Dental Stem Cells Regenerative Potential

Author : Barbara Zavan,Eriberto Bressan
Publisher : Humana Press
Page : 288 pages
File Size : 40,9 Mb
Release : 2016-07-25
Category : Science
ISBN : 9783319332994

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Dental Stem Cells: Regenerative Potential by Barbara Zavan,Eriberto Bressan Pdf

This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.

Author : Mona Marei
Publisher : Springer Nature
Page : 164 pages
File Size : 53,6 Mb
Release : 2022-06-01
Category : Science
ISBN : 9783031025815

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Regenerative Dentistry by Mona Marei Pdf

Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry

Author : Sepanta Hosseinpour,Laurence J. Walsh,Keyvan Moharamzadeh
Publisher : Springer Nature
Page : 276 pages
File Size : 53,6 Mb
Release : 2021-01-25
Category : Medical
ISBN : 9783030598099

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Regenerative Approaches in Dentistry by Sepanta Hosseinpour,Laurence J. Walsh,Keyvan Moharamzadeh Pdf

This book provides evidence-based information in the field of regenerative dentistry discussing the most recent advances, current clinical applications, limitations and future directions. The coverage encompasses the regeneration of alveolar bone, the dentine-pulp complex, enamel, the periodontium and other tissues associated with the oral cavity. A full description is provided of regenerative approaches in dentistry including regenerative endodontics and tooth repair, regenerative periodontics, regenerative assisted orthodontics, regenerative approaches in oral medicine, and dental tissue derived stem cells and their potential applications. The book is written by an international team of leading experts. It will be beneficial for students, practitioners and researchers in the fields of endodontics, periodontics and implantology.

Author : Fikrettin Şahin,Ayşegül Doğan,Selami Demirci
Publisher : Springer
Page : 317 pages
File Size : 43,7 Mb
Release : 2016-06-08
Category : Science
ISBN : 9783319289472

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Dental Stem Cells by Fikrettin Şahin,Ayşegül Doğan,Selami Demirci Pdf

This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells. Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer’s Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.

Author : Mikihito Kajiya,Anne George,Takehito Ouchi,Giovanna Orsini
Publisher : Frontiers Media SA
Page : 178 pages
File Size : 41,8 Mb
Release : 2022-02-22
Category : Science
ISBN : 9782889744763

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Stem Cells in Oral Cavity: From Development to Regeneration by Mikihito Kajiya,Anne George,Takehito Ouchi,Giovanna Orsini Pdf

Author : Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam
Publisher : Academic Press
Page : 933 pages
File Size : 51,6 Mb
Release : 2014-11-05
Category : Technology & Engineering
ISBN : 9780123977786

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Stem Cell Biology and Tissue Engineering in Dental Sciences by Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam Pdf

Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color

Author : Patrick Kimuyu
Publisher : GRIN Verlag
Page : 20 pages
File Size : 49,7 Mb
Release : 2018-02-07
Category : Medical
ISBN : 9783668631489

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Mesenchymal Stem Cells as New Candidates for Stemcell Based Dental Therapies by Patrick Kimuyu Pdf

Project Report from the year 2018 in the subject Medicine - Medical Frontiers and Special Areas, grade: 1, Egerton University, language: English, abstract: This paper will provide a comprehensive review on the origin and types of MSCs in the dental tissue and the oral cavity. It will also discuss their therapeutic mechanisms that make them useful in dentistry and dental treatments. Over the past few decades, stem cell research has gained extensive scientific inquiry. This aspect is attributable to the significance of stem cells in tissue engineering. It is apparent that tissue regeneration has emerged as a reliable medical approach for the treatment of tissue disorders and injuries. Initially, embryonic stem cells were preferred as candidates for regenerative medicine because these cells can be induced to replicate in a pluripotent state. However, stem cell research involving embryonic stem cells has attracted immense controversy. It is also associated with legal and ethical issues, thus limiting the use of embryonic stem cells in regenerative medicine. Fortunately, the discovery of mesenchymal stem cells (MSCs), also referred to as adult stem cells, has restored promise for the development of stem cell therapies. Unlike embryonic stem cells, MSCs are free from legal and ethical concerns. MSCs are usually pluripotent progenitor cells that are generated in an array of tissues in both foetal and adult life. It is reported that these progenitor cells differentiate into cell types of the tissues that generate them, although studies indicate that they can differentiate cell types of other tissues. Currently, MSCs are used for regenerative therapies for a number of tissue disorders and injuries including bone regeneration. For instance, MSCs generated by the dental pulps and the oral cavity tissues have been found to possess the potential for dental tissue regeneration. These cells have also been found to useful in non-dental tissue repair.

