Methods And Biostatistics In Oncology

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Methods and Biostatistics in Oncology

Raphael. L.C Araújo,Rachel P. Riechelmann
Methods and Biostatistics in Oncology Book PDF

Author : Raphael. L.C Araújo,Rachel P. Riechelmann
Publisher : Springer
Page : 348 pages
File Size : 55,9 Mb
Release : 2018-04-16
Category : Medical
ISBN : 9783319713243

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Methods and Biostatistics in Oncology by Raphael. L.C Araújo,Rachel P. Riechelmann Pdf

This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach. Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology. Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal. Addressing that gap, this book discusses more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.

Biostatistics for Oncologists

Kara-Lynne Leonard, MD, MS,Adam Sullivan, PhD
Biostatistics for Oncologists Book PDF

Author : Kara-Lynne Leonard, MD, MS,Adam Sullivan, PhD
Publisher : Springer Publishing Company
Page : 200 pages
File Size : 50,5 Mb
Release : 2018-04-28
Category : Medical
ISBN : 9780826168597

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Biostatistics for Oncologists by Kara-Lynne Leonard, MD, MS,Adam Sullivan, PhD Pdf

Biostatistics for Oncologists is the first practical guide providing the essential biostatistical concepts, oncology-specific examples, and applicable problem sets for medical oncologists, radiation oncologists, and surgical oncologists. The book also serves as a review for medical oncology and radiation oncology residents or fellows preparing for in-service and board exams. All examples are relevant to oncology and demonstrate how to apply core conceptual knowledge and applicable methods related to hypothesis testing, correlation and regression, categorical data analysis and survival analysis to the field of oncology. The book also provides guidance on the fundamentals of study design and analysis. Written for oncologists by oncologists, this practical text demystifies challenging statistical concepts and provides concise direction on how to interpret, analyze, and critique data in oncology publications, as well as how to apply statistical knowledge to understanding, designing, and analyzing clinical trials. With practical problem sets and twenty-five multiple choice practice questions with answers, the book is an indispensable review for anyone preparing for in-service exams, boards, MOC, or looking to hone a lifelong skill. Key Features: Practically explains biostatistics concepts important for passing the hematology, medical oncology, and radiation oncology boards and MOC exams. Provides guidance on how to read, understand, and critique data in oncology publications. Gives relevant examples that are important for analyzing data in oncology, including the design and analysis of clinical trials. Tests your comprehension of key biostatistical concepts with problem sets at the end of each section and a final section devoted to board-style multiple choice questions and answers Includes digital access to the eBook

Handbook of Statistics in Clinical Oncology, Third Edition

John Crowley,Antje Hoering
Handbook of Statistics in Clinical Oncology Third Edition Book PDF

Author : John Crowley,Antje Hoering
Publisher : CRC Press
Page : 661 pages
File Size : 48,5 Mb
Release : 2012-03-26
Category : Mathematics
ISBN : 9781439862001

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Handbook of Statistics in Clinical Oncology, Third Edition by John Crowley,Antje Hoering Pdf

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Statistical Approaches in Oncology Clinical Development

Satrajit Roychoudhury,Soumi Lahiri
Statistical Approaches in Oncology Clinical Development Book PDF

Author : Satrajit Roychoudhury,Soumi Lahiri
Publisher : CRC Press
Page : 243 pages
File Size : 47,8 Mb
Release : 2018-12-07
Category : Mathematics
ISBN : 9781351650472

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Statistical Approaches in Oncology Clinical Development by Satrajit Roychoudhury,Soumi Lahiri Pdf

