Metabolic Profiling Its Role In Biomarker Discovery And Gene Function Analysis

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Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

George G. Harrigan,Royston Goodacre
Metabolic Profiling Its Role in Biomarker Discovery and Gene Function Analysis Book PDF

Author : George G. Harrigan,Royston Goodacre
Publisher : Springer Science & Business Media
Page : 342 pages
File Size : 46,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461503330

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Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis by George G. Harrigan,Royston Goodacre Pdf

It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

Metabolome Analyses:

Seetharaman Vaidyanathan,George G. Harrigan,Royston Goodacre
Metabolome Analyses Book PDF

Author : Seetharaman Vaidyanathan,George G. Harrigan,Royston Goodacre
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 45,9 Mb
Release : 2006-03-20
Category : Science
ISBN : 9780387252407

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Metabolome Analyses: by Seetharaman Vaidyanathan,George G. Harrigan,Royston Goodacre Pdf

Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.

Proteomic and Metabolomic Approaches to Biomarker Discovery

Haleem J. Issaq
Proteomic and Metabolomic Approaches to Biomarker Discovery Book PDF

Author : Haleem J. Issaq
Publisher : Academic Press
Page : 489 pages
File Size : 48,7 Mb
Release : 2013-05-20
Category : Science
ISBN : 9780123947956

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Proteomic and Metabolomic Approaches to Biomarker Discovery by Haleem J. Issaq Pdf

Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research. Describes the use of biomarkers to reduce clinical errors in research Includes techniques from a range of biomarker discoveries Covers all steps involved in biomarker discovery, from study design to study execution

Metabolic Profiling

Georgios A. Theodoridis,Helen G. Gika,Ian D. Wilson
Metabolic Profiling Book PDF

Author : Georgios A. Theodoridis,Helen G. Gika,Ian D. Wilson
Publisher : Humana
Page : 291 pages
File Size : 43,8 Mb
Release : 2019-04-30
Category : Science
ISBN : 149399252X

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Metabolic Profiling by Georgios A. Theodoridis,Helen G. Gika,Ian D. Wilson Pdf

This volume explores the different approaches and techniques used by researchers to study the recent challenges and developments in metabolic profiling. This book is divided into IV parts. Part I contains chapters that highlight basic concepts, such as experimental design, data treatment, metabolite identification, and harmonization. Part II describes experimental protocols for both targeted and untargeted metabolomics covering the basic analytical technologies: LC-MS, GC-MS, NMR and CE-MS. In addition the protocols describe methods for the study of tissues, feces, blood and other types of biological samples as well as the application of chemical derivatization for GC-MS. Parts III and IV present the use of metabolomics in the study of food, plants and the life sciences, with examples from the quest for the discovery of disease biomarkers, physical exercise omics and metabolic profiling of food, fruit and wine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Metabolic Profiling: Methods and Protocols is a valuable resource for researchers who are interested in expanding their knowledge of this rapidly developing field.

Metabolomics as a Tool in Nutrition Research

J-L Sebedio,L Brennan
Metabolomics as a Tool in Nutrition Research Book PDF

Author : J-L Sebedio,L Brennan
Publisher : Elsevier
Page : 269 pages
File Size : 48,8 Mb
Release : 2014-11-28
Category : Technology & Engineering
ISBN : 9781782420927

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Metabolomics as a Tool in Nutrition Research by J-L Sebedio,L Brennan Pdf

Metabolomics is a multidisciplinary science used to understand the ways in which nutrients from food are used in the body and how this can be optimised and targeted at specific nutritional needs. Metabolomics as a Tool in Nutrition Research provides a review of the uses of metabolomics in nutritional research. Chapters cover the most important aspects of the topic such as analysis techniques, bioinformatics and integration with other ‘omic’ sciences such as proteomics and genomics. The final chapters look at the impact of exercise on metabolomic profiles and future trends in metabolomics for nutrition research.

Biomarkers

Vishal S. Vaidya,Joseph V. Bonventre
Biomarkers Book PDF

Author : Vishal S. Vaidya,Joseph V. Bonventre
Publisher : John Wiley & Sons
Page : 646 pages
File Size : 49,9 Mb
Release : 2010-10-05
Category : Science
ISBN : 9780470452240

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Biomarkers by Vishal S. Vaidya,Joseph V. Bonventre Pdf

This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

The Handbook of Metabonomics and Metabolomics

John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
The Handbook of Metabonomics and Metabolomics Book PDF

Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
Publisher : Elsevier
Page : 573 pages
File Size : 52,6 Mb
Release : 2011-08-11
Category : Science
ISBN : 9780080468006

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The Handbook of Metabonomics and Metabolomics by John C. Lindon,Jeremy K. Nicholson,Elaine Holmes Pdf

Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies* aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification* covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

Biomarkers in Liver Disease

Victor R. Preedy,Vinood B. Patel
Biomarkers in Liver Disease Book PDF

Author : Victor R. Preedy,Vinood B. Patel
Publisher : Springer
Page : 0 pages
File Size : 46,9 Mb
Release : 2017-07-14
Category : Medical
ISBN : 9400776748

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Biomarkers in Liver Disease by Victor R. Preedy,Vinood B. Patel Pdf

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Plant Metabolomics

Kazuki Saito,Richard A. Dixon,Lothar Willmitzer
Plant Metabolomics Book PDF

Author : Kazuki Saito,Richard A. Dixon,Lothar Willmitzer
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 49,8 Mb
Release : 2006-06-29
Category : Science
ISBN : 9783540297826

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Plant Metabolomics by Kazuki Saito,Richard A. Dixon,Lothar Willmitzer Pdf

Metabolomics – which deals with all metabolites of an organism – is a rapidly-emerging sector of post-genome research fields. It plays significant roles in a variety of fields from medicine to agriculture and holds a fundamental position in functional genomics studies and their application in plant biotechnology. This volume comprehensively covers plant metabolomics for the first time. The chapters offer cutting-edge information on analytical technology, bioinformatics and applications. They were all written by leading researchers who have been directly involved in plant metabolomics research throughout the world. Up-to-date information and future developments are described, thereby producing a volume which is a landmark of plant metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all plant science fields.

