Methods In Redox Signaling

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Methods in Redox Signaling

Dipak Kumar Das
Methods in Redox Signaling Book PDF

Author : Dipak Kumar Das
Publisher : Unknown
Page : 0 pages
File Size : 55,6 Mb
Release : 2010
Category : Cellular signal transduction
ISBN : 1934854069

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Methods in Redox Signaling by Dipak Kumar Das Pdf

Methods in Redox Signaling is the first and only comprehensive handbook on the experimental methods used to study redox signaling. Formerly recognized as destructive mechanisms, reactive oxygen species (ROS) have now been recognized as saviors by protecting the cells through redox signaling. This evolving science involves the pathobiology of various disease processes including cancer, cardiovascular diseases, wound healing, and many other degenerative diseases. Although the concept of reactive oxygen species has been known to some for decades, their potential role in the biological system has only been recognized in recent years. With the identification of these new mechanisms and their potential, the exploration in this area is expanding rapidly and the scientific articles are pouring in. Being relatively young, a vast majority of the mechanisms of redox signaling, especially those related to disease processes still remain unknown. Methods in Redox Signaling provides a valuable tool for the growing number of scientists engaging in the research and investigation involving redox regulation of degenerative diseases.

Cellular Implications of Redox Signaling

Carlos Gitler,Avihai Danon
Cellular Implications of Redox Signaling Book PDF

Author : Carlos Gitler,Avihai Danon
Publisher : World Scientific
Page : 440 pages
File Size : 53,6 Mb
Release : 2003-07-30
Category : Science
ISBN : 9781783261154

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Cellular Implications of Redox Signaling by Carlos Gitler,Avihai Danon Pdf

Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved. This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells. Contents:The Role of Thioredoxin and Glutaredoxin Systems in Disulfide Reduction and Thiol Redox ControlSelenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox SignalingIron–Sulfur Proteins: Properties and FunctionsThe Ferredoxin Ferredoxin/Thioredoxin Thioredoxin System. A Light-Dependent Redox Regulatory System in Oxygenic Photosynthetic CellsThioredoxin and Redox Regulation: Beginnings in Photosynthesis Lead to a Role in Germination and Improvement of CerealsThe Role of Thioredoxin in Regulatory Cellular FunctionsProtein S-Thiolation, S-Nitrosylation, and Irreversible Sulfhydryl Oxidation: Roles in Redox RegulationRadical Scavenging by Thiols: Biological Significance and Implications for Redox Signaling and Antioxidant DefenseAscorbate and Glutathione Metabolism in Plants: H2O2-Processing and SignalingDisulfide Bond Formation in the Periplasm and Cytoplasm of Escherichia ColiThe Thiol Redox Paradox in the Requirement for Disulfide Isomerization in the Eukaryotic Endoplasmic ReticulumMechanisms Controlling Redox Balance in Cells. Inhibition of Thioredoxin and of Thioredoxin ReductaseRegulatory Disulfides Controlling Transcription Factor Activity in the Bacterial and Yeast Responses to Oxidative StressRedox Signaling During Light-Regulated Translation in ChloroplastsRegulation of mRNA Translation and Stability in Iron Metabolism: Is There a Redox Switch?Redox Flow as an Instrument for Gene RegulationThe Permeability Transition Pore as Source and Target of Oxidative Stress Readership: Researchers and graduate students in the life sciences, especially biochemistry.

Redox-Mediated Signal Transduction

John T. Hancock,Myra E. Conway
Redox Mediated Signal Transduction Book PDF

Author : John T. Hancock,Myra E. Conway
Publisher : Unknown
Page : 199 pages
File Size : 45,9 Mb
Release : 2019
Category : Cell interaction
ISBN : 1493994638

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Redox-Mediated Signal Transduction by John T. Hancock,Myra E. Conway Pdf

This volume explores the scope of the cellular redox analysis and the importance of not being limited by frequently changing and evolving technology. The chapters in this book cover a wide range of topics such as redox components in animal and plant cells and the role of reactive oxygen species, reactive nitrogen species, and hydrogen sulphide in cell signaling; measuring modifications using Flow Cytometry, ELISA assays, and Western blot analysis; measurement of oxidative stress in mitochondira and biological systems; and the use of the genetically encoded fluorescent probe HyPer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and informative, Redox-Mediated Signal Transduction: Methods and Protocols, Second Edition is a valuable resource for both novice and expert researchers who want to expand their studies into new areas and new systems in the evolving redox field.

Pulmonary Vasculature Redox Signaling in Health and Disease

Yong-Xiao Wang
Pulmonary Vasculature Redox Signaling in Health and Disease Book PDF

Author : Yong-Xiao Wang
Publisher : Springer
Page : 422 pages
File Size : 45,6 Mb
Release : 2017-10-18
Category : Medical
ISBN : 9783319632452

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Pulmonary Vasculature Redox Signaling in Health and Disease by Yong-Xiao Wang Pdf

The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.

