Metal Ions In Biochemistry

Author : Pabitra Krishna Bhattacharya,Prakash B. Samnani
Publisher : CRC Press
Page : 293 pages
File Size : 49,9 Mb
Release : 2020-12-13
Category : Science
ISBN : 9781000292640

Get Book

Metal Ions in Biochemistry by Pabitra Krishna Bhattacharya,Prakash B. Samnani Pdf

The second edition of Metal Ions in Biochemistry deals with the multidisciplinary subject of bio-inorganic chemistry, encompassing the disciplines of inorganic chemistry, biochemistry and medicine. The book deals with the role of metal ions in biochemistry, emphasising that biochemistry is mainly the chemistry of metal-biochemical complexes. Hence, the book starts with the structures of biochemicals and the identification of their metal binding sites. Thermodynamic and kinetic properties of the complexes are explained from the point of view of the nature of metal-ligand bonds. Various catalytic and structural roles of metal ions in biochemicals are discussed in detail. Features The role of Na+ and K+ in brain chemistry. The role of zinc insulin in glucose metabolism and its enhancement by vanadium and chromium compounds. Discussion of the role of zinc signals, zinc fingers and cascade effect in biochemistry. Haemoglobin synthesis and the role of vitamin B12 in it. The role of lanthanides in biochemical systems. A detailed discussion of the role of non-metals in biochemistry, a topic missing in most of the books on bio-inorganic chemistry. The study of bio-inorganic chemistry makes biochemists rethink the mechanistic pathways of biochemical reactions mediated by metal ions. There is a realisation of the role of metal complexes and inorganic ions as therapeutics such as iron in leukaemia, thalassemia and sickle cell anaemia, iodine in hypothyroidism and zinc, vanadium and chromium in glucose metabolism. The most recent realisation is of the use of zinc in the prevention and treatment of COVID-19.

Author : P. K. Bhattacharya
Publisher : Unknown
Page : 128 pages
File Size : 48,5 Mb
Release : 2005
Category : Electronic
ISBN : 184265831X

Get Book

Metal Ions in Biochemistry by P. K. Bhattacharya Pdf

Author : Astrid Sigel,Helmut Sigel
Publisher : CRC Press
Page : 860 pages
File Size : 52,9 Mb
Release : 1996-02-05
Category : Science
ISBN : 0824795490

Get Book

Metal Ions in Biological Systems by Astrid Sigel,Helmut Sigel Pdf

Volume 32 covers metal ion bonding to phosphate, sugar and nucleobase residues; the ambidentate as well as the stacking properties of nucleotides; kinetic aspects as well as properties of nucleobase and nucleotide analogs; and the oligonucleotides and nucleic acids. It examines electron transfer reactions over a large number of base repairs in DNA, the role of metal ions in ribozymes, ternary metal-nucleic acid base-protein complexes, metal responsive gene regulation, and the structure-activity relationships of anticancer drugs and their action on DNA, including cisplatin and the role of proteins.

Author : Michael Moustakas
Publisher : MDPI
Page : 180 pages
File Size : 41,8 Mb
Release : 2021-09-06
Category : Science
ISBN : 9783036510545

Get Book

The Role of Metal Ions in Biology, Biochemistry and Medicine by Michael Moustakas Pdf

Metal ions are fundamental elements for the maintenance of the lifespan of plants, animals and humans. Their substantial role in biological systems was recognized a long time ago. They are essential for the maintenance of life and their absence can cause growth disorders, severe malfunction, carcinogenesis or death. They are protagonists as macro- or microelements in several structural and functional roles, participating in many bio-chemical reactions, and arise in several forms. They participate in intra- and intercellular communications, in maintaining electrical charges and osmotic pressure, in photosynthesis and electron transfer processes, in the maintenance of pairing, stacking and the stability of nucleotide bases and also in the regulation of DNA transcription. They contribute to the proper functioning of nerve cells, muscle cells, the brain and the heart, the transport of oxygen and to many other biological processes up to the point that we cannot even imagine a life without metals. In this book, the papers published in the Special Issue “The Role of Metal Ions in Biology, Biochemistry and Medicine” are summarized, providing a picture of metal ion uses in biology, biochemistry and medicine, but also pointing out the toxicity impacts on plants, animals, humans and the environment.

