Mechanobiology

Author : J. F. Stoltz
Publisher : IOS Press
Page : 758 pages
File Size : 41,8 Mb
Release : 2004
Category : Medical
ISBN : 1586034367

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Mechanobiology by J. F. Stoltz Pdf

Mechanobiology is now a vigorous branch of biomechanics and biorheology which is mainly concerned with the study of the influence of mechanical forces on cells and tissues and their clinical or therapeutical applications. As we are now at the age of proteomics and genomics and of cell micromechanical approaches, using methods like laser tweezers or confocal microscopy, mechanobiology brings new challenges. With these new researches, mechanobiology is the promise of new diagnostic and therapeutic approaches. T to the system under scrutiny and that stresses are implicated in tissue physiology (for example by the production of the extracellular matrix), secretions (i.e. production of NO and prostaglandins by endothelial cells), or for the induction of specific functions via intercellular communication; hence the interest from pharmacology in studies on new molecules. Moreover, these new findings have led to the development of tissue engineering, which is the concept of substitute tissue developed in vitro, from bioresorbable or non-bioresorbable scaffolds and from cells harvested in a physiologic mechanical environment such as from cartilage, bone and vessels. At the same time, the problem of cell grafting in tissue repair and especially the use of stem cells have led to new therapeutic fields.

Author : Van C. Mow,Rik Huiskes
Publisher : Lippincott Williams & Wilkins
Page : 746 pages
File Size : 50,6 Mb
Release : 2005
Category : Medical
ISBN : 0781739330

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Basic Orthopaedic Biomechanics & Mechano-biology by Van C. Mow,Rik Huiskes Pdf

Biomaterials / Ahmed El-Ghannam and Paul Ducheyne -- Biomechanics of the spine / Ian A. F. Stokes and James C. Iatridis -- Biomechanics of fracture fixation and fracture healing / Lutz E. Claes and Keita Ito -- Biomechanics and preclinical testing of artificial joints: the hip / Rik Huiskes and Jan Stolk -- Biomechanics of total knee replacement designs / Peter S. Walker.

Author : Jiro Nagatomi,Eno Essien Ebong
Publisher : CRC Press
Page : 960 pages
File Size : 53,5 Mb
Release : 2018-12-07
Category : Medical
ISBN : 9780429816734

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Mechanobiology Handbook, Second Edition by Jiro Nagatomi,Eno Essien Ebong Pdf

Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

Author : Glen L. Niebur
Publisher : Elsevier
Page : 256 pages
File Size : 53,7 Mb
Release : 2019-12-01
Category : Science
ISBN : 9780128179321

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Mechanobiology by Glen L. Niebur Pdf

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli Provides a review of diseases with known or purported mechanobiological underpinnings Includes the role of mechanobiology in tissue engineering and regenerative medicine Covers experimental methods to capture mechanobiological phenomena

Author : Simon C. F. Rawlinson
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 53,5 Mb
Release : 2017-01-31
Category : Science
ISBN : 9781118966150

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Mechanobiology by Simon C. F. Rawlinson Pdf

An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

Author : Boris Martinac
Publisher : Springer Nature
Page : 134 pages
File Size : 46,9 Mb
Release : 2024-05-13
Category : Electronic
ISBN : 9783031453793

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Mechanobiology by Boris Martinac Pdf

Author : Jiro Nagatomi
Publisher : CRC Press
Page : 566 pages
File Size : 55,7 Mb
Release : 2011-03-15
Category : Medical
ISBN : 9781420091212

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Mechanobiology Handbook by Jiro Nagatomi Pdf

Mechanobiology—the study of the effects of mechanical environments on the biological processes of cells—has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanobiologists aim to create new therapies and further biological understanding by quantifying the mechanical environment of cells and the molecular mechanisms of mechanically induced pathological conditions. To achieve these goals, investigators must be familiar with both the basic concepts of mechanics and the modern tools of cellular/molecular biology. Unfortunately, current literature contains numerous studies that misuse standard mechanical estimations and terminology, or fail to implement appropriate molecular analyses. Therefore, the Mechanobiology Handbook not only presents cutting-edge research findings across various fields and organ systems, but also provides the elementary chapters on mechanics and molecular analysis techniques to encourage cross-field understanding and appropriate planning. Aided by the continuous advancement of research tools in both mechanics and biology, more sophisticated experiments and analyses are possible—thus fueling the growth of the field of mechanobiology. Considering the complexity of the mechanics and the biology of the human body, most of the world of biomechanics remains to be studied. Since the field is still developing, the Mechanobiology Handbook does not force one unified theory, but brings out many different viewpoints and approaches to stimulate further research questions.