Redox Signaling and Regulation in Biology and Medicine

Claus Jacob,Paul G. Winyard
Redox Signaling and Regulation in Biology and Medicine Book PDF

Author : Claus Jacob,Paul G. Winyard
Publisher : John Wiley & Sons
Page : 514 pages
File Size : 47,5 Mb
Release : 2009-05-06
Category : Science
ISBN : 9783527627592

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Redox Signaling and Regulation in Biology and Medicine by Claus Jacob,Paul G. Winyard Pdf

This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.

Thiol Redox Transitions in Cell Signaling

Anonim
Thiol Redox Transitions in Cell Signaling Book PDF

Author : Anonim
Publisher : Academic Press
Page : 392 pages
File Size : 52,9 Mb
Release : 2010-08-19
Category : Science
ISBN : 0123810043

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Thiol Redox Transitions in Cell Signaling by Anonim Pdf

This volume, along with its companion (volume 474), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines

Redox Signaling and Biomarkers in Ageing

Ufuk Çakatay
Redox Signaling and Biomarkers in Ageing Book PDF

Author : Ufuk Çakatay
Publisher : Springer Nature
Page : 447 pages
File Size : 49,5 Mb
Release : 2021-12-02
Category : Medical
ISBN : 9783030849658

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Redox Signaling and Biomarkers in Ageing by Ufuk Çakatay Pdf

This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.

Sulfides: Advances in Research and Application: 2011 Edition

Anonim
Sulfides Advances in Research and Application 2011 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 127 pages
File Size : 54,8 Mb
Release : 2012-01-09
Category : Science
ISBN : 9781464927812

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Sulfides: Advances in Research and Application: 2011 Edition by Anonim Pdf

Sulfides: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Sulfides in a concise format. The editors have built Sulfides: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Sulfides in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Sulfides: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Oxidative Stress and Redox Regulation

Ursula Jakob,Dana Reichmann
Oxidative Stress and Redox Regulation Book PDF

Author : Ursula Jakob,Dana Reichmann
Publisher : Springer Science & Business Media
Page : 488 pages
File Size : 45,7 Mb
Release : 2013-03-15
Category : Science
ISBN : 9789400757875

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Oxidative Stress and Redox Regulation by Ursula Jakob,Dana Reichmann Pdf

Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Oxidants and Redox Signaling in Inflammation

Gabor Csanyi,Rikard Holmdahl
Oxidants and Redox Signaling in Inflammation Book PDF

Author : Gabor Csanyi,Rikard Holmdahl
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 50,5 Mb
Release : 2019-07-10
Category : Electronic
ISBN : 9782889458882

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Oxidants and Redox Signaling in Inflammation by Gabor Csanyi,Rikard Holmdahl Pdf

During the last two decades, our view of the role of reactive oxygen species (ROS) in inflammatory processes has changed dramatically. ROS that are constantly produced at lower levels by living cells metabolizing oxygen contribute to normal cellular function and tissue homeostasis. ROS are produced at higher levels in inflammation and regulate the inflammatory response in specific ways. The role of ROS in inflammation is complex and primarily determined by their relative amount, chemical properties, reactivity, subcellular localization and molecular environment, specificity for their biological targets, and availability and mechanisms of antioxidant defense systems. This eBook comprises twelve reviews and original articles that provide new findings on the role of ROS in the regulation of inflammatory processes, highlight emerging topics in redox signaling, describe new ROS detection techniques and discuss alternative therapeutic strategies to treat inflammatory disorders. The editorial that precedes the published articles briefly summarizes the main findings of each research paper. We hope that this collection of research articles contribute to a better understanding of ROS in inflammation.

Mitochondrial Function, Part A

Anonim
Mitochondrial Function Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 502 pages
File Size : 50,7 Mb
Release : 2009-04-03
Category : Science
ISBN : 9780080915333

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Mitochondrial Function, Part A by Anonim Pdf

The first of two new volumes covering mitochondria, Mitochondrial Function, Part A presents modern methods that have been developed to examine mitochondrial electron transport chain complexes, iron-sulfur proteins and reactive oxygen species. These new techniques provide investigators with sensitive, original approaches to the study of disease states associated with mitochondrial malfunction. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. New methods focusing on the examination of normal and abnormal mitochondrial function are presented in an easy-to-follow format by the researchers who developed them Along with companion volume covering mitochondrial diseases and defects, provides a comprehensive overview of modern techniques in the study of mitochondrial malfunction Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods

Redox-Signaling in Neurodegenerative Diseases: Biomarkers, Targets, and Therapies