Statistical Approaches in Oncology Clinical Development : Current Paradigm and Methodological Advancement presents an overview of statistical considerations in oncology clinical trials, both early and late phase of development. It illustrates how novel statistical methods can enrich the design and analysis of modern oncology trials. The authors include many relevant real life examples from the pharmaceutical industry and academia based on their first-hand experience. Along with relevant references, the book highlights current regulatory views. The book covers all aspects of cancer clinical trial starting from early phase development. The early part of the book covers novel phase I dose escalation design, exposure response analysis, and innovative phase II design. This includes early development strategy for cancer immunotherapy trials. The contributors also emphasized the role of biomarker and modern era of precision medicine. The second part focuses on the late stage development. This includes the application of adaptive design, safety analysis, and quality of life (QoL) data analysis. The final part discusses current regulatory perspective and challenges. Features: Covers a wide spectrum of topics related to real-life statistical challenges in oncology clinical trials. Provides a comprehensive overview of novel statistical methods to improve trial design and statistical analysis. Detailed case studies illustrate the real life applications. Satrajit Roychoudhury is a Senior Director and a member of the Statistical Research and Innovation group in Pfizer Inc. Prior to joining; he was a member of Statistical Methodology and consulting group in Novartis. He has 11 years of extensive experience in working with different phases of clinical trial. His area of research includes early phase oncology trials, survival analysis, model informed drug development, and use of Bayesian methods in clinical trials. He is industry co-chair for the ASA Biopharmaceutical Section Regulatory-Industry Workshop and has provided statistical training in major conferences including the Joint Statistical Meetings, ASA Biopharmaceutical Section Regulatory-Industry Workshop, and ICSA Applied Statistics Symposium. Soumi Lahiri has 12 years of extensive experience in working different therapeutic areas. She is the former Director of Biostatistics in Clinical Oncology, GlaxoSmithKline. She has also worked in the oncology division of Novartis Pharmaceutical Company for two years. She is an active member of the ASA Biopharmaceutical section and former chair of the membership committee.

Frontiers of Biostatistical Methods and Applications in Clinical Oncology

Shigeyuki Matsui,John Crowley
Frontiers of Biostatistical Methods and Applications in Clinical Oncology Book PDF

Author : Shigeyuki Matsui,John Crowley
Publisher : Springer
Page : 438 pages
File Size : 46,9 Mb
Release : 2017-10-03
Category : Medical
ISBN : 9789811001260

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Frontiers of Biostatistical Methods and Applications in Clinical Oncology by Shigeyuki Matsui,John Crowley Pdf

This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.

Biostatistical Applications in Cancer Research

Craig Beam
Biostatistical Applications in Cancer Research Book PDF

Author : Craig Beam
Publisher : The Rosen Publishing Group
Page : 250 pages
File Size : 42,8 Mb
Release : 2002-12-31
Category : Mathematics
ISBN : 1402072260

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Biostatistical Applications in Cancer Research by Craig Beam Pdf

Biostatistics is defined as much by its application as it is by theory. This book provides an introduction to biostatistical applications in modern cancer research that is both accessible and valuable to the cancer biostatistician or to the cancer researcher, learning biostatistics. The topical areas include active areas of the application of biostatistics to modern cancer research: survival analysis, screening, diagnostics, spatial analysis and the analysis of microarray data. Biostatistics is an essential component of basic and clinical cancer research. The text, authored by distinguished figures in the field, addresses clinical issues in statistical analysis. The spectrum of topics discussed ranges from fundamental methodology to clinical and translational applications.

Handbook of Statistics in Clinical Oncology

John Crowley,Antje Hoering
Handbook of Statistics in Clinical Oncology Book PDF

Author : John Crowley,Antje Hoering
Publisher : CRC Press
Page : 566 pages
File Size : 43,6 Mb
Release : 2001-04-27
Category : Mathematics
ISBN : 0824790251

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Handbook of Statistics in Clinical Oncology by John Crowley,Antje Hoering Pdf

This book compiles state-of-the-art statistical approaches to solving problems in clinical oncology, focusing on clinical trials in phases I, II, and III, as well as quality of life and economic analyses, and exploratory methods. Examines trial design treatment based on toxicity and survival! Featuring over 1000 references, more than 40 world-renowned contributors, and 300 equations, tables, and drawings, the Handbook of Statistics in Clinical Oncology provides a comprehensive discussion of sample size considers analytical problems generated by controlling treatment costs and maintaining quality of life demonstrates the breadth and depth of current activity in the field of survival analysis sets the limits on what can and cannot be concluded from single and multiple clinical trials and more! The best single source for up-to-date graphical, tree-based, and other statistical methods, the Handbook of Statistics in Clinical Oncology is fascinating reading for oncologists, cancer researchers, biostatisticians, applied statisticians, and medical and graduate students in these disciplines.

