Mechanisms Of Organ Dysfunction In Critical Illness

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Mechanisms of Organ Dysfunction in Critical Illness

Timothy W. Evans,Mitchell P. Fink
Mechanisms of Organ Dysfunction in Critical Illness Book PDF

Author : Timothy W. Evans,Mitchell P. Fink
Publisher : Springer Science & Business Media
Page : 410 pages
File Size : 51,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642561078

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Mechanisms of Organ Dysfunction in Critical Illness by Timothy W. Evans,Mitchell P. Fink Pdf

The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.

Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

E. Abraham,Mervyn Singer
Mechanisms of Sepsis Induced Organ Dysfunction and Recovery Book PDF

Author : E. Abraham,Mervyn Singer
Publisher : Springer Science & Business Media
Page : 476 pages
File Size : 54,5 Mb
Release : 2007-08-27
Category : Medical
ISBN : 3540301585

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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery by E. Abraham,Mervyn Singer Pdf

There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

Sepsis and Organ Dysfunction

A.E. Baue,G. Berlot,A. Gullo
Sepsis and Organ Dysfunction Book PDF

Author : A.E. Baue,G. Berlot,A. Gullo
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9788847022713

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Sepsis and Organ Dysfunction by A.E. Baue,G. Berlot,A. Gullo Pdf

Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism's homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.

Multiple Organ Failure

Arthur E. Baue,Eugen Faist,Donald Fry
Multiple Organ Failure Book PDF

Author : Arthur E. Baue,Eugen Faist,Donald Fry
Publisher : Springer Science & Business Media
Page : 712 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461212225

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Multiple Organ Failure by Arthur E. Baue,Eugen Faist,Donald Fry Pdf

Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

Sepsis, Kidney and Multiple Organ Dysfunction

Claudio Ronco,Rinaldo Bellomo,Alessandra Brendolan
Sepsis Kidney and Multiple Organ Dysfunction Book PDF

Author : Claudio Ronco,Rinaldo Bellomo,Alessandra Brendolan
Publisher : Karger Medical and Scientific Publishers
Page : 417 pages
File Size : 50,9 Mb
Release : 2004-01-01
Category : Medical
ISBN : 9783805577557

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Sepsis, Kidney and Multiple Organ Dysfunction by Claudio Ronco,Rinaldo Bellomo,Alessandra Brendolan Pdf

Severe sepsis is among the most common causes of death in the United States and the most common cause of death in the Intensive Care Units worldwide, and its recognition and treatment remain the most important challenges of critical care medicine. Severe sepsis and septic shock have a profound effect on kidney function and the function of other organs through complex mechanisms, which involve the immune response, multiple pro and anti-inflammatory pathways, intracellular dysfunction and hemodynamic instability. Their optimal management requires complex knowledge of general medicine, immunology, nephrology, extra-corporeal technology, fluid resuscitation and critical care endocrinology. In order to deliver optimal patient care, nephrologists and intensive care medicine specialists need to understand and be highly knowledgeable in the epidemiology of sepsis, the mechanisms of injury which determine outcome and the fundamental aspects of new insights into fluid resuscitation, acid-base physiology and glucose control. They also need to have a clear appreciation of new technical developments in the monitoring of critically ill patients and in the delivery of advanced extra-corporeal blood purification therapies.Experts from the fields of intensive care medicine, nephrology, endocrinology, acid-base physiology, extra-corporeal blood purification technology and immunology have contributed to the present book, providing a cutting edge view of developments in each field which contribute to the care of patients with severe sepsis, acute renal failure and multiple organ failure. The resulting mix of fundamental knowledge and recent developments from clinical trials and laboratory research constitute a valuable tool for all professionals involved in the care of the critically ill patient.