Andreia Neves Carvalho,Luciano Saso,Jack Van Horssen,Vasco Branco
Redox Signaling in Neurodegenerative Diseases Biomarkers Targets and Therapies Book PDF

Author : Andreia Neves Carvalho,Luciano Saso,Jack Van Horssen,Vasco Branco
Publisher : Frontiers Media SA
Page : 152 pages
File Size : 41,7 Mb
Release : 2023-05-16
Category : Science
ISBN : 9782832523537

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Redox-Signaling in Neurodegenerative Diseases: Biomarkers, Targets, and Therapies by Andreia Neves Carvalho,Luciano Saso,Jack Van Horssen,Vasco Branco Pdf

Redox homeostasis results from the balance between the production of reactive species (e.g. ROS, RNS, etc) and their detoxification by endogenous or exogenous antioxidants. ROS play several important physiological roles, however, their excessive production or impaired detoxification is associated with oxidative stress and cellular injury. Importantly, oxidative damage to vulnerable central nervous system (CNS) cells is a common pathological feature of several neurodegenerative diseases. Antioxidants have been considered as attractive potential therapeutic agents to prevent or halt disease progression but the clinical efficacy of antioxidant treatment strategies is still marginal. Improvement of antioxidant therapy effectiveness might involve adjustment of preclinical to clinical settings and development of new efficient delivery methods and will require a more in-depth knowledge of cellular redox-signaling mechanisms. Promising novel redox-based therapeutic strategies are gaining relevance to combat oxidative stress associated with neurodegenerative diseases. These include boosting the endogenous antioxidant machinery through activation of the antioxidant master regulator Nrf2 (nuclear factor erythroid 2-related factor 2) or modulation of ROS production by NOX (nicotinamide adenine dinucleotide phosphate (NADPH) oxidase) inhibitors. Redox regulation of key cellular functions is currently recognized as an important cellular signaling mechanism and events such as post-translational modifications (e.g. S_glutathionylation, S_nitrosylation, glycosylation, etc) play important roles in redox signal transduction and might be instrumental to uncover pathological mechanisms and identify novel therapeutic targets in neurodegenerative diseases. This Research Topic focuses on redox signaling mechanisms and aims to provide novel insights into the role of redox-signaling, with particular emphasis on redox regulation involving post-translational modifications, in the pathophysiology of neurodegenerative diseases. Moreover, it aims to present an overview of the potential of antioxidants as therapeutics for CNS disorders with a special focus on emerging novel therapeutic redox-based strategies. We are particularly interested in studies: -addressing new redox-based molecular mechanisms contributing to neurodegenerative diseases; -exploring the role of naturally occurring compounds, standard medications, and nutraceuticals with antioxidant properties in modulating redox-signaling pathways and limiting and/or preventing oxidative damage associated with these disorders; -addressing mechanistically the role of post-translational modifications in the pathophysiology of neurodegenerative disorders.

Chromosomes: Advances in Research and Application: 2011 Edition

Anonim
Chromosomes Advances in Research and Application 2011 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 190 pages
File Size : 51,8 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464924910

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Chromosomes: Advances in Research and Application: 2011 Edition by Anonim Pdf

Chromosomes: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chromosomes. The editors have built Chromosomes: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chromosomes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chromosomes: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Computational Methods for Predicting Post-Translational Modification Sites

Dukka B. KC
Computational Methods for Predicting Post Translational Modification Sites Book PDF

Author : Dukka B. KC
Publisher : Springer Nature
Page : 337 pages
File Size : 49,8 Mb
Release : 2022-06-13
Category : Science
ISBN : 9781071623176

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Computational Methods for Predicting Post-Translational Modification Sites by Dukka B. KC Pdf

This volume describes computational approaches to predict multitudes of PTM sites. Chapters describe in depth approaches on algorithms, state-of-the-art Deep Learning based approaches, hand-crafted features, physico-chemical based features, issues related to obtaining negative training, sequence-based features, and structure-based features. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Authoritative and cutting-edge, Computational Methods for Predicting Post-Translational Modification Sites aims to be a useful guide for researchers who are interested in the field of PTM site prediction.

Thiol Redox Transitions in Cell Signaling, Part A

Anonim
Thiol Redox Transitions in Cell Signaling Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 416 pages
File Size : 53,6 Mb
Release : 2010-07-22
Category : Science
ISBN : 0123813468

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Thiol Redox Transitions in Cell Signaling, Part A by Anonim Pdf

Thiol Redox Transitions in Cell Signaling, Part A, along with its companion (volume 475), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. This first installment of Cadenas and Packer's two-volume treatment specifically deals with glutathionylation and dethiolation, and peroxide removal by peroxiredoxins/thioredoxins and glutathione peroxidases. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines