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Middle Molecular Strategy by Koichi Fukase,Takayuki Doi Pdf
This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.
Middle Molecular Strategy by Koichi Fukase,Takayuki Doi Pdf
This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.
Plant Stress Tolerance Physiological & Molecular Strategies by A. Hemantaranjan Pdf
The book entitled "Plant Stress Tolerance – Physiological & Molecular Strategies" has been especially edited for holistic development of the science of agriculture and crop production under distinctly changing environment. Resource utilization is always overlooked; hence a brief focus on sustainability has been remarkably presented to prove the meaningfulness of this publication. This book brings ingenious applied researches highlighting the major environmental factors coupled with scrupulous strategies in solving abiotic stresses in varied micro and macro agro-climatic conditions , in general, and unfolding the basis for tolerance mechanisms in plant systems, in particular.
Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules by Yuichi Kobayashi Pdf
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.
Author : Eli A. Friedman Publisher : John Wiley & Sons Page : 586 pages File Size : 43,8 Mb Release : 1978 Category : Medical ISBN : UOM:39015004445568
Molecular Basis and Emerging Strategies for Anti-aging Interventions by Syed Ibrahim Rizvi,Ufuk Çakatay Pdf
This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.
Optimal Treatment Strategies in End-stage Renal Failure by Claude Jacobs Pdf
During the past 4O years there have been major conceptual and technical advances in the domain of dialysis methods and renal/organ transplantation for long-term treatment of patients with End-Stage Renal Failure (ESRF). This now enables better defined, more selective strategies of treatment tobe undertaken, according to patient-specific criteria such as age or underlying renal disease also taking into account the lifetime duration of these treatments. For many patients this implies necessary successive changes of mode of therapy depending on their availability, occurrence ofmedical/technical complications or failure and social-environmental and economic factors. This rationale has inspired the structure of this volume which is divided into four sections: 1/ A descriptive overview of the various modes of renal replacement therapy (RRT): Extracorporeal dialysis/filtration, peritoneal dialysis, kidney and multi-organ transplantation.2/ Most appropriate indications and use of these methods, respective advantages, drawbacks and outcome in children,pregnant women and elderly patients 3/ In diabetic patients and in patients with hereditary/congenital diseases. 4/ The ethical issues generated by this new domain in Medicine by limitations in treatment facilities or medical dilemmas for acceptance, best technical choices, withdrawal or terminationof RRT in individual patients. Finally, contributors form Eastern European Countries, Africa and Far Eastern Countries analyse the current status of RRT in their respective geographical area and the ways and means required for a wider implementation of RRT in thus far lesser economically developed countries where the greatmajority of the populations still have no access to these life-saving therapeutic procedures.
Modeling and Control of Dialysis Systems by Ahmad Taher Azar Pdf
This book is the first text of its kind that presents both the traditional and the modern aspects of dialysis modeling and control in a clear, insightful and highly comprehensive writing style. It provides an in-depth analysis of the mathematical models and algorithms, and demonstrates their applications in real world problems of significant complexity. It explains concepts in a clear, matter-of-fact style. The material of this book will be useful to advanced undergraduate and graduate biomedical engineering students. Also, researchers and practitioners in the field of dialysis, control systems, soft computing will benefit from it. In order to make the reader aware of the applied side of the subject, the book includes: Chapter openers with a chapter outline, chapter objectives, key terms list, and abstract. Solved numerical examples to illustrate the application of a particular concept, and also to encourage good problem-solving skills. More than 1000 questions to give the readers a better insight to the subject. Case studies to understand the significance of the joint usage of the dialysis modeling and control techniques in interesting problems of the real world. latest information, including latest research surveys and references related to the subjects
Molecular Strategies of Creatures to Survive in Acidic Environments by Hiroshi Kobayashi Pdf
Creatures often suffer changes in conditions of their surroundings from the womb to the tomb through the climate alterations and their own movements, and may have various strategies in place to overcome such environmental changes. Among the conditions they encounter, the pH of environments surrounding creatures varies dramatically during lifespans, especially in microorganisms. In humans, the skin covering the body prevents acidification inside the body, and cells are surrounded by body fluid whose pH is kept at 7.4. Nevertheless, pH surrounding cells is often acidified, especially diseased areas, such as cancer nests, inflammatory loci, and infarction areas. Life sciences at the molecular level have been focused on studies in near neutral pH conditions because neutral pH is favourable for many creatures. For a deeper understanding of life, it is essential to clarify molecular mechanisms of how organisms and cells keep their activities when their surroundings are acidified, in the “acidic world”. This book summarises the current achievements concerning how cellular functions are kept in acidic environments for a wide range of living organisms, from bacteria to humans. Research results obtained to date allow the prediction that all creatures have different sets of genes and use them under different pH conditions. However, we only know little about the “acidic world”, and a huge number of uncovered questions are waiting to be resolved. Their elucidation would help to open up a new way of understanding life.
Molecular Strategies Aimed to Boost NK Cell-based Immunotherapy of Cancer by Loredana Cifaldi,Daniel Olive,James Di Santo Pdf
In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.
Strategies and Applications in Quantum Chemistry by Y. Ellinger,M. Defranceschi Pdf
At the time when increasing numbers of chemists are being attracted by the fascination of supposedly easy computing and associated colourful imaging, this book appears as a counterpoint. The first part focuses on fundamental concepts of quantum chemistry, covering MCSCF theory, perturbation treatments, basis set developments, density matrices, wave function instabilities to correlation effects, and momentum space theory. The second part is devoted to more practical studies, ranging from the characterisation of exotic interstellar molecules, the accurate determination of spectroscopic constants, excited states structures and EPR parameters through photochemical and charge-transfer processes, cluster chemistry and fullerenes, muonium chemistry, to the possible prediction of the response of materials to electric fields in view of nonlinear optical applications. Audience: Graduate students and researchers whose work involves quantum chemistry, molecular physics, and materials modelling.
Flow Chemistry in Drug Discovery by Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz Pdf
This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development.
Hepatitis B Virus: Molecular Mechanisms In Disease And Novel Strategies For Therapy by Wolfgang Helmut Caselmann,Rajen Koshy Pdf
The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-associated liver carcinogenesis and their possible relevance to therapy and to the prevention of infection. Rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy, are discussed.