Material Based Mechanobiology

Author : Jun Nakanishi,Koichiro Uto
Publisher : Royal Society of Chemistry
Page : 365 pages
File Size : 49,7 Mb
Release : 2022-08-12
Category : Technology & Engineering
ISBN : 9781839161858

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Material-based Mechanobiology by Jun Nakanishi,Koichiro Uto Pdf

This book focuses on recent progress in mechanobiology from the materials science perspective, encompassing innovative material designs for force measurements and actuation to resolve dynamic mechanobiology and mechanoarchitectonics, by better mimicking physiologically relevant and time-evolving cellular mechanical environments. It also shows the marriage between cutting-edge materials science which enable spatiotemporal manipulation of material and cell dynamics in multi-dimensions and molecular biological techniques such as genome editing and next generation sequencing for cell fate/motility engineering and disease modelling, with the aim of providing valuable insights into the latest technological advances and discoveries in areas such as stem cell, fibroblast, heart, tumour, and epithelial mechanobiology.

Author : Jun Nakanishi,Koichiro Uto
Publisher : Royal Society of Chemistry
Page : 365 pages
File Size : 44,7 Mb
Release : 2022-08-12
Category : Technology & Engineering
ISBN : 9781839165382

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Material-based Mechanobiology by Jun Nakanishi,Koichiro Uto Pdf

Mechanobiology is a new research field that investigates how the physical forces and changes in mechanical properties of cells and tissues contribute to their development, physiology and disease. One unique feature in the mechanical regulation, distinct from chemical/biochemical one, is that it can directly react with the multi-layered architectures of living systems, ranging from nano-scale proteins, subcellular organelles, cells, tissues, organs to whole bodies; one could term it “mechanoarchitectonics”. Another important aspect is its time-dependent dynamic feature. Not only time evolution in cells and extracellular matrices, but their intrinsic viscoelastic nature makes mechanical interaction dissipative and such feature is critical in cellular mechanical responses. This book focuses on recent progress in mechanobiology from the materials science perspective, encompassing innovative material designs for force measurements and actuation to resolve dynamic mechanobiology and mechanoarchitectonics, by better mimicking physiologically relevant and time-evolving cellular mechanical environments. It also shows the marriage between cutting-edge materials science which enable spatiotemporal manipulation of material and cell dynamics in multi-dimensions and molecular biological techniques such as genome editing and next generation sequencing for cell fate/motility engineering and disease modelling, with the aim of providing valuable insights into the latest technological advances and discoveries in areas such as stem cell, fibroblast, heart, tumour, and epithelial mechanobiology. Edited by leaders in the field, this book will be suitable for a broad range of readers, including materials scientists, biomaterial and biomedical engineering researchers and those working in chemical and mechanical engineering to expand possibilities of system designs for the developments of medical technologies based on mechanobiology.

Author : Kuruvilla Joseph,Runcy Wilson,Gejo George,Saritha Appukuttan
Publisher : Royal Society of Chemistry
Page : 291 pages
File Size : 48,8 Mb
Release : 2023-06-14
Category : Technology & Engineering
ISBN : 9781839165351

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Lignin-based Materials by Kuruvilla Joseph,Runcy Wilson,Gejo George,Saritha Appukuttan Pdf

Providing a neat overview of the current research for the biomaterials science community, this book is a one-stop resource for researchers and practitioners working on lignin-based biomaterials..

Author : Ronen Zaidel-Bar
Publisher : Springer Nature
Page : 337 pages
File Size : 47,7 Mb
Release : 2023-01-01
Category : Sports & Recreation
ISBN : 9781071628515

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Mechanobiology by Ronen Zaidel-Bar Pdf

This detailed book collects methodologies exploring mechanobiology, the involvement of mechanical forces in cell fate specification and in controlling single and collective cell behaviors such as directed migration, morphogenesis, wound healing, and the immune response. The volume features methods to quantify the mechanical properties of cells and adhesion proteins, to expose cells to external mechanical forces, to quantitatively characterize mechano-responses at various scales, to measure forces applied by cells on the extracellular matrix, as well as chapters on force measurement inside cells, probing cell signaling and gene expression in response to force, and biophysical modeling of cell shape and protein dynamics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary material and reagents, step-by-step and readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mechanobiology: Methods and Protocols aims to provide meaningful tools for cell and developmental biologists approaching the study of cell and tissue dynamics from a mechanobiological perspective, molecular biologists interested in the effects of force on proteins, as well as for cancer biologists and biophysicists.

Author : Sougata Jana,Subrata Jana,Abraham J Domb
Publisher : Royal Society of Chemistry
Page : 603 pages
File Size : 41,6 Mb
Release : 2022-10-14
Category : Technology & Engineering
ISBN : 9781839164989

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Polysaccharide-based Biomaterials by Sougata Jana,Subrata Jana,Abraham J Domb Pdf

With contributions from around the world, the editors have pulled together a tightly curated set of chapters which showcase how polysaccharide-based materials are employed in a range of biomedical systems.

