Microarrays In Diagnostics And Biomarker Development

Microarrays In Diagnostics And Biomarker Development Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Microarrays In Diagnostics And Biomarker Development book. This book definitely worth reading, it is an incredibly well-written.

Microarrays in Diagnostics and Biomarker Development

Bertrand Jordan
Microarrays in Diagnostics and Biomarker Development Book PDF

Author : Bertrand Jordan
Publisher : Springer Science & Business Media
Page : 241 pages
File Size : 55,8 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783642282034

Get Book

Microarrays in Diagnostics and Biomarker Development by Bertrand Jordan Pdf

Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards “nanoarrays”, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.

Bioarrays

Krishnarao Appasani
Bioarrays Book PDF

Author : Krishnarao Appasani
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 48,6 Mb
Release : 2007-10-04
Category : Science
ISBN : 9781597453288

Get Book

Bioarrays by Krishnarao Appasani Pdf

This book provides an integrated collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine. It is the first book to comprehensively integrate molecular diagnostics and molecular pathology. This book serves as an indispensable reference for graduate students, post-docs, and professors as well as an explanatory analysis for executives and scientists in biotechnology and pharmaceutical companies.

Applying Genomic and Proteomic Microarray Technology in Drug Discovery, Second Edition

Robert S. Matson
Applying Genomic and Proteomic Microarray Technology in Drug Discovery Second Edition Book PDF

Author : Robert S. Matson
Publisher : CRC Press
Page : 325 pages
File Size : 41,9 Mb
Release : 2013-03-13
Category : Medical
ISBN : 9781439855638

Get Book

Applying Genomic and Proteomic Microarray Technology in Drug Discovery, Second Edition by Robert S. Matson Pdf

Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. Updated and revised to reflect recent progress in the field, the second edition discusses: Expanded omics-driven applications, including the areas of metabolomics and chemical biology The commercialization of the microarray platform, with a historical perspective aimed at recognizing key technological developments Solid-supports (substrates) and surface chemistries currently used in the creation of nucleic acid and protein microarrays Different approaches to producing microarrays that achieve spot equality with the same number of molecules properly oriented The development of the gene expression microarray and representative applications The development of protein microarray technology, including its history and key applications Unique to this edition is a new chapter on multiplex assays that examines the development and applications of arrays across diverse platforms. It discusses applications for qPCR, multiplex lateral flow, and multiplex bead assays. It also presents platform-to-platform comparisons. Microarrays remain an invaluable tool for omics-based research not only in drug discovery, but in the life sciences, in clinical research, and for diagnostic applications worldwide. This volume presents the current state of the art on the utility of this technology to solve a host of important biological problems.

Biomarkers in Drug Development

Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
Biomarkers in Drug Development Book PDF

Author : Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
Publisher : John Wiley & Sons
Page : 559 pages
File Size : 44,9 Mb
Release : 2011-09-20
Category : Medical
ISBN : 9781118210420

Get Book

Biomarkers in Drug Development by Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari Pdf

Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.

Biomarker Validation

Harald Seitz,Sarah Schumacher
Biomarker Validation Book PDF

Author : Harald Seitz,Sarah Schumacher
Publisher : John Wiley & Sons
Page : 264 pages
File Size : 42,5 Mb
Release : 2015-02-23
Category : Science
ISBN : 9783527680665

Get Book

Biomarker Validation by Harald Seitz,Sarah Schumacher Pdf

Built on a decade of experience with novel molecular diagnostics, this practice-oriented guide shows how to cope with validation issues during all stages of biomarker development, from the first clinical studies to the eventual commercialization of a new diagnostic test.

Rapid Test

Laura Anfossi
Rapid Test Book PDF

Author : Laura Anfossi
Publisher : BoD – Books on Demand
Page : 104 pages
File Size : 50,6 Mb
Release : 2018-09-26
Category : Medical
ISBN : 9781789239010

Get Book

Rapid Test by Laura Anfossi Pdf

Rapid tests, also known as point-of-care tests, have been in use for decades in the clinical and medical area and have become increasingly popular as an efficient screening method for conducting on-site analysis thanks to their simplicity, speed, specificity and sensitivity. Nowadays, rapid tests are widely applied for clinical, drug, food, forensic and environmental analysis and fields of application are rapidly increasing together with advances in the technology. The growing interest in rapid tests and their expanding application in diverse fields, together with requirements of improved sensitivity, reliability, multiple detection capacity and robustness, are prompting innovation in the design of novel platforms, and in the exploitation of innovative detection strategies. The book covers advances in materials, technology and test design.

Microarray Technology and Cancer Gene Profiling

Simone Mocellin
Microarray Technology and Cancer Gene Profiling Book PDF

Author : Simone Mocellin
Publisher : Springer
Page : 0 pages
File Size : 41,7 Mb
Release : 2010-11-19
Category : Medical
ISBN : 1441922989

Get Book

Microarray Technology and Cancer Gene Profiling by Simone Mocellin Pdf

Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.

Tumors in Domestic Animals

Donald J. Meuten
Tumors in Domestic Animals Book PDF

Author : Donald J. Meuten
Publisher : John Wiley & Sons
Page : 1000 pages
File Size : 49,6 Mb
Release : 2016-11-08
Category : Medical
ISBN : 9781119181194

Get Book

Tumors in Domestic Animals by Donald J. Meuten Pdf

Tumors in Domestic Animals, Fifth Edition is a fully revised new edition of the most comprehensive and authoritative reference on veterinary tumor pathology in common domestic animals, now in full color throughout with the most current advances in research and diagnostics. Now in full color with hundreds of exquisite new images showing diagnostic features, pathogenesis, and techniques Adds new sections on relevant clinical pathology and oncology Updated throughout to include the very latest advances in research and diagnostics Takes a logical, user-friendly system approach Written by leading experts on animal tumor pathology

Neuroscience Biomarkers and Biosignatures

Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Neuroscience Biomarkers and Biosignatures Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 128 pages
File Size : 45,5 Mb
Release : 2008-01-08
Category : Medical
ISBN : 9780309178280

Get Book

Neuroscience Biomarkers and Biosignatures by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.

