Mesenchymal Stromal Cells

Author : Lucas G. Chase,Mohan C Vemuri
Publisher : Springer Science & Business Media
Page : 458 pages
File Size : 40,5 Mb
Release : 2012-12-12
Category : Science
ISBN : 9781627032001

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Mesenchymal Stem Cell Therapy by Lucas G. Chase,Mohan C Vemuri Pdf

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Author : Mohan C Vemuri,Lucas G. Chase,Mahendra S. Rao
Publisher : Humana Press
Page : 534 pages
File Size : 52,6 Mb
Release : 2017-05-04
Category : Science
ISBN : 1493957791

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Mesenchymal Stem Cell Assays and Applications by Mohan C Vemuri,Lucas G. Chase,Mahendra S. Rao Pdf

Mesenchymal Stem Cells have seen an unprecedented level of interest in the last decade, primarily due to their relative ease of isolation, the large numbers of cells present in the adult, and the ability to propagate these cells in culture. In Mesenchymal Stem Cell Assays and Applications, expert researchers from across the globe explore the latest techniques to propagate, characterize, and engineer this special cell type. Chapters outline a set of protocols and assays used by leading investigators in the field, providing standards that can be applied by all researchers to the population of cells used in their experiments. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Ground-breaking and current, Mesenchymal Stem Cell Assays and Applications is a necessary handbook for all researchers working with this ambiguous population of cells.

Author : Mani T. Valarmathi
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 54,5 Mb
Release : 2019-01-23
Category : Science
ISBN : 9781789849844

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Stromal Cells by Mani T. Valarmathi Pdf

Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

Author : Peiman Hematti,Armand Keating
Publisher : Springer Science & Business Media
Page : 697 pages
File Size : 50,9 Mb
Release : 2013-01-16
Category : Science
ISBN : 9781461457114

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Mesenchymal Stromal Cells by Peiman Hematti,Armand Keating Pdf

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.

Author : Feridoun Karimi-Busheri,Michael Weinfeld
Publisher : Springer
Page : 238 pages
File Size : 50,6 Mb
Release : 2016-11-10
Category : Science
ISBN : 9783319454573

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Biobanking and Cryopreservation of Stem Cells by Feridoun Karimi-Busheri,Michael Weinfeld Pdf

Biobanking is considered to be one of the ten ideas changing the world with an estimated value of $45 billion by 2025. Despite the challenges, as the climate for innovation in the biobanking industry continues to flourish around the world, it is certain that amazing discoveries will emerge from this large-scale method of preserving and accessing human samples; biobanking is no longer just a place for collecting and storing samples. This book will cover a wide variety of subjects from across the future biobanking spectrum including scientific strategies, personalized medicine, regenerative medicine and stem cell challenges, disease surveillance, population genetics and innovative methods of biobanking.

Author : Lindolfo da Silva Meirelles,Karen Bieback,Marcela F. Bolontrade
Publisher : Frontiers Media SA
Page : 283 pages
File Size : 40,8 Mb
Release : 2021-03-24
Category : Science
ISBN : 9782889666256

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Current Progress in Mesenchymal Stem/Stromal Cell Research by Lindolfo da Silva Meirelles,Karen Bieback,Marcela F. Bolontrade Pdf

Author : Darwin J. Prockop,Donald G. Phinney,Bruce A. Bunnell
Publisher : Humana Press
Page : 0 pages
File Size : 51,7 Mb
Release : 2008-03-07
Category : Science
ISBN : 1588297713

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Mesenchymal Stem Cells by Darwin J. Prockop,Donald G. Phinney,Bruce A. Bunnell Pdf

For over forty years, mesenchymal stem cells (MSCs) have been scrutinized and studied, garnering much attention due to their broad therapeutic efficacy. In this essential book, leaders in the field were assembled to contribute detailed methodologies for the isolation and characterization of human and rodent MSCs. Cutting edge and easy to use, this book is the perfect resource for scientists attempting to pursue this important and ever-developing field of research.

Author : Birgit Weyand,Massimo Dominici,Ralf Hass,Roland Jacobs,Cornelia Kasper
Publisher : Springer
Page : 309 pages
File Size : 51,6 Mb
Release : 2014-07-08
Category : Technology & Engineering
ISBN : 9783642379444

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Mesenchymal Stem Cells - Basics and Clinical Application II by Birgit Weyand,Massimo Dominici,Ralf Hass,Roland Jacobs,Cornelia Kasper Pdf