Author : Helmut Sigel
Publisher : CRC Press
Page : 464 pages
File Size : 49,6 Mb
Release : 1985-07-30
Category : Science
ISBN : 0824774256

Get Book

Metal Ions in Biological Systems by Helmut Sigel Pdf

Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 21 describes the underlying theories of nuclear magnetic resonance (NMR), promoting a wider use of NMR in studies of paramagnetic species. In six concise chapters by leading international authorities, Applications of Nuclear Magnetic Resonance to Paramagnetic Species outlines the most recent developments regarding the use of nuclear relaxation as a source for structural information ... examines studies of magnetically coupled metalloproteins and metal-porphyrin induced dipolar shifts for conformational analysis ... and evaluates the potential of paramagnetic ions as agents for enhancing NMR image contrast. With over 500 references that facilitate further research, Applications of Nuclear Magnetic Resonance to Paramagnetic Species is an essential resource for scientists and students in such disciplines as biophysics; bioinorganic, inorganic, and coordination chemistry; biochemistry; molecular biology; and enzymology. Book jacket.

Author : Astrid Sigel
Publisher : CRC Press
Page : 744 pages
File Size : 55,8 Mb
Release : 2001-01-30
Category : Medical
ISBN : 9781482270150

Get Book

Metal Ions in Biological Systems by Astrid Sigel Pdf

"Focuses on the vibrant area of probing enzymes or proteins by metal ions and small complexes. Offers a summary of the basic characteristics of the amide bond, emphasizing its proton and metal ion interactions, including a quantitative analysis of its hydrolysis and formation."

Author : Helmut Sigel,Astrid Sigel
Publisher : CRC Press
Page : 538 pages
File Size : 41,9 Mb
Release : 1988-03-30
Category : Science
ISBN : 0824777131

Get Book

Metal Ions in Biological Systems by Helmut Sigel,Astrid Sigel Pdf

Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Devoted solely to the vibrant research area of nickel and its role in biology, Volume 23 offers a comprehensive account of this important subject from the perspectives of 24 distinguished, international authorities. In 11 stimulating, in-depth chapters, Nickel and Its Role in Biology covers nickel and its function in the environment, in aquatic systems, in plants, as well as its metabolism in man and animals ... treats nickel ion binding to amino acids and peptides ... examines nickel in proteins and enzymes, including hydrogenases ... considers the interaction of nickel with nucleic acids and their constituents ... displays thoroughly the toxicology of nickel compounds ... and describes the analysis of nickel in biological materials. With more than 1,400 references to assist further research, Nickel and Its Role in Biology is an essential resource for scientists and students in several disciplines, including biochemistry; bioinorganic, inorganic, and coordination chemistry; biophysics; molecular biology; enzymology; pharmacology; clinical chemistry; nutrition; and toxicology. Book jacket.

Author : Michael Moustakas
Publisher : Unknown
Page : 180 pages
File Size : 41,6 Mb
Release : 2021
Category : Electronic
ISBN : 3036510559

Get Book

The Role of Metal Ions in Biology, Biochemistry and Medicine by Michael Moustakas Pdf

Metal ions are fundamental elements for the maintenance of the lifespan of plants, animals and humans. Their substantial role in biological systems was recognized a long time ago. They are essential for the maintenance of life and their absence can cause growth disorders, severe malfunction, carcinogenesis or death. They are protagonists as macro- or microelements in several structural and functional roles, participating in many bio-chemical reactions, and arise in several forms. They participate in intra- and intercellular communications, in maintaining electrical charges and osmotic pressure, in photosynthesis and electron transfer processes, in the maintenance of pairing, stacking and the stability of nucleotide bases and also in the regulation of DNA transcription. They contribute to the proper functioning of nerve cells, muscle cells, the brain and the heart, the transport of oxygen and to many other biological processes up to the point that we cannot even imagine a life without metals. In this book, the papers published in the Special Issue “The Role of Metal Ions in Biology, Biochemistry and Medicine” are summarized, providing a picture of metal ion uses in biology, biochemistry and medicine, but also pointing out the toxicity impacts on plants, animals, humans and the environment.

Author : Astrid Sigel
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 44,9 Mb
Release : 2012-01-02
Category : Education
ISBN : 9789400721715

Get Book

Interplay Between Metal Ions and Nucleic Acids by Astrid Sigel Pdf

Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.