Sepsis, An Issue of Critical Care Clinics, E-Book

Mervyn Singer,Manu Shankar-Hari
Sepsis An Issue of Critical Care Clinics E Book Book PDF

Author : Mervyn Singer,Manu Shankar-Hari
Publisher : Elsevier Health Sciences
Page : 128 pages
File Size : 52,5 Mb
Release : 2017-11-27
Category : Medical
ISBN : 9780323566346

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Sepsis, An Issue of Critical Care Clinics, E-Book by Mervyn Singer,Manu Shankar-Hari Pdf

This issue of Critical Care Clinics, edited by Mervyn singer and Manu Shankar-Hari, includes: Sepsis 3.0 Definitions; Epidemiology and Outcomes; Pathophysiology of sepsis; Pathophysiology of Septic shock; Mechanism of organ dysfunction in sepsis; Endocrine and metabolic alterations in sepsis: challenges and treatments; The immune system in sepsis; Nutrition and Sepsis; Common sense approach to managing sepsis; Biomarkers for sepsis and their use; Personalizing sepsis care; Novel interventions - What’s new and the future; and Long term outcomes following Sepsis.

Sepsis and Organ Dysfunction

A.E. Baue,G. Berlot,A. Gullo,J.-L. Vincent
Sepsis and Organ Dysfunction Book PDF

Author : A.E. Baue,G. Berlot,A. Gullo,J.-L. Vincent
Publisher : Springer Science & Business Media
Page : 168 pages
File Size : 53,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9788847022843

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Sepsis and Organ Dysfunction by A.E. Baue,G. Berlot,A. Gullo,J.-L. Vincent Pdf

An experienced physician knows how to recognize a patient suffering from sepsis, but cannot accurately determine whether the patient will survive. Cardinal elements of the treatment for sepsis include specific antibiotic and vasoactive drugs, enteral and parenteral nutrition, artificial respiration, and optimization of the oxygen transport to tissues. Nonetheless, with a certain frequency, these techniques are insufficient to ensure the recovery of a critically ill patient, especially when it is necessary to overcome functional alterations subsequent to organ and vital-system overload. The key elements in the progression of the sepsis-MODS syndrome are tied to numerous factors. These include: the severity and location of the lesion; the patient's age; the remaining functional reserve; the presence of mediatory which may be stimulatory, inhibitory or both.

Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

E. Abraham,Mervyn Singer
Mechanisms of Sepsis Induced Organ Dysfunction and Recovery Book PDF

Author : E. Abraham,Mervyn Singer
Publisher : Springer
Page : 453 pages
File Size : 50,7 Mb
Release : 2006-09-25
Category : Medical
ISBN : 3540301577

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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery by E. Abraham,Mervyn Singer Pdf

There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

Brain Disorders in Critical Illness

Robert D. Stevens,Tarek Sharshar,E. Wesley Ely
Brain Disorders in Critical Illness Book PDF

Author : Robert D. Stevens,Tarek Sharshar,E. Wesley Ely
Publisher : Cambridge University Press
Page : 432 pages
File Size : 50,5 Mb
Release : 2013-09-19
Category : Medical
ISBN : 9781107434424

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Brain Disorders in Critical Illness by Robert D. Stevens,Tarek Sharshar,E. Wesley Ely Pdf

Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.

Mechanisms of Vascular Disease

Robert Fitridge,M. M. Thompson
Mechanisms of Vascular Disease Book PDF

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 54,7 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

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Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Essentials of Shock Management

Gil Joon Suh
Essentials of Shock Management Book PDF

Author : Gil Joon Suh
Publisher : Springer
Page : 147 pages
File Size : 52,9 Mb
Release : 2018-11-30
Category : Medical
ISBN : 9789811054068

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Essentials of Shock Management by Gil Joon Suh Pdf

This book is designed to offer the reader first-rate guidance on shock management in the real world. Comprehensive, evidence-based, and up-to-date instruction is provided on optimal care of patients with different types of shock – septic, hemorrhagic, cardiogenic, anaphylactic, and obstructive – at all stages from initial response through to ICU admission. As well as management, the coverage encompasses pathophysiology, clinical presentation, diagnosis, and emerging trends. A further key feature is the use of a scenario-based approach to present a series of cases based on real-life experiences. Here, a narrative style and Q&A form are employed to vividly convey scenarios that may be encountered in clinical practice and to elucidate decision making in complex circumstances. When readers experience difficulty in answering the questions, the earlier sections can be consulted to identify the correct response. This book will be of great value for all health care professionals. In particular, it will be very helpful for novice or inexperienced practitioners in emergency medicine, critical care medicine, and traumatology.

