Mesenchymal Stem Cell In Veterinary Sciences

Author : Mudasir Bashir Gugjoo,Amar Pal
Publisher : Springer Nature
Page : 347 pages
File Size : 47,7 Mb
Release : 2020-11-09
Category : Science
ISBN : 9789811560378

Get Book

Mesenchymal Stem Cell in Veterinary Sciences by Mudasir Bashir Gugjoo,Amar Pal Pdf

This book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs. Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.

Author : Mudasir Bashir Gugjoo
Publisher : Springer Nature
Page : 418 pages
File Size : 44,9 Mb
Release : 2022-08-05
Category : Medical
ISBN : 9789811932779

Get Book

Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine by Mudasir Bashir Gugjoo Pdf

This book reviews the potential therapeutic and reproductive applications of mesenchymal stem cells in veterinary regenerative and reproductive medicine. The systemic approach focuses on musculoskeletal structures like cartilage, bone, muscle, tendon, ligaments and nervous tissues. It also focuses on other body systems like gastrointestinal, cardiovascular, urogenital, respiratory and integumentary system. Besides, the special glands or organs like endocrine glands and eye and its adnexa are also focused. The book chapters discusses the problems and the need for regenerative medicine employing MSCs. It provides an ex vivo basis of MSCs therapeutics and reproductive potential followed by their in vivo applications. The book further provides an understanding on the behavior and mechanisms of action of mesenchymal stem cells. The book also abridges challenges and provides future prospects of mesenchymal stem cells in clinical and reproductive applications. As such, the book offers a valuable resource for students, veterinarians, and scientists working in the regenerative and reproductive sciences in human and veterinary medicine.

Author : Ratan Kumar Choudhary,Shanti Choudhary
Publisher : Springer Nature
Page : 375 pages
File Size : 44,5 Mb
Release : 2022-02-05
Category : Science
ISBN : 9789811634642

Get Book

Stem Cells in Veterinary Science by Ratan Kumar Choudhary,Shanti Choudhary Pdf

This book explores the potential applications of animal stem cells in veterinary medicine. It begins with an overview of stem cells and their application in treating various animal diseases, including mastitis. In turn, the book discusses the challenges of using stem cells in regenerative medicine and emphasizes the importance of understanding the action of stem cells and preclinical evidence for ensuring safety and therapeutic efficacy. It also presents methods for the identification, characterization, and quantification of stem cells. Further, it discusses the therapeutic applications of different stem cells, including milk-derived, testicular, and mesenchymal stem cells in veterinary medicine. Lastly, it discusses strategies for and therapeutic applications of genome editing by CRISPER/Cas9 in mammary stem cells. As such, the book offers a valuable resource for students and scientists working in the veterinary sciences and veterinarians.

Author : Lucas G. Chase,Mohan C Vemuri
Publisher : Springer Science & Business Media
Page : 458 pages
File Size : 53,8 Mb
Release : 2012-12-12
Category : Science
ISBN : 9781627032001

Get Book

Mesenchymal Stem Cell Therapy by Lucas G. Chase,Mohan C Vemuri Pdf

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 53,6 Mb
Release : 2009
Category : Electronic
ISBN : OCLC:1427489747

Get Book

The Isolation and Characteristics of Canine Mesenchymal Stem Cells by Anonim Pdf

Author : Eleonora Iacono,Barbara Merlo
Publisher : Mdpi AG
Page : 0 pages
File Size : 51,9 Mb
Release : 2023-01-05
Category : Science
ISBN : 3036559094

Get Book

Stem Cells in Domestic Animals by Eleonora Iacono,Barbara Merlo Pdf

Stem cells are an attractive tool for cell-based therapies in regenerative medicine, both for humans and animals. The research and review articles published in this first book of the Collection "Stem Cells in Domestic Animals: Applications in Health and Production" are excellent examples of the recent advances made in the field of stem/stromal cell research in veterinary medicine. In this field, sophisticated and new treatments are now required for improving patients' quality of life; in livestock animals, the goal of regenerative medicine is to improve not only animal welfare but also the quality of production, aiming to preserve human health. The contributions collected in this book concern both laboratory research and clinical applications of mesenchymal stem/stromal cells. The increasing knowledge of cell-based therapies may constitute an opportunity for researchers, veterinary practitioners, and animal owners to contribute to animal and human health and well-being.

Author : Alain A. Vertes,Nasib Qureshi,Arnold I. Caplan,Lee E. Babiss
Publisher : John Wiley & Sons
Page : 788 pages
File Size : 50,6 Mb
Release : 2015-12-02
Category : Science
ISBN : 9781119971399

Get Book

Stem Cells in Regenerative Medicine by Alain A. Vertes,Nasib Qureshi,Arnold I. Caplan,Lee E. Babiss Pdf

This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

Author : Mitchell Khan
Publisher : Nova Science Publishers
Page : 134 pages
File Size : 55,6 Mb
Release : 2021
Category : Science
ISBN : 1536192244

