Microarrays

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A Beginner’s Guide to Microarrays

Eric M. Blalock
A Beginner s Guide to Microarrays Book PDF

Author : Eric M. Blalock
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 44,7 Mb
Release : 2011-06-27
Category : Science
ISBN : 9781441987600

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A Beginner’s Guide to Microarrays by Eric M. Blalock Pdf

A Beginner's Guide to Microarrays addresses two audiences - the core facility manager who produces, hybridizes, and scans arrays, and the basic research scientist who will be performing the analysis and interpreting the results. User friendly coverage and detailed protocols are provided for the technical steps and procedures involved in many facets of microarray technology, including: -Cleaning and coating glass slides, -Designing oligonucleotide probes, -Constructing arrays for the detection and quantification of different bacterial species, -Preparing spotting solutions, -Troubleshooting spotting problems, -Setting up and running a core facility, -Normalizing background signal and controlling for systematic variance, -Designing experiments for maximum effect, -Analyzing data with statistical procedures, -Clustering data with machine-learning protocols.

Gene Expression Studies Using Affymetrix Microarrays

Hinrich Gohlmann,Willem Talloen
Gene Expression Studies Using Affymetrix Microarrays Book PDF

Author : Hinrich Gohlmann,Willem Talloen
Publisher : CRC Press
Page : 361 pages
File Size : 48,5 Mb
Release : 2009-07-15
Category : Science
ISBN : 9781420065169

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Gene Expression Studies Using Affymetrix Microarrays by Hinrich Gohlmann,Willem Talloen Pdf

The Affymetrix GeneChip system is one of the most widely adapted microarray platforms. However, due to the overwhelming amount of information available, many Affymetrix users tend to stick to the default analysis settings and may end up drawing sub-optimal conclusions. Written by a molecular biologist and a biostatistician with a combined decade of

Microarray Bioinformatics

Dov Stekel
Microarray Bioinformatics Book PDF

Author : Dov Stekel
Publisher : Cambridge University Press
Page : 296 pages
File Size : 40,6 Mb
Release : 2003-09-08
Category : Medical
ISBN : 052152587X

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Microarray Bioinformatics by Dov Stekel Pdf

This book is a comprehensive guide to all of the mathematics, statistics and computing you will need to successfully operate DNA microarray experiments. It is written for researchers, clinicians, laboratory heads and managers, from both biology and bioinformatics backgrounds, who work with, or who intend to work with microarrays. The book covers all aspects of microarray bioinformatics, giving you the tools to design arrays and experiments, to analyze your data, and to share your results with your organisation or with the international community. There are chapters covering sequence databases, oligonucleotide design, experimental design, image processing, normalisation, identifying differentially expressed genes, clustering, classification and data standards. The book is based on the highly successful Microarray Bioinformatics course at Oxford University, and therefore is ideally suited for teaching the subject at postgraduate or professional level.

DNA Microarrays, Part A: Array Platforms and Wet-Bench Protocols

Anonim
DNA Microarrays Part A Array Platforms and Wet Bench Protocols Book PDF

Author : Anonim
Publisher : Elsevier
Page : 512 pages
File Size : 54,8 Mb
Release : 2011-08-19
Category : Science
ISBN : 0080464653

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DNA Microarrays, Part A: Array Platforms and Wet-Bench Protocols by Anonim Pdf

Modern DNA microarray technologies have evolved over the past 25 years to the point where it is now possible to take many million measurements from a single experiment. These two volumes, Parts A & B in the Methods in Enzymology series provide methods that will shepard any molecular biologist through the process of planning, performing, and publishing microarray results. Part A starts with an overview of a number of microarray platforms, both commercial and academically produced and includes wet bench protocols for performing traditional expression analysis and derivative techniques such as detection of transcription factor occupancy and chromatin status. Wet-bench protocols and troubleshooting techniques continue into Part B. These techniques are well rooted in traditional molecular biology and while they require traditional care, a researcher that can reproducibly generate beautiful Northern or Southern blots should have no difficulty generating beautiful array hybridizations. Data management is a more recent problem for most biologists. The bulk of Part B provides a range of techniques for data handling. This includes critical issues, from normalization within and between arrays, to uploading your results to the public repositories for array data, and how to integrate data from multiple sources. There are chapters in Part B for both the debutant and the expert bioinformatician. Provides an overview of platforms Includes experimental design and wet bench protocols Presents statistical and data analysis methods, array databases, data visualization and meta-analysis