Core Topics in Critical Care Medicine

Fang Gao Smith,Joyce Yeung
Core Topics in Critical Care Medicine Book PDF

Author : Fang Gao Smith,Joyce Yeung
Publisher : Cambridge University Press
Page : 409 pages
File Size : 51,8 Mb
Release : 2010-04-22
Category : Medical
ISBN : 9781139489683

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Core Topics in Critical Care Medicine by Fang Gao Smith,Joyce Yeung Pdf

The critical care unit manages patients with a vast range of disease and injuries affecting every organ system. The unit can initially be a daunting environment, with complex monitoring equipment producing large volumes of clinical data. Core Topics in Critical Care Medicine is a practical, comprehensive, introductory-level text for any clinician in their first few months in the critical care unit. It guides clinicians in both the initial assessment and the clinical management of all CCU patients, demystifying the critical care unit and providing key knowledge in a concise and accessible manner. The full spectrum of disorders likely to be encountered in critical care are discussed, with additional chapters on transfer and admission, imaging in the CCU, structure and organisation of the unit, and ethical and legal issues. Written by Critical Care experts, Core Topics in Critical Care Medicine provides comprehensive, concise and easily accessible information for all trainees.

Mitochondrial Dysfunction

Lawrence H. Lash,Dean P. Jones
Mitochondrial Dysfunction Book PDF

Author : Lawrence H. Lash,Dean P. Jones
Publisher : Elsevier
Page : 528 pages
File Size : 47,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483218618

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Mitochondrial Dysfunction by Lawrence H. Lash,Dean P. Jones Pdf

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Controversies in Acute Kidney Injury

J.A. Kellum,C. Ronco,J.-L. Vincent
Controversies in Acute Kidney Injury Book PDF

Author : J.A. Kellum,C. Ronco,J.-L. Vincent
Publisher : Karger Medical and Scientific Publishers
Page : 266 pages
File Size : 42,7 Mb
Release : 2011-09-15
Category : Medical
ISBN : 9783805598118

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Controversies in Acute Kidney Injury by J.A. Kellum,C. Ronco,J.-L. Vincent Pdf

Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy.The publication at hand contains sections on prerenal azotemia syndromes, dying ‘of’ or ‘with’ AKI, pathophysiology of sepsis-induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.

Textbook of Post-ICU Medicine

Robert D. Stevens,Nicholas Hart,Margaret S. Herridge
Textbook of Post ICU Medicine Book PDF

Author : Robert D. Stevens,Nicholas Hart,Margaret S. Herridge
Publisher : Academic
Page : 649 pages
File Size : 54,8 Mb
Release : 2014
Category : Medical
ISBN : 9780199653461

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Textbook of Post-ICU Medicine by Robert D. Stevens,Nicholas Hart,Margaret S. Herridge Pdf

Surviving critical illness is not always the happy ending that we imagine for patients. Intensive care unit (ICU) teams have traditionally focused on short term goals such as stabilizing or reversing organ system dysfunction, with little understanding of what became of patients once they left the ICU. However, research conducted in recent years has demonstrated that many ICU survivors can suffer from ill health and mental health issues for months or years to follow. The Textbook of Post-ICU Medicine: The Legacy of Critical Care identifies the long term outcomes of ICU and the steps that can be taken to improve patients' health and wellbeing. Describing the major clinical syndromes affecting ICU survivors, the book delineates established or postulated biological mechanisms of the post-acute recovery process, and discusses strategies for treatment and rehabilitation to promote recovery in the ICU and in the long term. The book serves as a unique reference for general practitioners, internists and nurses caring for long term ICU survivors as well as specialists in intensive care medicine, neurology, psychiatry, and rehabilitation medicine.