Get Book

Human Mesenchymal Stem Cells by Mitchell Khan Pdf

"In Chapter 1, the COVID-19 pandemic and the damage mechanisms on the cellular level which can be ameliorated with the cellular therapies is thoroughly evaluated. Previous and ongoing stem cell clinical trial data from diseases with similar symptoms is gathered. All this accumulated data and current clinical trial results indicate that the cellular therapies could be the most effective treatment option for COVID-19 patients to ameliorate the damaged tissues and save lives. In Chapter 2, the authors examine activated mesenchymal stem cells for stroke repair. Stem Cell treatment has shown recovery in animal models of stroke, indicating an improved regenerative and repair potential. Though stem cells are still being used in clinical trials, there is no evidence that they enhance recovery in ischemic stroke patients. Nevertheless, the multipotent mesenchymal stem has widely been explored for stroke recovery. An'Activated MSC' as a therapeutic alternative to tackling ischemic stroke is proposed, thereby the activation of MSCs by cytokines, growth factors, hypoxia, pharmacological drugs, etc., could be a novel approach to improving stroke patients' responses to receiving MSCs. In Chapter 3, the potential benefits of in vitro culture of therapeutic stem cells in the presence of HB along with the ketogenic diet, whereby higher physiological concentrations of ketone bodies can be achieved in vivo, as an adjuvant to stem cell transplantation is assessed"--

Author : Atta-ur-Rahman,Shazia Anjum
Publisher : Bentham Science Publishers
Page : 283 pages
File Size : 47,7 Mb
Release : 2017-04-03
Category : Science
ISBN : 9781681084350

Get Book

Frontiers in Stem Cell and Regenerative Medicine Research by Atta-ur-Rahman,Shazia Anjum Pdf

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The fourth volume of this series features reviews on the use of stem cells through retrodifferentiation, mesodermal regeneration, hematopoiesis and mesenchymal stem cells. The volume also features a chapter on current knowledge on cell-based therapy in veterinary medicine.

Author : Charles J. Malemud,Eben Alsberg
Publisher : Springer
Page : 85 pages
File Size : 55,6 Mb
Release : 2016-12-10
Category : Science
ISBN : 9783319467337

Get Book

Mesenchymal Stem Cells and Immunomodulation by Charles J. Malemud,Eben Alsberg Pdf

This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two. Mesenchymal Stem Cells and Immunomodulation, part of Springer’s Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.

Author : Jan A. Nolta
Publisher : Springer Science & Business Media
Page : 170 pages
File Size : 48,8 Mb
Release : 2006-08-29
Category : Science
ISBN : 9781402039591

Get Book

Genetic Engineering of Mesenchymal Stem Cells by Jan A. Nolta Pdf

MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.

Author : Mirjana Pavlović,Ksenija Radotić
Publisher : Springer
Page : 234 pages
File Size : 48,7 Mb
Release : 2017-02-08
Category : Technology & Engineering
ISBN : 9783319477633

Get Book

Animal and Plant Stem Cells by Mirjana Pavlović,Ksenija Radotić Pdf

This book provides a multifaceted look into the world of stem cells and explains the similarities and differences between plant and human stem cells. It explores the intersection between animals and plants and explains their cooperative role in bioengineering studies. The book treats both theoretical and practical aspects of stem cell research. It covers the advantages and limitations of many common applications related to stem cells: their sources, categories, engineering of these cells, reprogramming of their functions, and their role as novel cellular therapeutic approach. Written by experts in the field, the book focuses on aspects of stem cells ranging from expansion-propagation to metabolic reprogramming. It introduces the emergence of cancer stem cells and different modalities in targeted cancer stem cell therapies. It is a valuable source of fresh information for academics and researchers, examining molecular mechanisms of animal and plant stem cell regulation and their usage for therapeutic applications. Students at all levels of medical or engineering backgrounds will enjoy the case studies that illustrate and explain mechanisms, interactions, targeted effects, and multimodal therapeutic approaches. Academics, researchers, and professionals who want to expand their knowledge in this field will find this book an exceptional resource.

Author : Randy Morrison
Publisher : Unknown
Page : 97 pages
File Size : 52,6 Mb
Release : 2017
Category : HEALTH & FITNESS
ISBN : 1634857208

Get Book

Mesenchymal Stromal Cells (MSCs) by Randy Morrison Pdf

Mesenchymal stromal cells (MSCs) are considered an important tool in tissue engineering due to their multilineage potential in vitro as in vivo beyond their capacity to produce bioactive molecules involved in tissue regeneration. MSCs are essential elements of the microenvironment because they are the precursors of all stromal cells. MSCs influence HPC functions, such as proliferation, apoptosis, and clonogenic growth, directly via cell-cell contacts or indirectly via the secretion of soluble factors. This book reviews the biology, mechanisms of action and clinical uses of MSCs. Chapter One analyzes the modulation of adhesion molecules on MSCs to help in understanding their possible contribution to cancer initiation and progression. Chapter Two studies adipose derived MSCs in cancer therapy. Chapter Three discusses the improvement of clinical uses of MSCs by 3D scaffold-free constructs. Chapter Four reviews the application of MSCs in veterinary medicine.

Author : Khalid Ahmed Al-Anazi
Publisher : BoD – Books on Demand
Page : 150 pages
File Size : 44,5 Mb
Release : 2020-04-22
Category : Science
ISBN : 9781789238075

Get Book

Update on Mesenchymal and Induced Pluripotent Stem Cells by Khalid Ahmed Al-Anazi Pdf

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

Author : Scott J. Roberts
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 43,6 Mb
Release : 2023-10-18
Category : Medical
ISBN : 9782832536223

Get Book

Insights in Veterinary Regenerative Medicine: 2022 by Scott J. Roberts Pdf