Microarray Technology And Cancer Gene Profiling

Author : Simone Mocellin
Publisher : Springer Science & Business Media
Page : 176 pages
File Size : 55,5 Mb
Release : 2007-08-28
Category : Medical
ISBN : 9780387399782

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Microarray Technology and Cancer Gene Profiling by Simone Mocellin Pdf

Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.

Author : Simone Mocellin
Publisher : Springer
Page : 0 pages
File Size : 47,6 Mb
Release : 2008-11-01
Category : Medical
ISBN : 038751600X

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Microarray Technology and Cancer Gene Profiling by Simone Mocellin Pdf

Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 40,6 Mb
Release : 2024-06-29
Category : Electronic
ISBN : 9789814472005

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DNA Microarray Technology and Data Analysis in Cancer Research by Anonim Pdf

Author : Wolf-Karsten Hofmann
Publisher : Cambridge University Press
Page : 230 pages
File Size : 47,6 Mb
Release : 2006-06-22
Category : Medical
ISBN : 9781139456913

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Gene Expression Profiling by Microarrays by Wolf-Karsten Hofmann Pdf

Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously, and offers a new means to classify cancer and other diseases. Gene expression profiling can also be used to predict clinical outcome and response to specific therapeutic agents. This survey spans recent applications of microarrays in clinical medicine, covering malignant disease including acute leukaemias, lymphoid malignancies and breast cancer, together with diabetes and heart disease. Investigators in oncology, pharmacology and related clinical sciences, as well as basic scientists, will value this review of a promising new diagnostic and prognostic technology.

Author : Robert Grützmann,Christian Pilarsky
Publisher : Humana Press
Page : 0 pages
File Size : 48,7 Mb
Release : 2009-11-06
Category : Medical
ISBN : 1934115762

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Cancer Gene Profiling by Robert Grützmann,Christian Pilarsky Pdf

Over the last few years, the methods for analyzing cancer-related genes on a molecular level have changed rapidly. The advent of incredible new technology, such as automated sequencing, has served as a catalyst for many advances in the area of gene profiling, and has enabled the research community to investigate populations of cells in a given tissue. Cancer Gene Profiling: Methods and Protocols examines the world of cancer gene profiling in light of these new advances, providing highly developed microarray techniques alongside modern methods for arraying tissues and proteomics. Chapters bring together the experiences of leading scientists in each method of profiling, providing a clear overview of the ground-breaking techniques used to perform these experiments effectively. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and state-of-the-art, Cancer Gene Profiling: Methods and Protocols is a fundamental guidebook for researchers in the field of cancer gene profiling, as well as for those individuals in the area of biomedical/translational research.

Author : Steen Knudsen
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 46,7 Mb
Release : 2006-11-03
Category : Science
ISBN : 9780470041093

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Cancer Diagnostics with DNA Microarrays by Steen Knudsen Pdf

Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers. Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers Offers clinicians summary presentation of state-of-the-art science of DNA microarrays Each chapter includes bibliographic and further reading suggestions Easily accessible, assuming no special training in statistics or bioinformatics Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.

Author : Gary Hardiman
Publisher : CRC Press
Page : 362 pages
File Size : 53,5 Mb
Release : 2009-04-02
Category : Medical
ISBN : 9781420094510

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Microarray Innovations by Gary Hardiman Pdf

In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr

Author : Luigi Marchionni
Publisher : DIANE Publishing
Page : 230 pages
File Size : 55,5 Mb
Release : 2009-05
Category : Medical
ISBN : 9781437911046

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Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes by Luigi Marchionni Pdf

Assesses the evidence that three marketed gene expression-based assays improve prognostic accuracy, treatment choice, and health outcomes in women diagnosed with early stage breast cancer. Three gene expression assays were evaluated; Oncotype DX¿, MammaPrint® and the Breast Cancer Profiling (BCP or H/I ratio) test, and for gene expression signatures underlying the assays. They sought evidence on: analytic performance of tests; clinical validity; clinical utility; harms; and impact on clinical decision making and health care costs. Conclusions: Oncotype DX is furthest along the validation pathway, with retrospective evidence that it predicts distant spread and chemotherapy benefit to a clinically relevant extent over standard predictors. Illus.

