Medicinal Chemistry

Medicinal Chemistry Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Medicinal Chemistry book. This book definitely worth reading, it is an incredibly well-written.

Basic Concepts in Medicinal Chemistry

Marc Harrold,Robin Zavod
Basic Concepts in Medicinal Chemistry Book PDF

Author : Marc Harrold,Robin Zavod
Publisher : ASHP
Page : 405 pages
File Size : 40,5 Mb
Release : 2013-01-18
Category : Medical
ISBN : 9781585283644

Get Book

Basic Concepts in Medicinal Chemistry by Marc Harrold,Robin Zavod Pdf

Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.

The Medicinal Chemist's Guide to Solving ADMET Challenges

Patrick Schnider
The Medicinal Chemist s Guide to Solving ADMET Challenges Book PDF

Author : Patrick Schnider
Publisher : Royal Society of Chemistry
Page : 541 pages
File Size : 53,7 Mb
Release : 2021-08-27
Category : Science
ISBN : 9781788012270

Get Book

The Medicinal Chemist's Guide to Solving ADMET Challenges by Patrick Schnider Pdf

Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.

An Introduction to Medicinal Chemistry

Graham L. Patrick
An Introduction to Medicinal Chemistry Book PDF

Author : Graham L. Patrick
Publisher : Oxford University Press
Page : 814 pages
File Size : 43,6 Mb
Release : 2013-01-10
Category : Medical
ISBN : 9780199697397

Get Book

An Introduction to Medicinal Chemistry by Graham L. Patrick Pdf

This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.

Medicinal Chemistry

Thomas Nogrady,Donald F. Weaver
Medicinal Chemistry Book PDF

Author : Thomas Nogrady,Donald F. Weaver
Publisher : Oxford University Press
Page : 649 pages
File Size : 52,5 Mb
Release : 2005-08-11
Category : Medical
ISBN : 9780190282967

Get Book

Medicinal Chemistry by Thomas Nogrady,Donald F. Weaver Pdf

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Essentials of Organic Chemistry

Paul M. Dewick
Essentials of Organic Chemistry Book PDF

Author : Paul M. Dewick
Publisher : John Wiley & Sons
Page : 711 pages
File Size : 52,6 Mb
Release : 2013-03-20
Category : Science
ISBN : 9781118681961

Get Book

Essentials of Organic Chemistry by Paul M. Dewick Pdf

Essentials of Organic Chemistry is an accessible introduction to the subject for students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Designed to provide a thorough grounding in fundamental chemical principles, the book focuses on key elements of organic chemistry and carefully chosen material is illustrated with the extensive use of pharmaceutical and biochemical examples. In order to establish links and similarities the book places prominence on principles and deductive reasoning with cross-referencing. This informal text also places the main emphasis on understanding and predicting reactivity rather than synthetic methodology as well as utilising a mechanism based layout and featuring annotated schemes to reduce the need for textual explanations. * tailored specifically to the needs of students of Pharmacy Medical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of Pharmacy Medicinal and Biological Chemistry.

Medicinal Chemistry

Thomas Nogrady,Donald F. Weaver
Medicinal Chemistry Book PDF

Author : Thomas Nogrady,Donald F. Weaver
Publisher : Oxford University Press
Page : 649 pages
File Size : 50,7 Mb
Release : 2005-08-11
Category : Medical
ISBN : 0195104552

Get Book

Medicinal Chemistry by Thomas Nogrady,Donald F. Weaver Pdf

Fully updated, this textbook takes a receptor-based, target-centred approach, presenting concepts central to the study of drug action in a logical, mechanistic way, grounded on molecular & biochemical principles.

Medicinal Chemistry of Anticancer Drugs

Carmen Avendaño,J. Carlos Menéndez
Medicinal Chemistry of Anticancer Drugs Book PDF

Author : Carmen Avendaño,J. Carlos Menéndez
Publisher : Elsevier
Page : 767 pages
File Size : 40,6 Mb
Release : 2015-06-11
Category : Science
ISBN : 9780444626677

Get Book

Medicinal Chemistry of Anticancer Drugs by Carmen Avendaño,J. Carlos Menéndez Pdf

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Advances in Medicinal Chemistry

B.E. Maryanoff,A.B. Reitz
Advances in Medicinal Chemistry Book PDF

Author : B.E. Maryanoff,A.B. Reitz
Publisher : Elsevier
Page : 321 pages
File Size : 43,8 Mb
Release : 1999-04-01
Category : Science
ISBN : 0080526373

Get Book

Advances in Medicinal Chemistry by B.E. Maryanoff,A.B. Reitz Pdf

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

Bioisosteres in Medicinal Chemistry

Nathan Brown
Bioisosteres in Medicinal Chemistry Book PDF

Author : Nathan Brown
Publisher : John Wiley & Sons
Page : 249 pages
File Size : 43,5 Mb
Release : 2012-06-18
Category : Medical
ISBN : 9783527654321

