Apoptosis In Cancer Pathogenesis And Anti Cancer Therapy

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Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy

Christopher D. Gregory
Apoptosis in Cancer Pathogenesis and Anti cancer Therapy Book PDF

Author : Christopher D. Gregory
Publisher : Springer
Page : 247 pages
File Size : 55,9 Mb
Release : 2016-08-24
Category : Medical
ISBN : 9783319394060

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Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy by Christopher D. Gregory Pdf

This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

Apoptosis in Carcinogenesis and Chemotherapy

George G. Chen,Paul B. S. Lai
Apoptosis in Carcinogenesis and Chemotherapy Book PDF

Author : George G. Chen,Paul B. S. Lai
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 47,7 Mb
Release : 2009-02-22
Category : Medical
ISBN : 9781402095979

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Apoptosis in Carcinogenesis and Chemotherapy by George G. Chen,Paul B. S. Lai Pdf

Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.

Application of Apoptosis to Cancer Treatment

Mels Sluyser
Application of Apoptosis to Cancer Treatment Book PDF

Author : Mels Sluyser
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 49,9 Mb
Release : 2005-04-14
Category : Medical
ISBN : 1402033036

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Application of Apoptosis to Cancer Treatment by Mels Sluyser Pdf

Novel drugs are being developed which interact with the programmed cell death (apoptotic) machinery in cancer cells, thereby causing these cells to commit suicide and to be removed from the body. Research is also directed to investigate why the cancer cells sometimes lose the ability to undergo apoptosis after a certain period of time and methods are being developed to reactivate this cell death process. This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients. Mels Sluyser is the Editor of the journals APOPTOSIS and ANTI-CANCER DRUGS. He brings together a collection of papers written by the world’s leading experts in these fields.

Apoptosis and Cancer

Seamus J. Martin
Apoptosis and Cancer Book PDF

Author : Seamus J. Martin
Publisher : S. Karger AG (Switzerland)
Page : 0 pages
File Size : 41,9 Mb
Release : 1997
Category : Apoptosis
ISBN : 3805565798

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Apoptosis and Cancer by Seamus J. Martin Pdf

The past five years have witnessed an explosion of research efforts in the study of how cells die. This book provides an up-to-date overview of our current knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. By synthesizing many of the recent developments in this area and placing them in perspective, it fulfills an important need. All the contributions are written by experts in their respective fields. The first two chapters give a basic introduction to the cell death machinery and its role in tumor development and progression; subsequent chapters cover current aspects of apoptosis research, including the involvement of cell cycle-related proteins (e.g. cyclin-dependent kinases) in apoptosis, the role of Bcl-2, Bcr-Abl, Rb, p53 and myc in the regulation of cell death, and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukemia and neuroblastoma. It is also discussed how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells. Compiling the most recent research results on the relationship between apoptosis and cancer in one handy volume, this book will provide a valuable reference for scientists working in cancer research as well as newcomers to the field.

Apoptosis and Cancer

Hugo Barcenilla,David Diaz
Apoptosis and Cancer Book PDF

Author : Hugo Barcenilla,David Diaz
Publisher : Springer Nature
Page : 215 pages
File Size : 51,6 Mb
Release : 2022-09-10
Category : Medical
ISBN : 9781071625538

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Apoptosis and Cancer by Hugo Barcenilla,David Diaz Pdf

This volume discusses methods used in the fields of molecular and cellular biology for detecting and studying cell death, especially in cancer and cancer therapy. Chapters in this book cover topics such as non-destructive, real-time Annexin V apoptosis assay; assessment of the immune response to tumor cell apoptosis and efferocytosis; mass cytometry assessment of cell phenotypes and signaling states in human whole blood; cell cycle analysis of ER stress and autophagy; and simultaneous detection of inflammasome activation and membrane damage during pyroptosis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Apoptosis and Cancer: Methods and Protocols is a valuable resource and practical guide for both novice and expert researchers looking into the “meaning of death.”

Programmed Cell Death in Cancer Progression and Therapy

Roya Khosravi-Far,Eileen White
Programmed Cell Death in Cancer Progression and Therapy Book PDF

Author : Roya Khosravi-Far,Eileen White
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 49,7 Mb
Release : 2007-12-29
Category : Medical
ISBN : 9781402065545

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Programmed Cell Death in Cancer Progression and Therapy by Roya Khosravi-Far,Eileen White Pdf

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.

Cell Apoptosis and Cancer

Albina W. Taylor
Cell Apoptosis and Cancer Book PDF

Author : Albina W. Taylor
Publisher : Nova Publishers
Page : 208 pages
File Size : 47,8 Mb
Release : 2007
Category : Apoptosis
ISBN : 1600215068

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Cell Apoptosis and Cancer by Albina W. Taylor Pdf

Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. Cancer and cell apoptosis is the central focus of this significant book.

