Sepsis Kidney And Multiple Organ Dysfunction

Author : Claudio Ronco,Rinaldo Bellomo,Alessandra Brendolan
Publisher : Karger Medical and Scientific Publishers
Page : 417 pages
File Size : 53,5 Mb
Release : 2004-01-01
Category : Medical
ISBN : 9783805577557

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Sepsis, Kidney and Multiple Organ Dysfunction by Claudio Ronco,Rinaldo Bellomo,Alessandra Brendolan Pdf

Severe sepsis is among the most common causes of death in the United States and the most common cause of death in the Intensive Care Units worldwide, and its recognition and treatment remain the most important challenges of critical care medicine. Severe sepsis and septic shock have a profound effect on kidney function and the function of other organs through complex mechanisms, which involve the immune response, multiple pro and anti-inflammatory pathways, intracellular dysfunction and hemodynamic instability. Their optimal management requires complex knowledge of general medicine, immunology, nephrology, extra-corporeal technology, fluid resuscitation and critical care endocrinology. In order to deliver optimal patient care, nephrologists and intensive care medicine specialists need to understand and be highly knowledgeable in the epidemiology of sepsis, the mechanisms of injury which determine outcome and the fundamental aspects of new insights into fluid resuscitation, acid-base physiology and glucose control. They also need to have a clear appreciation of new technical developments in the monitoring of critically ill patients and in the delivery of advanced extra-corporeal blood purification therapies.Experts from the fields of intensive care medicine, nephrology, endocrinology, acid-base physiology, extra-corporeal blood purification technology and immunology have contributed to the present book, providing a cutting edge view of developments in each field which contribute to the care of patients with severe sepsis, acute renal failure and multiple organ failure. The resulting mix of fundamental knowledge and recent developments from clinical trials and laboratory research constitute a valuable tool for all professionals involved in the care of the critically ill patient.

Author : A.E. Baue,G. Berlot,A. Gullo,J.L. Vincent
Publisher : Springer Science & Business Media
Page : 181 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9788847022294

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Sepsis and Organ Dysfunction by A.E. Baue,G. Berlot,A. Gullo,J.L. Vincent Pdf

Sepsis evolution and organ dysfunction are still an enigmatic topic. Severe infection causes an important aggression of the whole body, and the so-called inflammation mediators play an important role in this evolution. It is however certain that the immune system is a key factor in sepsis progression. The volume focuses on some primary aspects such as the research of the rationale of the immune system activation during sepsis, on the molecular strategies available for ARDS treatment and on techniques of emofiltration and absorption of endotoxins through apheresis in the septic patient.

Author : E. Abraham,Mervyn Singer
Publisher : Springer Science & Business Media
Page : 476 pages
File Size : 50,9 Mb
Release : 2007-08-27
Category : Medical
ISBN : 3540301585

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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery by E. Abraham,Mervyn Singer Pdf

There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

Author : A.E. Baue,G. Berlot,A. Gullo,J.-L. Vincent
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 53,5 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9788847022843

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Sepsis and Organ Dysfunction by A.E. Baue,G. Berlot,A. Gullo,J.-L. Vincent Pdf

An experienced physician knows how to recognize a patient suffering from sepsis, but cannot accurately determine whether the patient will survive. Cardinal elements of the treatment for sepsis include specific antibiotic and vasoactive drugs, enteral and parenteral nutrition, artificial respiration, and optimization of the oxygen transport to tissues. Nonetheless, with a certain frequency, these techniques are insufficient to ensure the recovery of a critically ill patient, especially when it is necessary to overcome functional alterations subsequent to organ and vital-system overload. The key elements in the progression of the sepsis-MODS syndrome are tied to numerous factors. These include: the severity and location of the lesion; the patient's age; the remaining functional reserve; the presence of mediatory which may be stimulatory, inhibitory or both.

Author : Timothy W. Evans,Mitchell P. Fink
Publisher : Springer Science & Business Media
Page : 434 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642561078

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Mechanisms of Organ Dysfunction in Critical Illness by Timothy W. Evans,Mitchell P. Fink Pdf

The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.

Author : Arthur E. Baue,Eugen Faist,Donald Fry
Publisher : Springer Science & Business Media
Page : 750 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461212225

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Multiple Organ Failure by Arthur E. Baue,Eugen Faist,Donald Fry Pdf

Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

Author : A.E. Baue,G. Berlot,A. Gullo
Publisher : Springer Science & Business Media
Page : 175 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9788847022713

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Sepsis and Organ Dysfunction by A.E. Baue,G. Berlot,A. Gullo Pdf

Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism's homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.

