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In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr
Methods in Microarray Normalization by Phillip Stafford Pdf
This organized text compiles, for the first time, the most useful normalization methods developed for interpreting microarray data. Experts examine the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review modern software, including discussions on key algorithms, comparative data, and download locations. The book contains the latest microarray innovations from companies such as Agilent, Affymetrix, and GeneGo as well as new, readily adaptable normalization methods for expression and CGH arrays. It also lists of open-source molecular profiling normalization algorithms available and where to access them.
Microarray Technology and Its Applications by Uwe R. Müller,Dan V. Nicolau Pdf
Ithasbeenstatedthatourknowledgedoublesevery20years,butthatmaybe an understatement when considering the Life Sciences. A series of discoveries and inventions have propelled our knowledge from the recognition that DNA isthegeneticmaterialtoabasicmolecularunderstandingofourselvesandthe living world around us in less than 50 years. Crucial to this rapid progress was thediscoveryofthedouble-helicalstructureofDNA,whichlaidthefoundation forallhybridizationbasedtechnologies. Thediscoveriesofrestrictionenzymes, ligases, polymerases, combined with key innovations in DNA synthesis and sequencing ushered in the era of biotechnologyas a new science with profound sociological and economic implications that are likely to have a dominating in?uence on the development of our society during this century. Given the process by which science builds on prior knowledge, it is perhaps unfair to single out a few inventions and credit them with having contributed most to thisavalancheofknowledge. Yet,therearesurelysomethatwillberecognized as having had a more profound impact than others, not just in the furthering of our scienti?c knowledge, but by leveraging commercial applications that provide a tangible return to our society. The now famous Polymerase Chain Reaction, or PCR, is surely one of those, as it has uniquely catalyzed molecular biology during the past 20 years, and continues to have a signi?cant impact on all areas that involve nucleic acids, ranging from molecular pathology to forensics. Ten years ago micro- ray technology emerged as a new and powerful tool to study nucleic acid - quences in a highly multiplexed manner, and has since found equally exciting and useful applications in the study of proteins, metabolites, toxins, viruses, whole cells and even tissues.
Microorganisms are the most diverse group of organisms and play important and distinctive roles in their ecosystems. They interact with their peers and other organisms (e.g., plants, animals) to form a complicated food web, significantly impacting ecosystem functions and services. However, understanding the diversity, composition, structure, function, activity, and dynamics of microbial communities remains challenging. Over the past decade, microarray-based technologies have been developed to address such challenges. This book is focused on current microarray technologies and their applications in environmental microbiology. In the first chapter, microarray technologies and applications are briefly introduced and, in following chapters, microarray probe design, development and evaluation, and data analysis are described in detail. In later chapters, more attention is paid to phylogenetic arrays (e.g., PhyloChip) and functional gene arrays (e.g., GeoChip). These generic tools - for analyzing microbial communities from disparate environments, ecosystems, and habitats (including soil, water, sediment, animals, and humans) - are described in detail with examples of specific applications. Also included are microarrays for analyzing microbial communities from specific environments, such as soil, bioleaching ecosystems, and human microbiomes, as well as microarrays for detecting specific microorganisms (e.g., pathogens) in the environment. The book's contributors also discuss the advantages and limitations of microarray technologies compared to high throughput sequencing technologies. This book is recommended for anyone working on microbial communities, biofilms, or environmental microbiology. [Subject: Microbiology, Life Science, Environmental Science]
Microarray Data Analysis by Michael J. Korenberg Pdf
In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. Information on an array of topics is included in this innovative book including in-depth insights into presentations of genomic signal processing. Also detailed is the use of tiling arrays for large genomes analysis. The protocols follow the successful Methods in Molecular BiologyTM series format, offering step-by-step instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls.
Innovations in Neonatal-perinatal Medicine by Oommen P. Mathew,Jatinder Bhatia Pdf
Innovations in technology and new therapies have changed the face of medicine in the last few decades. These include advances in fetal diagnosis (preimplantation genetics, chorionic villous sampling and amniocentesis), drugs that have been developed to treat unique conditions in neonates such as respiratory distress syndrome (surfactant) and pulmonary hypertension (inhaled nitric oxide), as well as technological advances and interventions resulting in diagnostic (ultrasounds and MRI) and therapeutic interventions (intrauterine transfusion to ECMO). Research in fertility treatments has resulted in test tube babies and cloned animals, and that has also fostered technological advances in diagnostic and therapeutic interventions. The primary purpose of Innovations in Neonatal-Perinatal Medicine is to highlight these innovations in technology and therapy that have not only changed the way doctors deliver care to fetus and neonate but also reduced neonatal mortality thereby saving millions of lives in the process. These issues are addressed by the authors who are experts in their respective fields. the book will be valuable not only to healthcare providers but also to educators and policy makers.
