 109 pages
File Size : 54,9 Mb
Release : 2015-07-09
Category : Medical
ISBN : 9783319129372

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Peritoneal Surface Malignancies by Emel Canbay,Yutaka Yonemura Pdf

This book has been designed to provide the full description of the comprehensive management of peritoneal surface malignancies as a new emerging specialty. Combined treatment of cytoreductive surgery (CRS) and hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) introduced by our leader Paul H. Sugarbaker are performed to treat peritoneal metastases by surgeons all around the world. Therefore this book is focused on detailed surgical anatomy of the peritoneum, preoperative clinical assessment of the peritoneal surface malignancy, patient preparation and operation room equipments, different surgical procedures for CRS and reconstruction, intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) and neoadjuvant intraperitoneal chemotherapy, early postoperative intraperitoneal chemotherapy (EPIC) and molecular basis of peritoneal surface malignancies. The chapter on molecular mechanisms of the formation of peritoneal carcinomatosis provides insight into a rapidly expanding knowledge within this speciality. This book should be valuable for surgical oncologists who deal with multimodal treatment for peritoneal surface malignancies, as well as for the trained peritonectomy surgeons. For the senior surgeons, it will also introduce new techniques and approaches in this field such as dealing with the omental cakes and massive organ involvement that requires multi-organ resection.

Cancer Regional Therapy

Yuman Fong,T. Clark Gamblin,Ernest S. Han,Byrne Lee,Jonathan S. Zager
Cancer Regional Therapy Book PDF

Author : Yuman Fong,T. Clark Gamblin,Ernest S. Han,Byrne Lee,Jonathan S. Zager
Publisher : Springer Nature
Page : 490 pages
File Size : 42,6 Mb
Release : 2019-12-10
Category : Medical
ISBN : 9783030288914

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Cancer Regional Therapy by Yuman Fong,T. Clark Gamblin,Ernest S. Han,Byrne Lee,Jonathan S. Zager Pdf

This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field. Cancer Regional Therapy summarizes the history, current technology, common procedures, and future prospects in this field and includes procedures from many surgical and interventional radiologic disciplines.

Treatment of Peritoneal Metastasis, An Issue of Surgical Oncology Clinics of North America, E-Book

Edward A. Levine
Treatment of Peritoneal Metastasis An Issue of Surgical Oncology Clinics of North America E Book Book PDF

Author : Edward A. Levine
Publisher : Elsevier Health Sciences
Page : 209 pages
File Size : 43,9 Mb
Release : 2018-06-30
Category : Medical
ISBN : 9780323610834

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Treatment of Peritoneal Metastasis, An Issue of Surgical Oncology Clinics of North America, E-Book by Edward A. Levine Pdf

This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Edward A. Levine, is devoted to Treatment of Peritoneal Metastasis. Dr. Levine has assembled expert authors to review the following topics: History of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy; Imaging for peritoneal metastases; Patient selection for cytoreductive surgery; Pharmacodynamics and pharmacokinetics of intraperitoneal chemotherapy; Genomics and peritoneal metastases; Techniques and safety issue for intraperitoneal chemotherapy; Learning curve for cytoreductive surgery; Peritoneal metastases from gastric cancer; Peritoneal metastases from mesothelioma; Peritoneal metastases from appendiceal cancer; Peritoneal metastasis from colorectal cancer; Peritoneal metastases from ovarian cancer; Palliative care of advanced peritoneal disease; and more!

Peritoneal Carcinomatosis: Principles of Management

Paul H. Sugarbaker
Peritoneal Carcinomatosis Principles of Management Book PDF

Author : Paul H. Sugarbaker
Publisher : Springer Science & Business Media
Page : 434 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461312475

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Peritoneal Carcinomatosis: Principles of Management by Paul H. Sugarbaker Pdf

Paul Sugarbaker and his colleagues have persevered in the study and treat ment of peritoneal carcinomatosis. The peritoneal cavity has many unique and incompletely appreciated properties. These properties, coupled with the biologic behavior of many cancers, results in the seeding and growth of these cancers on the peritoneum. Many of these cancers remain localized to the peritoneum only, never metastasizing to other sites. One possible reason for this may be the obstruction of the afferent lymphatics on the undersurface of the diaphragm. The mucopolysaccharides produced by many of these neoplasma are probably viscous enough to obstruct these lymphatics, leading to the syndrome of pseudomyxoma peritonei. Many of the neoplasms taking residence on the peritoneum have extremely long cell-cycle times and are resistant to radiotherapy and many chemotherapeutic agents. How ever, much can be done for these patients - resection of primary cancers, omentectomies to reduce ascites formation, management of recurrent ascites, management of intestinal obstruction, nutritional care, and, hopefully, intraperitoneal chemotherapy. We have reviewed many of these problems in the past [1-7]. Dr. Sugarbaker and his colleagues have organized the current state of knowledge and technology for continuing use. The book provides a basis for thoughtful, prospective research planning. John S. Spratt, M. D. , F. A. C. S. Professor of Surgery The James Graham Brown Cancer Center University of Louisville Louisville, Kentucky References 1. Long RTL, Spratt JS, Dowling E.

