Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer

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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer

Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer Book PDF

Author : Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 52,5 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783642281600

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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer by Michail Ignatiadis,Christos Sotiriou,Klaus Pantel Pdf

This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

Circulating Tumor Cells in Breast Cancer Metastatic Disease

Roberto Piñeiro
Circulating Tumor Cells in Breast Cancer Metastatic Disease Book PDF

Author : Roberto Piñeiro
Publisher : Springer Nature
Page : 177 pages
File Size : 43,5 Mb
Release : 2020-04-17
Category : Medical
ISBN : 9783030358051

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Circulating Tumor Cells in Breast Cancer Metastatic Disease by Roberto Piñeiro Pdf

This book is aimed to summarise the key aspects of the role of circulating tumour cells (CTCs) in breast cancer, with special attention to their contribution to tumour progression and establishment of metastatic disease. We aim to give a clear overview of the knowledge about CTCs, framed in the context of breast cancer, by analysing basic and clinical research carried out so far. In a broader sense, we will address what are the main clinical needs of this disease based on its molecular heterogeneity (subtypes) and lay out the knowledge and understanding that CTCs are giving about it and how they are contributing and can still improve the better monitoring and management of breast cancer patients. We will discuss the evidences of the use of CTCs as a tool to monitor cancer progression and therapy response, based on the prognostic and predictive value they have, as well as a tool to unravel mechanisms of resistance to therapy and to identify new biomarkers allowing to predict therapy success. Moreover, we will analyse the main aspects of ongoing clinical trials and how they can contribute to determine the clinical utility of CTCs as a breast cancer biomarker. We will also touch upon general knowledge or basic notions of the biology of the metastatic process in epithelial cancers, in order to understand the origin and biology of CTCs. In this sense, we will pay special attention to EMT (epithelial to mesenchymal transition), dormancy and minimal residual disease, three key aspects that determine the outcome of the disease. We will also cover general aspects on the isolation and characterization techniques applies to the study of CTCs, and also the possibilities that the study of CTCs, as a biomarker with biological function, is opening in terms of understanding the biology of metastatic cells and the identification of therapeutic targets based on the functional and molecular characterization of CTCs. Lastly, we will try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine.

Biological Mechanisms of Minimal Residual Disease and Systemic Cancer

Julio A. Aguirre-Ghiso
Biological Mechanisms of Minimal Residual Disease and Systemic Cancer Book PDF

Author : Julio A. Aguirre-Ghiso
Publisher : Springer
Page : 162 pages
File Size : 44,5 Mb
Release : 2018-11-08
Category : Medical
ISBN : 9783319977461

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Biological Mechanisms of Minimal Residual Disease and Systemic Cancer by Julio A. Aguirre-Ghiso Pdf

This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.

Circulating Molecular Biomarkers: Next-Generation Tools for Monitoring Minimal Residual Disease in Cancer Patients

Zohreh Amoozgar,Rana Jahanban-Esfahlan,Mehdi - Jaymand
Circulating Molecular Biomarkers Next Generation Tools for Monitoring Minimal Residual Disease in Cancer Patients Book PDF

Author : Zohreh Amoozgar,Rana Jahanban-Esfahlan,Mehdi - Jaymand
Publisher : Frontiers Media SA
Page : 137 pages
File Size : 46,8 Mb
Release : 2023-08-16
Category : Medical
ISBN : 9782832531921

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Circulating Molecular Biomarkers: Next-Generation Tools for Monitoring Minimal Residual Disease in Cancer Patients by Zohreh Amoozgar,Rana Jahanban-Esfahlan,Mehdi - Jaymand Pdf

Traditional cancer diagnosis relies on tissue biopsy, blood testing as well as medical imaging. By the detection moment, in most cases the tumor size may reach several millimeters and the risk of distant metastasis is unavoidable. Even, following drug treatment, there is no accurate and timely way to follow up the success of treatment. New reliable tumor-specific biomarkers/tools that allow non-invasive early cancer detection as well as monitoring of anti-cancer therapeutic regime is highly demanded. To tackle limitations of traditional cancer management, liquid biopsy has emerged which screen bodily fluids using ultrasensitive biosensing systems capable of simultaneous capturing and studying horizontal gene transfer (HGT) materials including circulating tumor cells (CTCs), exosomes, cell-free DNA, and apoptotic bodies. These are messengers and/or delivery systems by which tumor cells are communicating as well as transforming/sharing new phenotypes with each other resulting in drug resistance, distant metastatic outbreaks, and cancer recurrence. Acting as next-generation prognostic and therapeutic tools call for understanding the molecular mechanisms by which HGT works to tran

Breast Cancer

Phuc Van Pham
Breast Cancer Book PDF

Author : Phuc Van Pham
Publisher : BoD – Books on Demand
Page : 570 pages
File Size : 47,5 Mb
Release : 2017-04-05
Category : Medical
ISBN : 9789535129998

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Breast Cancer by Phuc Van Pham Pdf

Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

Breast Cancer and Surgery

Nilufer Bulut
Breast Cancer and Surgery Book PDF

Author : Nilufer Bulut
Publisher : BoD – Books on Demand
Page : 228 pages
File Size : 42,5 Mb
Release : 2018-11-21
Category : Medical
ISBN : 9781789235661

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Breast Cancer and Surgery by Nilufer Bulut Pdf

The book 'Breast Cancer and Surgery' summarizes the treatment options from the onset of breast carcinogenesis to early-local advanced and metastatic breast cancer. Chemotherapy alternatives, drug resistance and local and surgical treatment preferences are extensively discussed and this information is especially directed at clinicians, researchers, and students. This book includes a comparison between different chemotherapy agents and targeted therapies with published phase II-III studies. The importance of palliative care and dietary supplements administered during the treatment course in reducing the comorbidity of patients is emphasized. Photodynamic treatments have been included in this book. A comprehensive and up-to-date information exchange that can be accessed through a single source is provided to all researchers interested in breast cancer.

Tumor Liquid Biopsies

Florence Schaffner,Jean-Louis Merlin,Nikolas von Bubnoff
Tumor Liquid Biopsies Book PDF

Author : Florence Schaffner,Jean-Louis Merlin,Nikolas von Bubnoff
Publisher : Springer
Page : 368 pages
File Size : 45,8 Mb
Release : 2019-10-25
Category : Medical
ISBN : 3030264386

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Tumor Liquid Biopsies by Florence Schaffner,Jean-Louis Merlin,Nikolas von Bubnoff Pdf

This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Molecular Medicine

Sinem Nalbantoglu,Hakima Amri
Molecular Medicine Book PDF

Author : Sinem Nalbantoglu,Hakima Amri
Publisher : BoD – Books on Demand
Page : 168 pages
File Size : 51,7 Mb
Release : 2019-11-06
Category : Science
ISBN : 9781839627590

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Molecular Medicine by Sinem Nalbantoglu,Hakima Amri Pdf

Molecular medicine is an applied science focused on human genes/transcripts, proteins, metabolites, and metabolic networks that describes molecular and cellular processes of health and disease onset and progression. Molecular medicine-based integrative identification and characterization of biomarker targets and their clinical translations is essential to explain/decipher the mechanism(s) underlying physiological pathways and pathological conditions, and acquire cell-targeted early interventional and therapeutic strategies in the context of precision medicine and public health. Principally, Molecular Medicine provides an overview of the latest headlines/developments of systems and molecular medicine, highlighting the emerging high-throughput technologies, promising potential applications, and progress in biomedical research and development strategies.

Circulating Tumor Cells

Richard J. Cote,Ram Datar
Circulating Tumor Cells Book PDF

Author : Richard J. Cote,Ram Datar
Publisher : Springer
Page : 333 pages
File Size : 52,6 Mb
Release : 2016-02-03
Category : Medical
ISBN : 9781493933631

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Circulating Tumor Cells by Richard J. Cote,Ram Datar Pdf

This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive “liquid biopsy” procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development. In recent years there has been rapid growth and worldwide developments on CTCs, which span both the basic sciences and biomedical engineering fields.

Biomarkers in Breast Cancer

Giampietro Gasparini,Daniel F. Hayes
Biomarkers in Breast Cancer Book PDF

Author : Giampietro Gasparini,Daniel F. Hayes
Publisher : Springer Science & Business Media
Page : 335 pages
File Size : 40,8 Mb
Release : 2008-01-17
Category : Medical
ISBN : 9781592599158

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Biomarkers in Breast Cancer by Giampietro Gasparini,Daniel F. Hayes Pdf

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Micrometastasis

Klaus Pantel
Micrometastasis Book PDF

Author : Klaus Pantel
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 41,7 Mb
Release : 2003-07-31
Category : Medical
ISBN : 1402011555

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Micrometastasis by Klaus Pantel Pdf

Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocytochemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information. In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed. The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients.