Author : Astrid Sigel
Publisher : Routledge
Page : 524 pages
File Size : 44,6 Mb
Release : 2018-05-04
Category : Science
ISBN : 9781351432139

Get Book

Metal Ions in Biological Systems by Astrid Sigel Pdf

Continues the tradition of excellence established in previous volumes in this acclaimed series. Volume 36 focuses on the vibrant research area concerning the interrelation between free radicals and metal ions and their resulting effects on life processes; it offers an authoritative and timely account of this fascinating area of research in 21 chapters.

Author : Helmut Sigel
Publisher : CRC Press
Page : 814 pages
File Size : 42,8 Mb
Release : 2000-01-27
Category : Science
ISBN : 0824702883

Get Book

Metal Ions in Biological Systems by Helmut Sigel Pdf

"Highlights the availability of magnesium to organisms, its uptake and transport in microorganisms and plants as well as its role in health and disease of animals and humans including its toxicology."

Author : Helmut Sigel
Publisher : CRC Press
Page : 816 pages
File Size : 46,6 Mb
Release : 2000-01-27
Category : Medical
ISBN : 9781482289893

Get Book

Metal Ions in Biological Systems by Helmut Sigel Pdf

"Highlights the availability of magnesium to organisms, its uptake and transport in microorganisms and plants as well as its role in health and disease of animals and humans including its toxicology."

Author : Astrid Sigel,Helmut Sigel
Publisher : CRC Press
Page : 828 pages
File Size : 44,6 Mb
Release : 1995-02-22
Category : Science
ISBN : 0824793838

Get Book

Metal Ions in Biological Systems by Astrid Sigel,Helmut Sigel Pdf

"Volume 31, devoted solely to the role of vanadium in life processes, offers a comprehensive and timely account of this fascinating field by 37 distinguished, international authorities. Highlights the properties of the various oxidation states of vanadium, their affinity for biogenic ligands, the effects of vanadium species on enzyme activity, the role of vanadium in nitrogenases and haloperoxidases, and more."

Author : Helmut Sigel
Publisher : CRC Press
Page : 526 pages
File Size : 43,7 Mb
Release : 1983-03-25
Category : Science
ISBN : 0824774620

Get Book

Metal Ions in Biological Systems by Helmut Sigel Pdf

"Metal Ions in Biological Systems" is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. "Volume 43" focuses on the vibrant research area concerning the cycling of elements, metals, and non-metals in biology and geology; in 10 chapters this book offers an authoritative and timely account on this fascinating subject.

Author : Astrid Sigel,Eva Freisinger,Roland K.O. Sigel
Publisher : Walter de Gruyter GmbH & Co KG
Page : 547 pages
File Size : 46,7 Mb
Release : 2021-03-08
Category : Science
ISBN : 9783110685701

Get Book

Metal Ions in Bio-Imaging Techniques by Astrid Sigel,Eva Freisinger,Roland K.O. Sigel Pdf

Volume 22, entitled Metal Ions in Bio-Imaging Techniques, of the series Metal Ions in Life Sciences deals with metal ions as tools in imaging. This dates back to the first half of the past century, when barium sulfate was orally given to patients undergoing X-ray examination. The use of contrast agents has since developed into a large interdisciplinary field encompassing not only medicine, but also chemistry, material sciences, physics, biology, engineering, and computer sciences. MILS-22 provides deep and current insights in 17 stimulating chapters on the new research frontiers of this fast growing field on bio-imaging ... and beyond. For example, adding bio-sensing yields theranostic agents, meaning diagnosis and therapy linked in the same molecule; ions of Gd, Mn, Fe, Co, Ir, 99mTc, etc., are involved. Other important topics are, e.g., metal complexes in paramagnetic Chemical Exchange Transfer (paraCEST), radiometals for Positron Emission Tomography (PET) imaging, or paramagnetic metal ion probes for 19F magnetic resonance imaging. MILS-22 is written by 57 internationally recognized experts from 12 countries, that is, from the US via Europe to China. The impact of this vibrant research area is manifested by more than 2300 references and nearly 120 figures, mostly in color, and several informative tables. To conclude, Metal Ions in Bio-Imaging Techniques is an essential resource for scientists working in the wide range from material sciences, enzymology, analytic, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that also excellent information for teaching is provided.