Metabolic Profiling

Author : Georgios A. Theodoridis,Helen G. Gika,Ian D. Wilson
Publisher : Humana
Page : 291 pages
File Size : 46,5 Mb
Release : 2019-04-30
Category : Science
ISBN : 149399252X

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Metabolic Profiling by Georgios A. Theodoridis,Helen G. Gika,Ian D. Wilson Pdf

This volume explores the different approaches and techniques used by researchers to study the recent challenges and developments in metabolic profiling. This book is divided into IV parts. Part I contains chapters that highlight basic concepts, such as experimental design, data treatment, metabolite identification, and harmonization. Part II describes experimental protocols for both targeted and untargeted metabolomics covering the basic analytical technologies: LC-MS, GC-MS, NMR and CE-MS. In addition the protocols describe methods for the study of tissues, feces, blood and other types of biological samples as well as the application of chemical derivatization for GC-MS. Parts III and IV present the use of metabolomics in the study of food, plants and the life sciences, with examples from the quest for the discovery of disease biomarkers, physical exercise omics and metabolic profiling of food, fruit and wine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Metabolic Profiling: Methods and Protocols is a valuable resource for researchers who are interested in expanding their knowledge of this rapidly developing field.

Author : George G. Harrigan,Royston Goodacre
Publisher : Springer Science & Business Media
Page : 342 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461503330

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Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis by George G. Harrigan,Royston Goodacre Pdf

It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

Author : Thomas O. Metz
Publisher : Humana Press
Page : 391 pages
File Size : 48,8 Mb
Release : 2011-04-06
Category : Science
ISBN : 1617379867

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Metabolic Profiling by Thomas O. Metz Pdf

At the intersection of metabolite analysis, metabolic fingerprinting, and metabolomics, the study of metabolic profiling has evolved steadily over the course of time as have the methods and technologies involved in its study. In Metabolic Profiling: Methods and Protocols, expert researchers in the field present protocols that are illustrative of the evolution of metabolic profiling from single molecule analysis to global metabolome profiling. Comprised of the most essential techniques, this volume covers topics from inborn errors of metabolism and drug metabolite analysis to nuclear magnetic resonance metabolic profiles. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Metabolic Profiling: Methods and Protocols serves as a resource for both established and new investigators in this vital and ever-developing field.

Author : Georgios Theodoridis,Ian D. Wilson,Andrew W. Nicholls
Publisher : Unknown
Page : 192 pages
File Size : 48,8 Mb
Release : 2014
Category : Electronic books
ISBN : 1909453609

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Global metabolic profiling clinical applications by Georgios Theodoridis,Ian D. Wilson,Andrew W. Nicholls Pdf

Author : Martin Grootveld
Publisher : Royal Society of Chemistry
Page : 395 pages
File Size : 50,5 Mb
Release : 2014-11-06
Category : Science
ISBN : 9781849735162

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Metabolic Profiling by Martin Grootveld Pdf

Multivariate analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens can provide a 'fingerprint' of their biomolecular/metabolic status. Therefore, if applied correctly, valuable information regarding disease indicators, disease strata and sub-strata and disease activities can be obtained. This exemplary new book highlights applications of these techniques in the areas of drug therapy and toxicology, cancer, obesity and diabetes, as well as outlining applications to cardiovascular, infectious, inflammatory and oral diseases in detail. The book gives particular reference to cautionary measures that must be applied to the diagnosis and classification of these conditions or physiological criteria. Comprehensively covering a wide range of topics, of particular interest is the focus on experimental design and 'rights and wrongs' of the techniques commonly applied by researchers, and the very recent development of powerful 'Pattern Recognition' techniques. The book provides a detailed introduction to the area, applications and common pitfalls of the techniques discussed before moving into detailed coverage of specific disease areas, each highlighted in individual chapters. This title will provide an invaluable resource to Medicinal chemists, Biochemists and toxicologists working in industry and academia.

Author : Martin Grootveld
Publisher : Royal Society of Chemistry
Page : 420 pages
File Size : 53,9 Mb
Release : 2014
Category : Medical
ISBN : 9781849731638

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Metabolic Profiling by Martin Grootveld Pdf

An exemplary new book on applications of metabolomic profiling techniques in the areas of drug therapy and toxicology, cancer, obesity, diabetes and cardiovascular, infectious, inflammatory, and oral diseases.

