Mesenchymal Stromal Cells As Tumor Stromal Modulators

Author : Marcela Bolontrade,Mariana García
Publisher : Academic Press
Page : 642 pages
File Size : 41,9 Mb
Release : 2016-10-24
Category : Medical
ISBN : 9780128031032

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Mesenchymal Stromal Cells as Tumor Stromal Modulators by Marcela Bolontrade,Mariana García Pdf

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Author : Peiman Hematti,Armand Keating
Publisher : Springer Science & Business Media
Page : 695 pages
File Size : 44,7 Mb
Release : 2013-01-16
Category : Science
ISBN : 9781461457114

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Mesenchymal Stromal Cells by Peiman Hematti,Armand Keating Pdf

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.

Author : Randy Morrison
Publisher : Unknown
Page : 97 pages
File Size : 43,7 Mb
Release : 2017
Category : HEALTH & FITNESS
ISBN : 1634857208

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Mesenchymal Stromal Cells (MSCs) by Randy Morrison Pdf

Mesenchymal stromal cells (MSCs) are considered an important tool in tissue engineering due to their multilineage potential in vitro as in vivo beyond their capacity to produce bioactive molecules involved in tissue regeneration. MSCs are essential elements of the microenvironment because they are the precursors of all stromal cells. MSCs influence HPC functions, such as proliferation, apoptosis, and clonogenic growth, directly via cell-cell contacts or indirectly via the secretion of soluble factors. This book reviews the biology, mechanisms of action and clinical uses of MSCs. Chapter One analyzes the modulation of adhesion molecules on MSCs to help in understanding their possible contribution to cancer initiation and progression. Chapter Two studies adipose derived MSCs in cancer therapy. Chapter Three discusses the improvement of clinical uses of MSCs by 3D scaffold-free constructs. Chapter Four reviews the application of MSCs in veterinary medicine.

Author : Yaoliang Tang,Buddhadeb Dawn
Publisher : Academic Press
Page : 288 pages
File Size : 43,6 Mb
Release : 2015-09-02
Category : Medical
ISBN : 9780128004975

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Mesenchymal Stem Cell Derived Exosomes by Yaoliang Tang,Buddhadeb Dawn Pdf

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Author : Arthur Zimmermann
Publisher : Springer
Page : 0 pages
File Size : 55,9 Mb
Release : 2016-11-02
Category : Medical
ISBN : 3319269542

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract by Arthur Zimmermann Pdf

This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years. Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.

Author : Chi Hin Cho,Tao Hu
Publisher : Academic Press
Page : 242 pages
File Size : 40,9 Mb
Release : 2020-05-24
Category : Science
ISBN : 9780128199381

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Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies by Chi Hin Cho,Tao Hu Pdf

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Author : Christian Lattermann,Henning Madry,Norimasa Nakamura,Elizaveta Kon
Publisher : Springer Nature
Page : 335 pages
File Size : 43,8 Mb
Release : 2021-10-09
Category : Medical
ISBN : 9783030794859

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Early Osteoarthritis by Christian Lattermann,Henning Madry,Norimasa Nakamura,Elizaveta Kon Pdf

Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis. Published in collaboration with ISAKOS, this volume appeals to all stakeholders in surgical orthopaedics and sports medicine.

Author : Richard Bucala
Publisher : World Scientific
Page : 335 pages
File Size : 44,5 Mb
Release : 2012
Category : Medical
ISBN : 9789814343725

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Fibrocytes in Health and Disease by Richard Bucala Pdf

This volume provides a comprehensive and multidisciplinary overview of fibrocytes, written by the main researchers in the field. It is aimed at a broad audience of scientists and clinicians with an interest in the role of circulating fibrocytes in the etiopathogenesis of different fibrosing disorders, atherosclerosis, autoimmunity, and cancer.

Author : Lauren Kokai,Kacey Marra,J. Peter Rubin
Publisher : Academic Press
Page : 486 pages
File Size : 45,8 Mb
Release : 2021-08-19
Category : Science
ISBN : 9780128193778

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Scientific Principles of Adipose Stem Cells by Lauren Kokai,Kacey Marra,J. Peter Rubin Pdf

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications

Author : Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 47,8 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783642281600

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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer by Michail Ignatiadis,Christos Sotiriou,Klaus Pantel Pdf

This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

Author : Mina Sarani,Abolfazl Heydari,Majid Darroudi
Publisher : Frontiers Media SA
Page : 107 pages
File Size : 40,6 Mb
Release : 2023-09-13
Category : Technology & Engineering
ISBN : 9782832534892

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Green Synthesis of Nanomaterials: Cytotoxicity and Drug Delivery by Mina Sarani,Abolfazl Heydari,Majid Darroudi Pdf

Over the past few decades, the increasing requirement for green chemistry and nanotechnology led to the adoption of green synthetic routes for the synthesis of nanomaterials using plants, microorganisms, and others. Hence, the green synthesis of nanomaterials has been considered by researchers through an eco-friendly path, which has led to much research in recent years on the synthesis of nanomaterials using plants as a non-toxic, cost-effective, accessible, easy, and environmentally friendly synthetic pathway. Synthesized nanomaterials through green chemistry are non-toxic and can be a good choice for medical applications such as drug delivery, imaging, biotechnology, and biomedical. In the case of drug delivery, these nanomaterials can be a launching pad for the treatment of many diseases such as cancer. The synthesis of nanomaterials will be done with widely synthetic routes including physical, chemical, and biosynthetic routes which are very usual. Commonly, the used chemical methods are too expensive and employ hazardous and toxic chemicals which impose various risks to the environment. The biosynthetic route is a safe, biocompatible, environment-friendly green approach to synthesize nanomaterials using plants and microorganisms for biomedical applications. This synthesis can be carried out with fungi, algae, bacteria, and plants, etc. Some parts of plants such as leaves, fruits, roots, stems, seeds have been used for the synthesis of various nanomaterials. According to the unique characters of green-synthesized nanomaterials, they can be a very suitable choice for medical applications such as drug delivery, imaging, MRI, and etc. with the purpose of treating a variety of diseases.

Author : Mandi Murph
Publisher : BoD – Books on Demand
Page : 430 pages
File Size : 50,5 Mb
Release : 2011-09-12
Category : Medical
ISBN : 9789533072937

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Research on Melanoma by Mandi Murph Pdf

The book Research on Melanoma: A Glimpse into Current Directions and Future Trends, is divided into sections to represent the most cutting-edge topics in melanoma from around the world. The emerging epigenetics of disease, novel therapeutics under development and the molecular signaling aberrations are explained in detail. Since there are a number of areas in which unknowns exist surrounding the complex development of melanoma and its response to therapy, this book illuminates and comprehensively discusses such aspects. It is relevant for teaching the novice researcher who wants to initiate projects in melanoma and the more senior researcher seeking to polish their existing knowledge in this area. Many chapters include visuals and illustrations designed to easily guide the reader through the ideas presented.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 49,8 Mb
Release : 2024-06-02
Category : Electronic
ISBN : 9789814401982

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Stem Cells by Anonim Pdf

Author : Martin Götte,Karin Forsberg-Nilsson
Publisher : Springer Nature
Page : 314 pages
File Size : 55,6 Mb
Release : 2021-06-07
Category : Science
ISBN : 9783030734534

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Proteoglycans in Stem Cells by Martin Götte,Karin Forsberg-Nilsson Pdf

This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Author : Jai Prakash
Publisher : CRC Press
Page : 392 pages
File Size : 42,6 Mb
Release : 2022-01-27
Category : Medical
ISBN : 9781000470703

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The Tumor Stroma by Jai Prakash Pdf

The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.