Clinical Trials in Oncology, Third Edition

Stephanie Green,Jacqueline Benedetti,Angela Smith,John Crowley
Clinical Trials in Oncology Third Edition Book PDF

Author : Stephanie Green,Jacqueline Benedetti,Angela Smith,John Crowley
Publisher : CRC Press
Page : 266 pages
File Size : 41,5 Mb
Release : 2012-05-09
Category : Mathematics
ISBN : 9781439814482

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Clinical Trials in Oncology, Third Edition by Stephanie Green,Jacqueline Benedetti,Angela Smith,John Crowley Pdf

The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to cancer clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. In addition, the book has been restructured to have separate chapters and expanded discussions on general clinical trials issues, and issues specific to Phases I, II, and III. New sections cover innovations in Phase I designs, randomized Phase II designs, and overcoming the challenges of array data. Although this book focuses on cancer trials, the same issues and concepts are important in any clinical setting. As always, the authors use clear, lucid prose and a multitude of real-world examples to convey the principles of successful trials without the need for a strong statistics or mathematics background. Armed with Clinical Trials in Oncology, Third Edition, clinicians and statisticians can avoid the many hazards that can jeopardize the success of a trial.

Handbook of Statistics in Clinical Oncology

John Crowley,Antje Hoering,Donna Ankerst
Handbook of Statistics in Clinical Oncology Book PDF

Author : John Crowley,Antje Hoering,Donna Ankerst
Publisher : CRC Press
Page : 642 pages
File Size : 54,8 Mb
Release : 2005-12-01
Category : Mathematics
ISBN : 9781420027761

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Handbook of Statistics in Clinical Oncology by John Crowley,Antje Hoering,Donna Ankerst Pdf

A compendium of cutting-edge statistical approaches to solving problems in clinical oncology, Handbook of Statistics in Clinical Oncology, Second Edition focuses on clinical trials in phases I, II, and III, proteomic and genomic studies, complementary outcomes and exploratory methods. Cancer Forum called the first edition a

Computational Biology

Tuan Pham
Computational Biology Book PDF

Author : Tuan Pham
Publisher : Springer Science & Business Media
Page : 309 pages
File Size : 52,5 Mb
Release : 2009-09-23
Category : Medical
ISBN : 9781441908117

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Computational Biology by Tuan Pham Pdf

This volume covers techniques in computational biology and their applications in oncology. It details advanced statistical methods, heuristic algorithms, cluster analysis, data modeling, and image and pattern analysis applied to cancer research.

The Evolution of the Use of Mathematics in Cancer Research

Pedro Jose Gutiérrez Diez,Irma H. Russo,Jose Russo
The Evolution of the Use of Mathematics in Cancer Research Book PDF

Author : Pedro Jose Gutiérrez Diez,Irma H. Russo,Jose Russo
Publisher : Springer Science & Business Media
Page : 404 pages
File Size : 51,7 Mb
Release : 2012-02-17
Category : Medical
ISBN : 9781461423973

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The Evolution of the Use of Mathematics in Cancer Research by Pedro Jose Gutiérrez Diez,Irma H. Russo,Jose Russo Pdf

The book will provide an exhaustive and clear explanation of how Statistics, Mathematics and Informatics have been used in cancer research, and seeks to help cancer researchers in achieving their objectives. To do so, state-of-the-art Biostatistics, Biomathematics and Bioinformatics methods will be described and discussed in detail through illustrative and capital examples taken from cancer research work already published. The book will provide a guide for cancer researchers in using Statistics, Mathematics and Informatics, clarifying the contribution of these logical sciences to the study of cancer, thoroughly explaining their procedures and methods, and providing criteria to their appropriate use.

Handbook of Statistics in Clinical Oncology, Second Edition

John Crowley,Antje Hoering,Donna Ankerst
Handbook of Statistics in Clinical Oncology Second Edition Book PDF

Author : John Crowley,Antje Hoering,Donna Ankerst
Publisher : Chapman and Hall/CRC
Page : 640 pages
File Size : 43,8 Mb
Release : 2005-12-01
Category : Mathematics
ISBN : 0824723392

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Handbook of Statistics in Clinical Oncology, Second Edition by John Crowley,Antje Hoering,Donna Ankerst Pdf

