Oxidative Stress And Redox Regulation

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Oxidative Stress and Redox Regulation

Ursula Jakob,Dana Reichmann
Oxidative Stress and Redox Regulation Book PDF

Author : Ursula Jakob,Dana Reichmann
Publisher : Springer Science & Business Media
Page : 488 pages
File Size : 43,5 Mb
Release : 2013-03-15
Category : Science
ISBN : 9789400757875

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Oxidative Stress and Redox Regulation by Ursula Jakob,Dana Reichmann Pdf

Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Redox Regulation of Cell Signaling and Its Clinical Application

Junji Yodoi
Redox Regulation of Cell Signaling and Its Clinical Application Book PDF

Author : Junji Yodoi
Publisher : CRC Press
Page : 344 pages
File Size : 42,7 Mb
Release : 1999-03-29
Category : Medical
ISBN : 9781482276077

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Redox Regulation of Cell Signaling and Its Clinical Application by Junji Yodoi Pdf

Presents recent developments in the rapidly expanding field of redox regulation research. The book examines insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult

Oxidative Stress and Redox Regulation in Plants

Anonim
Oxidative Stress and Redox Regulation in Plants Book PDF

Author : Anonim
Publisher : Academic Press
Page : 591 pages
File Size : 44,5 Mb
Release : 2009-10-09
Category : Science
ISBN : 9780123786234

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Oxidative Stress and Redox Regulation in Plants by Anonim Pdf

The field of redox is rapidly changing, specifically in relation to plants where redox reactions are exacerbated compared to non-photosynthetic organisms. The development of proteomics has allowed the identification of hundreds of molecular targets of these systems, and the recent discovery of glutaredoxin's ability to bind iron sulfur centers (ISCs) and to participate in ISC assembly in other apoproteins has provided many new insights. This volume presents new research on oxidative stress in plants, ranging from the production of reactive oxygen species or reactive nitrogen species, to their accumulation, their involvement in signal transduction, and their degradation, while also covering the links among oxidative stress and biotic and abiotic stresses. Cutting-edge reviews written from a broad range of scientific perspectives For over 40 years, series has enjoyed a reputation for excellence Contributors internationally recognized authorities in their respective fields

Oxidative Stress, Inflammation, and Health

Young-Joon Surh
Oxidative Stress Inflammation and Health Book PDF

Author : Young-Joon Surh
Publisher : CRC Press
Page : 670 pages
File Size : 52,7 Mb
Release : 2005-05-24
Category : Medical
ISBN : 9781420028256

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Oxidative Stress, Inflammation, and Health by Young-Joon Surh Pdf

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-an

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Luc Montagnier,Rene Olivier,Catherine Pasquier
Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases Book PDF

Author : Luc Montagnier,Rene Olivier,Catherine Pasquier
Publisher : CRC Press
Page : 575 pages
File Size : 48,9 Mb
Release : 1997-10-06
Category : Medical
ISBN : 9781482292213

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Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases by Luc Montagnier,Rene Olivier,Catherine Pasquier Pdf

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers t

Redox Regulation of Differentiation and De-differentiation

Carsten Berndt,Christopher Horst Lillig
Redox Regulation of Differentiation and De differentiation Book PDF

Author : Carsten Berndt,Christopher Horst Lillig
Publisher : CRC Press
Page : 544 pages
File Size : 55,6 Mb
Release : 2021-08-26
Category : Science
ISBN : 9781000435382

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Redox Regulation of Differentiation and De-differentiation by Carsten Berndt,Christopher Horst Lillig Pdf

Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine. Key Features Provides the first summary on this important topic Reviews redox-dependent development of model organisms and single organs Highlights the redox-regulated pathways important for differentiation processes Illustrates the potential of redox medicine Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration Written by leading experts in the field Related Titles Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 978-1-77188-067-1) Clarke, M. & J. Frampton. Stem Cells: Biology and Application (ISBN 9780-8153-4511-4) Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Wong, E., ed. Autophagy and Signaling (ISBN 978-0-367-65772-7)

Thiol Metabolism and Redox Regulation of Cellular Functions

Alfonso Pompella,Gábor Bánhegyi,Maria Wellman-Rousseau
Thiol Metabolism and Redox Regulation of Cellular Functions Book PDF

Author : Alfonso Pompella,Gábor Bánhegyi,Maria Wellman-Rousseau
Publisher : IOS Press
Page : 366 pages
File Size : 40,6 Mb
Release : 2002
Category : Medical
ISBN : 1586032828

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Thiol Metabolism and Redox Regulation of Cellular Functions by Alfonso Pompella,Gábor Bánhegyi,Maria Wellman-Rousseau Pdf

This volume contains contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry. It is focused on the biological/pathophysiological implications of newly-discovered functions of cellular thiols, such as glutathione in the first place.

