Mesenchymal Stem Cells As New Candidates For Stemcell Based Dental Therapies

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Mesenchymal Stem Cells as New Candidates for Stemcell Based Dental Therapies

Patrick Kimuyu
Mesenchymal Stem Cells as New Candidates for Stemcell Based Dental Therapies Book PDF

Author : Patrick Kimuyu
Publisher : GRIN Verlag
Page : 20 pages
File Size : 47,8 Mb
Release : 2018-02-07
Category : Medical
ISBN : 9783668631489

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Mesenchymal Stem Cells as New Candidates for Stemcell Based Dental Therapies by Patrick Kimuyu Pdf

Project Report from the year 2018 in the subject Medicine - Medical Frontiers and Special Areas, grade: 1, Egerton University, language: English, abstract: This paper will provide a comprehensive review on the origin and types of MSCs in the dental tissue and the oral cavity. It will also discuss their therapeutic mechanisms that make them useful in dentistry and dental treatments. Over the past few decades, stem cell research has gained extensive scientific inquiry. This aspect is attributable to the significance of stem cells in tissue engineering. It is apparent that tissue regeneration has emerged as a reliable medical approach for the treatment of tissue disorders and injuries. Initially, embryonic stem cells were preferred as candidates for regenerative medicine because these cells can be induced to replicate in a pluripotent state. However, stem cell research involving embryonic stem cells has attracted immense controversy. It is also associated with legal and ethical issues, thus limiting the use of embryonic stem cells in regenerative medicine. Fortunately, the discovery of mesenchymal stem cells (MSCs), also referred to as adult stem cells, has restored promise for the development of stem cell therapies. Unlike embryonic stem cells, MSCs are free from legal and ethical concerns. MSCs are usually pluripotent progenitor cells that are generated in an array of tissues in both foetal and adult life. It is reported that these progenitor cells differentiate into cell types of the tissues that generate them, although studies indicate that they can differentiate cell types of other tissues. Currently, MSCs are used for regenerative therapies for a number of tissue disorders and injuries including bone regeneration. For instance, MSCs generated by the dental pulps and the oral cavity tissues have been found to possess the potential for dental tissue regeneration. These cells have also been found to useful in non-dental tissue repair.

Regenerative Dentistry

Mona Marei
Regenerative Dentistry Book PDF

Author : Mona Marei
Publisher : Springer Nature
Page : 164 pages
File Size : 55,8 Mb
Release : 2022-06-01
Category : Science
ISBN : 9783031025815

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Regenerative Dentistry by Mona Marei Pdf

Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry

Dental Stem Cells: Regenerative Potential

Barbara Zavan,Eriberto Bressan
Dental Stem Cells Regenerative Potential Book PDF

Author : Barbara Zavan,Eriberto Bressan
Publisher : Humana Press
Page : 288 pages
File Size : 46,5 Mb
Release : 2016-07-25
Category : Science
ISBN : 9783319332994

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Dental Stem Cells: Regenerative Potential by Barbara Zavan,Eriberto Bressan Pdf

This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.

Mesenchymal Stem Cell Therapy

Lucas G. Chase,Mohan C Vemuri
Mesenchymal Stem Cell Therapy Book PDF

Author : Lucas G. Chase,Mohan C Vemuri
Publisher : Springer Science & Business Media
Page : 458 pages
File Size : 55,5 Mb
Release : 2012-12-12
Category : Science
ISBN : 9781627032001

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Mesenchymal Stem Cell Therapy by Lucas G. Chase,Mohan C Vemuri Pdf

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Stem Cell Biology and Tissue Engineering in Dental Sciences

Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam
Stem Cell Biology and Tissue Engineering in Dental Sciences Book PDF

Author : Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam
Publisher : Academic Press
Page : 933 pages
File Size : 42,5 Mb
Release : 2014-11-05
Category : Technology & Engineering
ISBN : 9780123977786

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Stem Cell Biology and Tissue Engineering in Dental Sciences by Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam Pdf

Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color

Stem Cell in Medicine

Anonim
Stem Cell in Medicine Book PDF

Author : Anonim
Publisher : Elsevier
Page : 428 pages
File Size : 55,9 Mb
Release : 2023-09-11
Category : Science
ISBN : 9780443134128

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Stem Cell in Medicine by Anonim Pdf