Microarrays

James V. Rogers
Microarrays Book PDF

Author : James V. Rogers
Publisher : Nova Biomedical Books
Page : 0 pages
File Size : 42,8 Mb
Release : 2014
Category : Analytical biochemistry
ISBN : 1629486698

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Microarrays by James V. Rogers Pdf

The sequencing of the human genome was a pivotal event in science that opened the door to exploring the structure and function of genes and their regulation. The activation or suppression of transcribed genes is critical to the orchestration of everyday biological processes at the cellular, tissue, and physiological levels. The rapid advance of science and technology has yielded the development of the microarray technique, which has propelled a much deeper understanding of the genome. By combining these technological advances in microarrays with statistical and bioinformatics software, investigators are now able to perform scientific investigations geared towards answering unique biological problems that encompass many fields of research from genetics and evolution to molecular medicine, health, and disease. This book provides an overview of the use and application of microarrays throughout the life sciences to address diverse complex biological questions. In this collection, authors present information on using microarrays to unlock molecular mechanisms and gene expression patterns associated with research areas ranging from biodefense, pathological changes, and monitoring antimicrobial resistance genes to diagnostics, marine biodiversity, and dermal toxicology.

Microarrays for an Integrative Genomics

Isaac S. Kohane,Alvin T. Kho,Atul J. Butte
Microarrays for an Integrative Genomics Book PDF

Author : Isaac S. Kohane,Alvin T. Kho,Atul J. Butte
Publisher : Bradford Books
Page : 306 pages
File Size : 49,5 Mb
Release : 2003
Category : Science
ISBN : 026211271X

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Microarrays for an Integrative Genomics by Isaac S. Kohane,Alvin T. Kho,Atul J. Butte Pdf

An introduction to the use of DNA microarrays in functional genomics.

Protein Microarrays

Mark Schena
Protein Microarrays Book PDF

Author : Mark Schena
Publisher : Jones & Bartlett Learning
Page : 510 pages
File Size : 49,6 Mb
Release : 2005
Category : Protein microarrays
ISBN : 0763731277

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Protein Microarrays by Mark Schena Pdf

Protein Microarrays is one of the first books in this exciting new technology and will be an essential reference for most biologists and biotechnology professionals.

Analyzing Microarray Gene Expression Data

Geoffrey J. McLachlan,Kim-Anh Do,Christophe Ambroise
Analyzing Microarray Gene Expression Data Book PDF

Author : Geoffrey J. McLachlan,Kim-Anh Do,Christophe Ambroise
Publisher : John Wiley & Sons
Page : 366 pages
File Size : 52,8 Mb
Release : 2005-02-18
Category : Mathematics
ISBN : 9780471726128

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Analyzing Microarray Gene Expression Data by Geoffrey J. McLachlan,Kim-Anh Do,Christophe Ambroise Pdf

A multi-discipline, hands-on guide to microarray analysis of biological processes Analyzing Microarray Gene Expression Data provides a comprehensive review of available methodologies for the analysis of data derived from the latest DNA microarray technologies. Designed for biostatisticians entering the field of microarray analysis as well as biologists seeking to more effectively analyze their own experimental data, the text features a unique interdisciplinary approach and a combined academic and practical perspective that offers readers the most complete and applied coverage of the subject matter to date. Following a basic overview of the biological and technical principles behind microarray experimentation, the text provides a look at some of the most effective tools and procedures for achieving optimum reliability and reproducibility of research results, including: An in-depth account of the detection of genes that are differentially expressed across a number of classes of tissues Extensive coverage of both cluster analysis and discriminant analysis of microarray data and the growing applications of both methodologies A model-based approach to cluster analysis, with emphasis on the use of the EMMIX-GENE procedure for the clustering of tissue samples The latest data cleaning and normalization procedures The uses of microarray expression data for providing important prognostic information on the outcome of disease