Author : Julien Delarocque
Publisher : Cuvillier Verlag
Page : 108 pages
File Size : 50,7 Mb
Release : 2021-05-17
Category : Medical
ISBN : 9783736964266

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Metabolic profiling of hyperinsulinemic horses by Julien Delarocque Pdf

Insulin dysregulation mediates the increased risk for laminitis associated with the two most common equine endocrinopathies, pituitary pars intermedia dysfunction (PPID) and the equine metabolic syndrome (EMS). This thesis aimed to describe the metabolic profile of horses with this condition to help elucidate the cause for the increased insulin production it elicits and possibly uncover some pathomechanisms leading to laminitis. Besides identifying metabolites correlated to the level of the insulin response to an oral glucose test, such as carnitine, arginine and DOPA, this project revealed the potential of such molecules in recognizing horses with insulin dysregulation without complex diagnostic tests. Additionally, it allowed to concretely quantify the reduction of the insulin response to oral carbohydrates following weight loss, while differentiating the respective metabolic impact of weight gain and worsened insulin dysregulation. Lastly, metabolites associated with subsequent laminitis were described. Altogether, the results provided new concepts for the identification of insulin dysregulation, supported an association between this condition and vascular dysfunction, helped distinguish the metabolic impact of weight variations from the effect of insulin dysregulation, and suggested that carnitine and arginine could be investigated as nutritional supplements to treat insulin dysregulation.

Author : Poonam Yadav,Guanlin Li,Jose M. Mulet
Publisher : Frontiers Media SA
Page : 197 pages
File Size : 50,6 Mb
Release : 2024-02-21
Category : Science
ISBN : 9782832545058

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Transcriptome & Metabolic Profiling: An Insight Into the Abiotic Stress Response Crosstalk in Plants by Poonam Yadav,Guanlin Li,Jose M. Mulet Pdf

Author : Thomas O. Metz
Publisher : Humana Press
Page : 391 pages
File Size : 49,5 Mb
Release : 2011-01-11
Category : Science
ISBN : 1617379840

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Metabolic Profiling by Thomas O. Metz Pdf

At the intersection of metabolite analysis, metabolic fingerprinting, and metabolomics, the study of metabolic profiling has evolved steadily over the course of time as have the methods and technologies involved in its study. In Metabolic Profiling: Methods and Protocols, expert researchers in the field present protocols that are illustrative of the evolution of metabolic profiling from single molecule analysis to global metabolome profiling. Comprised of the most essential techniques, this volume covers topics from inborn errors of metabolism and drug metabolite analysis to nuclear magnetic resonance metabolic profiles. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Metabolic Profiling: Methods and Protocols serves as a resource for both established and new investigators in this vital and ever-developing field.

Author : Jeremy Nicholson,Ara Darzi,Elaine Holmes,John C. Lindon
Publisher : Academic Press
Page : 430 pages
File Size : 47,5 Mb
Release : 2016-02-11
Category : Science
ISBN : 9780128004142

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Metabolic Phenotyping in Personalized and Public Healthcare by Jeremy Nicholson,Ara Darzi,Elaine Holmes,John C. Lindon Pdf

Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches.In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream. Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making Discusses longitudinal sampling from individual patients for stratified medicine Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 55,7 Mb
Release : 2014
Category : Electronic
ISBN : 1909453625

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Global metabolic profiling by Anonim Pdf

Author : William J. Griffiths
Publisher : Royal Society of Chemistry
Page : 336 pages
File Size : 43,5 Mb
Release : 2008
Category : Medical
ISBN : 9780854042999

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Metabolomics, Metabonomics and Metabolite Profiling by William J. Griffiths Pdf

In this comprehensive resource the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology.

Author : Seetharaman Vaidyanathan,George G. Harrigan,Royston Goodacre
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 53,6 Mb
Release : 2006-03-20
Category : Science
ISBN : 9780387252407

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Metabolome Analyses: by Seetharaman Vaidyanathan,George G. Harrigan,Royston Goodacre Pdf

Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.

Author : Haleem J. Issaq
Publisher : Academic Press
Page : 489 pages
File Size : 43,5 Mb
Release : 2013-05-20
Category : Science
ISBN : 9780123947956

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Proteomic and Metabolomic Approaches to Biomarker Discovery by Haleem J. Issaq Pdf

Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research. Describes the use of biomarkers to reduce clinical errors in research Includes techniques from a range of biomarker discoveries Covers all steps involved in biomarker discovery, from study design to study execution

Author : Wolfram Weckwerth
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 44,7 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781597452441

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Metabolomics by Wolfram Weckwerth Pdf

Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic analysis. Leading researchers in the field present protocols for the application of complementary analytical methods, such as gas chromatography-mass spectrometry (GC-MS). Metabolomics: Methods and Protocols contains forward-looking protocols, which provide the essential groundwork for future efforts in elucidating the structure of the unknowns detected in metabolomic studies.