Stem Cells in Medicine, Volume 199 in the Progress in Molecular Biology and Translational Science series, provides the most topical and informative research in the field of stem cells. Sections in this new release update on an Introduction to stem cells, Stem cell engineering, Xeno-free culture and proliferation of hPSCs on 2D biomaterials, 3D scaffold preparation for stem cell culture and differentiation, GMP grade production of hPSCs, Human hepatic stem cell assay, Cardiomyocyte cell sheets derived from hPSCs and muscle cells for myocardial infarction treatment, Stem cell therapy for osteoarthritis, hPSC-derived RPE transplantation for the treatment of macular degeneration, and much more. The book provides not only fundamental aspects and cultural and production methods of stem cells, but also the critical engineering aspects of stem cells such as drug screening using hepatocytes and disease treatment by transplantation of retinal pigment epithelium and cardiomyocytes which are derived from human pluripotent stem cells. Provides accurate reviews from selected experts on the topic of stem cell culture and differentiation Presents useful graphic materials for ease of reading Includes the latest insights and future perspectives on stem cell therapy

Dental Pulp Stem Cells

Sibel Yildirim
Dental Pulp Stem Cells Book PDF

Author : Sibel Yildirim
Publisher : Springer Science & Business Media
Page : 89 pages
File Size : 48,7 Mb
Release : 2012-10-15
Category : Science
ISBN : 9781461456872

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Dental Pulp Stem Cells by Sibel Yildirim Pdf

Stem cell technology is moving forward at a tremendous rate. Recent discoveries have surprised even the most expert researchers. While every piece of new data broadens the current knowledge and contributes to this moving forward, the new data also serve as paradigm shifters of fundamental knowledge of cell biology. While the question ‘What is a Stem Cell’ may now seem to basic to even discuss, there are still some discrepancies, however, between groups in terms of their functional roles. Teeth develop from the ectoderm of the first branchial arch and the ectomesenchyme of the neural crest. Deciduous teeth start to form between the sixth and eighth weeks, and permanent teeth begin to form in the twentieth weeks. Several studies have demonstrated that the pulp from both adult teeth and deciduous teeth contains dental pulp stem cells. Several factors have made them very attractive as a model system for many researchers; they are multipotent, ethically and non-controversially available in large numbers, immuno-compatible, developmentally primitive, easy to isolate and have high expansion potential in vitro. However, many controversies still exist in the field. There are several unanswered questions in the biology of dental pulp and odontoblasts. This new volume in the SpringerBriefs in Stem Cells series presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration.​

Mesenchymal Stem Cell Derived Exosomes

Yaoliang Tang,Buddhadeb Dawn
Mesenchymal Stem Cell Derived Exosomes Book PDF

Author : Yaoliang Tang,Buddhadeb Dawn
Publisher : Academic Press
Page : 288 pages
File Size : 55,9 Mb
Release : 2015-09-02
Category : Medical
ISBN : 9780128004975

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Mesenchymal Stem Cell Derived Exosomes by Yaoliang Tang,Buddhadeb Dawn Pdf

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics

Xiao-Dong Chen
A Roadmap to Nonhematopoietic Stem Cell Based Therapeutics Book PDF

Author : Xiao-Dong Chen
Publisher : Academic Press
Page : 544 pages
File Size : 41,5 Mb
Release : 2018-08-31
Category : Science
ISBN : 9780128119211

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A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics by Xiao-Dong Chen Pdf

A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent. Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies

Stem Cells and Its Use in Dentistry

Meghanand Nayak,Manoj Upadhayay
Stem Cells and Its Use in Dentistry Book PDF

Author : Meghanand Nayak,Manoj Upadhayay
Publisher : Unknown
Page : 168 pages
File Size : 44,5 Mb
Release : 2018-02-26
Category : Electronic
ISBN : 3668644233

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Stem Cells and Its Use in Dentistry by Meghanand Nayak,Manoj Upadhayay Pdf

Professorial Dissertation from the year 2018 in the subject Medicine - Dentistry, grade: -, Teerthanker Mahaveer University (Teerthanker Mahaveer Dental College & Research Centre), course: Dentistry, language: English, abstract: One of the fundamental properties of stem cell is that it does not have any tissue-specific structure that allows it to perform a specialized function. Unspecialized stem cells can give rise to specialized cells including heart muscle cells, blood cells, or nerve cells. This process is called differentiation. Several types of stem cell have been discovered from germ cells, the embryo, fetus, and adult. Each of these has promised to revolutionize the future of regenerative medicine through the provision of cell-replacement therapies to treat a variety of debilitating diseases. Stem cell research opens-up the new field of 'cell-based therapies' and, as such, several safety measures have also to be evaluated. Regenerative medicine is based on stem cells. The dental pulp contains the progenitor/stem cells which have the self-renewal capability, multi-lineage differentiation capacity and clonogenic efficiency. Dental stem cells can generate many types of tissues including bone, nerve, cartilage, teeth, and fat. However, the biology of these mysterious cells have yet to be understood and a lot more basic research is needed before new therapies using stem-cell-differentiated derivatives can be applied. Recently stem cells banks are present, and even some of these banks do not only freeze cord stem cells but also dental stem cells of baby teeth. Hence this review attempts to study the history, current concepts, evolution of stem cells in dentistry, dental stem cell banking in India, characterization of the stem cells in dentin regeneration and stem cell therapy in dentistry.