Microarrays

Jang B. Rampal
Microarrays Book PDF

Author : Jang B. Rampal
Publisher : Springer Science & Business Media
Page : 923 pages
File Size : 42,7 Mb
Release : 2007-07-27
Category : Medical
ISBN : 9781588295897

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Microarrays by Jang B. Rampal Pdf

Microarray Technology, Volumes 1 and 2, present information in designing and fabricating arrays and binding studies with biological analytes while providing the reader with a broad description of microarray technology tools and their potential applications. The first volume deals with methods and protocols for the preparation of microarrays. The second volume details applications and data analysis, which is important in analyzing the enormous data coming out of microarray experiments. Among the topics discussed in Volume 1: Synthesis Methods, are matrices in the synthesis of microarrays, array optimization processes, array-based comparative genomic hybridization, 60-mer oligonucleotide probes, bifunctional reagents NTMTA and NTPAC, and high density arrays using digital microarray synthesis platforms. Other topics include multiplex ligation-dependent probe amplification (MLPA), hybridization conditions in situ-synthesized oligo arrays, peptide arrays, high density replication tools (HDRT), protocols for the quantification of oligo hybridization, glyco-bead arrays, and an investigation into the emerging nano technology. Microarray Technology, Volumes 1 and 2, provide ample information to all levels of scientists from novice to those intimately familiar with array technology.

Microarrays

Kilian Dill,Robin Liu,Piotr Grodzinsky
Microarrays Book PDF

Author : Kilian Dill,Robin Liu,Piotr Grodzinsky
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 42,6 Mb
Release : 2008-12-30
Category : Science
ISBN : 9780387727196

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Microarrays by Kilian Dill,Robin Liu,Piotr Grodzinsky Pdf

Combinatorial chemistry is used to find materials that form sensor microarrays. This book discusses the fundamentals, and then proceeds to the many applications of microarrays, from measuring gene expression (DNA microarrays) to protein-protein interactions, peptide chemistry, carbodhydrate chemistry, electrochemical detection, and microfluidics.

DNA Microarrays

Bertrand Jordan
DNA Microarrays Book PDF

Author : Bertrand Jordan
Publisher : Springer Science & Business Media
Page : 158 pages
File Size : 46,9 Mb
Release : 2001-08-28
Category : Medical
ISBN : 3540415084

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DNA Microarrays by Bertrand Jordan Pdf

DNA Arrays for expression measurement: an historical perspective. (Bertrand R. Jordan). Expression profiling with cDNA microarrays: a user's perspective and guide. (Sean Grimmond and Andy Greenfield). cDNA microarrays on nylon membranes with enzyme colorimetric detection. (Konan Peck and Yuh-Pyng Sher). cDNA macroarrays and microarrays on nylon membranes with radioactive detection. (Beatrice Loriod, Geneviève Victorero and Catherine Nguyen). Oligonucleotide chips for expression analysis: principles and practical procedures. (Pierre Casellas, Annick Peleraux and Sylvaine Galiegue). Gene expression Data mining and analysis (Alvis Brazma, Alan Robinson and Jaak Vilo). Future trends in the use of DNA arrays for expression measurement. (Bertrand R. Jordan).

Microarrays for the Neurosciences

Daniel H. Geschwind,Jeffrey P. Gregg
Microarrays for the Neurosciences Book PDF

Author : Daniel H. Geschwind,Jeffrey P. Gregg
Publisher : MIT Press
Page : 366 pages
File Size : 45,5 Mb
Release : 2002
Category : DNA microarrays
ISBN : 0262072297

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Microarrays for the Neurosciences by Daniel H. Geschwind,Jeffrey P. Gregg Pdf

The effort to sequence the human genome has generated a new discipline, functional genomics, or the study of the relationship between the genetic code and its biologic potential. Gene expression studies are made possible not only by the decoding of the human genome, but by the development of new technologies. The preeminent technology in this area, DNA microarrays, is helping to revolutionize the field of neuroscience.

