Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis

Author : György Berencsi III
Publisher : Springer Science & Business Media
Page : 467 pages
File Size : 47,9 Mb
Release : 2012-04-05
Category : Medical
ISBN : 9789400742161

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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis by György Berencsi III Pdf

The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Author : Anonim
Publisher : Springer
Page : 474 pages
File Size : 44,6 Mb
Release : 2012-04-06
Category : Electronic
ISBN : 9400742177

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Maternal Fetal Transmission of Human Viruses and Their Influence on Tumorigenesis by Anonim Pdf

Author : György Berencsi III
Publisher : Springer Science & Business Media
Page : 467 pages
File Size : 53,8 Mb
Release : 2012-04-07
Category : Medical
ISBN : 9789400742154

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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis by György Berencsi III Pdf

The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Author : Janos Minarovits,Hans Helmut Niller
Publisher : Springer
Page : 137 pages
File Size : 50,8 Mb
Release : 2015-12-11
Category : Science
ISBN : 9783319247380

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Patho-Epigenetics of Infectious Disease by Janos Minarovits,Hans Helmut Niller Pdf

Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment.

Author : Louis Flamand,Irmeli Lautenschlager,Gerhard Krueger,Dharam Ablashi
Publisher : Elsevier
Page : 362 pages
File Size : 43,5 Mb
Release : 2014-02-11
Category : Medical
ISBN : 9780444627162

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Human Herpesviruses HHV-6A, HHV-6B and HHV-7 by Louis Flamand,Irmeli Lautenschlager,Gerhard Krueger,Dharam Ablashi Pdf

Completely revised and updated, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis. The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkin's disease lymphoma (HHV-6B), and glioma (HHV-6A). Descriptions of current and novel molecular and serological diagnostic assays, along with detailed protocols, are included to aid researchers and clinicians in discriminating potential false positives originating from chromosomally integrated HHV-6, and in differentiating between active and latent infection. Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition is a valuable reference for both clinical and basic scientists, including epidemiologists, virologists, practicing clinicians, infectious disease specialists, pathologists, and all scientists entering the field of herpes virus research. The work is a practical and thorough resource for a foundational understanding of HHV-6 and HHV-7, while providing a cutting-edge translational and clinical reference to those looking to understand and diagnose associated viral diseases. Delivers the latest molecular diagnostic tests, the present-day gold standard for monitoring HHV-6 Provides expert analysis of T-cell immune response against HHV-6 Presents tools for differential diagnosis in HHV-6 viral infections Includes new information on the previously-largely-unknown biological consequences of ciHHV-6 Offers coverage of new discoveries relating to HHV-7

Author : Joseph G. Sinkovics
Publisher : Springer
Page : 815 pages
File Size : 41,9 Mb
Release : 2016-04-01
Category : Medical
ISBN : 9783319222790

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RNA/DNA and Cancer by Joseph G. Sinkovics Pdf

In this book, the author Joseph G. Sinkovics liberally shares his views on the cancer cell which he has been observing in vivo and in vitro, over a life time. Readers will learn how, as an inherent faculty of the RNA/DNA complex, the primordial cell survival pathways are endogenously reactivated in an amplified or constitutive manner in the multicellular host, and are either masquerading as self-elements or as placentas, to which the multicellular host is evolutionarily trained to extend full support. The host obliges. The author explains that there is no such evidence that “malignantly transformed” human cells survive in nature. However, when cared for in the laboratory, these cells live and replicate as immortalized cultures. These cells retain their vitality upon storage in liquid nitrogen. One can only imagine an astrophysical environment in which such cells could survive; perhaps, first their seemingly humble exosomes would populate that environment. Immortal cell populations so created may survive as individuals, or may even re-organize themselves into multicellular colonies, as representatives of life for the duration of the Universe. This thought-provoking book is the work of a disciplined investigator and clinician with an impeccable reputation, and he enters a territory that very few if any before him have approached from the same angles. It will appeal to researchers with an interest in cell survival pathways and those researching cancer cells.

Author : John Loike,Ruth Fischbach
Publisher : Lulu.com
Page : 249 pages
File Size : 51,8 Mb
Release : 2014
Category : Bioethics
ISBN : 9781304768582

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Science-Based Bioethics by John Loike,Ruth Fischbach Pdf

This book has two primary aims, to analyze how advancing scientific discoveries uncover or elicit bioethical concerns and challenges and to provide the essential scientific background and bioethical information that allows scientists, healthcare professionals and clinical researchers to better comprehend, appreciate and address the complex bioethical dilemmas that our society confronts.

Author : Anonim
Publisher : Unknown
Page : 742 pages
File Size : 53,7 Mb
Release : 1989
Category : Medicine
ISBN : UOM:39015014022886

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Research Awards Index by Anonim Pdf

Author : M. A. Epstein,B. G. Achong
Publisher : Springer Science & Business Media
Page : 467 pages
File Size : 51,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642672361

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The Epstein-Barr Virus by M. A. Epstein,B. G. Achong Pdf

The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 1472 pages
File Size : 51,8 Mb
Release : 1962
Category : Medicine
ISBN : IND:30000090352927

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Research Grants Index by National Institutes of Health (U.S.). Division of Research Grants Pdf

Author : Elke Winterhager,Ivo Bendix,Suzanne Lee Miller
Publisher : Unknown
Page : 0 pages
File Size : 45,7 Mb
Release : 2020
Category : Electronic
ISBN : OCLC:1368434926

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Causes and Consequences of Intrauterine Growth Restriction by Elke Winterhager,Ivo Bendix,Suzanne Lee Miller Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 696 pages
File Size : 48,7 Mb
Release : 1961
Category : Medicine
ISBN : MINN:31951000421476J

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Research Grants Index by National Institutes of Health (U.S.). Division of Research Grants Pdf

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V)
Publisher : National Academies
Page : 436 pages
File Size : 51,8 Mb
Release : 1990-02-01
Category : Science
ISBN : 9780309039956

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Health Effects of Exposure to Low Levels of Ionizing Radiation by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V) Pdf

This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 44,5 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Abhay P. S. Rathore,Vivian Vasconcelos Costa,Ashley L. St John
Publisher : Frontiers Media SA
Page : 165 pages
File Size : 52,7 Mb
Release : 2022-02-28
Category : Medical
ISBN : 9782889745869

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Viral Infection at the Maternal-Fetal Interface by Abhay P. S. Rathore,Vivian Vasconcelos Costa,Ashley L. St John Pdf