Author : Dimitrios Vlachakis
Publisher : BoD – Books on Demand
Page : 79 pages
File Size : 48,5 Mb
Release : 2019-06-19
Category : Medical
ISBN : 9781838801755

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Gene Expression Profiling in Cancer by Dimitrios Vlachakis Pdf

The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer.

Author : Marc Ladanyi,William L. Gerald
Publisher : Springer Science & Business Media
Page : 419 pages
File Size : 43,9 Mb
Release : 2003-05-01
Category : Medical
ISBN : 9781592593866

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Expression Profiling of Human Tumors by Marc Ladanyi,William L. Gerald Pdf

A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.

Author : Anonim
Publisher : Taylor & Francis
Page : 321 pages
File Size : 55,5 Mb
Release : 2024-06-29
Category : Electronic
ISBN : 9781134182749

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Microarray Technology Through Applications by Anonim Pdf

Author : Antonio Russo,Stefano Iacobelli,Juan Iovanna
Publisher : Springer Science & Business Media
Page : 190 pages
File Size : 43,5 Mb
Release : 2011-11-03
Category : Medical
ISBN : 9781617793585

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Diagnostic, Prognostic and Therapeutic Value of Gene Signatures by Antonio Russo,Stefano Iacobelli,Juan Iovanna Pdf

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.

Author : Robert S. Matson
Publisher : CRC Press
Page : 260 pages
File Size : 44,7 Mb
Release : 2004-12-28
Category : Medical
ISBN : 9780203491133

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Applying Genomic and Proteomic Microarray Technology in Drug Discovery by Robert S. Matson Pdf

Microarrays play an increasingly significant role in drug discovery. Written by a leader in the field, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. The author addresses the drawbacks, helping

Author : Uwe R. Müller,Dan V. Nicolau
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 43,9 Mb
Release : 2005
Category : Medical
ISBN : 3540229310

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Microarray Technology and Its Applications by Uwe R. Müller,Dan V. Nicolau Pdf

The genomics revolution would not have been possible without the 'parallelisation' offered by microarray technology. This technological - and commercial - success has been since emulated by other applications areas, with a tremendous amplification of innovation. This book describes the fundamentals and latest developments in microarray technology, as well as its future directions. It presents detailed overviews of the different techniques of fabricating microarrays, of the chemistries and preparative steps involved, of the different types of microarrays, and of the instrumentation and optical issues involved.

Author : Steve Russell,Lisa A. Meadows,Roslin R. Russell
Publisher : Academic Press
Page : 460 pages
File Size : 41,8 Mb
Release : 2008-11-21
Category : Science
ISBN : 9780080919768

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Microarray Technology in Practice by Steve Russell,Lisa A. Meadows,Roslin R. Russell Pdf

Using chips composed of thousands of spots, each with the capability of holding DNA molecules corresponding to a given gene, DNA microarray technology has enabled researchers to measure simultaneously gene expression across the genome. As with other large-scale genomics approaches, microarray technologies are broadly applicable across disciplines of life and biomedical sciences, but remain daunting to many researchers. This guide is designed to demystify the technology and inform more biologists about this critically important experimental technique. Cohesive overview of the technology and available platforms, followed by detailed discussion of experimental design and analysis of microarray experiments Up-to-date description of normalization methods and current methods for sample amplification and labeling Deep focus on oligonucleotide design, printing, labeling and hybridization, data acquisition, normalization, and meta-analysis Additional uses of microarray technology such as ChIP (chromatin immunoprecipitation) with hybridization to DNA arrays, microarray-based comparative genomic hybridization (CGH), and cell and tissue arrays