Micrometastasis

Author : Klaus Pantel
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 47,8 Mb
Release : 2003-07-31
Category : Medical
ISBN : 1402011555

Get Book

Micrometastasis by Klaus Pantel Pdf

Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocytochemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information. In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed. The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients.

Author : Anonim
Publisher : Elsevier
Page : 266 pages
File Size : 40,8 Mb
Release : 2004-10-21
Category : Science
ISBN : 0080490271

Get Book

Advances in Clinical Chemistry by Anonim Pdf

Volume thirty-eight in the series of the internationally acclaimed Advances in Clinical Chemistry, contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting edge microarray technology. In keeping with the tradition of the series, this volume emphasizes novel laboratory advances with application not only to both clinical laboratory diagnostics, but as well as practical basic science studies. This volume of Advances in Clinical Chemistry is an indispensable resource and practical guide for twenty-first century practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general. Selected Contents on: -Biochemical markers in atherosclerosis and cancer -Molecular diagnostics in metastatic diseases -Single cell mRNA analysis -Protein detecting microarray technology -Evaluation of nerve agents and poisoning

Author : U. Reinhold,W. Tilgen
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642595370

Get Book

Minimal Residual Disease in Melanoma by U. Reinhold,W. Tilgen Pdf

Knowledge about diagnostic procedures in melanoma has in creased rapidly within the past few years. Single tumor cells have been identified in normal tissue such as sentinel lymph nodes, as well as in bone marrow, peripheral blood, and other bodily fluids and cells, by molecular technologies. The introduction of polymerase chain reaction-based methods can be regarded as a prototype of this dramatic development towards molecular approaches in new diagnostic procedures. This fact opens up the possibility of clinical use in patients and of influencing treatment strategies. Considerable discrepancies have been described, how ever, in the success rates of these new techniques for the detec tion of minimal residual disease in cancer patients. Despite fav orable results reported by different groups of investigators, it will take several years to define the clinical and pathophysiological relevance of new diagnostic procedures. The 1st International Symposium "Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance of Microme tastases", held in September 1999 in Homburg/Saar, Germany, fo cused on recent developments in this particular area of cancer re search. The purpose of the meeting was to stimulate discussion and exchange of new data and ideas by renowned international scientists. The aim of this volume is to summarize major topics of basic research and clinical investigations presented by invited experts in this fascinating but still. controversial field of melanoma re search.

Author : Eleftherios P. Mamounas
Publisher : Elsevier Health Sciences
Page : 246 pages
File Size : 43,8 Mb
Release : 2010-07-30
Category : Medical
ISBN : 9781455700707

Get Book

Early-Stage Breast Cancer: New Developments and Controversies, An Issue of Surgical Oncology Clinics - E- Book by Eleftherios P. Mamounas Pdf

This issue of the Surgical Oncology Clinics will focus on new advances in Breast Cancer Surgery, and will include articles on Chemoprevention, Breast MRI, Genomics, Sentinel Node Biopsy, Extra-axillary Sentinel Nodes, Skin-Sparing and Nipple Sparing Mastectomy, Oncoplastic Techniques, Neoadjuvant Hormonal Therapy, Neoadjuvant Chemotherapy, Adjuvant Hormonal Therapy, Adjuvant Chemotherapy, and Biologic Targeted Therapies.

Author : Annamaria Agnes,Alberto Biondi,Laura Lorenzon,Domenico M. D’Ugo
Publisher : Frontiers Media SA
Page : 403 pages
File Size : 48,9 Mb
Release : 2022-09-07
Category : Medical
ISBN : 9782889769117

Get Book

Gastric Cancer Phenotype and Treatment by Annamaria Agnes,Alberto Biondi,Laura Lorenzon,Domenico M. D’Ugo Pdf

Author : M. Kaminishi,K. Takubo,K. Mafune
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 44,6 Mb
Release : 2006-03-20
Category : Medical
ISBN : 9784431277132

Get Book

The Diversity of Gastric Carcinoma by M. Kaminishi,K. Takubo,K. Mafune Pdf

• Japan is a leader in screening for and treating gastric cancer - this title first publishes Japan’s newest research in English • Contributors are internationally recognized specialists with publications on gastrointestinal cancers in many high ranking medical journals from Europe and the USA • Michio Kaminishi was president of the 3rd International Conference of the ISGC

Author : Nabil Ismaili
Publisher : BoD – Books on Demand
Page : 162 pages
File Size : 50,9 Mb
Release : 2011-07-18
Category : Medical
ISBN : 9789533073446

Get Book

Management of Gastric Cancer by Nabil Ismaili Pdf

Gastric cancer is the fifth most common cancer and the second most common cause of cancer death worldwide. More than 50% of the patients have advanced disease at diagnosis and in this case the disease has a poor outcome. The staging of gastric cancers is based on endoscopic ultrasound, computed tomography, magnetic resonance imaging, positron emission tomography, in addition to the laparoscopic staging. Many improvements in the surgical techniques have been seen in the last decade. Laparoscopic surgery is an emerging approach which offers important advantages: less blood loss, reduced postoperative pain, accelerated recovery, early return to normal bowel function and reduced hospital stay. D1 lymphadenectomy, with a goal of examining 15 or greater lymph nodes is a standard. D2 dissection is considered as a standard in several institutions especially in eastern Asia. Perioperative chemotherapy and adjuvant concurrent radiochemotherapy are recognized as standards treatments. Palliative chemotherapy is the mainstay treatment of advanced stages of the disease (metastatic and non-operable tumors). Despite these treatment advances, the prognosis of gastric cancer remains poor with a 5-year survival ranging from 10 to 15% in all stages combined.