Artificial Intelligence Applications and Innovations by Ilias Maglogiannis,Kostas Karpouzis Pdf
Artificial Intelligence applications build on a rich and proven theoretical background to provide solutions to a wide range of real life problems. The ever expanding abundance of information and computing power enables researchers and users to tackle higly interesting issues for the first time, such as applications providing personalized access and interactivity to multimodal information based on preferences and semantic concepts or human-machine interface systems utilizing information on the affective state of the user. The purpose of the 3rd IFIP Conference on Artificial Intelligence Applications and Innovations (AIAI) is to bring together researchers, engineers, and practitioners interested in the technical advances and business and industrial applications of intelligent systems. AIAI 2006 is focused on providing insights on how AI can be implemented in real world applications.
Innovative Leukemia and Lymphoma Therapy by Gertjian J. L. Kaspers,Bertrand Coiffier,Michael C. Heinrich,Elihu H. Estey Pdf
Innovative Leukemia and Lymphoma Therapy provides a complete and up-to-date overview of the exciting new treatment modalities in leukemia and lymphoma that are being introduced in the clinic today. Written by international experts in the field, this volume examines clinical studies on topics such as:tyrosine kinase inhibitors, histon deacetyla
Leukemia: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf
Leukemia: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Leukemia. The editors have built Leukemia: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Leukemia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Leukemia: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Recent Advances in Information and Communication Technology 2016 by Phayung Meesad,Sirapat Boonkrong,Herwig Unger Pdf
This proceedings book presents recent research work and results in the area of communication and information technologies. The chapters of this book contain the main, well-selected and reviewed contributions of scientists who met at the 12th International Conference on Computing and Information Technology (IC2IT) held during 7th - 8th July 2016 in Khon Kaen, Thailand The book is divided into three parts: “User Centric Data Mining and Text Processing”, “Data Mining Algoritms and their Applications” and “Optimization of Complex Networks”.
10th International Conference on Practical Applications of Computational Biology & Bioinformatics by Mohd Saberi Mohamad,Miguel P. Rocha,Florentino Fdez-Riverola,Francisco J. Domínguez Mayo,Juan F. De Paz Pdf
Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next generation sequencing technologies, together with novel and ever evolving distinct types of omics data technologies, have put an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis of the datasets produced and their integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Clearly, Biology is more and more a science of information requiring tools from the computational sciences. In the last few years, we have seen the surge of a new generation of interdisciplinary scientists that have a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. PACBB‘16 hopes to contribute to this effort promoting this fruitful interaction. PACBB'16 technical program included 21 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Therefore, the conference will certainly promote the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists). The scientific content will certainly be challenging and will promote the improvement of the work being developed by each of the participants.
Diagnostic Pediatric Hematopathology by Maria A. Proytcheva Pdf
An accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood, this is an excellent reference to ensure accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph node disease. It will be a valuable tool in the practice of pathologists, pediatric pathologists, and hematopathologists.
Applied Time Series Analysis and Innovative Computing by Sio-Iong Ao Pdf
Applied Time Series Analysis and Innovative Computing contains the applied time series analysis and innovative computing paradigms, with frontier application studies for the time series problems based on the recent works at the Oxford University Computing Laboratory, University of Oxford, the University of Hong Kong, and the Chinese University of Hong Kong. The monograph was drafted when the author was a post-doctoral fellow in Harvard School of Engineering and Applied Sciences, Harvard University. It provides a systematic introduction to the use of innovative computing paradigms as an investigative tool for applications in time series analysis. Applied Time Series Analysis and Innovative Computing offers the state of art of tremendous advances in applied time series analysis and innovative computing paradigms and also serves as an excellent reference work for researchers and graduate students working on applied time series analysis and innovative computing paradigms.
Innovative Data Communication Technologies and Application by Jennifer S. Raj,Khaled Kamel,Pavel Lafata Pdf
This book presents the latest research in the fields of computational intelligence, ubiquitous computing models, communication intelligence, communication security, machine learning, informatics, mobile computing, cloud computing, and big data analytics. The best selected papers, presented at the International Conference on Innovative Data Communication Technologies and Application (ICIDCA 2021), are included in the book. The book focuses on the theory, design, analysis, implementation, and application of distributed systems and networks.
Computational Collective Intelligence by Ngoc Thanh Nguyen,George A. Papadopoulos,Piotr Jędrzejowicz,Bogdan Trawiński,Gottfried Vossen Pdf
This two-volume set (LNAI 10448 and LNAI 10449) constitutes the refereed proceedings of the 9th International Conference on Collective Intelligence, ICCCI 2017, held in Nicosia, Cyprus, in September 2017. The 117 full papers presented were carefully reviewed and selected from 248 submissions. The conference focuseson the methodology and applications of computational collective intelligence, included: multi-agent systems, knowledge engineering and semantic web, social networks and recommender systems, text processing and information retrieval, data mining methods and applications, sensor networks and internet of things, decision support & control systems, and computer vision techniques.