A compendium of cutting-edge statistical approaches to solving problems in clinical oncology, Handbook of Statistics in Clinical Oncology, Second Edition focuses on clinical trials in phases I, II, and III, proteomic and genomic studies, complementary outcomes and exploratory methods. Cancer Forum called the first edition a “1⁄4good reference book for statisticians who will be designing and analyzing cancer trials." The second edition includes over 1000 references, more than forty world-renowned contributors, and 300 equations, tables, and drawings. During the five years since publication of the first edition, there has been an explosion in the technological capabilities supporting genomic and proteomic research, which are is now firmly implanted in clinical oncology. Reflecting these developments, the second edition contains a new section devoted to analyses of high-throughput data and bioinformatics. Previous chapters of the first edition have been revised to reflect current state of the art in their respective domains. The intended audience is primarily statisticians working in cancer and more generally, in any discipline of medicine. But oncologists too will find the material accessible and will benefit from a rudimentary understanding of the fundamental concepts laid forth in each chapter. Completely revised while keeping the features that made the first edition a bestseller, this is the best single source for up-to-date statistical approaches to research in clinical medicine. More than just an update of the handbook that became the gold standard, this second edition brings you fully into the genomic era of medicine.

Textbook of Clinical Trials in Oncology

Susan Halabi,Stefan Michiels
Textbook of Clinical Trials in Oncology Book PDF

Author : Susan Halabi,Stefan Michiels
Publisher : CRC Press
Page : 701 pages
File Size : 43,9 Mb
Release : 2019-04-24
Category : Medical
ISBN : 9781351620963

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Textbook of Clinical Trials in Oncology by Susan Halabi,Stefan Michiels Pdf

There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others

Bayesian Approaches in Oncology Using R and OpenBUGS

Atanu Bhattacharjee
Bayesian Approaches in Oncology Using R and OpenBUGS Book PDF

Author : Atanu Bhattacharjee
Publisher : CRC Press
Page : 260 pages
File Size : 45,5 Mb
Release : 2020-12-21
Category : Mathematics
ISBN : 9781000329988

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Bayesian Approaches in Oncology Using R and OpenBUGS by Atanu Bhattacharjee Pdf

Bayesian Approaches in Oncology Using R and OpenBUGS serves two audiences: those who are familiar with the theory and applications of bayesian approach and wish to learn or enhance their skills in R and OpenBUGS, and those who are enrolled in R and OpenBUGS-based course for bayesian approach implementation. For those who have never used R/OpenBUGS, the book begins with a self-contained introduction to R that lays the foundation for later chapters. Many books on the bayesian approach and the statistical analysis are advanced, and many are theoretical. While most of them do cover the objective, the fact remains that data analysis can not be performed without actually doing it, and this means using dedicated statistical software. There are several software packages, all with their specific objective. Finally, all packages are free to use, are versatile with problem-solving, and are interactive with R and OpenBUGS. This book continues to cover a range of techniques related to oncology that grow in statistical analysis. It intended to make a single source of information on Bayesian statistical methodology for oncology research to cover several dimensions of statistical analysis. The book explains data analysis using real examples and includes all the R and OpenBUGS codes necessary to reproduce the analyses. The idea is to overall extending the Bayesian approach in oncology practice. It presents four sections to the statistical application framework: Bayesian in Clinical Research and Sample Size Calcuation Bayesian in Time-to-Event Data Analysis Bayesian in Longitudinal Data Analysis Bayesian in Diagnostics Test Statistics This book is intended as a first course in bayesian biostatistics for oncology students. An oncologist can find useful guidance for implementing bayesian in research work. It serves as a practical guide and an excellent resource for learning the theory and practice of bayesian methods for the applied statistician, biostatistician, and data scientist.

Modern Clinical Trial Analysis

Wan Tang,Xin Tu
Modern Clinical Trial Analysis Book PDF

Author : Wan Tang,Xin Tu
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 54,5 Mb
Release : 2012-09-05
Category : Medical
ISBN : 9781461443223

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Modern Clinical Trial Analysis by Wan Tang,Xin Tu Pdf

This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. The intent of the book is to provide an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out analyses. While classic topics such as survival data analysis, analysis of diagnostic test data and assessment of measurement reliability are well known and covered in depth by available topic-specific texts, this volume serves a different purpose: it provides a quick introduction to each topic for self-learning, particularly for those who have not done any formal coursework on a given topic but must learn it due to its relevance to their multidisciplinary research. In addition, the chapters on these classic topics will reflect issues particularly relevant to modern clinical trials such as longitudinal designs and new methods for analyzing data from such study designs. The coverage of these topics provides a quick introduction to these important statistical issues and methods for addressing them. As with the classic topics, this part of the volume on modern topics will enable researchers to grasp the statistical methods for addressing these emerging issues underlying modern clinical trials and to apply them to their research studies.