Peritoneal Tumors and Metastases

Beate Rau,Alfred Königsrainer,Faheez Mohamed,Paul H. Sugarbaker
Peritoneal Tumors and Metastases Book PDF

Author : Beate Rau,Alfred Königsrainer,Faheez Mohamed,Paul H. Sugarbaker
Publisher : Springer Nature
Page : 407 pages
File Size : 48,8 Mb
Release : 2021-05-13
Category : Medical
ISBN : 9783030626402

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Peritoneal Tumors and Metastases by Beate Rau,Alfred Königsrainer,Faheez Mohamed,Paul H. Sugarbaker Pdf

This book provides surgeons and oncologists with a well-founded and detailed overview of the available treatment options for peritoneal malignancy and differential selection of the appropriate forms of therapy. Systemic chemotherapy options are also considered, as are surgical cytoreduction (CRS) and all forms of intraperitoneal chemotherapy (IPC) especially hyperthermic IPC (HIPEC), and immunotherapy, including specific procedures such as PIPAC. Subsequent chapters address perioperative care, complications and recurrences, as well as psycho-oncological, palliative medical and nursing care. The process of parietal and visceral peritonectomy in the large and small intestine is additionally illustrated by three video clips accessible online. Covering a broad range of aspects, including peritoneal metastasis and intraperitoneal chemotherapy, the book offers a valuable tool for surgeons, oncologists and anesthesiologists alike.

Perioperative Chemotherapy

U. Metzger,F. Largiader,H.-J. Senn
Perioperative Chemotherapy Book PDF

Author : U. Metzger,F. Largiader,H.-J. Senn
Publisher : Springer Science & Business Media
Page : 170 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642824326

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Perioperative Chemotherapy by U. Metzger,F. Largiader,H.-J. Senn Pdf

One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.

Treatment of Peritoneal Surface Malignancies

Angelo Di Giorgio,Enrico Pinto
Treatment of Peritoneal Surface Malignancies Book PDF

Author : Angelo Di Giorgio,Enrico Pinto
Publisher : Springer
Page : 396 pages
File Size : 41,5 Mb
Release : 2015-02-14
Category : Medical
ISBN : 9788847057111

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Treatment of Peritoneal Surface Malignancies by Angelo Di Giorgio,Enrico Pinto Pdf

This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authors’ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.

Peritoneal Carcinomatosis: A Multidisciplinary Approach

wim ceelen
Peritoneal Carcinomatosis A Multidisciplinary Approach Book PDF

Author : wim ceelen
Publisher : Springer Science & Business Media
Page : 535 pages
File Size : 55,9 Mb
Release : 2007-03-06
Category : Medical
ISBN : 9780387489933

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Peritoneal Carcinomatosis: A Multidisciplinary Approach by wim ceelen Pdf

This is the first volume to provide a multidisciplinary approach to peritoneal carcinomatosis encompassing molecular mechanisms, histopathology, regional and systemic cytotoxic therapy, and surgical options. Illustrations aid the reader throughout in the many facets of this disease. The book will be of particular interest for medical, surgical and gynecological oncologists faced with the complexities of decision making in patients suffering from PC.

Staging Laparoscopy

P. Hohenberger,K. Conlon
Staging Laparoscopy Book PDF

Author : P. Hohenberger,K. Conlon
Publisher : Springer Science & Business Media
Page : 181 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642562907

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Staging Laparoscopy by P. Hohenberger,K. Conlon Pdf

Included here is a discussion of the pathophysiological aspects and risks of laparoscopic staging (such as trocar metastases) on the basis of international experience.

Peritoneal Carcinomatosis from Ovarian Cancer

Konstantinos N. Chatzigeorgiou,John N. Bontis
Peritoneal Carcinomatosis from Ovarian Cancer Book PDF

Author : Konstantinos N. Chatzigeorgiou,John N. Bontis
Publisher : Nova Science Publishers
Page : 234 pages
File Size : 46,6 Mb
Release : 2005
Category : Metastasis
ISBN : UCLA:L0097728349

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Peritoneal Carcinomatosis from Ovarian Cancer by Konstantinos N. Chatzigeorgiou,John N. Bontis Pdf