Cardiovascular Biomarkers

David A. Morrow
Cardiovascular Biomarkers Book PDF

Author : David A. Morrow
Publisher : Springer Science & Business Media
Page : 640 pages
File Size : 46,8 Mb
Release : 2010-04-28
Category : Medical
ISBN : 9781597450515

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Cardiovascular Biomarkers by David A. Morrow Pdf

In the four pages committed to a discussion of myocardial infarction in the first edition of Harrison’s Principles of Internal Medicine, published in 1950, there was no mention of use of the laboratory for management of patients. Thirty years later, when the first edition of Braunwald’s Heart Disease, A Textbook of Cardiovascular Medicine was published, 2 out of the 1943 pages in the text contained a discussion of the laboratory examinations in acute myocardial infarction. Our knowledge base of the multitude of ways that physicians can and should use the clinical chemistry laboratory has expanded dramatically since these classic texts were published. The nomenclature has changed: terms such as “cardiac enzymes” have given way to “cardiac biomarkers. ” The number of assays has multiplied, and the operating characteristics of available assays are impr- ing at a gratifying but dizzying rate. We now use biomarkers to diagnose cardiovascular diseases and also to frame our treatment strategies. Thus, there is a clear need for a scholarly compilation of the state of the art of cardiac biomarkers. Dr. David Morrow has expertly edited an authoritative book that answers this need. The 34 chapters in Cardiovascular Biomarkers: Pathophysiology and Disease Mana- ment were written by a group of individuals who are internationally recognized thought leaders and experts in clinical and laboratory medicine.

The Handbook of Plant Metabolomics

Wolfram Weckwerth,Guenter Kahl
The Handbook of Plant Metabolomics Book PDF

Author : Wolfram Weckwerth,Guenter Kahl
Publisher : John Wiley & Sons
Page : 422 pages
File Size : 53,5 Mb
Release : 2013-02-28
Category : Science
ISBN : 9783527669905

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The Handbook of Plant Metabolomics by Wolfram Weckwerth,Guenter Kahl Pdf

This is the newest title in the successful Molecular Plant Biology Handbook Series. Just like the other titles in the series this new book presents an excellent overview of different approaches and techniques in Metabolomics. Contributors are either from ivy-league research institutions or from companies developing new technologies in this dynamic and fast-growing field. With its approach to introduce current techniques in plant metabolomics to a wider audience and with many labs and companies considering to introduce metabolomics for their research, the title meets a growing market. The Kahl books are in addition a trusted brand for the plant science community and have always sold above expectations.

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 46,5 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Metabonomics

Jacob T. Bjerrum
Metabonomics Book PDF

Author : Jacob T. Bjerrum
Publisher : Humana
Page : 0 pages
File Size : 40,6 Mb
Release : 2016-10-05
Category : Science
ISBN : 1493948377

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Metabonomics by Jacob T. Bjerrum Pdf

This volume on metabonomics provides detailed information on the procedures involved in nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectrometry (GS-MS), liquid chromatography-mass spectrometry (LC-MS), and capillary electrophoresis-mass spectrometry (CE-MS). Chapters focus on technologies and chemometrics, generation of metabonomics data, extraction of meaningful information from data, drug development, toxicology, diagnostics, and describing metabonomics as an essential part of systems biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Integrating Biomedical Information

Assa Reichert
Integrating Biomedical Information Book PDF

Author : Assa Reichert
Publisher : IOS Press
Page : 430 pages
File Size : 49,9 Mb
Release : 2006
Category : Medical
ISBN : 1586036149

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Integrating Biomedical Information by Assa Reichert Pdf

Organisations in health care are moving into the information age since two or three decades. Never was the pace of this movement as fast as today. "Integrating Biomedical Information: from e-Cell to e-Patient", the title of this EFMI publication, indicates the broad spectrum of Medical Informatics. Both concepts in the title are new - the result of data collection, data processing and information analysis. It is expected this data and information to be the knowledge base for a better understanding of mankind and also to assist us in making information (evidence) based decisions in health care. We expect that this will give us a better perspective of the human body, its functions and that it will ultimately lead us to better health care. Recent developments in clinical terminology construction have brought together specialists from different disciplines, such as Medicine, Computer Science, Philosophy, and Linguistics. Different genres of clinical terminologies co-exist: the former distinction between formal terminologies, classifications, vocabularies, nomenclatures and thesauri is increasingly being challenged by the notion of "ontology". There are controversies between linguistic approaches (aiming at representing term meanings) and ontological ones (which strive for a representation of biomedical reality). There is also an increasing quest for "good practice" recommendations for biomedical terminologies.) This book is the third volume of the EFMI STC conferences. This series is a subseries of the MIR-conferences published by IOS Press.

Proteomics for Biological Discovery

Timothy D. Veenstra,John R. Yates, III
Proteomics for Biological Discovery Book PDF

Author : Timothy D. Veenstra,John R. Yates, III
Publisher : John Wiley & Sons
Page : 361 pages
File Size : 42,8 Mb
Release : 2006-06-12
Category : Science
ISBN : 9780470007730

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Proteomics for Biological Discovery by Timothy D. Veenstra,John R. Yates, III Pdf

Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics. Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Accessible to the novice while providing experienced investigators essential information Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.