Author : Yu Sun,Deok-Ho Kim,Craig A. Simmons
Publisher : Cambridge University Press
Page : 385 pages
File Size : 55,9 Mb
Release : 2015-11-12
Category : Science
ISBN : 9781107078390

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Integrative Mechanobiology by Yu Sun,Deok-Ho Kim,Craig A. Simmons Pdf

Experts describe state-of-the-art micro-nano techniques for cell mechanobiology and introduce the most recent advances in the field.

Author : Larry A. Taber
Publisher : Springer Nature
Page : 545 pages
File Size : 48,7 Mb
Release : 2020-06-15
Category : Technology & Engineering
ISBN : 9783030432096

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Continuum Modeling in Mechanobiology by Larry A. Taber Pdf

This book examines key theoretical tools that are currently used to develop mathematical models as an aid in understanding the biological response of cells and tissues to mechanical stimuli. Problems in growth and remodeling, tissue and organ development, and functional adaptation are all covered. Chapters on tensor analysis and nonlinear elasticity provide the necessary background for understanding the engineering theories that are currently used to solve challenges in mechanobiology. This is an ideal book for biomechanical engineers who work on problems in mechanobiology and tissue engineering.

Author : Jun Nakanishi,Koichiro Uto
Publisher : Royal Society of Chemistry
Page : 365 pages
File Size : 50,8 Mb
Release : 2022-08-12
Category : Technology & Engineering
ISBN : 9781839161858

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Material-based Mechanobiology by Jun Nakanishi,Koichiro Uto Pdf

This book focuses on recent progress in mechanobiology from the materials science perspective, encompassing innovative material designs for force measurements and actuation to resolve dynamic mechanobiology and mechanoarchitectonics, by better mimicking physiologically relevant and time-evolving cellular mechanical environments. It also shows the marriage between cutting-edge materials science which enable spatiotemporal manipulation of material and cell dynamics in multi-dimensions and molecular biological techniques such as genome editing and next generation sequencing for cell fate/motility engineering and disease modelling, with the aim of providing valuable insights into the latest technological advances and discoveries in areas such as stem cell, fibroblast, heart, tumour, and epithelial mechanobiology.

Author : Marcial Escudero,Gonzalo Nieto Feliner,Lisa Pokorny,Daniel Spalink,Juan Viruel
Publisher : Frontiers Media SA
Page : 171 pages
File Size : 52,5 Mb
Release : 2021-01-08
Category : Science
ISBN : 9782889663675

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Phylogenomic Approaches to Deal with Particularly Challenging Plant Lineages by Marcial Escudero,Gonzalo Nieto Feliner,Lisa Pokorny,Daniel Spalink,Juan Viruel Pdf

Author : Stefaan Verbruggen
Publisher : Academic Press
Page : 527 pages
File Size : 46,6 Mb
Release : 2018-08-09
Category : Technology & Engineering
ISBN : 9780128129531

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Mechanobiology in Health and Disease by Stefaan Verbruggen Pdf

Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Author : Jiro Nagatomi,Eno Essien Ebong
Publisher : CRC Press
Page : 682 pages
File Size : 53,9 Mb
Release : 2018-12-07
Category : Medical
ISBN : 9780429816741

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Mechanobiology Handbook, Second Edition by Jiro Nagatomi,Eno Essien Ebong Pdf

Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

Author : Shu Chien,Adam J. Engler,Peter Yingxiao Wang
Publisher : Springer
Page : 302 pages
File Size : 40,7 Mb
Release : 2016-08-10
Category : Medical
ISBN : 9781493956173

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Molecular and Cellular Mechanobiology by Shu Chien,Adam J. Engler,Peter Yingxiao Wang Pdf

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Author : Markus Hecker,Dirk J. Duncker
Publisher : Springer Nature
Page : 352 pages
File Size : 46,9 Mb
Release : 2021-03-10
Category : Medical
ISBN : 9783030631642

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Vascular Mechanobiology in Physiology and Disease by Markus Hecker,Dirk J. Duncker Pdf

This volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.