Advances in Cell and Molecular Diagnostics

Pongali Raghavendra,Thammineni Pullaiah
Advances in Cell and Molecular Diagnostics Book PDF

Author : Pongali Raghavendra,Thammineni Pullaiah
Publisher : Academic Press
Page : 298 pages
File Size : 46,5 Mb
Release : 2018-01-10
Category : Medical
ISBN : 9780128136805

Get Book

Advances in Cell and Molecular Diagnostics by Pongali Raghavendra,Thammineni Pullaiah Pdf

Advances in Cell and Molecular Diagnostics brings the scientific advances in the translation and validation of cellular and molecular discoveries in medicine into the clinical diagnostic setting. It enumerates the description and application of technological advances in the field of cellular and molecular diagnostic medicine, providing an overview of specialized fields, such as biomarker, genetic marker, screening, DNA-profiling, NGS, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, and biomarker toxicologies. In addition, it presents novel discoveries and clinical pathologic correlations, including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, and the description or polymorphisms linked to disease states. This book is a valuable resource for oncologists, practitioners and several members of the biomedical field who are interested in understanding how to apply cutting-edge technologies into diagnostics and healthcare. Encompasses the current scientific advances in the translation and validation of cellular and molecular discoveries into the clinical diagnostic setting Explains the application of cellular and molecular diagnostics methodologies in clinical trials Focuses on translating preclinical tests to the bedside in order to help readers apply the most recent technologies to healthcare

Development and Application of Biomarkers

Roger L. Lundblad
Development and Application of Biomarkers Book PDF

Author : Roger L. Lundblad
Publisher : CRC Press
Page : 294 pages
File Size : 50,8 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439819807

Get Book

Development and Application of Biomarkers by Roger L. Lundblad Pdf

First introduced to biomedical research in 1980, the term biomarker has taken on a life of its own in recent years and has come to mean a number of things. In biomedical science, biomarker has evolved to most commonly mean a characteristic that can be used either as a diagnostic or a prognostic, but most significantly as a screening indicator for p

Molecular Diagnostics: Promises and Possibilities

Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Molecular Diagnostics Promises and Possibilities Book PDF

Author : Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Publisher : Springer Science & Business Media
Page : 527 pages
File Size : 49,8 Mb
Release : 2010-01-29
Category : Medical
ISBN : 9789048132614

Get Book

Molecular Diagnostics: Promises and Possibilities by Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen Pdf

A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment

Institute of Medicine,National Cancer Policy Forum
Developing Biomarker Based Tools for Cancer Screening Diagnosis and Treatment Book PDF

Author : Institute of Medicine,National Cancer Policy Forum
Publisher : National Academies Press
Page : 112 pages
File Size : 54,7 Mb
Release : 2006-11-18
Category : Medical
ISBN : 9780309101349

Get Book

Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment by Institute of Medicine,National Cancer Policy Forum Pdf

Research has long sought to identify biomarkers that could detect cancer at an early stage, or predict the optimal cancer therapy for specific patients. Fueling interest in this research are recent technological advances in genomics, proteomics, and metabolomics that can enable researchers to capture the molecular fingerprints of specific cancers and fine-tune their classification according to the molecular defects they harbor. The discovery and development of new markers of cancer could potentially improve cancer screening, diagnosis, and treatment. Given the potential impact cancer biomarkers could have on the cost effectiveness of cancer detection and treatment, they could profoundly alter the economic burden of cancer as well. Despite the promise of cancer biomarkers, few biomarker-based cancer tests have entered the market, and the translation of research findings on cancer biomarkers into clinically useful tests seems to be lagging. This is perhaps not surprising given the technical, financial, regulatory, and social challenges linked to the discovery, development, validation, and incorporation of biomarker tests into clinical practice. To explore those challenges and ways to overcome them, the National Cancer Policy Forum held the conference "Developing Biomarker-Based Tools for Cancer Screening, Diagnosis and Treatment: The State of the Science, Evaluation, Implementation, and Economics" in Washington, D.C., from March 20 to 22, 2006. At this conference, experts gave presentations in one of six sessions. In addition, seven small group discussions explored the policy implications surrounding biomarker development and adoption into clinical practice. Developing Biomarker-based Tools for Developing Cancer Screening, Diagnosis, and Treatment: The State of the Science, Evaluation, Implementation, and Economics-Workshop Summary presents the conference proceedings and will be used by an Institute of Medicine (IOM) committee to develop consensus-based recommendations for moving the field of cancer biomarkers forward.

The Handbook of Biomarkers

Kewal K. Jain
The Handbook of Biomarkers Book PDF

Author : Kewal K. Jain
Publisher : Humana Press
Page : 760 pages
File Size : 41,5 Mb
Release : 2017-09-16
Category : Science
ISBN : 9781493974313

Get Book

The Handbook of Biomarkers by Kewal K. Jain Pdf

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today.

Evolution of Translational Omics

Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Evolution of Translational Omics Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 51,9 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185

Get Book

Evolution of Translational Omics by Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials Pdf

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.