Microbial Status And Genetic Evaluation Of Mice And Rats

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Microbial Status and Genetic Evaluation of Mice and Rats

National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research
Microbial Status and Genetic Evaluation of Mice and Rats Book PDF

Author : National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research
Publisher : National Academies Press
Page : 167 pages
File Size : 55,9 Mb
Release : 2000-11-30
Category : Science
ISBN : 9780309071956

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Microbial Status and Genetic Evaluation of Mice and Rats by National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research Pdf

US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats. In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.

Microbial Status and Genetic Evaluation of Mice and Rats

National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research
Microbial Status and Genetic Evaluation of Mice and Rats Book PDF

Author : National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research
Publisher : National Academies Press
Page : 166 pages
File Size : 48,9 Mb
Release : 2000-10-30
Category : Science
ISBN : 9780309171472

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Microbial Status and Genetic Evaluation of Mice and Rats by National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research Pdf

US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats. In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.

Microbial and Phenotypic Definition of Rats and Mice

National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research
Microbial and Phenotypic Definition of Rats and Mice Book PDF

Author : National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research
Publisher : National Academies Press
Page : 113 pages
File Size : 52,7 Mb
Release : 1999-07-26
Category : Science
ISBN : 9780309172820

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Microbial and Phenotypic Definition of Rats and Mice by National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research Pdf

US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

Guidance for the Description of Animal Research in Scientific Publications

National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research
Guidance for the Description of Animal Research in Scientific Publications Book PDF

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research
Publisher : National Academies Press
Page : 42 pages
File Size : 49,9 Mb
Release : 2011-09-16
Category : Science
ISBN : 9780309219549

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Guidance for the Description of Animal Research in Scientific Publications by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research Pdf

The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.

Guide for the Care and Use of Laboratory Animals

National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals
Guide for the Care and Use of Laboratory Animals Book PDF

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals
Publisher : National Academies Press
Page : 246 pages
File Size : 51,8 Mb
Release : 2011-01-27
Category : Science
ISBN : 9780309154000

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Guide for the Care and Use of Laboratory Animals by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals Pdf

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Gnotobiotics

Trenton R Schoeb,Kathryn A Eaton
Gnotobiotics Book PDF

Author : Trenton R Schoeb,Kathryn A Eaton
Publisher : Academic Press
Page : 428 pages
File Size : 50,5 Mb
Release : 2017-08-11
Category : Medical
ISBN : 9780128045831

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Gnotobiotics by Trenton R Schoeb,Kathryn A Eaton Pdf

Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. Reviews and defines gnotobiotic animal species Analyzes microbiota in numerous contexts Presents detailed coverage of the protocols and operation of a gnotobiotic facility

Nutrient Requirements of Laboratory Animals,

National Research Council,Board on Agriculture,Committee on Animal Nutrition,Subcommittee on Laboratory Animal Nutrition
Nutrient Requirements of Laboratory Animals Book PDF

Author : National Research Council,Board on Agriculture,Committee on Animal Nutrition,Subcommittee on Laboratory Animal Nutrition
Publisher : National Academies Press
Page : 188 pages
File Size : 50,7 Mb
Release : 1995-02-01
Category : Science
ISBN : 9780309051262

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Nutrient Requirements of Laboratory Animals, by National Research Council,Board on Agriculture,Committee on Animal Nutrition,Subcommittee on Laboratory Animal Nutrition Pdf

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

The Laboratory Mouse

Peggy J. Danneman,Mark A. Suckow,Cory Brayton
The Laboratory Mouse Book PDF

Author : Peggy J. Danneman,Mark A. Suckow,Cory Brayton
Publisher : CRC Press
Page : 247 pages
File Size : 46,8 Mb
Release : 2012-09-25
Category : Medical
ISBN : 9781439854228

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The Laboratory Mouse by Peggy J. Danneman,Mark A. Suckow,Cory Brayton Pdf

Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a

The Laboratory Mouse, Second Edition

Peggy J. Danneman,Mark A. Suckow,Cory Brayton
The Laboratory Mouse Second Edition Book PDF

Author : Peggy J. Danneman,Mark A. Suckow,Cory Brayton
Publisher : CRC Press
Page : 259 pages
File Size : 54,6 Mb
Release : 2012-09-25
Category : Medical
ISBN : 9781439854211

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The Laboratory Mouse, Second Edition by Peggy J. Danneman,Mark A. Suckow,Cory Brayton Pdf

Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.

Management of Animal Care and Use Programs in Research, Education, and Testing

Robert H. Weichbrod,Gail A. (Heidbrink) Thompson,John N. Norton
Management of Animal Care and Use Programs in Research Education and Testing Book PDF

Author : Robert H. Weichbrod,Gail A. (Heidbrink) Thompson,John N. Norton
Publisher : CRC Press
Page : 917 pages
File Size : 54,8 Mb
Release : 2017-09-07
Category : Medical
ISBN : 9781498748452

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Management of Animal Care and Use Programs in Research, Education, and Testing by Robert H. Weichbrod,Gail A. (Heidbrink) Thompson,John N. Norton Pdf

AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).

Rodents

National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Rodents
Rodents Book PDF

Author : National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Rodents
Publisher : National Academies Press
Page : 180 pages
File Size : 51,6 Mb
Release : 1996-09-08
Category : Science
ISBN : 9780309049368

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Rodents by National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Rodents Pdf

In the 15 years since the last Institute of Laboratory Animal Resources report on the general management of rodents was published, important advances in biomedical research and increased public awareness have created a new environment for animal research. Modern technology-such as insertion of functional genes from other species into mice or rats, elimination of a single selected gene or function in mice, and the re-creation of elements of the human immune system in mice-has greatly expanded the usefulness of rodents in drug development and as models of human diseases. The technologic requirements of such advanced systems have led to improved understanding and implementation of environmental requirements for the care and use of rodents in research. The intent of this report is to provide current information to laboratory animal scientists (including both animal-care technicians and veterinarians), investigators, research technicians, and administrators on general elements of rodent care and use that should be considered both for optimal design and conduct of research and to meet current standards of care and use.

Genetics of the Mouse

Jean Louis Guénet,Fernando Benavides,Jean-Jacques Panthier,Xavier Montagutelli
Genetics of the Mouse Book PDF

Author : Jean Louis Guénet,Fernando Benavides,Jean-Jacques Panthier,Xavier Montagutelli
Publisher : Springer
Page : 417 pages
File Size : 49,5 Mb
Release : 2014-11-29
Category : Science
ISBN : 9783662442876

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Genetics of the Mouse by Jean Louis Guénet,Fernando Benavides,Jean-Jacques Panthier,Xavier Montagutelli Pdf

This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

Mouse Behavioral Testing

Douglas Wahlsten
Mouse Behavioral Testing Book PDF

Author : Douglas Wahlsten
Publisher : Academic Press
Page : 304 pages
File Size : 42,9 Mb
Release : 2010-11-25
Category : Nature
ISBN : 0123756758

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Mouse Behavioral Testing by Douglas Wahlsten Pdf

Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully

The Laboratory Mouse

Hans Hedrich
The Laboratory Mouse Book PDF

Author : Hans Hedrich
Publisher : Academic Press
Page : 868 pages
File Size : 46,7 Mb
Release : 2012-06-14
Category : Science
ISBN : 9780123820099

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The Laboratory Mouse by Hans Hedrich Pdf

The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research Book PDF

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Publisher : National Academies Press
Page : 223 pages
File Size : 42,9 Mb
Release : 2003-08-22
Category : Science
ISBN : 9780309167857

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Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research Pdf

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.