Mechanisms Of Cell Death And Opportunities For Therapeutic Development

Author : Diaqing Liao
Publisher : Academic Press
Page : 298 pages
File Size : 51,5 Mb
Release : 2021-10-26
Category : Science
ISBN : 9780128142097

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Mechanisms of Cell Death and Opportunities for Therapeutic Development by Diaqing Liao Pdf

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Author : Hala Gali-Muhtasib,Omar Nasser Rahal
Publisher : BoD – Books on Demand
Page : 154 pages
File Size : 42,7 Mb
Release : 2020-01-15
Category : Science
ISBN : 9781789847482

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Programmed Cell Death by Hala Gali-Muhtasib,Omar Nasser Rahal Pdf

This book incorporates developments in our understanding of cell death mechanisms and highlights recent advances in programmed cell death regulation processes. It provides the reader with the network of pathways targeted by herbal anticancer drugs and discusses the role of endoplasmic reticulum stress in cell death mechanisms in addition to highlighting the mechanisms of autophagy and its role in diseases. This book provides valuable material for researchers and for teaching postgraduate students. Emphasis on recent advances and their clinical applications offers insights to researchers that will likely lead to the development of novel therapeutic approaches.

Author : Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca
Publisher : Unknown
Page : 236 pages
File Size : 55,5 Mb
Release : 1999
Category : Science
ISBN : STANFORD:36105024897386

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Mechanisms of Cell Death by Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca Pdf

Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics

Author : Yufang Shi,John A. Cidlowski,David W. Scott,Jia-Rui Wu,Yun Bo Shi
Publisher : Springer Science & Business Media
Page : 229 pages
File Size : 41,8 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475758900

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Molecular Mechanisms of Programmed Cell Death by Yufang Shi,John A. Cidlowski,David W. Scott,Jia-Rui Wu,Yun Bo Shi Pdf

The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner, H. Robert Horvitz, and John E. Sulston for their seminal discoveries concerning "genetic regulation of organ development and programmed cell death." This clearly marked the prime importance of understanding the molecular mechanisms controlling cell death. The 1 st International Symposium on Programmed Cell Death was held in the Shanghai Science Center of the Chinese Academy of Sciences on September 8-12, 1996. A number of key issues in apoptosis were discussed at the meeting, and progress in major areas of apopto sis research was summarized by expert participants at the meeting and published by Plenum Publishing Corporation as a book entitled Programmed Cell Death. In the last six years, we have witnessed a real explosion in our knowledge on how cells undergo apoptosis, thereby participating in various developmental and pathophysiological processes. At this ever exciting time, we organized the 2nd International Symposium on Programmed Cell Death.

Author : Yusuf Tutar
Publisher : BoD – Books on Demand
Page : 184 pages
File Size : 43,7 Mb
Release : 2022-04-06
Category : Science
ISBN : 9781839691935

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Regulation and Dysfunction of Apoptosis by Yusuf Tutar Pdf

The book provides a comprehensive review of apoptotic cell death. It discusses the mechanism of apoptosis and emerging principles of drug resistance in cancer. The development of novel drug targets and drug delivery systems for inhibiting or inducing apoptosis are the ultimate goal. Further, upregulation of anti-apoptotic proteins and loss of pro-apoptotic proteins strongly favors apoptosis evasion. The ability of cancer cells to evade apoptosis is critical for the progression and clonal expansion of malignantly transformed cells. Defective apoptosis imparts proliferative advantage to cancer cells or cells with the potential to become cancerous. The mechanisms employed by cancer cells to evade apoptosis can be used in the strategic design of therapeutic regimens aimed at exploiting apoptotic signaling networks to ensure tumor-specific cell death. This book presents knowledge of the molecular mechanisms of defective apoptosis that could be translated into the development of novel therapeutic agents and therapeutic modalities for cancer treatment.

