Minimal Residual Disease In Acute Leukemia 1986

Author : A. Hagenbeek,B. Löwenberg
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 51,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400942738

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Minimal Residual Disease in Acute Leukemia 1986 by A. Hagenbeek,B. Löwenberg Pdf

Relapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia. Leukemia recurs most frequently in patients with acute myeloblastic leukemia (AML) and high risk acute lymphoblastic leukemia (ALL) following chemotherapy and less often in patients with low risk ALL and particularly in patient groups> submitted to allogeneic marrow transplantation. ' It is likely that the great majority of these recurrences originate from residual leukemic cells that survive initial remission-induction chemotherapy. Today, several research groups throughout the world place emphasis on studies concerned with the detection and treatment of 'minimal residual disease' (MRD). These investigations are conducted with the common objective to tackle the remaining cells. 'Minimal Residual Disease in Acute Leukemia: 1986' summarizes the fast advancements in this area. Several disciplines are concerned with the analysis of leukemic cells. The perspectives of cytogenetic and molecular genetic approaches for applica tion in the detection of MRD are reviewed. In this respect, modern cyto genetics provide highly specific tumor markers. The resolution of cyto genetic methods can be particularly improved when combined with other techniques which select relevant subpopulations of cells. Characterization of oncogenes and gene rearrangements, including those of immunoglobulin and T-cell receptor genes, and the measurement of gene products, have been established. Techniques based on these approaches offer interesting tools for the detection of MRD. New possibilities of employing monoclonal anti bodies are also presented.

Author : Bob Löwenberg
Publisher : Unknown
Page : 0 pages
File Size : 54,9 Mb
Release : 1984
Category : Electronic
ISBN : 9024723388

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Minimal Residual Disease an Acute Leukemia by Bob Löwenberg Pdf

Author : Theodore F. Zipf,Dennis A. Johnston
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 48,6 Mb
Release : 2002-10-21
Category : Medical
ISBN : 9781592593187

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Leukemia and Lymphoma by Theodore F. Zipf,Dennis A. Johnston Pdf

In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 55,7 Mb
Release : 1990
Category : Electronic
ISBN : OCLC:81962737

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Minimal Residual Disease in Acute Leukemia by Anonim Pdf

Author : Raanani P Ed
Publisher : S. Karger AG (Switzerland)
Page : 0 pages
File Size : 48,6 Mb
Release : 2004
Category : Blood
ISBN : 3805577737

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Minimal Residual Disease in Hematologic Malignancies by Raanani P Ed Pdf

Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'. Providing a comprehensive overview on the significance of MRD in the evaluation, treatment and follow-up of hematologic malignancies, it will be of great value to hematologists, researchers interested in leukemias and lymphomas as well as laboratory technicians.

Author : Mourad Aribi
Publisher : BoD – Books on Demand
Page : 163 pages
File Size : 50,6 Mb
Release : 2020-02-26
Category : Medical
ISBN : 9781789854305

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Normal and Malignant B-Cell by Mourad Aribi Pdf

Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology.

Author : Ajay Vora
Publisher : Springer
Page : 342 pages
File Size : 48,8 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319397085

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Childhood Acute Lymphoblastic Leukemia by Ajay Vora Pdf

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Author : Mark R. Litzow,Elizabeth A. Raetz
Publisher : Springer Nature
Page : 439 pages
File Size : 41,6 Mb
Release : 2022-01-01
Category : Medical
ISBN : 9783030851477

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Clinical Management of Acute Lymphoblastic Leukemia by Mark R. Litzow,Elizabeth A. Raetz Pdf

This book provides a state-of-the-art overview of acute lymphoblastic leukemia (ALL). The first section of the book presents the translational science behind ALL, reviewing molecular pathways and targets in B- and T-cell ALL, as well as techniques and application of minimal residual disease testing. The second section spotlights ALL management strategies for patients across the spectrum, from infants to the elderly. The final section outlines current and new advances in ALL treatment, including new monoclonal antibodies and allogenic and autologous HSCT. Written by experts in the field, Clinical Management of Acute Lymphoblastic Leukemia: From Bench to Bedside is a valuable resource that will guide patient management, stimulate investigative efforts, and increase understanding of the biologic underpinnings of the disease.