Apoptosis and Cancer Chemotherapy

John A. Hickman,Caroline Dive
Apoptosis and Cancer Chemotherapy Book PDF

Author : John A. Hickman,Caroline Dive
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 41,5 Mb
Release : 1999-04-08
Category : Medical
ISBN : 9781592597208

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Apoptosis and Cancer Chemotherapy by John A. Hickman,Caroline Dive Pdf

The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu lar regulation. This book, in a series of thoughtful and provocative ar ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance.

Apoptosis, Senescence and Cancer

David A. Gewirtz,Shawn E. Holt,Steven Grant
Apoptosis Senescence and Cancer Book PDF

Author : David A. Gewirtz,Shawn E. Holt,Steven Grant
Publisher : Springer Science & Business Media
Page : 596 pages
File Size : 40,8 Mb
Release : 2007-12-17
Category : Medical
ISBN : 9781588295279

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Apoptosis, Senescence and Cancer by David A. Gewirtz,Shawn E. Holt,Steven Grant Pdf

Provides insight into established practices and research into apoptosis and senescence by examining techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. This book concludes with established cancer therapies.

Nitric Oxide and Cancer: Pathogenesis and Therapy

Benjamin Bonavida
Nitric Oxide and Cancer Pathogenesis and Therapy Book PDF

Author : Benjamin Bonavida
Publisher : Springer
Page : 308 pages
File Size : 51,5 Mb
Release : 2015-05-12
Category : Medical
ISBN : 9783319136110

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Nitric Oxide and Cancer: Pathogenesis and Therapy by Benjamin Bonavida Pdf

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

Novel Apoptotic Regulators in Carcinogenesis

George G. Chen,Paul B.S. Lai
Novel Apoptotic Regulators in Carcinogenesis Book PDF

Author : George G. Chen,Paul B.S. Lai
Publisher : Springer Science & Business Media
Page : 305 pages
File Size : 41,6 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9789400749177

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Novel Apoptotic Regulators in Carcinogenesis by George G. Chen,Paul B.S. Lai Pdf

Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.

Apoptosis in Hormone-Dependent Cancers

Martin Tenniswood,Horst Michna
Apoptosis in Hormone Dependent Cancers Book PDF

Author : Martin Tenniswood,Horst Michna
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 45,8 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9783662031223

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Apoptosis in Hormone-Dependent Cancers by Martin Tenniswood,Horst Michna Pdf

It is now widely accepted that cells have the ability to initiate a program of gene-directed death, a process called "apoptosis" which may also be used as an innovative strategy for therapeutic intervention in cancer therapy. Experts in this area report on the regulation and control of apoptosis in hormone dependent (neoplastic) tissue and the possibility to exploit active cell death for therapeutic application.

Beyond Apoptosis

Igor B. Roninson,J. Martin Brown,Dale E. Bredesen
Beyond Apoptosis Book PDF

Author : Igor B. Roninson,J. Martin Brown,Dale E. Bredesen
Publisher : CRC Press
Page : 0 pages
File Size : 43,7 Mb
Release : 2008-09-19
Category : Medical
ISBN : 084939192X

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Beyond Apoptosis by Igor B. Roninson,J. Martin Brown,Dale E. Bredesen Pdf

Addressing a major field of interest for oncologists, cell biologists, and other biomedical researchers, Beyond Apoptosis provides an overview of how different biological mechanisms of cell death, senescence and mitotic catastrophe stop the growth of tumor cells treated with anticancer agents. Written by internationally renowned contributors, this text includes: morphological illustrations, as well as a DVD containing documents and video clips from various time-lapse microscopic studies of cell death and mitotic catastrophe the role and limitations of apoptosis as a determinant of the toxicity of anticancer agents alternative mechanisms of the antiproliferative actions of anticancer drugs and radiation, such as non-apoptotic cell death, cell senescence, and mitotic catastrophe non-apoptotic forms of cell death, such as necrosis, paraptosis, autophagic cell death, and others morphological and kinetic differences of the various forms of cell death

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases

Marek Los,Spencer B. Gibson
Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases Book PDF

Author : Marek Los,Spencer B. Gibson
Publisher : Springer Science & Business Media
Page : 411 pages
File Size : 48,9 Mb
Release : 2006-06-20
Category : Medical
ISBN : 9780387236957

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Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases by Marek Los,Spencer B. Gibson Pdf

As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.

Death Receptors in Cancer Therapy

Wafik S. El-Deiry
Death Receptors in Cancer Therapy Book PDF

Author : Wafik S. El-Deiry
Publisher : Springer Science & Business Media
Page : 374 pages
File Size : 50,9 Mb
Release : 2007-11-15
Category : Medical
ISBN : 9781592598519

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Death Receptors in Cancer Therapy by Wafik S. El-Deiry Pdf

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.