Mirna Maturation

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MiRNA Maturation

Christoph Arenz
MiRNA Maturation Book PDF

Author : Christoph Arenz
Publisher : Unknown
Page : 192 pages
File Size : 50,9 Mb
Release : 2014
Category : Biomedicine
ISBN : 1627037039

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MiRNA Maturation by Christoph Arenz Pdf

In miRNA Maturation: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study miRNA maturation. These included established methods such as fluorescent and non-fluorescent methods for homogenous assays of Dicer-mediated miRNA maturation or an in vivo assay for Drosha activity. Moreover, the volume also contains useful, but less-common methods that are hard to find elsewhere. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, miRNA Maturation: Methods and Protocols seeks to widen the view on miRNA as biological mediator and potential drug target.

MicroRNAs in Development

Eran Hornstein
MicroRNAs in Development Book PDF

Author : Eran Hornstein
Publisher : Academic Press
Page : 327 pages
File Size : 52,6 Mb
Release : 2012-03-02
Category : Medical
ISBN : 9780123870384

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MicroRNAs in Development by Eran Hornstein Pdf

This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. Concentrates on microRNAs in development Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA With an international team of authors, this volume is a must-have addition for researchers and students alike

Developmental Timing

Anonim
Developmental Timing Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 46,6 Mb
Release : 2013-09-04
Category : Science
ISBN : 0123969689

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Developmental Timing by Anonim Pdf

This new volume of Current Topics in Developmental Biology covers developmental timing, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as the timing of developmental programs in Drosophila, temporal patterning of neural progenitors, and environmental modulation of developmental timing.

MicroRNAs in Development and Cancer

Frank J. Slack
MicroRNAs in Development and Cancer Book PDF

Author : Frank J. Slack
Publisher : World Scientific
Page : 299 pages
File Size : 46,8 Mb
Release : 2011
Category : Science
ISBN : 9781848163669

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MicroRNAs in Development and Cancer by Frank J. Slack Pdf

MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.

Hormones, Metabolism and the Benefits of Exercise

Bruce Spiegelman
Hormones Metabolism and the Benefits of Exercise Book PDF

Author : Bruce Spiegelman
Publisher : Springer
Page : 108 pages
File Size : 43,8 Mb
Release : 2018-03-07
Category : Science
ISBN : 9783319727905

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Hormones, Metabolism and the Benefits of Exercise by Bruce Spiegelman Pdf

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

MicroRNA in Development and in the Progression of Cancer

Shree Ram Singh,Pranela Rameshwar
MicroRNA in Development and in the Progression of Cancer Book PDF

Author : Shree Ram Singh,Pranela Rameshwar
Publisher : Springer Science & Business
Page : 410 pages
File Size : 49,6 Mb
Release : 2014-04-21
Category : Medical
ISBN : 9781489980656

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MicroRNA in Development and in the Progression of Cancer by Shree Ram Singh,Pranela Rameshwar Pdf

miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

MiRNAs in Differentiation and Development

Anonim
MiRNAs in Differentiation and Development Book PDF

Author : Anonim
Publisher : Academic Press
Page : 334 pages
File Size : 44,5 Mb
Release : 2017-07-17
Category : Science
ISBN : 9780128498637

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MiRNAs in Differentiation and Development by Anonim Pdf

MiRNAs in Differentiation and Development, Volume 333, the latest in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. Topics in this updated volume include chapters on the Regulation of the DNA damage response by miRNAs, miRNAs and the p53 network, the Impact of miRNAs in the cellular response to hypoxia, miRNAs in oncogenesis and tumor suppression, and the Role of miRNAs in metastatic dissemination. The IRCMB series has a worldwide readership, maintaining a high standard by publishing articles on timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists drawn from international sources Offers a wide range of perspectives on specific subjects

MicroRNAs in Plant Development and Stress Responses

Ramanjulu Sunkar
MicroRNAs in Plant Development and Stress Responses Book PDF

Author : Ramanjulu Sunkar
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 44,7 Mb
Release : 2012-02-21
Category : Science
ISBN : 9783642273841

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MicroRNAs in Plant Development and Stress Responses by Ramanjulu Sunkar Pdf

Precise regulation of gene expression in both time and space is vital to plant growth, development and adaptation to biotic and abiotic stress conditions. This is achieved by multiple mechanisms, with perhaps the most important control being exerted at the level of transcription. However, with the recent discovery of microRNAs another ubiquitous mode of gene regulation that occurs at the post-transcriptional level has been identified. MicroRNAs can silence gene expression by targeting complementary or partially complementary mRNAs for degradation or translational inhibition. Recent studies have revealed that microRNAs play fundamental roles in plant growth and development, as well as in adaptation to biotic and abiotic stresses. This book highlights the roles of individual miRNAs that control and regulate diverse aspects of plant processes.

microRNAs in Development

Anonim
microRNAs in Development Book PDF

Author : Anonim
Publisher : Academic Press
Page : 327 pages
File Size : 42,9 Mb
Release : 2012-11-15
Category : Science
ISBN : 9780123870391

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microRNAs in Development by Anonim Pdf

This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. Concentrates on microRNAs in development Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA With an international team of authors, this volume is a must-have addition for researchers and students alike

Regulation of microRNAs

Helge Großhans
Regulation of microRNAs Book PDF

Author : Helge Großhans
Publisher : Springer Science & Business Media
Page : 175 pages
File Size : 45,7 Mb
Release : 2010-12-10
Category : Science
ISBN : 9781441978233

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Regulation of microRNAs by Helge Großhans Pdf

Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.

miRNA Maturation

Christoph Arenz
miRNA Maturation Book PDF

Author : Christoph Arenz
Publisher : Humana
Page : 0 pages
File Size : 41,6 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493960164

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miRNA Maturation by Christoph Arenz Pdf

In miRNA Maturation: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study miRNA maturation. These included established methods such as fluorescent and non-fluorescent methods for homogenous assays of Dicer-mediated miRNA maturation or an in vivo assay for Drosha activity. Moreover, the volume also contains useful, but less-common methods that are hard to find elsewhere. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, miRNA Maturation: Methods and Protocols seeks to widen the view on miRNA as biological mediator and potential drug target.