Author : Anna Porwit,Marie Christine Béné
Publisher : Cambridge University Press
Page : 247 pages
File Size : 40,6 Mb
Release : 2018-01-25
Category : Medical
ISBN : 9781107503830

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Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies by Anna Porwit,Marie Christine Béné Pdf

This practical manual offers an active understanding of how to implement flow-cytometry when facing complex, haematological diseases.

Author : Nicolaus Kröger,Mohamad Mohty,Carlo Dufour
Publisher : Unknown
Page : 688 pages
File Size : 46,5 Mb
Release : 2020-10-08
Category : Medical
ISBN : 1013273672

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The EBMT Handbook by Nicolaus Kröger,Mohamad Mohty,Carlo Dufour Pdf

This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Author : Simon Bailey,Rod Skinner
Publisher : Oxford University Press, USA
Page : 624 pages
File Size : 46,6 Mb
Release : 2010
Category : Medical
ISBN : 9780199299676

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Paediatric Haematology and Oncology by Simon Bailey,Rod Skinner Pdf

While survival rates for children with cancer have increased in recent times, the increased use of more aggressive therapies has brought with it significant adverse effects. Therefore, the aim of pediatric oncologists has become to achieve "cure at least cost" by the appropriate reduction of the intensity and/or duration of treatment in carefully identified good prognosis patients. By comprehensively covering these issues, this handbook aims to provide residents in pediatric hematology and oncology, as well as staff in related medical or other healthcare disciplines, with an easily accessible source of information about the basic principles of childhood cancer and leukemia, as well as much of the more detailed specialist knowledge required to care for children with these conditions. Divided into sections to allow quick access to the necessary information, the handbook covers general principles of diagnosis and treatment, short and long term care, and oncological emergencies before moving on to chapters on specific disease. Normal values and useful websites are also included for reference.

Author : Laurent Degos,David C Linch,Bob Löwenberg
Publisher : CRC Press
Page : 972 pages
File Size : 40,8 Mb
Release : 1999-01-01
Category : Medical
ISBN : 1853173223

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Textbook of Malignant Haematology by Laurent Degos,David C Linch,Bob Löwenberg Pdf

This textbook provides a concise overview of malignant haematology, including reviews of cell and molecular biology, and implications for new trends in treatment.

Author : Wolf-Dieter Ludwig,Eckhard Thiel
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 53,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642848957

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Recent Advances in Cell Biology of Acute Leukemia by Wolf-Dieter Ludwig,Eckhard Thiel Pdf

The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias.

Author : Thomas Büchner,Wolfgang Hiddemann,Bernhard Wörmann,Günter Schellong,Jörg Ritter,Ursula Creutzig
Publisher : Springer Science & Business Media
Page : 1005 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642603778

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Acute Leukemias VI by Thomas Büchner,Wolfgang Hiddemann,Bernhard Wörmann,Günter Schellong,Jörg Ritter,Ursula Creutzig Pdf

For 10 years the book series Acute Leukemias has been providing updates on the rapid progress being made internationally concerning this group of diseases. The fifth volume mainly addressed experimental approaches, but the present issue presents both therapeutic and prognostic aspects of the most recent results from major multicenter clinical trials. Additional chapters report new trends in leukemia cell biology,the monitoring of minimal residual disease, and secondary leukemias, as well as new antileukemic drugs, antimicrobial strategies, and the use of cytokines. The combined efforts against acute leukemias described in this book explain the recent improvements in the outcome of patients suffering from acute leukemias.

Author : Anjali S. Advani,Hillard M. Lazarus
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 48,8 Mb
Release : 2010-11-18
Category : Medical
ISBN : 9781607617075

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Adult Acute Lymphocytic Leukemia by Anjali S. Advani,Hillard M. Lazarus Pdf

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.