Author : Wafik S. El-Deiry
Publisher : Springer Science & Business Media
Page : 374 pages
File Size : 43,6 Mb
Release : 2007-11-15
Category : Medical
ISBN : 9781592598519

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Death Receptors in Cancer Therapy by Wafik S. El-Deiry Pdf

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Author : Avi Ashkenazi,Junying Yuan,Jim Wells
Publisher : Elsevier
Page : 504 pages
File Size : 47,5 Mb
Release : 2014-06-25
Category : Science
ISBN : 9780124171756

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Regulated Cell Death Part A by Avi Ashkenazi,Junying Yuan,Jim Wells Pdf

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Author : Hao Wu
Publisher : Springer Science & Business Media
Page : 272 pages
File Size : 43,5 Mb
Release : 2013-11-19
Category : Science
ISBN : 9781461493020

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Cell Death by Hao Wu Pdf

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

Author : Raphael Carl Lee,Florin Despa,Kimm Jon Hamann,New York Academy of Sciences
Publisher : Unknown
Page : 352 pages
File Size : 44,8 Mb
Release : 2005
Category : Medical
ISBN : UVA:X030008975

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Cell Injury by Raphael Carl Lee,Florin Despa,Kimm Jon Hamann,New York Academy of Sciences Pdf

When cells are damaged, as often occurs during trauma and metabolic stress, a highly evolved cell healing process follows that was designed to enhance cell survival or remove irreparably injured cells. Following injury, cells attempt to seal breaks in their membranes, chaperone removal or refolding of altered proteins, repair damaged DNA, or if necessary commit to programmed cell death. When cell injury is too extensive to permit reparative responses, acute cellular necrosis or apoptosis can result. Understanding injury at the subcellular organelle and molecular levels is essential for development of new therapeutic strategies and for optimal management of injured victims. In this volume, various modes of injury that can occur are described, as well as the basic molecular healing responses and pathways of metabolic survival or death.

Author : Richard A. Lockshin
Publisher : Wiley-Liss
Page : 538 pages
File Size : 46,7 Mb
Release : 1998-04-13
Category : Science
ISBN : UOM:39015040344601

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When Cells Die by Richard A. Lockshin Pdf

When Cells Die A Comprehensive Evaluation of Apoptosis and Programmed Cell Death Edited by Richard A. Lockshin, Zahra Zakeri, and Jonathan L. Tilly Cell death is fast becoming one of the most dynamic areas of biological research -involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods -making it difficult for scientists to get an overview of the field. When Cells Die establishes a coherent framework for the study of cell death -cutting across viewpoints and disciplines and consolidating disparate research efforts. Leading international researchers describe a wide range of topics, including evaluation methods for programmed cell death and apoptosis in numerous tissues and circumstances; genetic mechanism, signal transduction, and observed manifestations of physiological cell death; model systems ranging from nematodes to humans; relevant work in cancer research, AIDS, immune disorders, fertility, eye disease, and Alzheimer's disease; and more. Written to provide an in-depth overview of cell death, the book is divided into five major parts: * The phenomenon of cell death * Themes and approaches to cell death * Cell death where mitosis is high and evanescence is desirable * Cell death in long-lived cells * The clinical relevance of apoptosis. When Cells Die offers a comprehensive introduction to an intriguing discipline, insight into areas in need of exploration, and information on new techniques and therapeutic applications -all supported with diagrams and flowcharts and a fully cross-referenced and indexed text. It is important reading for anyone working in cell and developmental biology, neuroscience, immunology, cancer research, and virology. It is also useful for advanced undergraduate and graduate-level students, postdoctoral fellows, and researchers just entering the field.

Author : Douglas R. Green
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2011
Category : Science
ISBN : 0879698888

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Means to an End by Douglas R. Green Pdf

One million cells in our bodies die every secondthey commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

Author : Christopher D. Gregory
Publisher : Springer
Page : 247 pages
File Size : 50,9 Mb
Release : 2016-08-24
Category : Medical
ISBN : 9783319394060

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Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy by Christopher D. Gregory Pdf

This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

Author : Anonim
Publisher : Academic Press
Page : 352 pages
File Size : 49,8 Mb
Release : 2014-07-24
Category : Science
ISBN : 9780128016190

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Regulated Cell Death Part B by Anonim Pdf

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 44,6 Mb
Release : 2000
Category : Electronic
ISBN : 1573313203

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Mechanisms of Cell Death by Anonim Pdf

Author : Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca
Publisher : Unknown
Page : 236 pages
File Size : 54,5 Mb
Release : 1999
Category : Science
ISBN : STANFORD:36105024897386

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Mechanisms of Cell Death by Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca Pdf

Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics