Metallointercalators

Author : Janice Aldrich-Wright
Publisher : Springer
Page : 449 pages
File Size : 52,9 Mb
Release : 2011-04-06
Category : Science
ISBN : 9783211990797

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Metallointercalators by Janice Aldrich-Wright Pdf

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

Author : Timothy D. Veenstra,John R. Yates, III
Publisher : John Wiley & Sons
Page : 363 pages
File Size : 55,5 Mb
Release : 2019-07-18
Category : Science
ISBN : 9781118279243

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Proteomics for Biological Discovery by Timothy D. Veenstra,John R. Yates, III Pdf

An update to the popular guide to proteomics technology applications in biomedical research Building on the strength of the original edition, this book presents the state of the art in the field of proteomics and offers students and scientists new tools and techniques to advance their own research. Written by leading experts in the field, it provides readers with an understanding of new and emerging directions for proteomics research and applications. Proteomics for Biological Discovery begins by discussing the emergence of proteomics technologies and summarizing the potential insights to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are thoroughly covered, from underlying concepts to limitations and future directions. Later chapters provide an overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, applied proteomics, and bioinformatics relevant to proteomics. Chapters cover: Quantitative Proteomics for Differential Protein Expression Profiling; Protein Microarrays; Protein Biomarker Discovery; Biomarker Discovery using Mass Spectrometry Imaging; Protein-Protein Interactions; Mass Spectrometry Of Intact Protein Complexes; Crosslinking Applications in Structural Proteomics; Functional Proteomics; High Resolution Interrogation of Biological Systems via Mass Cytometry; Characterization of Drug-Protein Interactions by Chemoproteomics; Phosphorylation; Large-Scale Phosphoproteomics; and Probing Glycoforms of Individual Proteins Using Antibody-Lectin Sandwich Arrays. Presents a comprehensive and coherent review of the major issues in proteomic technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Features new coverage of mass spectrometry for high throughput proteomic measurements, and novel quantitation strategies such as spectral counting and stable isotope labeling Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Offers new chapters on biomarker discovery, global phosphorylation analysis, proteomic profiling using antibodies, and single cell mass spectrometry Proteomics for Biological Discovery is an excellent advanced resource for graduate students, postdoctoral fellows, and scientists across all the major fields of biomedical science.

Author : Hans-Achim Wagenknecht
Publisher : John Wiley & Sons
Page : 245 pages
File Size : 49,5 Mb
Release : 2006-05-12
Category : Science
ISBN : 9783527606900

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Charge Transfer in DNA by Hans-Achim Wagenknecht Pdf

The past few years have witnessed intense research in this fascinating field as well as many controversial discussions. Now the time is ripe for a comprehensive book covering not only theoretical aspects, but also such mechanistic topics as principles and mechanisms of photoinduced charge injection, transport and trapping in DNA, sequence-dependent DNA dynamics, spectroscopic investigations of hole transport and much more. From the contents: * Principles and Mechanisms of Photoinduced Charge Injection, Transport and Trapping in DNA * Sequence-Dependent DNA Dynamics: The Regulator of DNA-Mediated Charge Transport * Excess Electron Transfer in DNA Probed with Flavin and Thymine Dimer Modified Oligonucleotides * Dynamics of Photoinitiated Hole and Electron Injection in Duplex DNA * Spectroscopic Investigation of Oxidative Hole Transfer via Adenine Hopping in DNA * Chemical Probing of Reductive Electron Transfer in DNA * Chemical Approach for Modulating Hole Transport in DNA * Spectroscopic Investigation of Charge Transfer in DNA * Spectroscopic Probing of Ultrafast Structural Relaxation and Electron Transfer Dynamics in DNA Edited by Hans-Achim Wagenknecht, and written by renowned international authors, this book provides an excellent overview with high quality contributions, making it a "must-have" for everyone working in the field.

Author : Gary B. Schuster
Publisher : Springer
Page : 219 pages
File Size : 53,5 Mb
Release : 2004-02-25
Category : Science
ISBN : 9783540398806

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Long-Range Charge Transfer in DNA I by Gary B. Schuster Pdf

Author : Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel
Publisher : Walter de Gruyter GmbH & Co KG
Page : 588 pages
File Size : 44,8 Mb
Release : 2018-02-05
Category : Science
ISBN : 9783110470734

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Metallo-Drugs: Development and Action of Anticancer Agents by Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel Pdf

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Author : Stephen J. Lippard,Jeremy Mark Berg
Publisher : University Science Books
Page : 444 pages
File Size : 49,9 Mb
Release : 1994
Category : Medical
ISBN : 0935702725

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Principles of Bioinorganic Chemistry by Stephen J. Lippard,Jeremy Mark Berg Pdf

The use of unnatural metals - which have been introduced into human biology as diagnostic probes and drugs - is another active area of tremendous medical significance.

Author : Tadhg P. Begley
Publisher : Wiley-Blackwell
Page : 836 pages
File Size : 44,7 Mb
Release : 2009-02-03
Category : Science
ISBN : STANFORD:36105210630849

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Wiley Encyclopedia of Chemical Biology, Volume 3 by Tadhg P. Begley Pdf

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Author : John George Hardy,Felix H Schacher
Publisher : Royal Society of Chemistry
Page : 416 pages
File Size : 45,9 Mb
Release : 2015-07-13
Category : Technology & Engineering
ISBN : 9781782622673

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Functional Metallosupramolecular Materials by John George Hardy,Felix H Schacher Pdf

There is great interest in metallosupramolecular materials because of their use in magnetic, photonic and electronic materials. Functional Metallosupramolecular Materials focuses on the applications of these materials covering the chemistry underlying the synthesis of a variety of ligands to coordinate various metal ions and the generation of 2D and 3D materials based on these constructs. The book starts by looking at different metallosupramolecular systems including naturally occurring functional metallosupramolecular materials; DNA-based metallosupramolecular materials; metallopolymers; metallogels as well as functional materials based on MOFs. Subsequent chapters then systematically cover the different applications such as molecular computation, spin-crossover, light harvesting and as photocatalysts for the production of solar fuels. The book provides an overview of functional metallosupramolecular materials that will be of interest to graduate students, academics and industrial chemists interested in supramolecular chemistry, materials science and the materials applications.

Author : Nick Hadjiliadis,Einar Sletten
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 54,6 Mb
Release : 2009-03-30
Category : Science
ISBN : 1405194103

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Metal Complex - DNA Interactions by Nick Hadjiliadis,Einar Sletten Pdf

Metal ions and metal complexes have long been recognized ascritically important components of nucleic acid chemistry, both inregulation of gene expression and as promising therapeutic agents.Understanding how metal complexes interact with DNA has become anactive research area at the interface between chemistry, molecularbiology and medicine. Metal Complex - DNA Interactions provides a comprehensiveoverview of this increasingly diverse field, presenting recentdevelopments and the latest research with particular emphasis onmetal-based drugs and metal ion toxicity. The text is divided intofour parts: Basic Structural and Kinetic Aspects: includes chapterson sequence-selective metal binding to DNA and thermodynamicmodels. Medical Applications: focuses on anticancer platinumdrugs, including discussions on DNA repair in antitumor effects ofplatinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describesprobes for DNA recognition, artificial restriction agents,metallo-DNAzymes for metal sensing applications and metal iondependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies ofmercury–DNA interactions, chromium-induced DNA damage andrepair, and the effect of arsenic and nickel on DNAintegrity. This book will be a valuable resource for academic researchersand professionals from a range of pharmaceutical and chemicalindustries, particularly those involved in the development of newand less toxic anticancer metallo-drugs, and in the field ofenvironmental and toxicological chemistry.

