Migraine And Headache Pathophysiology

Author : Messoud Ashina,Pierangelo Geppetti
Publisher : Springer
Page : 272 pages
File Size : 49,5 Mb
Release : 2015-04-14
Category : Medical
ISBN : 9783319156217

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Pathophysiology of Headaches by Messoud Ashina,Pierangelo Geppetti Pdf

This book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches – migraine, tension-type headache (TTH), and cluster headache – and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system and cortical spreading depression in migraine. Detailed information is provided on insights into primary headaches from imaging studies, including functional magnetic resonance imaging and positron emission tomography and on their neurophysiology and biochemistry. A further series of important chapters describe present knowledge of the pathophysiology of each specific type of headache and consider future directions. Written by acknowledged experts in their fields from Europe and the United States, clinicians and students will find Pathophysiology of Headaches to be an excellent source of up-to-date information on why patients experience headaches. In addition, it will be of value for pain researchers investigating the underlying mechanisms of headache.

Author : Robert A. Davidoff
Publisher : Oxford University Press
Page : 533 pages
File Size : 45,9 Mb
Release : 2002-02-14
Category : Medical
ISBN : 9780198031352

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Migraine by Robert A. Davidoff Pdf

Migraine: Manifestations, Pathophysiology, and Management, Second Edition, is a much expanded, updated monograph that focuses in detail on migraine's diverse variations, its pathophysiology, and its treatment. Authored by a clinician/scientist who himself suffers from migraine, the book's premise is that the clinical significance of migraine and its treatment are intelligible only if the physician understands the anatomical, physiological, and pharmacological factors underlying both head pain and the other manifestations of migraine. The book provides clear clinical descriptions of the myriad of specific migraine syndromes, and discusses the rationale for, and elements of, a sensitive, inclusive patient history. Also covered are important but sometimes ignored topics such as environmental triggering of migraine and myofascial syndromes. The Second Edition also bridges the gap between basic science and clinical practice by explaining those substantive advances made in understanding fundamental mechanisms of head pain and aura. Recent knowledge about genetics, hormonal changes, cerebral circulation, nitric oxide, peptides, central sensitization of trigeminal neurons, and the role of periaqueductal gray matter buttress the discussion of basic mechanisms. On the treatment side, the Second Edition reflects the impressive advances in pharmacological approaches to migraine. There is a greatly expanded section on the triptans and their mechanisms of action, and rationales and practical information about the use of all other viable anti-migraine and prophylactic drugs. Psychobiological aspects of stress and stress management, elimination of environmental stimuli, the educational facets of management, and aspects of the patient/physician interaction so crucial in the treatment of migraine are all discussed. Special problems associated with the care of women, children, the elderly, patients with intractable headaches, and emergency department patients are thoroughly reviewed. In sum, this scholarly, well-referenced book offers in one volume a comprehensive scientific and clinical discussion of migraine headache.

Author : Hans-Christoph Diener,Marcia Wilkinson
Publisher : Springer Science & Business Media
Page : 174 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642733277

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Drug-Induced Headache by Hans-Christoph Diener,Marcia Wilkinson Pdf

M. WILKINSON Patients with frequent or daily headaches pose a very difficult problem for the physician who has to treat them, particularly as many patients think that there should be a medicine or medicines which give them instant relief. In the search for the compound which would meet this very natural desire, many drugs have been manufactured and the temptation for the physician is either to increase the dose of a drug which seems to be, at any rate, partially effective, or to add one or more drugs to those which the patient is already taking. Although there have been some references to the dangers of overdosage of drugs for migraine in the past, it was not until relatively recently that it was recognized that drugs given for the relief of headache, if taken injudiciously, may themselves cause headache. The first drugs to be implicated in this way were ergotamine and phenazone. In the case of ergotamine tartrate, the dangers of ergotism were well known as this was a disorder which had been known and written about for many years. In the treatment of headache, fully blown ergotism is rare and in recent years has usually been due to self-medication in doses much greater than those prescribed although there are a few recorded cases where toxic amounts have been given.