Engineered MSCs from Patient-Specific iPS Cells, by Irina Eberle, Mohsen Moslem, Reinhard Henschler, Tobias Cantz Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application, by Beate Wagner, Reinhard Henschler The Implications of Stem Cell Applications for Diseases of the Respiratory System, by Mei Ling Lim, Philipp Jungebluth, Paolo Macchiarini Potential of Mesenchymal Stem Cell Applications in Plastic and Reconstructive Surgery, by Birgit Weyand, Peter M. Vogt General Principles for the Regeneration of Bone and Cartilage, by Michael Jagodzinski, C. Haasper Adult Mesenchymal Stem Cells Explored in the Dental Field, by K. M. Fawzy El-Sayed, C. Dörfer, F. Fändrich, F. Gieseler, M. H. Moustafa, H. Ungefroren Mesenchymal Stem Cell Therapy and Lung Diseases, by Khondoker M. Akram, Sohel Samad, Monica Spiteri, Nicholas R. Forsyth Mesenchymal Stem Cells as Cellular Immunotherapeutics in Allogeneic Hematopoietic Stem Cell Transplantation, by Claudia Papewalis, Daniela Topolar, Barbara Götz, Stefan Schönberger, Dagmar Dilloo New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes, by Aline M. Betancourt Interactions Between Mesenchymal Stem Cells and Dendritic Cells, by Grazia Maria Spaggiari, Lorenzo Moretta MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential, by Naomi D’souza, Jorge Sans Burns, Giulia Grisendi, Olivia Candini, Elena Veronesi, Serena Piccinno, Edwin M. Horwitz, Paolo Paolucci, Pierfranco Conte, Massimo Dominici Sources of Mesenchymal Stem Cells: Current and Future Clinical Use, by Michela Pozzobon, Martina Piccoli, Paolo De Coppi Role of the EU Framework in Regulation of Stem Cell-Based Products, by Giovanni Migliaccio, Cristina Pintus

Author : Randy Morrison
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 51,6 Mb
Release : 2016-09
Category : Mesenchymal stem cells
ISBN : 1634856996

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Mesenchymal Stromal Cells (MSCs) by Randy Morrison Pdf

Mesenchymal stromal cells (MSCs) are considered an important tool in tissue engineering due to their multilineage potential in vitro as in vivo beyond their capacity to produce bioactive molecules involved in tissue regeneration. MSCs are essential elements of the microenvironment because they are the precursors of all stromal cells. MSCs influence HPC functions, such as proliferation, apoptosis, and clonogenic growth, directly via cell-cell contacts or indirectly via the secretion of soluble factors. This book reviews the biology, mechanisms of action and clinical uses of MSCs. Chapter One analyzes the modulation of adhesion molecules on MSCs to help in understanding their possible contribution to cancer initiation and progression. Chapter Two studies adipose derived MSCs in cancer therapy. Chapter Three discusses the improvement of clinical uses of MSCs by 3D scaffold-free constructs. Chapter Four reviews the application of MSCs in veterinary medicine.

Author : Joan Oliva,Josep M. Canals,Mayasari Lim,Simone Pacini
Publisher : Frontiers Media SA
Page : 336 pages
File Size : 49,8 Mb
Release : 2022-08-12
Category : Science
ISBN : 9782889767700

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Mesenchymal Stromal Cells: Preclinical and Clinical Challenges by Joan Oliva,Josep M. Canals,Mayasari Lim,Simone Pacini Pdf

Author : Hematti Peiman,Sowmya Viswanathan
Publisher : Academic Press
Page : 362 pages
File Size : 44,5 Mb
Release : 2016-08-11
Category : Medical
ISBN : 9780128028407

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Mesenchymal Stromal Cells by Hematti Peiman,Sowmya Viswanathan Pdf

Mesenchymal Stromal Cells: Translational Pathways to Clinical Adoption provides the latest information on the necessary steps for successful production of stem cells for a clinical trial. Written by professionals with hands-on experience in bringing MSC therapies to the clinic, and building on the biology and mechanisms of action, this unique book covers the development and production of clinical-grade products that are suitable for use in humans. From design of a cell production facility, to obtaining regulatory approval and reimbursement issues, it is a useful guide for researchers and administrators across biomedical research. Provides methodologies for clinical MSC production, from designing a facility, to post-market approval Includes real-life examples of MSC production in academic centers and MSC production for biopharmaceutical clinical trials Offers a unique perspective on the clinical aspects of MSC studies Presents the principles of clinical trials that can be applied to the production of various cell therapies

Author : Kerry Atkinson
Publisher : John Wiley & Sons
Page : 1080 pages
File Size : 41,5 Mb
Release : 2017-01-17
Category : Science
ISBN : 9781118907511

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The Biology and Therapeutic Application of Mesenchymal Cells, 2 Volume Set by Kerry Atkinson Pdf

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.

Author : Khalid Ahmed Al-Anazi
Publisher : Unknown
Page : 128 pages
File Size : 55,6 Mb
Release : 2020
Category : Electronic
ISBN : 1789238080

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Update on Mesenchymal and Induced Pluripotent Stem Cells by Khalid Ahmed Al-Anazi Pdf

Author : Marcela Bolontrade,Mariana García
Publisher : Academic Press
Page : 642 pages
File Size : 42,7 Mb
Release : 2016-10-24
Category : Medical
ISBN : 9780128031032

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Mesenchymal Stromal Cells as Tumor Stromal Modulators by Marcela Bolontrade,Mariana García Pdf

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Author : Phuc Van Pham
Publisher : BoD – Books on Demand
Page : 302 pages
File Size : 51,7 Mb
Release : 2017-11-29
Category : Science
ISBN : 9789535136156

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Mesenchymal Stem Cells by Phuc Van Pham Pdf

Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.