Author : Thimmaiah Govindaraju
Publisher : CRC Press
Page : 426 pages
File Size : 55,9 Mb
Release : 2019-01-30
Category : Science
ISBN : 9780429767678

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Templated DNA Nanotechnology by Thimmaiah Govindaraju Pdf

Nucleic acids have structurally evolved over billions of years to effectively store and transfer genetic information. In the 1980s, Nadrian Seeman’s idea of constructing a 3D lattice from DNA led to utilizing DNA as nanomolecular building blocks to create emergent molecular systems and nanomaterial objects. This bottom-up approach to construct nanoscale architectures with DNA marked the beginning of a new field, DNA nanotechnology, contributing significantly to the broad area of nanoscience and nanotechnology. The molecular architectonics of small "designer" molecules and short DNA sequences through complementary binding interaction engenders well-defined functional nanoarchitectures with realistic applications in areas ranging from biology to materials science and is termed "DNA nanoarchitectonics." This book discusses novel approaches adapted by leading researchers from all over the world to create functional nucleic acid molecular systems and nanoarchitectures. Individual chapters contributed by active practitioners provide fundamental and advanced knowledge emanated from their own and others’ work. Each chapter includes numerous illustrations, historical perspectives, case studies and practical examples, critical discussions, and future prospects. This book can serve as a practical handbook or as a textbook for advanced undergraduate- and graduate-level students of nanotechnology and DNA nanotechnology, supramolecular chemistry, and nanoarchitectonics and researchers working on macromolecular science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in sensors, biosensors, nanoswitches and nanodevices, diagnostics, drug delivery, and therapeutics.

Author : Martine Demeunynck,Christian Bailly,W. David Wilson
Publisher : John Wiley & Sons
Page : 754 pages
File Size : 53,6 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605668

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Small Molecule DNA and RNA Binders by Martine Demeunynck,Christian Bailly,W. David Wilson Pdf

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

Author : Jose Perez-Martin
Publisher : Springer Science & Business Media
Page : 176 pages
File Size : 49,7 Mb
Release : 2008-12-10
Category : Medical
ISBN : 9780387767178

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Programmed Cell Death in Protozoa by Jose Perez-Martin Pdf

Under the name of programmed cell death (PCD) are included diverse molecular mechanisms of cell suicide which play an essential role in the development of multicellular organisms. The best known PCD mechanism in multicellular organisms is called apoptosis. However, recent studies indicate that PCD is also present in protozoa and unicellular eukaryotes. The eleven chapters of this book give the reader a comprehensive update of the progress in the understanding of the mechanisms of PCD in protozoa. The chapters have been written by experts in this field of research and are arranged following an evolutionary point of view.

Author : Nils Metzler-Nolte,Ulrich Schatzschneider
Publisher : Walter de Gruyter
Page : 149 pages
File Size : 51,9 Mb
Release : 2009-09-10
Category : Science
ISBN : 9783110211368

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Bioinorganic Chemistry by Nils Metzler-Nolte,Ulrich Schatzschneider Pdf

This book presents a unique introduction into the field of bioinorganic chemistry through practical laboratory experiments. Topics include many aspects of modern bioinorganic chemistry such as model systems for metalloenzymes, biosensors, metal bioconjugates and metal-based drugs. Each chapter contains a brief introduction, followed by detailed experimental procedures, completed with all necessary background information for the student as well as their instructors. A valuable supplement to standard textbooks of inorganic and bioinorganic chemistry Essential for all instructors teaching laboratory courses in general and inorganic chemistry

Author : Astrid Sigel,Helmut Sigel
Publisher : CRC Press
Page : 736 pages
File Size : 46,7 Mb
Release : 1996-02-29
Category : Science
ISBN : 0824796888

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Metal Ions in Biological Systems by Astrid Sigel,Helmut Sigel Pdf

"Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts."

Author : Anonim
Publisher : ScholarlyEditions
Page : 169 pages
File Size : 43,7 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781481604185

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Alkylating Agents—Advances in Research and Application: 2012 Edition by Anonim Pdf

Alkylating Agents—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Alkylating Agents. The editors have built Alkylating Agents—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Alkylating Agents in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Alkylating Agents—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.