Mitochondrial Dysfunction Caused By Drugs And Environmental Toxicants

Author : Yvonne Will,James A. Dykens
Publisher : John Wiley & Sons
Page : 816 pages
File Size : 40,7 Mb
Release : 2018-03-23
Category : Science
ISBN : 9781119329749

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Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants by Yvonne Will,James A. Dykens Pdf

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Author : Yvonne Will,James A. Dykens
Publisher : John Wiley & Sons
Page : 816 pages
File Size : 41,6 Mb
Release : 2018-03-21
Category : Science
ISBN : 9781119329732

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Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants by Yvonne Will,James A. Dykens Pdf

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Author : James A. Dykens,Yvonne Will
Publisher : John Wiley & Sons
Page : 648 pages
File Size : 43,6 Mb
Release : 2008-09-11
Category : Science
ISBN : 9780470372524

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Drug-Induced Mitochondrial Dysfunction by James A. Dykens,Yvonne Will Pdf

This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.

Author : Lawrence H. Lash,Dean P. Jones
Publisher : Elsevier
Page : 528 pages
File Size : 45,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483218618

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Mitochondrial Dysfunction by Lawrence H. Lash,Dean P. Jones Pdf

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Author : Jalal Pourahmad,Mohsen Rezaei
Publisher : Academic Press
Page : 316 pages
File Size : 54,9 Mb
Release : 2021-07-28
Category : Science
ISBN : 9780128224090

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Mitochondrial Metabolism by Jalal Pourahmad,Mohsen Rezaei Pdf

Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 42,5 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Author : Ana Cristina Andreazza,Gustavo Scola
Publisher : BoD – Books on Demand
Page : 246 pages
File Size : 42,5 Mb
Release : 2015-07-08
Category : Medical
ISBN : 9789535121404

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Toxicology Studies by Ana Cristina Andreazza,Gustavo Scola Pdf

The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed. Since the bioactivation of many toxins and toxicants and its consequences on human health are not clearly known, this book offers a quick overview of cellular toxicology through the cell, drug and environmental toxicity. This book does not strive to be comprehensive but instead offers a quick overview of principle aspects of toxins and toxicants in order to familiarize the key principles of toxicology. The book is divided into three main sections,; the first one discusses the role of mitochondrial dysfunction, oxidative stress and mitochondrial drug development. The second and third sections bring light to forensic toxicology and drug poisoning followed by environmental toxicity.

Author : Richard H. Haas
Publisher : MDPI
Page : 268 pages
File Size : 40,7 Mb
Release : 2019-10-01
Category : Science
ISBN : 9783039213276

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Mitochondrial Dysfunction in Aging and Diseases of Aging by Richard H. Haas Pdf

This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.

Author : Marcos Roberto de Oliveira
Publisher : Elsevier
Page : 800 pages
File Size : 54,7 Mb
Release : 2022-11-30
Category : Science
ISBN : 9780323884631

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Mitochondrial Intoxication by Marcos Roberto de Oliveira Pdf

Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. Features a wide range of toxicants and their effects on mitochondrial physiology Covers molecular markers of mitochondrial intoxication Includes case studies that illustrate the health impacts of toxicity upon mitochondria Considers future directions regarding the study of mitochondrial intoxication

Author : Jaime M. Ross,Giuseppe Coppotelli,Lars Olson
Publisher : MDPI
Page : 543 pages
File Size : 42,8 Mb
Release : 2018-09-28
Category : Electronic book
ISBN : 9783038422518

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Mitochondrial Dysfunction in Ageing and Diseases by Jaime M. Ross,Giuseppe Coppotelli,Lars Olson Pdf

This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS

Author : Eylem Taskin,Celal Guven,Yusuf Sevgiler
Publisher : BoD – Books on Demand
Page : 498 pages
File Size : 50,8 Mb
Release : 2018-08-29
Category : Medical
ISBN : 9781789236743

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Mitochondrial Diseases by Eylem Taskin,Celal Guven,Yusuf Sevgiler Pdf

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Author : Dr. Joseph Mercola
Publisher : Hay House, Inc
Page : 218 pages
File Size : 45,9 Mb
Release : 2019-04-30
Category : Health & Fitness
ISBN : 9781401956790

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KetoFast by Dr. Joseph Mercola Pdf

From Dr. Joseph Mercola, one of the world's foremost authorities on alternative health: a guide to using the principles of ketogenic eating, meal planning, and timing to treat disease, promote weight loss, and optimize health. We all know that food is medicine--yet going without food is one of the single best things you can do for your health. Short, doable fasts, when strategically timed, are an incredibly powerful metabolic intervention, dovetailing perfectly with a ketogenic diet to activate your body's fat-burning mode. This in turn can ward off insulin resistance, reduce oxidative stress and inflammation, optimize brain function, prevent neurological problems, support weight loss, and more. In this in-depth yet accessible guide, Dr. Joseph Mercola explores the profound health benefits that result when ketogenic living and well-planned fasting are combined. Topics include: • How our food is making us sick and what we can do about it • The physiology and mechanisms of fasting, including stem cell activation • How the cyclical ketogenic diet--with fasting included--differs from the conventional keto diet • How fasting works and how safe it is for you • How regular one-day fasts support fat burning and detoxification while minimizing hunger and side effects • How to monitor your progress with lab tests • And much more "This will be an exciting journey for you," Dr. Mercola writes. "I am beyond excited for you to implement what I consider to be one of the most powerful physical strategies to help you not only recover your health, but also improve it to levels you likely never believed were possible."

Author : Thomas Seyfried
Publisher : John Wiley & Sons
Page : 482 pages
File Size : 52,8 Mb
Release : 2012-05-18
Category : Science
ISBN : 9781118310304

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Cancer as a Metabolic Disease by Thomas Seyfried Pdf

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Author : John N. Hathcock
Publisher : Unknown
Page : 328 pages
File Size : 48,6 Mb
Release : 1982
Category : Food
ISBN : CHI:27597848

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Nutritional Toxicology by John N. Hathcock Pdf

Author : Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
Publisher : John Wiley & Sons
Page : 584 pages
File Size : 47,7 Mb
Release : 2016-03-22
Category : Medical
ISBN : 9781119053392

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Drug Discovery Toxicology by Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy Pdf

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices