Mechanotransduction

Author : Paul A. Sundaram
Publisher : Academic Press
Page : 160 pages
File Size : 47,8 Mb
Release : 2020-11-18
Category : Technology & Engineering
ISBN : 9780128178836

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Mechanotransduction by Paul A. Sundaram Pdf

Mechanotransduction: Cell Signaling to Cell Response covers the cell machinery responsible for the process of mechanotransduction and the manner in which cells respond to an external mechanical stimulus. The effect of mechanical stimulus on individual cells and entire tissues is discussed, with an emphasis on the practical results of this physiological process. Mechanotransduction of stem cells and cancerous cells are also covered, along with future directions in this yet nascent field. This book gives insights on basic processes that occur (or may occur) in the human body as a result of the application of mechanical stimulus. It is ideal for both biomedical engineers and biologists, and is an ideal resource for teaching. It provides a current state of conceptual and practical aspects of the field and will enable students and professionals to venture further into this incipient area which is of fundamental importance to biomedical engineering and biology fields. Covers fundamental concepts of signaling in cells as a result of mechanical stimulus Includes the physiological results of mechanical stimulus on the human body Explores the advantages of mechanical loads on the human body

Author : Irina Kiseleva,Andre Kamkin
Publisher : Springer Science & Business Media
Page : 384 pages
File Size : 48,5 Mb
Release : 2010-11-18
Category : Science
ISBN : 9789048198818

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Mechanosensitivity and Mechanotransduction by Irina Kiseleva,Andre Kamkin Pdf

This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Author : Matti Weckström,Pasi Tavi
Publisher : Springer Science & Business Media
Page : 158 pages
File Size : 42,8 Mb
Release : 2007-12-22
Category : Medical
ISBN : 9780387488684

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Cardiac Mechanotransduction by Matti Weckström,Pasi Tavi Pdf

This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.

Author : Mohammad Mofrad,Mohammad R. K. Mofrad,Roger D. Kamm
Publisher : Unknown
Page : 496 pages
File Size : 49,9 Mb
Release : 2014-07-01
Category : SCIENCE
ISBN : 1316140725

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Cellular Mechanotransduction by Mohammad Mofrad,Mohammad R. K. Mofrad,Roger D. Kamm Pdf

This book focuses on the process of stress sensing and transducing mechanical force into biochemical signals.

Author : Anonim
Publisher : Academic Press
Page : 384 pages
File Size : 48,9 Mb
Release : 2014-07-29
Category : Science
ISBN : 9780123983275

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Mechanotransduction by Anonim Pdf

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Author : Shaik O. Rahaman,David Krizaj,Nicholas Veldhuis,Shizuya Saika
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 46,9 Mb
Release : 2022-11-11
Category : Medical
ISBN : 9782889763399

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New Insights Into Mechanotransduction by Immune Cells in Physiological and Pathological Conditions by Shaik O. Rahaman,David Krizaj,Nicholas Veldhuis,Shizuya Saika Pdf

Author : Wei Xiong,Zhigang Xu
Publisher : Springer
Page : 60 pages
File Size : 51,8 Mb
Release : 2018-04-27
Category : Medical
ISBN : 9789811085574

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Mechanotransduction of the Hair Cell by Wei Xiong,Zhigang Xu Pdf

This book summarizes the emerging experimental evidence on hair-cell mechanotransduction, and covers hair’s cellular structure, biophysical properties, molecular components and functions. Auditory hair cells convert sound-induced vibration into electrical signals. This biological process, mechanotransduction, is what allows us to hear and communicate in our daily lives. However, our grasp of hair-cell mechanotransduction is still far from complete. Recent advances in molecular genetics and biophysics have helped us gain deeper insights into this process, especially the molecular constituent and operation of the channel complex. This book provides a cutting-edge snapshot for all readers who are interested in or studying how auditory hair cells detect sound.

Author : Anonim
Publisher : Academic Press
Page : 332 pages
File Size : 42,5 Mb
Release : 2021-10-22
Category : Science
ISBN : 9780128215241

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Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases by Anonim Pdf

Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis, Volume 87, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in "Current Topics in Membranes" series Updated release includes the latest information on Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis

Author : Airong Qian,Cory J. Xian,Lifang Hu,Changqi Zhu
Publisher : Frontiers Media SA
Page : 136 pages
File Size : 49,9 Mb
Release : 2023-01-09
Category : Science
ISBN : 9782832511206

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Development, metabolism, senescence and mechanotransduction of bone by Airong Qian,Cory J. Xian,Lifang Hu,Changqi Zhu Pdf

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 467 pages
File Size : 52,5 Mb
Release : 2006-09-29
Category : Science
ISBN : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Author : Shu Chien,Adam J. Engler,Peter Yingxiao Wang
Publisher : Springer
Page : 302 pages
File Size : 54,9 Mb
Release : 2016-08-10
Category : Medical
ISBN : 9781493956173

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Molecular and Cellular Mechanobiology by Shu Chien,Adam J. Engler,Peter Yingxiao Wang Pdf

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Author : Andre Kamkin,Irina Kiseleva
Publisher : Springer Science & Business Media
Page : 390 pages
File Size : 51,7 Mb
Release : 2007-10-06
Category : Science
ISBN : 9781402064265

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Mechanosensitive Ion Channels by Andre Kamkin,Irina Kiseleva Pdf

This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.

Author : Simon C. F. Rawlinson
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 46,9 Mb
Release : 2017-01-31
Category : Science
ISBN : 9781118966150

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Mechanobiology by Simon C. F. Rawlinson Pdf

An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

Author : Natalie K Gordon retired,Richard Gordon
Publisher : World Scientific
Page : 784 pages
File Size : 40,5 Mb
Release : 2016-09-15
Category : Science
ISBN : 9789814740692

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Embryogenesis Explained by Natalie K Gordon retired,Richard Gordon Pdf

The greatest mystery of life is how a single fertilized egg develops into a fully functioning, sometimes conscious multicellular organism. Embryogenesis Explained offers a new theory of how embryos build themselves, and combines simple physics with the most recent biochemical and genetic breakthroughs, based on the authors' prediction and then discovery of differentiation waves. They explain their ideas in a form accessible to the lay person and a broad spectrum of scientists and engineers. The diverse subjects of development, genetics and evolution, and their physics, are brought together to explain this major, previously unanswered scientific question of our time. As a follow up on The Hierarchical Genome, this book is a shorter but conceptually expanded work for the reader who is interested in science. It is useful as a starting point for the curious layman or the scientist or professional encountering the problem of embryogenesis without the formal biology background. There is also material useful for the seasoned biologist caught up in the new rush of information about the role of mechanics in developmental biology and cellular level mechanics in medicine.

Author : Anonim
Publisher : Academic Press
Page : 453 pages
File Size : 42,8 Mb
Release : 1992-01-08
Category : Science
ISBN : 0080585108

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Current Topics in Membranes by Anonim Pdf

Current Topics in Membranes