Novel Perspectives of Stem Cell Manufacturing and Therapies

Diana Kitala,Ana Colette Maurício
Novel Perspectives of Stem Cell Manufacturing and Therapies Book PDF

Author : Diana Kitala,Ana Colette Maurício
Publisher : BoD – Books on Demand
Page : 180 pages
File Size : 52,6 Mb
Release : 2021-04-14
Category : Technology & Engineering
ISBN : 9781839625039

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Novel Perspectives of Stem Cell Manufacturing and Therapies by Diana Kitala,Ana Colette Maurício Pdf

In the 1950s, Nobel Prize winner Dr. E. Donnall Thomas was the first to successfully transplant hematopoietic stem cells. Since then, studies on stem cells have evolved and expanded worldwide. There are more than 650,000 scientific publications on stem cells and more than 8000 stem cell clinical trials. This book summarizes types of stem cells, key studies, ongoing trials, and future perspectives. It also includes ethical, formal, and legal aspects to give the reader a comprehensive view of the field.

Periodontal Advancements: A Guide to the Latest in Gum Health

Dr Ravi Kiran
Periodontal Advancements A Guide to the Latest in Gum Health Book PDF

Author : Dr Ravi Kiran
Publisher : Inkbound Publishers
Page : 209 pages
File Size : 41,9 Mb
Release : 2021-06-25
Category : Medical
ISBN : 9788197081347

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Periodontal Advancements: A Guide to the Latest in Gum Health by Dr Ravi Kiran Pdf

Stay updated on the latest advancements in periodontal care with this comprehensive guide. Covering new treatments, technologies, and research in gum health, this book is an invaluable resource for dental practitioners and researchers.

Tissue Barriers in Disease, Injury and Regeneration

Nikolai V. Gorbunov
Tissue Barriers in Disease Injury and Regeneration Book PDF

Author : Nikolai V. Gorbunov
Publisher : Elsevier
Page : 208 pages
File Size : 42,8 Mb
Release : 2021-06-19
Category : Science
ISBN : 9780128227565

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Tissue Barriers in Disease, Injury and Regeneration by Nikolai V. Gorbunov Pdf

Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium

Mesenchymal Stem Cells and Craniofacial Regeneration

Jing Wang ,YunFeng Lin
Mesenchymal Stem Cells and Craniofacial Regeneration Book PDF

Author : Jing Wang ,YunFeng Lin
Publisher : Bentham Science Publishers
Page : 408 pages
File Size : 40,5 Mb
Release : 2016-10-19
Category : Science
ISBN : 9781681083155

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Mesenchymal Stem Cells and Craniofacial Regeneration by Jing Wang ,YunFeng Lin Pdf

This monograph provides a current and in-depth review of scholarly information about mesenchymal stem cells and their application in the craniofacial region of the human body. Chapters in this volume cover biological and conceptual information about mesenchymal stem cells, induced pluripotent stem cells, craniofacial regeneration, new methods of scaffold fabrication, tooth regeneration and three-dimensional printing in dentistry. The book is suitable for clinicians and cell biologists aiming to gain a better understanding of the promising field of craniofacial regenerative medicine.

Stem Cells in Craniofacial Development and Regeneration

George T.J. Huang,Irma Thesleff
Stem Cells in Craniofacial Development and Regeneration Book PDF

Author : George T.J. Huang,Irma Thesleff
Publisher : John Wiley & Sons
Page : 578 pages
File Size : 52,7 Mb
Release : 2013-04-15
Category : Science
ISBN : 9781118279236

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Stem Cells in Craniofacial Development and Regeneration by George T.J. Huang,Irma Thesleff Pdf

Stem Cells, Craniofacial Development and Regeneration is an introduction to stem cells with an emphasis on their role in craniofacial development. Divided into five sections, chapters build from basic introductory information on the definition and characteristics of stem cells to more indepth explorations of their role in craniofacial development. Section I covers embryonic and adult stem cells with a focus on the craniofacial region, while sections II-IV cover the development and regeneration of craniofacial bone, tooth, temporomandibular joint, salivary glands and muscle. Concluding chapters describe the current, cutting-edge research utilizing stem cells for craniofacial tissue bioengineering to treat lost or damaged tissue. The authoritative resource for dentistry students as well as craniofacial researchers at the graduate and post-graduate level, Stem Cells, Craniofacial Development and Regeneration explores the rapidly expanding field of stem cells and regeneration from the perspective of the dentistry and craniofacial community, and points the way forward in areas of tissue bioengineering and craniofacial stem cell therapies.