Cellular Implications of Redox Signaling

Carlos Gitler,Avihai Danon
Cellular Implications of Redox Signaling Book PDF

Author : Carlos Gitler,Avihai Danon
Publisher : World Scientific
Page : 440 pages
File Size : 42,8 Mb
Release : 2003-07-30
Category : Science
ISBN : 9781783261154

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Cellular Implications of Redox Signaling by Carlos Gitler,Avihai Danon Pdf

Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved. This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells. Contents:The Role of Thioredoxin and Glutaredoxin Systems in Disulfide Reduction and Thiol Redox ControlSelenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox SignalingIron–Sulfur Proteins: Properties and FunctionsThe Ferredoxin Ferredoxin/Thioredoxin Thioredoxin System. A Light-Dependent Redox Regulatory System in Oxygenic Photosynthetic CellsThioredoxin and Redox Regulation: Beginnings in Photosynthesis Lead to a Role in Germination and Improvement of CerealsThe Role of Thioredoxin in Regulatory Cellular FunctionsProtein S-Thiolation, S-Nitrosylation, and Irreversible Sulfhydryl Oxidation: Roles in Redox RegulationRadical Scavenging by Thiols: Biological Significance and Implications for Redox Signaling and Antioxidant DefenseAscorbate and Glutathione Metabolism in Plants: H2O2-Processing and SignalingDisulfide Bond Formation in the Periplasm and Cytoplasm of Escherichia ColiThe Thiol Redox Paradox in the Requirement for Disulfide Isomerization in the Eukaryotic Endoplasmic ReticulumMechanisms Controlling Redox Balance in Cells. Inhibition of Thioredoxin and of Thioredoxin ReductaseRegulatory Disulfides Controlling Transcription Factor Activity in the Bacterial and Yeast Responses to Oxidative StressRedox Signaling During Light-Regulated Translation in ChloroplastsRegulation of mRNA Translation and Stability in Iron Metabolism: Is There a Redox Switch?Redox Flow as an Instrument for Gene RegulationThe Permeability Transition Pore as Source and Target of Oxidative Stress Readership: Researchers and graduate students in the life sciences, especially biochemistry.

Oxidative Stress Mechanisms and their Modulation

Mohinder Bansal,Naveen Kaushal
Oxidative Stress Mechanisms and their Modulation Book PDF

Author : Mohinder Bansal,Naveen Kaushal
Publisher : Springer
Page : 183 pages
File Size : 44,8 Mb
Release : 2014-10-17
Category : Science
ISBN : 9788132220329

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Oxidative Stress Mechanisms and their Modulation by Mohinder Bansal,Naveen Kaushal Pdf

Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.

Reactive Oxygen Species and Oxidative Damage in Plants Under Stress

Dharmendra K. Gupta,José M. Palma,Francisco J. Corpas
Reactive Oxygen Species and Oxidative Damage in Plants Under Stress Book PDF

Author : Dharmendra K. Gupta,José M. Palma,Francisco J. Corpas
Publisher : Springer
Page : 370 pages
File Size : 55,5 Mb
Release : 2015-09-07
Category : Science
ISBN : 9783319204215

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Reactive Oxygen Species and Oxidative Damage in Plants Under Stress by Dharmendra K. Gupta,José M. Palma,Francisco J. Corpas Pdf

This book provides detailed and comprehensive information on oxidative damage caused by stresses in plants with especial reference to the metabolism of reactive oxygen species (ROS). In plants, as in all aerobic organisms, ROS are common by-products formed by the inevitable leakage of electrons onto O2 from the electron transport activities located in chloroplasts, mitochondria, peroxisomes and in plasma membranes or as a consequence of various metabolic pathways confined in different cellular loci. Environmental stresses such as heat, cold, drought, salinity, heavy-metal toxicity, ozone and ultraviolet radiation as well as pathogens/contagion attack lead to enhanced generation of ROS in plants due to disruption of cellular homeostasis. ROS play a dual role in plants; at low concentrations they act as signaling molecules that facilitate several responses in plant cells, including those promoted by biotic and abiotic agents. In divergence, at high levels they cause damage to cellular constituents triggering oxidative stress. In either case, small antioxidant molecules and enzymes modulate the action of these ambivalent species.