A Practical Approach to Microarray Data Analysis

Daniel P. Berrar,Werner Dubitzky,Martin Granzow
A Practical Approach to Microarray Data Analysis Book PDF

Author : Daniel P. Berrar,Werner Dubitzky,Martin Granzow
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 54,7 Mb
Release : 2007-05-08
Category : Science
ISBN : 9780306478154

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A Practical Approach to Microarray Data Analysis by Daniel P. Berrar,Werner Dubitzky,Martin Granzow Pdf

In the past several years, DNA microarray technology has attracted tremendous interest in both the scientific community and in industry. With its ability to simultaneously measure the activity and interactions of thousands of genes, this modern technology promises unprecedented new insights into mechanisms of living systems. Currently, the primary applications of microarrays include gene discovery, disease diagnosis and prognosis, drug discovery (pharmacogenomics), and toxicological research (toxicogenomics). Typical scientific tasks addressed by microarray experiments include the identification of coexpressed genes, discovery of sample or gene groups with similar expression patterns, identification of genes whose expression patterns are highly differentiating with respect to a set of discerned biological entities (e.g., tumor types), and the study of gene activity patterns under various stress conditions (e.g., chemical treatment). More recently, the discovery, modeling, and simulation of regulatory gene networks, and the mapping of expression data to metabolic pathways and chromosome locations have been added to the list of scientific tasks that are being tackled by microarray technology. Each scientific task corresponds to one or more so-called data analysis tasks. Different types of scientific questions require different sets of data analytical techniques. Broadly speaking, there are two classes of elementary data analysis tasks, predictive modeling and pattern-detection. Predictive modeling tasks are concerned with learning a classification or estimation function, whereas pattern-detection methods screen the available data for interesting, previously unknown regularities or relationships.

Microarrays

Hans-Joachim Müller,Thomas Roeder
Microarrays Book PDF

Author : Hans-Joachim Müller,Thomas Roeder
Publisher : Elsevier
Page : 229 pages
File Size : 48,5 Mb
Release : 2005-12-12
Category : Science
ISBN : 9780080916668

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Microarrays by Hans-Joachim Müller,Thomas Roeder Pdf

Microarrays is an invaluable laboratory manual for anyone conducting experiments in the field of molecular biology or medical biochemistry who needs to understand and use microarray technologies. These technologies are especially appropriate in genome analysis, diagnostics, and studies involving differential gene expression. Providing straightforward explanations, the authors demonstrate proven methods for biochip application and an overview of presently available instruments, biochips, and software. Chapters cover the different requirements for DNA and protein chips, as well as spotters and scanners. The book also covers high throughput screening, patent research, and the minimum requirements for setting up or expanding a microarray laboratory. Covers microarray applications, technology, and execution Written in an approachable yet informative tone Includes more than 100 detailed figures and graphs Examines the history of microarrays and their future potential Defines key terms from related disciplines Contains a full chapter on the importance of database research and patents Describes how to develop or improve one's own microarray laboratory

DNA Microarrays

Mark Schena
DNA Microarrays Book PDF

Author : Mark Schena
Publisher : Scion Publishing Ltd
Page : 289 pages
File Size : 48,8 Mb
Release : 2007-10-01
Category : Science
ISBN : 9781907904394

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DNA Microarrays by Mark Schena Pdf

DNA Microarrays: Methods Express covers the very latest in DNA microarray technology, with a clear focus on how these techniques can be used in the lab to gain the very best results. The authors are from some of the leading laboratories in the field and write with real authority on the latest methodology. Every chapter provides detailed step-by-step protocols with valuable hints and tips for success, as well as giving typical experimental results and selected literature citations. This book is a 'must have' manual for researchers in all fields of biology, medicine and agriculture.