Mitochondrial Dysfunction In Aging And Diseases Of Aging

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Mitochondrial Dysfunction in Aging and Diseases of Aging

Richard H. Haas
Mitochondrial Dysfunction in Aging and Diseases of Aging Book PDF

Author : Richard H. Haas
Publisher : MDPI
Page : 268 pages
File Size : 54,8 Mb
Release : 2019-10-01
Category : Science
ISBN : 9783039213276

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Mitochondrial Dysfunction in Aging and Diseases of Aging by Richard H. Haas Pdf

This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.

Mitochondrial Dysfunction in Ageing and Diseases

Jaime M. Ross,Giuseppe Coppotelli,Lars Olson
Mitochondrial Dysfunction in Ageing and Diseases Book PDF

Author : Jaime M. Ross,Giuseppe Coppotelli,Lars Olson
Publisher : MDPI
Page : 543 pages
File Size : 41,6 Mb
Release : 2018-09-28
Category : Electronic book
ISBN : 9783038422518

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Mitochondrial Dysfunction in Ageing and Diseases by Jaime M. Ross,Giuseppe Coppotelli,Lars Olson Pdf

This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS

Mitochondrial Dysfunction in Aging and Diseases of Aging

Richard H. Haas
Mitochondrial Dysfunction in Aging and Diseases of Aging Book PDF

Author : Richard H. Haas
Publisher : Unknown
Page : 1 pages
File Size : 51,5 Mb
Release : 2019
Category : Electronic books
ISBN : 3039213288

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Mitochondrial Dysfunction in Aging and Diseases of Aging by Richard H. Haas Pdf

This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.

Mitochondrial Dysfunction

Lawrence H. Lash,Dean P. Jones
Mitochondrial Dysfunction Book PDF

Author : Lawrence H. Lash,Dean P. Jones
Publisher : Elsevier
Page : 528 pages
File Size : 48,7 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483218618

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Mitochondrial Dysfunction by Lawrence H. Lash,Dean P. Jones Pdf

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

The Mitochondrion in Aging and Disease

Anonim
The Mitochondrion in Aging and Disease Book PDF

Author : Anonim
Publisher : Academic Press
Page : 290 pages
File Size : 48,7 Mb
Release : 2014-08-19
Category : Science
ISBN : 9780123948403

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The Mitochondrion in Aging and Disease by Anonim Pdf

Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed. Reviews current topics of interest Written by experts in the field

Mitochondrial Dysfunction and Nanotherapeutics

Marcos Roberto de Oliveira
Mitochondrial Dysfunction and Nanotherapeutics Book PDF

Author : Marcos Roberto de Oliveira
Publisher : Academic Press
Page : 602 pages
File Size : 43,6 Mb
Release : 2021-07-15
Category : Science
ISBN : 9780323886185

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Mitochondrial Dysfunction and Nanotherapeutics by Marcos Roberto de Oliveira Pdf

Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. Contains detailed information on mitochondrial dysfunction Reviews our current understanding of the role of mitochondria in aging Includes coverage of specific conditions, including sports and affective disorders, among others Discusses mitochondria targeted delivery of therapeutic compounds

Mitochondria Dysfunction

Tailor Fran
Mitochondria Dysfunction Book PDF

Author : Tailor Fran
Publisher : Independently Published
Page : 0 pages
File Size : 48,8 Mb
Release : 2024-02-12
Category : Self-Help
ISBN : 9798879422375

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Mitochondria Dysfunction by Tailor Fran Pdf

Attention: We all age, and with it comes a decline in health. But have you ever considered the tiny powerhouses lurking inside your cells, playing a pivotal role in this process? 'Mitochondria dysfunction: The unexpected roles of Mitochondria in Aging and Diseases' delves into the fascinating and often surprising world of these cellular power plants, revealing their profound impact on your health and longevity. Interest: Imagine mitochondria as tiny factories fueled by oxygen and nutrients, generating the energy that keeps your body ticking. But what happens when these factories malfunction? This book unveils the unexpected ways in which mitochondrial dysfunction contributes to not just aging, but also a spectrum of diseases, from neurodegenerative disorders like Alzheimer's and Parkinson's to chronic conditions like heart disease and diabetes. Desire: This isn't just a scientific exploration; it's a guide to understanding your own health. You'll discover the latest research on how lifestyle choices, diet, and even exercise can influence mitochondrial function, potentially slowing down the aging process and reducing your risk of disease. The book empowers you to become an active participant in your own well-being, offering evidence-based strategies for optimizing your cellular powerhouses. Action: Forget fad diets and quick fixes. This book equips you with the knowledge to make informed decisions about your health. You'll learn about cutting-edge research in areas like mitochondrial-targeted therapies, offering a glimpse into the future of personalized medicine focused on rejuvenating your cellular powerhouses. 'More than just understanding aging and disease, this book empowers you to take control of your health and unlock the potential for a longer, healthier life.'