Get Book

Bioisosteres in Medicinal Chemistry by Nathan Brown Pdf

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

The Practice of Medicinal Chemistry

Camille Georges Wermuth
The Practice of Medicinal Chemistry Book PDF

Author : Camille Georges Wermuth
Publisher : Elsevier
Page : 736 pages
File Size : 53,6 Mb
Release : 2003-06-11
Category : Science
ISBN : 9780080497778

Get Book

The Practice of Medicinal Chemistry by Camille Georges Wermuth Pdf

The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. * The only book available dealing with the practical aspects of medicinal chemistry * Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production * Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry

The Handbook of Medicinal Chemistry

Andrew Davis,Simon E Ward
The Handbook of Medicinal Chemistry Book PDF

Author : Andrew Davis,Simon E Ward
Publisher : Royal Society of Chemistry
Page : 753 pages
File Size : 45,6 Mb
Release : 2015-07-07
Category : Science
ISBN : 9781782621836

Get Book

The Handbook of Medicinal Chemistry by Andrew Davis,Simon E Ward Pdf

Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

HIV-1 Integrase

Nouri Neamati
HIV 1 Integrase Book PDF

Author : Nouri Neamati
Publisher : John Wiley & Sons
Page : 710 pages
File Size : 55,8 Mb
Release : 2011-08-10
Category : Science
ISBN : 9781118015360

Get Book

HIV-1 Integrase by Nouri Neamati Pdf

This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.

Essentials of Medicinal Chemistry

Andrejus Korolkovas
Essentials of Medicinal Chemistry Book PDF

Author : Andrejus Korolkovas
Publisher : Wiley-Interscience
Page : 1220 pages
File Size : 49,5 Mb
Release : 1988-08-16
Category : Medical
ISBN : UOM:39015014473030

Get Book

Essentials of Medicinal Chemistry by Andrejus Korolkovas Pdf

This text/reference presents fundamental aspects of medicinal chemistry and contains comprehensive information on approximately 5,000 drugs currently in use, describing their therapeutic uses, their mechanisms of action, and their main side and harmful effects. Employs the latest World Health Organization (WHO) pharmacological classification and provides extensive information for drugs on WHO's latest list of basic or essential pharmaceuticals, including history: chemical, trade and generic names; chemical structure; obtention; physical and chemical properties; mechanisms of action; therapeutic uses; adverse reactions; biotransformation; chemical and pharmacological incompatibilities; bioavailability; dosage; storage; and assay.

Natural Products in Medicinal Chemistry

Stephen Hanessian
Natural Products in Medicinal Chemistry Book PDF

Author : Stephen Hanessian
Publisher : John Wiley & Sons
Page : 652 pages
File Size : 41,8 Mb
Release : 2013-12-18
Category : Medical
ISBN : 9783527676552

Get Book

Natural Products in Medicinal Chemistry by Stephen Hanessian Pdf

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Medicinal Chemistry

Ashutosh Kar
Medicinal Chemistry Book PDF

Author : Ashutosh Kar
Publisher : New Age International
Page : 832 pages
File Size : 40,9 Mb
Release : 2005
Category : Pharmacology
ISBN : 8122415652

Get Book

Medicinal Chemistry by Ashutosh Kar Pdf

The Qualified Success And General Appeal Of Medicinal Chemistry Is Not Only Confined To The Indian Subcontinent, But It Has Also Won An Overwhelming Popularity In Other Parts Of The World. Specific Care Has Been Taken To Maintain And Sustain The Fundamental Philosophy Of The Textbook Embracing Rigidly The Original Pattern And Style Of Presentation With A Particular Expatiated Treatment Of Synthesis Of Potential Medicinal Compounds For The Ultimate Benefits Of The Teachers And The Taught Alike.The Present Thoroughly Revised And Skilfully Expanded Fourth Edition Essentially Contains Three New And Important Chapters, Namely : Molecular Modeling And Drug Design (Chapter 3), Adrenocortical Steroids (Chapter 24), And Antimycobacterial Agents (Chapter 26) So As To Make The Textbook More Useful To Its Readers.With The Advent Of Thirty Chapters The Present Updated Form Of Medicinal Chemistry Will Prove To Be An Asset For M. Pharm./B. Pharm. Degree Students, M. Sc. Pharmaceutical Chemistry, M.Sc. Applied Chemistry And M. Sc. Industrial Chemistry Throughout The Indian Universities.Medicinal Chemistry Appears As A Newly Designed And Artistically Presented In A Two-Colour Scheme So As To Facilitate A Distinctly More Effective Use Of The Book.This Highly Readable, Lucid, Handy, And Exceptionally Knowledgeable Textbook Will Definitely Win A Better, Bigger, And Confident Place For Itself Amongst Its Valued Readers.