Author : Jessica O Winter,Shreyas Rao
Publisher : Royal Society of Chemistry
Page : 376 pages
File Size : 45,9 Mb
Release : 2022-12-07
Category : Technology & Engineering
ISBN : 9781839166020

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Biomaterial Based Approaches to Study the Tumour Microenvironment by Jessica O Winter,Shreyas Rao Pdf

The tumour microenvironment is increasingly recognized as an important contributor to cancer progression and treatment. However, most cancer studies continue to be performed in 2D tissue culture dishes that do not capture the characteristics of the tumour niche. This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies, including scaffold design and synthesis, chemical signalling and delivery, and co-culture, microfluidics, and organ-on-a-chip tools that can be used to mimic tumour microenvironment features. This book also includes discussion of emerging imaging methods compatible with tumour microenvironment mimicking biomaterials and discusses applications of such models in immuno-oncology, metastasis, and drug screening. Edited by two leaders in the field, this book will appeal to graduate students and researchers working in biomaterials science, chemical and biomedical engineering departments.

Author : Amit Gefen
Publisher : Springer Science & Business Media
Page : 562 pages
File Size : 43,9 Mb
Release : 2010-12-02
Category : Technology & Engineering
ISBN : 9783642142185

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Cellular and Biomolecular Mechanics and Mechanobiology by Amit Gefen Pdf

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Author : Jagan Mohan Dodda,Kalim Deshmukh,Deon Bezuidenhout
Publisher : Royal Society of Chemistry
Page : 677 pages
File Size : 48,7 Mb
Release : 2023-05-22
Category : Science
ISBN : 9781839167270

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Multicomponent Hydrogels by Jagan Mohan Dodda,Kalim Deshmukh,Deon Bezuidenhout Pdf

This book critically discusses the fundamental chemistry, synthesis, characterisation, physiochemical and biological properties of various types of multicomponent hydrogels. It reviews the different strategies employed in designing and synthesizing cutting-edge multicomponent hydrogels and their key applications in biomedical fields.

Author : Christopher R. Jacobs,Hayden Huang,Ronald Y. Kwon
Publisher : Garland Science
Page : 350 pages
File Size : 52,9 Mb
Release : 2012-11-16
Category : Medical
ISBN : 9781135042653

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Introduction to Cell Mechanics and Mechanobiology by Christopher R. Jacobs,Hayden Huang,Ronald Y. Kwon Pdf

Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical prope

Author : Jiro Nagatomi,Eno Essien Ebong
Publisher : CRC Press
Page : 705 pages
File Size : 41,7 Mb
Release : 2018-12-07
Category : Medical
ISBN : 9780429816741

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Mechanobiology Handbook, Second Edition by Jiro Nagatomi,Eno Essien Ebong Pdf

Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

Author : Seungman Park,Yun Chen
Publisher : Morgan & Claypool Publishers
Page : 135 pages
File Size : 52,6 Mb
Release : 2019-11-06
Category : Science
ISBN : 9781643273921

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Mechanics of Biological Systems by Seungman Park,Yun Chen Pdf

This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales – molecular, cellular, and tissue levels – sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

Author : Khawaja H. Haider
Publisher : Springer Nature
Page : 1422 pages
File Size : 43,9 Mb
Release : 2024-06-07
Category : Electronic
ISBN : 9789819971190

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Handbook of Stem Cell Applications by Khawaja H. Haider Pdf

Author : Damien Lacroix,Marzia Brunelli,Cécile Perrault,Adrien Baldit,Maryam Shariatzadeh,Ana Campos Marin,Andre Castro,Sara Barreto
Publisher : Springer
Page : 203 pages
File Size : 44,5 Mb
Release : 2018-07-31
Category : Science
ISBN : 9789811080753

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Multiscale Mechanobiology in Tissue Engineering by Damien Lacroix,Marzia Brunelli,Cécile Perrault,Adrien Baldit,Maryam Shariatzadeh,Ana Campos Marin,Andre Castro,Sara Barreto Pdf

This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.

Author : Amit Gefen
Publisher : Springer
Page : 562 pages
File Size : 45,6 Mb
Release : 2011-03-03
Category : Technology & Engineering
ISBN : 3642142192

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Cellular and Biomolecular Mechanics and Mechanobiology by Amit Gefen Pdf

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Author : Guoying Gu,Herbert Shea,Stefan Seelecke,Gursel Alici,Gianluca Rizzello
Publisher : Frontiers Media SA
Page : 167 pages
File Size : 53,9 Mb
Release : 2021-06-17
Category : Technology & Engineering
ISBN : 9782889669356

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Soft Robotics based on Electroactive Polymers by Guoying Gu,Herbert Shea,Stefan Seelecke,Gursel Alici,Gianluca Rizzello Pdf