Mitochondria and the Future of Medicine

Lee Know
Mitochondria and the Future of Medicine Book PDF

Author : Lee Know
Publisher : Chelsea Green Publishing
Page : 274 pages
File Size : 42,9 Mb
Release : 2018
Category : MEDICAL
ISBN : 9781603587679

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Mitochondria and the Future of Medicine by Lee Know Pdf

With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Mitochondrial Dysfunction: A Functional Medicine Approach to Aging and Diseases

John Binnington
Mitochondrial Dysfunction A Functional Medicine Approach to Aging and Diseases Book PDF

Author : John Binnington
Publisher : Foster Academics
Page : 0 pages
File Size : 51,7 Mb
Release : 2023-09-26
Category : Medical
ISBN : 1646465598

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Mitochondrial Dysfunction: A Functional Medicine Approach to Aging and Diseases by John Binnington Pdf

Mitochondria are double-membrane-bound organelles found in eukaryotic cells. They build cable-like structures and deliver energy to cells with the help of oxidative phosphorylation (OXPHOS) process. Aging causes a wide range of interrelated conditions and is also a leading cause of various human diseases. The age-associated changes in mitochondria are linked with deterioration in mitochondrial function. The accumulation of oxidative damage and mutations caused by reactive oxygen species (ROS), mitochondrial functionality, and DNA volume and integrity decline with age. Mitochondrial dysfunction includes an increase in oxidative damage and a reduction in oxidative capacity, and plays a significant role in biological aging. The accumulation of dysfunctional mitochondria occurs in all the tissues with aging, including brain, liver and skeletal muscle. These dysfunctional mitochondria are marked and removed through an autophagic process named mitophagy. Mitochondrial dysfunction occurs in many neurodegenerative diseases such as Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), Friedreich's ataxia (FRDA) and Alzheimer's disease (AD). This book explores all the important aspects of mitochondrial dysfunction and its impact on aging and diseases. Experts and students actively engaged in researches on mitochondrial dysfunction will find it full of crucial and unexplored concepts.

Mitochondrial Communication in Physiology, Disease and Aging

Nuno Raimundo,Anita Krisko
Mitochondrial Communication in Physiology Disease and Aging Book PDF

Author : Nuno Raimundo,Anita Krisko
Publisher : Frontiers Media SA
Page : 135 pages
File Size : 42,6 Mb
Release : 2019-08-20
Category : Electronic
ISBN : 9782889459636

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Mitochondrial Communication in Physiology, Disease and Aging by Nuno Raimundo,Anita Krisko Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Aging and Age-Related Disorders

Stephen Bondy,Kenneth Maiese
Aging and Age Related Disorders Book PDF

Author : Stephen Bondy,Kenneth Maiese
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 45,7 Mb
Release : 2010-09-02
Category : Medical
ISBN : 9781607616023

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Aging and Age-Related Disorders by Stephen Bondy,Kenneth Maiese Pdf

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.

Understanding the Process of Aging

Lester Packer
Understanding the Process of Aging Book PDF

Author : Lester Packer
Publisher : CRC Press
Page : 384 pages
File Size : 42,9 Mb
Release : 1999-01-12
Category : Medical
ISBN : 9781482292947

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Understanding the Process of Aging by Lester Packer Pdf

This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the researc

Mitochondrial Dynamics in Cardiovascular Medicine

Gaetano Santulli
Mitochondrial Dynamics in Cardiovascular Medicine Book PDF

Author : Gaetano Santulli
Publisher : Springer
Page : 646 pages
File Size : 42,9 Mb
Release : 2017-05-25
Category : Science
ISBN : 9783319553306

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Mitochondrial Dynamics in Cardiovascular Medicine by Gaetano Santulli Pdf

This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Handbook of Research on Critical Examinations of Neurodegenerative Disorders

Uddin, Md. Sahab,Amran, Md. Shah
Handbook of Research on Critical Examinations of Neurodegenerative Disorders Book PDF

Author : Uddin, Md. Sahab,Amran, Md. Shah
Publisher : IGI Global
Page : 597 pages
File Size : 42,5 Mb
Release : 2018-07-31
Category : Medical
ISBN : 9781522552833

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Handbook of Research on Critical Examinations of Neurodegenerative Disorders by Uddin, Md. Sahab,Amran, Md. Shah Pdf

Neurodegeneration is a key feature of several diseases that are referred to as neurodegenerative diseases. The process of neurodegeneration is not well-understood so the diseases that stem from it have, as yet, no cures. As such, studying the effects of these disorders can provide insight into the treatment, prevention, and future opportunities and challenges in this growing field. The Handbook of Research on Critical Examinations of Neurodegenerative Disorders is a critical scholarly resource that provides an extensive explanation of various neurodegenerative disorders based on existing studies to clarify etiology, pathological mechanisms, diagnosis, therapeutic interventions, as well as current status and future opportunities and challenges. Featuring coverage on a broad range of topics such as dementia, mitochondrial dysfunction, and risk factors, this book is geared towards neurobiologists, neuropsychologists, neurophysiologists, neuropathologists, medical professionals, academicians, and researchers seeking research on the complexity of neurodegenerative disorders.

Oxidative Stress in Mitochondria Disorders of Aging

M. Ebadi
Oxidative Stress in Mitochondria Disorders of Aging Book PDF

Author : M. Ebadi
Publisher : Unknown
Page : 0 pages
File Size : 51,6 Mb
Release : 2001
Category : Aging
ISBN : 3805572360

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Oxidative Stress in Mitochondria Disorders of Aging by M. Ebadi Pdf

Neurons are particularly vulnerable to age-associated decline in mitochondrial function due to their high energy demand. Thus, several models are proposed implicating mtDNA damage and mutation, and subsequent mitochondrial dysfunction, as an underlying factor in a substantial number of human pathologies including aging, neurodegenerative and neuromuscular diseases, and ischemia-reperfusion injury. Furthermore, the results of clinical, biochemical and molecular biology studies suggest that defective mitochondria contribute to neurodegenerative diseases in humans. For example, Friedreich's ataxia exhibits mitochondrial iron overload, Huntington's disease is characterized by defects in mitochondrial oxidative phosphorylation and aconitase deficiency, Parkinson's disease is associated with a deficiency in mitochondrial complex I activity, and Alzheimer's disease exhibits cytochrome oxidase deficiency. Neurologists, psychiatrists and biochemists will profit most from this special issue.