Author : Seymour Diamond,Roger K. Cady,Merle L. Diamond,Mark W. Green,Vincent T. Martin
Publisher : Academic Press
Page : 334 pages
File Size : 51,8 Mb
Release : 2015-03-13
Category : Science
ISBN : 9780128011621

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Headache and Migraine Biology and Management by Seymour Diamond,Roger K. Cady,Merle L. Diamond,Mark W. Green,Vincent T. Martin Pdf

There are two crucial issues in the treatment and management of headache patients: More than 50% of individuals experiencing headache have only been treated symptomatically, with no appropriate diagnosis established; and history and neurologic examination are essential to establishing a diagnosis, and thus selecting appropriate therapy. Headache and Migraine Biology and Management is a practical text that addresses these issues, featuring contributions from expert clinical authors. The book covers in detail topics including chronic and episodic migraine, post-traumatic headache, sinus headache, cluster headache, tension headache, and others. Chapters are also dedicated to treatment subjects, including psychiatric and psychological approaches, medication overuse, inpatient treatment, and pediatric issues. This book is an ideal resource for researchers and clinicians, uniting practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs. This resource is useful to those who want to understand headache biology, treat and manage symptoms, and for those performing research in the headache field. A practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs Features chapters from leading physicians and researchers in headache medicine Full-color text that includes both an overview of multiple disciplines and discusses the measures that can be used to treat headaches

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 51,6 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

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Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Author : Anne MacGregor,Alison Frith
Publisher : John Wiley & Sons
Page : 88 pages
File Size : 46,9 Mb
Release : 2013-05-20
Category : Medical
ISBN : 9781118682005

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ABC of Headache by Anne MacGregor,Alison Frith Pdf

In its different presentations, headache is one of the most commonsymptoms seen by family practitioners. The difficulty is indiagnosing the cause of the headache so that the appropriatetreatment is provided, or if referral to a specialist is therecommended course of action. The ABC of Headache helps with this dilemma and guidesthe healthcare professional to look for the possible causes ofpresenting symptoms. Based on real case histories, each chapterguides the reader from symptoms through to diagnosis andmanagement. This new ABC is a highly illustrated, informative, andpractical source of knowledge. With links to further informationand resources, it is a valuable text for healthcare professionalsat all levels of practice and training.

Author : Hubert Vaudry,Akira Arimura
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 55,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461502432

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Pituitary Adenylate Cyclase-Activating Polypeptide by Hubert Vaudry,Akira Arimura Pdf

Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Author : Gianluca Coppola,Wei-Ta Chen
Publisher : Springer Nature
Page : 236 pages
File Size : 52,5 Mb
Release : 2020-10-20
Category : Medical
ISBN : 9783030565381

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Neurophysiology of the Migraine Brain by Gianluca Coppola,Wei-Ta Chen Pdf

Roughly one in every five patients referred to a neurologist suffers from headaches; the majority have migraines. Although headache specialists understand migraine on a clinical basis, the pathophysiological changes that provoke and accompany the development of a migraine attack continue to elude us. Several decades have passed since the pioneering electroencephalographic study by Golla and Winter (1959), which underscored the role of abnormal rhythmic activities in migraine. Since then, there have been substantial advances in the field; a wealth of neurophysiological studies has enriched our understanding of the pathophysiological facets of the migraine pathology. Virtually every known technique of clinical electrophysiology has since been used to study the migraine brain and, more recently, new neurophysiological tools have been added to the arsenal. Nevertheless, applying the principles of peripheral and central neuromodulation offers a promising way to transfer the principles of synaptic plasticity to the patient’s bedside. This book belongs to the Headache Series endorsed by the European Headache Federation. Written by internationally recognized experts in their respective fields, it covers all aspects of clinical neurophysiological methods that represent significant advances in our understanding of the pathophysiology of migraine. It will offer a valuable toolkit for beginners, and a reference guide for experts.