Author : Culley C. Carson,N. Reed Dunnick
Publisher : Unknown
Page : 352 pages
File Size : 54,7 Mb
Release : 1985
Category : Endoscopes
ISBN : UOM:39015009506216

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Endourology by Culley C. Carson,N. Reed Dunnick Pdf

Author : Alan Fein
Publisher : Lippincott Williams & Wilkins
Page : 716 pages
File Size : 45,5 Mb
Release : 1997
Category : Medical
ISBN : UOM:39015041320873

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Sepsis and Multiorgan Failure by Alan Fein Pdf

Author : Jordi Rello,Jeffrey Lipman,Thiago Lisboa
Publisher : Springer Science & Business Media
Page : 243 pages
File Size : 45,5 Mb
Release : 2011-10-11
Category : Medical
ISBN : 9783642035197

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Sepsis Management by Jordi Rello,Jeffrey Lipman,Thiago Lisboa Pdf

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.

Author : Fang Gao Smith,Joyce Yeung
Publisher : Cambridge University Press
Page : 409 pages
File Size : 51,5 Mb
Release : 2010-04-22
Category : Medical
ISBN : 9781139489683

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Core Topics in Critical Care Medicine by Fang Gao Smith,Joyce Yeung Pdf

The critical care unit manages patients with a vast range of disease and injuries affecting every organ system. The unit can initially be a daunting environment, with complex monitoring equipment producing large volumes of clinical data. Core Topics in Critical Care Medicine is a practical, comprehensive, introductory-level text for any clinician in their first few months in the critical care unit. It guides clinicians in both the initial assessment and the clinical management of all CCU patients, demystifying the critical care unit and providing key knowledge in a concise and accessible manner. The full spectrum of disorders likely to be encountered in critical care are discussed, with additional chapters on transfer and admission, imaging in the CCU, structure and organisation of the unit, and ethical and legal issues. Written by Critical Care experts, Core Topics in Critical Care Medicine provides comprehensive, concise and easily accessible information for all trainees.

Author : Edwin A. Deitch,J. L. Vincent,Alastair Windsor
Publisher : Saunders
Page : 524 pages
File Size : 41,5 Mb
Release : 2002
Category : Multiple organ failure
ISBN : CHI:65664902

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Sepsis and Multiple Organ Dysfunction by Edwin A. Deitch,J. L. Vincent,Alastair Windsor Pdf

This is the definitive, gold-standard text on sepsis and multiple-organ dysfunction. It is comprehensive and thoroughly referenced: the one text in which all current knowledge on this important topic is brought together. The book is written by a team of international contributors, overseen by an internationally acclaimed editorial team.

Author : Vincenzo Neri,Lixing Huang,Jie Li
Publisher : BoD – Books on Demand
Page : 396 pages
File Size : 55,5 Mb
Release : 2021-10-27
Category : Medical
ISBN : 9781839694578

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Infections and Sepsis Development by Vincenzo Neri,Lixing Huang,Jie Li Pdf

Infection is a common clinical condition that may cause local inflammation but, in some cases, can lead to systemic inflammation, with sepsis and organ dysfunction. Septic shock is a condition of inadequate tissue perfusion and cellular use of oxygen due to the cytotoxic action of bacterial toxins. There is no relationship between the pathological characteristics and the severity of the primary septic outbreak and the development of septic shock, and the time that elapses until the start of the shock is not predictable. Thus, knowledge of the pathophysiology of septic shock is fundamental for treatment. This book presents a comprehensive overview of infectious agents and their therapeutic control, pathological conditions with infective etiology such as diabetic foot osteomyelitis and infections in neurosurgery, and the pathophysiology, diagnosis, and management of sepsis.

Author : Alessandra Stasi,Patrick M. Honore
Publisher : Frontiers Media SA
Page : 124 pages
File Size : 51,8 Mb
Release : 2023-11-17
Category : Medical
ISBN : 9782832539040

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Community Series in New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies, volume II by Alessandra Stasi,Patrick M. Honore Pdf

This Research Topic is the second volume of the “New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies” Community Series. Please see the first volume here. Sepsis is a systemic inflammatory response to an active infectious process in the host; the symptoms are mainly produced by host defense systems rather than by the invading pathogens, involving pro-inflammatory and anti-inflammatory processes. The association of Acute Kidney Injury (AKI) and sepsis ranges from 45% to 70% of cases, with a significantly increased risk of death, progression toward chronic kidney disease and increased health resource utilization. Despite relevant therapeutic advances, sepsis-related AKI remains associated with an unacceptably high morbidity/mortality risk, increased health resource utilization, as well as - in survivors - with increased risk of transition to chronic kidney disease. Currently there are no approved treatments for sepsis-related AKI. The main objective of this research topic is to shed new light on sepsis pathogenesis and provide new potential therapeutic strategies to prevent the progression to AKI.

Author : John A. Kellum,C. Ronco,J. L. Vincent
Publisher : Karger Medical and Scientific Publishers
Page : 267 pages
File Size : 46,9 Mb
Release : 2011
Category : Medical
ISBN : 9783805598101

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Controversies in Acute Kidney Injury by John A. Kellum,C. Ronco,J. L. Vincent Pdf

A timely update Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy. The publication at hand contains sections on prerenal azotemia syndromes, dying of' or with' AKI, pathophysiology of sepsis- induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.