MicroRNA

Junjie Xiao
MicroRNA Book PDF

Author : Junjie Xiao
Publisher : Academic Press
Page : 655 pages
File Size : 40,8 Mb
Release : 2022-07-19
Category : Science
ISBN : 9780323885584

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MicroRNA by Junjie Xiao Pdf

MicroRNA: From Bench to Bedside provides an in-depth, expansive overview of microRNA from fundamentals to clinical practice. It presents researchers with detailed insights on the topic of microRNA, exploring foundational knowledge that is followed by methodologies and the latest technologies for research and potential theragnostic and therapeutic applications for specific diseases. The book consists of eight parts, beginning with an introduction to microRNA and the current state of the field, followed by sections on biogenesis and maturation of microRNA, and methodology and bioinformatics, where chapters focus on isolation and detection techniques. Sections then move on to molecular mechanisms and gene regulation, considering topics such as transcriptional regulation and epigenetic regulation, as well as the role of microRNA as biomarkers. Additionally, microRNA and human disease and microRNA-based therapeutics are explored, focusing on a wide range of diseases such as cancer, age-related disease, cardiovascular disease, microRNA targeted therapy in hepatitis and therapeutic strategies for diabetes. The book concludes with a discussion on advances and future perspectives in microRNA investigation. Covers the topic of microRNA in detail, from foundational knowledge to clinical application Explores the physiological and pathological roles of microRNAs in various human diseases, including neurological, cardiovascular and age-related diseases Discusses future directions and challenges in the field Includes chapters on methodology and bioinformatics for microRNA research

MicroRNA Profiling

Sweta Rani
MicroRNA Profiling Book PDF

Author : Sweta Rani
Publisher : Springer Nature
Page : 258 pages
File Size : 50,8 Mb
Release : 2022-11-28
Category : Science
ISBN : 9781071628232

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MicroRNA Profiling by Sweta Rani Pdf

This second edition provides updated and comprehensive methods on miRNA biogenesis and their role in the development and progression of various human diseases. Chapters detail miRNA biogenesis, isolating RNA, extracellular vesicles (EVs), circulating miRNAs, analyzing miRNA and miRDeep-P2, protocols for total RNA isolation from cells, cell-derived products, isolation and characterization of exosomes, serum, plasma specimens, and software tools. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, MicroRNA Profiling: Methods and Protocols, Second Edition aims to provide comprehensive and accessible methods to undergraduate, graduate, and established scientist.

Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches

Fumihiko Maekawa,Kazuaki Nakamura,Shoji F. Nakayama
Chemicals in the Environment and Brain Development Importance of Neuroendocrinological Approaches Book PDF

Author : Fumihiko Maekawa,Kazuaki Nakamura,Shoji F. Nakayama
Publisher : Frontiers Media SA
Page : 155 pages
File Size : 51,9 Mb
Release : 2017-05-11
Category : Electronic book
ISBN : 9782889451722

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Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches by Fumihiko Maekawa,Kazuaki Nakamura,Shoji F. Nakayama Pdf

Mounting evidence shows that increasing numbers of children are being diagnosed with neurodevelopmental disorders, and it is clear that this increase cannot be explained by genetic background alone. A number of studies, including epidemiological studies, have found an association between in-utero and childhood exposure to certain chemicals, such as endocrine disruptors, psychoactive pharmaceuticals, volatile organic chemicals, persistent organic compounds and heavy metals, and children’s brain development. Yet, the mechanisms by which these chemicals impair brain development and function are not fully understood. In addition, little is known about how these chemicals enter and accumulate in the brain. Experimental approaches are essential to understand how those harmful chemicals enter children’s brain and pose discrete effects on specific brain sites. These approaches include the following: improvement of technologies for the detection and measurement of neuroendocrinological and behavioral changes in animal models: development of analytical methods for the identification and quantification of chemicals and their metabolites in the brain; development of in vitro cell line assays; and imaging technologies to illustrate cellular functions. In this research topic, we collected articles that provide state-of-the-art science and technologies that can help us identify environmental chemicals that influence brain development. We also included articles that lead to a better understanding of the actions and dynamics of these chemicals. The articles in this research topics supplied novel information about harmful endpoints of environmental chemicals. The reviews demonstrated the typical and novel interactions between environmental chemicals and the developing brain. We believe that these studies would lead to further understanding of neurodevelopmental disorders caused by environmental factors.

Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis

Anonim
Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis Book PDF

Author : Anonim
Publisher : Academic Press
Page : 255 pages
File Size : 42,5 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780124047440

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Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis by Anonim Pdf

This special volume of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis. Contributions from leading authorities Informs and updates on all the latest developments in the field