Antioxidants in Sport Nutrition

Manfred Lamprecht
Antioxidants in Sport Nutrition Book PDF

Author : Manfred Lamprecht
Publisher : CRC Press
Page : 304 pages
File Size : 44,9 Mb
Release : 2014-09-17
Category : Medical
ISBN : 9781466567573

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Antioxidants in Sport Nutrition by Manfred Lamprecht Pdf

The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Redox Homeostasis in Plants

Sanjib Kumar Panda,Yoshiharu Y. Yamamoto
Redox Homeostasis in Plants Book PDF

Author : Sanjib Kumar Panda,Yoshiharu Y. Yamamoto
Publisher : Springer
Page : 198 pages
File Size : 49,9 Mb
Release : 2019-04-23
Category : Science
ISBN : 9783319953151

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Redox Homeostasis in Plants by Sanjib Kumar Panda,Yoshiharu Y. Yamamoto Pdf

This book summarizes the latest research results on the role of reactive oxygen species (ROS) in plants, particularly in many abiotic stresses, and their regulation. Redox homeostasis refers to maintaining a balance of oxidised and reduced state of biomolecules in a biological system for all-round sustenance. In a living system, redox reactions contribute to the generation of reactive oxygen species (ROS), which act as signalling molecules for developmental as well as stress-response processes in plants. It is presumed that, being sessile and an aerobe requiring oxygen for mitochondrial energy production, as well as producing oxygen during photosynthesis, the redox homeostasis process is more complex and regulated in plants than in animals. Any imbalance in the homeostasis is mainly compensated for by the production of various ROS molecules, which, though they can cause severe oxidative damage in excess, can also ideally act as signalling molecules.

Antioxidants and Reactive Oxygen Species in Plants

Nicholas Smirnoff
Antioxidants and Reactive Oxygen Species in Plants Book PDF

Author : Nicholas Smirnoff
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 48,9 Mb
Release : 2008-04-15
Category : Science
ISBN : 9781405171465

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Antioxidants and Reactive Oxygen Species in Plants by Nicholas Smirnoff Pdf

Reactive oxygen species (ROS) are produced during the interaction of metabolism with oxygen. As ROS have the potential to cause oxidative damage by reacting with biomolecules, research on ROS has concentrated on the oxidative damage that results from exposure to environmental stresses and on the role of ROS in defence against pathogens. However, more recently, it has become apparent that ROS also have important roles as signalling molecules. A complex network of enzymatic and small molecule antioxidants controls the concentration of ROS and repairs oxidative damage, and research is revealing the complex and subtle interplay between ROS and antioxidants in controlling plant growth, development and response to the environment. This book covers these new developments, generally focussing on molecular and biochemical details and providing a point of entry to the detailed literature. It is directed at researchers and professionals in plant molecular biology, biochemistry and cell biology, in both the academic and industrial sectors.

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Luc Montagnier,Rene Olivier,Catherine Pasquier
Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases Book PDF

Author : Luc Montagnier,Rene Olivier,Catherine Pasquier
Publisher : CRC Press
Page : 576 pages
File Size : 50,7 Mb
Release : 1997-10-06
Category : Medical
ISBN : 0824798627

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Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases by Luc Montagnier,Rene Olivier,Catherine Pasquier Pdf

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Redox Signaling and Regulation in Biology and Medicine

Claus Jacob,Paul G. Winyard
Redox Signaling and Regulation in Biology and Medicine Book PDF

Author : Claus Jacob,Paul G. Winyard
Publisher : John Wiley & Sons
Page : 514 pages
File Size : 48,8 Mb
Release : 2009-05-06
Category : Science
ISBN : 9783527627592

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Redox Signaling and Regulation in Biology and Medicine by Claus Jacob,Paul G. Winyard Pdf

This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.