Ovarian cancer is the most common cause of death among all gynecological neoplasms. Ovarian epithelial cancer represents approximately 90% of all ovarian malignant tumours. The most usual pattern of spread and probably the earliest kind of metastasis of ovarian cancer is intraperitoneal spread, caused by apoptosis of viable cancer cells, even in cases where the ovarian surface has no visible rupture. Approximately 70% to 75% of all ovarian cancers are being diagnosed with peritoneal carcinomatosis and ascites in advanced stages III and IV. Peritoneal carcinomatosis from ovarian cancer may occur either concomitantly with the primary tumour or as a recurrence pattern of spread. Standard treatment consists of surgical debulking and postoperative systemic chemotherapy. Response rates to first-line chemotherapy with platinum/taxane combinations are high, about 70-80%, but the vast majority of patients will relapse. Peritoneal seeding is a major cause of surgical treatment failure among those patients, even after optimal debulking. However, progressing ovarian cancer tends to remain within the peritoneal cavity or, better-expressed, ovarian cancer is a cancer of the peritoneum. The administration of cytotoxic agents directly into the peritoneal cavity as treatment for malignancy was initially evaluated more than 40 years ago. Over the past two decades regional therapy of ovarian cancer has evolved from just an interesting pharmacokinetic concept into a viable management option for women with advanced disease. Several authors, and among them some of the world's leading experts on this field present the current knowledge and their experience on peritoneal carcinomatosis from ovarian cancer.

Treatment of Peritoneal Surface Malignancies, An Issue of Surgical Oncology Clinics, E-Book

Jesus Esquivel
Treatment of Peritoneal Surface Malignancies An Issue of Surgical Oncology Clinics E Book Book PDF

Author : Jesus Esquivel
Publisher : Elsevier Health Sciences
Page : 219 pages
File Size : 52,8 Mb
Release : 2012-10-30
Category : Medical
ISBN : 9781455754250

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Treatment of Peritoneal Surface Malignancies, An Issue of Surgical Oncology Clinics, E-Book by Jesus Esquivel Pdf

This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. Jesus Esquivel, will focus on the current status and future directions of the treatment of the most common peritoneal surface malignancies: appendix cancer, colorectal cancer, ovarian cancer, gastric cancer, and peritoneal mesothelioma. This issue will also outline some of the most common issues that arise regarding cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC), such as pharmacokinetic rationale of heat and intraperitoneal chemotherapy, HIPEC techniques and safety considerations, how to start a peritoneal surface malignancy program, anesthesia considerations during cytoreductive surgery and HIPEC, patient selection for cytoreductive surgery and HIPEC, and the role of dystemic chemotherapy in the management of peritoneal surface malignancies of appendiceal and colorectal origin.

Textbook of Gastrointestinal Oncology

Suayib Yalcin,Philip A. Philip
Textbook of Gastrointestinal Oncology Book PDF

Author : Suayib Yalcin,Philip A. Philip
Publisher : Springer Nature
Page : 716 pages
File Size : 49,8 Mb
Release : 2019-09-05
Category : Medical
ISBN : 9783030188900

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Textbook of Gastrointestinal Oncology by Suayib Yalcin,Philip A. Philip Pdf

This textbook discusses core principles and practices in gastrointestinal oncology and covers a wide range of practice areas such as pathology and radiologic images, epidemiology, genetics, staging, multidisciplinary management of specific gastrointestinal cancer, and pathology for each primary tumor site. The comprehensive coverage makes Textbook of Gastrointestinal Oncology a useful resource for the practitioner wishing to gain a greater understanding of the principles of managing malignant gastrointestinal disease, as well as medical oncology fellows, surgeons, radiation oncologists, gastroenterologists and fellows, and residents.

Management of Gastric Cancer

Paul H. Sugarbaker
Management of Gastric Cancer Book PDF

Author : Paul H. Sugarbaker
Publisher : Springer Science & Business Media
Page : 405 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461538820

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Management of Gastric Cancer by Paul H. Sugarbaker Pdf

Gastric cancer has been one of the great malignant scourges affecting man kind for as long as medical records have been kept. Until operative resection pioneered by Bilroth and others became available, no effective treatment was feasible and death from cancer was virtually inevitable. Even with resection by total gastrectomy, the chances of tumor eradication remained small. Over recent years, however, the situation has been changing. Some changes have resulted from better understanding of the disease, early detec tion, and better management techniques with applied clinical research, but the reasons for other changes are poorly understood. For example, the incidence of gastric cancer is decreasing, especially in westernized societies, where it has fallen from one of the most common cancers to no longer being in the top five causes of cancer death. Still it remains the number one killer of adult males in Japan and Korea. Whether the reduced incidence in western societies is a result of dietary changes or methods of food preservation, or some other reason, is as yet uncertain. Improvements in outcome have been reported from mass screening and early detection; more refined techniques of establishing early diagnosis, tumor type, and tumor extent; more radical surgical resection; and resection at earlier stages of disease.