Author : Shoji Natsugoe
Publisher : Springer
Page : 358 pages
File Size : 51,8 Mb
Release : 2019-01-23
Category : Medical
ISBN : 9789811046995

Get Book

Lymph Node Metastasis in Gastrointestinal Cancer by Shoji Natsugoe Pdf

This book provides the most comprehensive and up-to-date knowledge of lymph node micrometastasis (LMM) and sentinel node navigation surgery (SNNS) in gastrointestinal cancers. Lymph node metastasis is a critically important prognostic factor in gastrointestinal tract cancers such as tumors of the esophagus, stomach, and colorectum. An understanding of the basic aspects of lymphatics and lymph nodes, including anatomy, histology, physiology, immunology, and molecular biology, is fundamental for physicians who are involved in cancer treatment. Furthermore, owing to the development of molecular and biological methodology, the precise recognition of LMM and its clinical significance have been clarified recently. At the same time, SNNS has actually been anticipated in treatment of breast tumors, and it is now being introduced in gastrointestinal tract cancer. For the application of SNNS, the detection of lymph node metastasis including LMM is extremely significant, because the presence of LMM determines the direction for surgery and chemo and/or radiation therapy. With these considerations in mind, the expert contributors to this book review basic and clinical approaches for LMM and SNNS including methodology for gastrointestinal cancers. Thus this volume benefits not only surgeons who treat gastrointestinal cancers but also clinical oncologists and medical scientists such as physiologists and pathologists.

Author : Anonim
Publisher : Unknown
Page : 520 pages
File Size : 46,8 Mb
Release : 2010
Category : Cancer
ISBN : MINN:31951P01098980P

Get Book

Journal of the National Cancer Institute by Anonim Pdf

Author : Jochen A. Werner,R. Kim Davis
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642187223

Get Book

Metastases in Head and Neck Cancer by Jochen A. Werner,R. Kim Davis Pdf

-Richly illustrated; 109 illustrations, 57 in color -Cover a wide range of diagnostic and theraputic techniques, i.e. MRI, PET, surgical treatment, radiation therapy

Author : Anonim
Publisher : ScholarlyEditions
Page : 333 pages
File Size : 45,7 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464970061

Get Book

Pancreatic Cancer: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

Pancreatic Cancer: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pancreatic Cancer. The editors have built Pancreatic Cancer: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pancreatic Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pancreatic Cancer: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Rosalyn D. Blumenthal
Publisher : Springer Science & Business Media
Page : 452 pages
File Size : 45,6 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592598892

Get Book

Chemosensitivity by Rosalyn D. Blumenthal Pdf

A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.

Author : Dorothy C. Cardinni
Publisher : Nova Publishers
Page : 314 pages
File Size : 48,8 Mb
Release : 2008
Category : Medical
ISBN : 1600217265

Get Book

Research Focus on Gastric Cancer by Dorothy C. Cardinni Pdf

This book presents important leading-edge research on stomach cancer. Stomach cancer (also called "gastric cancer") is the growth of cancer cells in the lining and wall of the stomach. Stomach cancer represents roughly 2% (25,500) cases of all new cancer cases yearly in the United States, but it is much more common in Japan, Great Britain, South America, and Iceland. It is associated with high salt in the diet, smoking, and low intake of fruits and vegetables. Infection with H. pylori is the main risk factor in about 80% or more of gastric cancers. It is more common in men. A very small percentage of diffuse-type gastric cancers are thought to be genetic. Hereditary Diffuse Gastric Cancer (HDGC) has only recently been identified and research is ongoing, but genetic testing and treatment options are available for families at risk. Metastasis occurs in 80-90% of individuals with stomach cancer, with a five year survival rate of 75% in those diagnosed in early stages and less than 30% of those diagnosed in late stages.

Author : Kirby I. Bland,Edward M. Copeland,V. Suzanne Klimberg
Publisher : Elsevier Health Sciences
Page : 1605 pages
File Size : 46,7 Mb
Release : 2009-09-09
Category : Medical
ISBN : 9781437711219

Get Book

The Breast E-Book by Kirby I. Bland,Edward M. Copeland,V. Suzanne Klimberg Pdf

The Breast: Comprehensive Management of Benign and Malignant Diseases, 4th Edition, by Kirby I. Bland, MD, and Edward M. Copeland, III, MD, is a surgical reference that offers the most comprehensive, up-to-date resource on the diagnosis and management of, and rehabilitation following, surgery for benign and malignant diseases of the breast. With its multidisciplinary approach, sweeping updates, new contributors, and authoritative guidance, you’ll have exactly what you need to inspire patient confidence and provide the best possible outcomes. Features multidisciplinary advice from experts in surgery, radiation and medical oncology, pathology, molecular biology, pharmacokinetics, and genetics for a well-rounded perspective to enhance patient outcomes. Includes more than 1,500 figures and tables that offer high quality depictions of surgery and treatment procedures. Offers step-by-step guidance through both text and clinical boxes that makes the material relevant to everyday practice. Provides cross-referencing between chapters, as well as references to carefully selected journal articles, that makes further research easier. Uses a new full-color design to highlight key areas of the text and help you focus on important concepts. Presents updated coverage including an expanded section on pathology...and new chapters on granular cell tumors, targeted therapies, integration of radiotherapy and chemotherapy to keep you current. Includes revised chapters on the psychosocial consequences of breast cancer, lifestyle interventions for breast cancer patients, and patient and family resources that equip you to offer complete and compassionate care. Provides additional information on genetics to keep you up to date with the latest genetic discoveries linked to breast cancer and breast diseases. Features the work of many new contributors who provide the latest and freshest perspectives.

Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
Page : 666 pages
File Size : 50,9 Mb
Release : 2009-10-09
Category : Medical
ISBN : 9781603270878

Get Book

From Local Invasion to Metastatic Cancer by Stanley P. L. Leong Pdf

In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.