Author : David Borsook
Publisher : Oxford University Press, USA
Page : 400 pages
File Size : 40,8 Mb
Release : 2012-07-26
Category : Health & Fitness
ISBN : 9780199754564

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The Migraine Brain by David Borsook Pdf

The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches.

Author : Alan David Kaye,Rinoo V. Shah
Publisher : Cambridge University Press
Page : 547 pages
File Size : 50,9 Mb
Release : 2014-10-16
Category : Medical
ISBN : 9781107682894

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Case Studies in Pain Management by Alan David Kaye,Rinoo V. Shah Pdf

Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.

Author : Lars Edvinsson
Publisher : CRC Press
Page : 184 pages
File Size : 42,7 Mb
Release : 1999-02-19
Category : Health & Fitness
ISBN : 1853177377

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Migraine and Headache Pathophysiology by Lars Edvinsson Pdf

Migraine Pathophysiology provides an overview of current and accepted methodologies for the experimental study of migraine of primary headache syndromes in the laboratory in animals and man. It gives the reader a view of the current status and direct basic scientists and the pharmaceutical industry in choosing experimental situations for developing new therapies.

Author : Elizabeth Loder,Dawn A. Marcus
Publisher : PMPH-USA
Page : 212 pages
File Size : 41,6 Mb
Release : 2004
Category : Health & Fitness
ISBN : 1550091808

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Migraine in Women by Elizabeth Loder,Dawn A. Marcus Pdf

Fifteen specialists serve as chapter authors, covering sex hormones and genetics, as well as the social, cultural, psychiatric, and psychological factors that contribute to headache disorders. Their approach is evidence-based, but where there are gaps in research, the authors provide advice based on expert consensus and clinical experience. Each chapter opens with a case report that synthesizes the chapter's treatment recommendations, as well as key points listing the chapter's contents. The main body of the chapter features an introductory overview, a closing summary, tables, and an extensive list of suggestive reading.

Author : Mark E. Mehle
Publisher : Springer
Page : 250 pages
File Size : 50,9 Mb
Release : 2017-01-31
Category : Medical
ISBN : 9783319503769

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Sinus Headache, Migraine, and the Otolaryngologist by Mark E. Mehle Pdf

This volume will serve as a comprehensive and useful guide for ENT physicians in the recognition, diagnosis, and treatment of patients who suffer from sinus headaches and migraines. The text reviews key issues such as identification and management of migraine, and appropriate surgical and nonsurgical treatment that is often not part of ENT resident training. With 20% of women and 6% of men having migraines (only 50% recognized) this text will serve to expand management options to physicians already operating on sinuses or seeing cosmetic patients with head and neck concerns. Other forms of intervention in migraineurs, such as surgery, Botulinum Toxin injections and adjunctive and integrative therapy, are covered. Sinus Headache, Migraine, and the Otolaryngologist will be an invaluable resource for ENT and allergy specialists, and any physician or medical professional with an interest in sinus headache or migraine.

Author : Stephen D. Silberstein
Publisher : Routledge
Page : 298 pages
File Size : 40,8 Mb
Release : 2018-05-08
Category : Health & Fitness
ISBN : 9781351441315

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Headache in Clinical Practice by Stephen D. Silberstein Pdf

The authors of the first edition worked together again to revise data for the second edition of this popular volume. Based at three of the world's leading centers for the study and treatment of headache, these experts share their insights on every aspect of this common and irritating condition. In particular, the sections on migraine, cluster headache and vascular disease have been updated. Based on the classification system developed by the International Headache Society, Headache in Clinical Practice provides those interested in headache with an up-to-date compendium of current opinion, from epidemiology, pathophysiology and investigation, through options for intervention and management.

Author : Massimiliano Valeriani,Ishaq Abu-Arafeh,Aynur Özge
Publisher : Frontiers Media SA
Page : 99 pages
File Size : 49,6 Mb
Release : 2020-01-09
Category : Electronic
ISBN : 9782889633968

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Clinical and Pathophysiological Peculiarities of Headache in Children and Adolescents by Massimiliano Valeriani,Ishaq Abu-Arafeh,Aynur Özge Pdf