Reviews on New Drug Targets in Age-Related Disorders

Paul C. Guest
Reviews on New Drug Targets in Age Related Disorders Book PDF

Author : Paul C. Guest
Publisher : Springer Nature
Page : 274 pages
File Size : 53,7 Mb
Release : 2021-03-16
Category : Science
ISBN : 9783030550356

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Reviews on New Drug Targets in Age-Related Disorders by Paul C. Guest Pdf

Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in ‘omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from ‘omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest’s previous book Reviews on New Drug Targets in Age-Related Disorders.

Atlas of Liquid Biopsy

Ludmilla Thomé Domingos Chinen
Atlas of Liquid Biopsy Book PDF

Author : Ludmilla Thomé Domingos Chinen
Publisher : Springer Nature
Page : 208 pages
File Size : 41,6 Mb
Release : 2021-05-31
Category : Medical
ISBN : 9783030698799

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Atlas of Liquid Biopsy by Ludmilla Thomé Domingos Chinen Pdf

This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM). The field of “liquid biopsy” began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed. Cancer is an important cause of mortality, especially when detected in late stages. Even with all the advances that have been made in its treatment, cancer is still challenging, as many patients do not respond to any therapy. Many health agencies have considered early diagnosis as a feasible tool. In this context, it is of the utmost importance to know the morphology and characteristics of CTCs to determine a correct diagnosis. Currently much of the scientific community is committed to expanding our knowledge of CTCs, and this work makes a valuable contribution, presenting hundreds of cell images from patients with various types of cancer, in many different stages of disease, and after receiving various treatments. The Atlas of Liquid Biopsy: Circulating Tumor Cells and Other Rare Cells in Cancer Patients’ Blood is an essential reference guide for all physicians, biologists, biomedics, and professionals working at clinical and research laboratories, hospitals and research centers.

Minimal Residual Disease in Hematologic Malignancies

Raanani P Ed
Minimal Residual Disease in Hematologic Malignancies Book PDF

Author : Raanani P Ed
Publisher : S. Karger AG (Switzerland)
Page : 0 pages
File Size : 45,7 Mb
Release : 2004
Category : Blood
ISBN : 3805577737

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Minimal Residual Disease in Hematologic Malignancies by Raanani P Ed Pdf

Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'. Providing a comprehensive overview on the significance of MRD in the evaluation, treatment and follow-up of hematologic malignancies, it will be of great value to hematologists, researchers interested in leukemias and lymphomas as well as laboratory technicians.

Modern Techniques in Cytopathology

M.M. Bui,L. Pantanowitz
Modern Techniques in Cytopathology Book PDF

Author : M.M. Bui,L. Pantanowitz
Publisher : Karger Medical and Scientific Publishers
Page : 120 pages
File Size : 48,9 Mb
Release : 2020-01-13
Category : Medical
ISBN : 9783318065763

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Modern Techniques in Cytopathology by M.M. Bui,L. Pantanowitz Pdf

In the era of precision medicine, physicians are increasingly in need of more definitive diagnostic, prognostic, and predictive information derived from small biopsy specimens such as cytology samples in order to guide effective patient care. Cytopathology is well poised to meet this challenge. Whilst the traditional cytomorphologic component of cytology practice is still valid, enormous advances have been made in the field of cytopathology thanks to transformative technology and innovative individuals that have augmented the cytologists' ability to meet the demands of modern medicine. The purpose of this book is to describe, illustrate, and review many of the most recent developments regarding modern techniques employed in cytopathology. This latest monograph is intended for all cytologists including cytopathologists, cytotechnologists, cytology lab assistants, trainees, research scientists, and anyone who is interested in the field of cytopathology. We have invited pioneering experts in their respective fields to author these chapters. This book is not only the culmination of their groundbreaking work and effort but also presents a critical review of the current literature. We have attempted to provide readers with an informative and comprehensive aid so that they may better appreciate how emerging technology has been applied to cytology. Each chapter in this book presents a stand-alone contemporary review of emerging topics in cytopathology. We hope that you will find this monograph thought-provoking and a valuable reference for your practice.