Author : Rachel J. Waddington,Alastair J. Sloan
Publisher : John Wiley & Sons
Page : 184 pages
File Size : 40,5 Mb
Release : 2016-11-18
Category : Medical
ISBN : 9781118741047

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Tissue Engineering and Regeneration in Dentistry by Rachel J. Waddington,Alastair J. Sloan Pdf

Tissue Engineering and Regeneration in Dentistry: Current Strategies presents a thorough update on the current advances, methods and understanding in tissue engineering in dentistry. It offers invaluable tools, case studies, and methodologies for undertaking research, including important biological and practical considerations to facilitate successful migration of research from the bench to the clinic. Offers detailed coverage of the basic underlying principles and scientific evidence, and includes protocols to highlight practical applications Written by an internationally renowned team of expert contributors A must-have read for researchers and specialist clinicians in tissue engineering, oral biology, dental materials science, periodontology and oral surgery

Author : Kursad Turksen
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 44,7 Mb
Release : 2013-09-24
Category : Science
ISBN : 9781461480662

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Stem Cells: Current Challenges and New Directions by Kursad Turksen Pdf

This volume looks at the state-of-the-science in stem cells, discusses the current challenges, and examines the new directions the field is taking. Dr. Turksen, editor-in-chief of the journal "Stem Cell Reviews and Reports," has assembled a volume of internationally-known scientists who cover topics that are both clinically and research-oriented. The contents range from sources of stem cells through their physiological role in health and disease, therapeutic applications in regenerative medicine, and ethics and society. An initial overview and a final summary bookend the contents into a cohesive and invaluable volume.

Author : Sibel Yildirim
Publisher : Springer Science & Business Media
Page : 89 pages
File Size : 42,9 Mb
Release : 2012-10-15
Category : Science
ISBN : 9781461456865

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Dental Pulp Stem Cells by Sibel Yildirim Pdf

Stem cell technology is moving forward at a tremendous rate. Recent discoveries have surprised even the most expert researchers. While every piece of new data broadens the current knowledge and contributes to this moving forward, the new data also serve as paradigm shifters of fundamental knowledge of cell biology. While the question ‘What is a Stem Cell’ may now seem to basic to even discuss, there are still some discrepancies, however, between groups in terms of their functional roles. Teeth develop from the ectoderm of the first branchial arch and the ectomesenchyme of the neural crest. Deciduous teeth start to form between the sixth and eighth weeks, and permanent teeth begin to form in the twentieth weeks. Several studies have demonstrated that the pulp from both adult teeth and deciduous teeth contains dental pulp stem cells. Several factors have made them very attractive as a model system for many researchers; they are multipotent, ethically and non-controversially available in large numbers, immuno-compatible, developmentally primitive, easy to isolate and have high expansion potential in vitro. However, many controversies still exist in the field. There are several unanswered questions in the biology of dental pulp and odontoblasts. This new volume in the SpringerBriefs in Stem Cells series presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration.​

Author : Henry F. Duncan,Paul Roy Cooper
Publisher : Springer
Page : 194 pages
File Size : 53,6 Mb
Release : 2018-11-01
Category : Medical
ISBN : 9783319968483

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Clinical Approaches in Endodontic Regeneration by Henry F. Duncan,Paul Roy Cooper Pdf

This richly illustrated book combines explanation of the scientific base underpinning vital pulp treatment with description of current and emerging trends in clinical practice. It guides the reader through modern views on pulp diagnostics, deep caries, and pulp exposure management, leading to an analysis of the biological aspects of regenerative techniques such as angiogenesis, neurogenesis, inflammation, and epigenetics. In the later chapters, practical considerations relating to bioengineering, biomaterial choice, revitalization, and stem cell-based procedures are discussed and their likely therapeutic impact considered. Aimed at dental students, postgraduates, and research-minded dental practitioners, this translational book summarizes state-of-the-art scientific knowledge on dentin–pulp interactions and regenerative endodontics, while highlighting the opportunities to incorporate recent developments into everyday practice. Readers will also find extensive discussion of potential future developments and research avenues relating to each aspect of this exciting and rapidly developing field.

Author : Dr. Shandar Siddiqui,Dr. Imran Saba
Publisher : EduBubs Publishing House
Page : 179 pages
File Size : 43,8 Mb
Release : 2020-10-14
Category : Science
ISBN : 9788194292678

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Stem Cells by Dr. Shandar Siddiqui,Dr. Imran Saba Pdf

The Indian institution of dentures sitting in a glass of water beside the bed could berendered obsolete by scientists who are confident that people will soon be able to replace lost teeth by growing new ones instead of false teeth, a small ball of cells capable of growing into a new tooth will be implanted where the missing one used to be the procedure needs only a local anesthetic and the new tooth should be fully formed within a few months of the cells being implanted. Paul Sharpe, a specialist in the field of regenerative dentistry at the Dental Institute of king's College, London, says the new procedure has distinct advantages over false teeth that require a metal post to be driven into the jaw before being capped with a porcelain or plastic tooth. The surgery today can be extensive and you need to have good solid bone in the jaw and that is a major problem for some people," The method could be used on far more patients because the ball of cells that grows in to a tooth also produces bone that anchors to the jaw. The choice of growing a new tooth is likely to appeal to patients. "Anyone who has lost teeth will tell you that, given the chance, they would rather have their own teeth than false ones," The average indian over 50 has lost 12 teeth from a set of 32. The procedure is fairly simple. Doctors take stem cells from the patient. These are unique in their ability to form any of the tissues that make up the body. By carefully nurturing the stem cells in a laboratory, scientists can nudge the cells down a path that will make them grow into a tooth. After a couple of weeks, the ball of cells, known as bud, is ready to be implanted. Tests reveal what type of tooth - for example, a molar: an incisor - the bud will form, Using a local anaesthetic, the tooth bud is inserted through a small incision into the gum. Within months, the cells will have matured into a fully-formed tooth, fused to the jawbone. As the tooth grows, it releases chemicals that encourage nerves and blood vessels to link up with it.

Author : Giovanna Orsini,Victor E. Arana-Chavez,Thimios Mitsiadis
Publisher : Frontiers Media SA
Page : 248 pages
File Size : 54,8 Mb
Release : 2016-10-07
Category : Physiology
ISBN : 9782889199846

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Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges by Giovanna Orsini,Victor E. Arana-Chavez,Thimios Mitsiadis Pdf

Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters: 1. General principles on the use of stem cells for regenerating craniofacial and dental tissues 2. The roles of nerves, vessels and stem cell niches in tissue regeneration 3. Dental pulp regeneration and mechanisms of various odontoblast functions 4. Dental root and periodontal physiology, pathology and regeneration 5. Physiology and regeneration of the bone using various scaffolds and stem cell populations 6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells

Author : Anonim
Publisher : Elsevier
Page : 509 pages
File Size : 40,8 Mb
Release : 2003-12-18
Category : Science
ISBN : 0080546161

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Differentiation of Embryonic Stem Cells by Anonim Pdf

This volume covers all aspects of embryonic stem cell differentiation, including mouse embryonic stem cells, mouse embryonic germ cells, monkey and human embryonic stem cells, and gene discovery. * Early commitment steps and generation of chimeric mice * Differentiation to mesoderm derivatives * Gene discovery by manipulation of mouse embryonic stem cells

Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publisher : Academic Press
Page : 1202 pages
File Size : 53,9 Mb
Release : 2010-12-16
Category : Science
ISBN : 0123814235

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Principles of Regenerative Medicine by Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem Pdf

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs