Mobile Genetic Elements

Author : James Shapiro
Publisher : Elsevier
Page : 707 pages
File Size : 47,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323143196

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Mobile Genetic Elements by James Shapiro Pdf

Mobile Genetic Elements introduces the nonspecialist to the biology and genetics of mobile elements. It attempts to make the biochemistry of DNA rearrangements more accessible to embryologists and evolutionists, and to illuminate the related developmental cycles to the biochemist. The book also shows how natural the activity of mobile elements can be in diverse biological situations. The chapters describe several well-studied cases in which genetic determinants—often identified as specific nucleic acid sequences—repeatedly change their positions within or between cellular genomes. Because their genomic positions are not fixed, these determinants may conveniently be classed together under the rubric of mobile genetic elements. The book begins with a discussion of maize controlling elements. This is followed by separate chapters on the bacteriophages ? and Mu; nonviral mobile elements in bacteria; transposable Ty elements in brewer's yeast; Drosophila transposable element; and hybrid dysgenesis. Subsequent chapters cover vertebrate retroviruses; Agrobacterium oncogenesis in plants; flagellar phase variation in Salmonella; yeast mating type; and surface antigenic variation in trypanosomes.

Author : Paul J. Brindley
Publisher : CRC Press
Page : 138 pages
File Size : 50,5 Mb
Release : 2009-10-28
Category : Science
ISBN : 9781498712880

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Mobile Genetic Elements in Metazoan Parasites by Paul J. Brindley Pdf

Substantial proportions of the genome of most eukaryotes, including those of metazoan parasites, are comprised of repetitive sequences. Mobile genetic elements (MGEs) constitute much of the repetitive component, particularly the interspersed sequences. This volume of nine chapters addresses MGEs that have colonized the genomes of medically importan

Author : Wolfgang J. Miller,Pierre Capy
Publisher : Springer Science & Business Media
Page : 295 pages
File Size : 41,9 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781592597550

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Mobile Genetic Elements by Wolfgang J. Miller,Pierre Capy Pdf

Leading experts describe in step-by-step detail their most productive transposon-based methods and strategies for studying genome structure, function, and evolution. These readily reproducible techniques cover a wide range, including mutagenesis, transgenesis, gene silencing, and molecular systematics. Among the highlights are a series of DNA hybridization methods for analyzing the distribution and dynamics of mobile DNA at the hosts' genomic level, techniques for studying LTR retrotransposons in heterologous host systems, and mutagenesis protocols for investigating gene functions in a broad range of organisms. These cutting-edge methods offer investigators powerful genetic tools for dissecting the function of a specific gene, elaborating on the mechanisms leading to genetic change and diversity, and studying the evolutionary impact of mobile DNA on the biology and evolution of organisms.

Author : Michael Chandler,Martin Gellert,Alan M. Lambowitz,Phoebe A. Rice,Suzanne B. Sandmeyer
Publisher : John Wiley & Sons
Page : 1321 pages
File Size : 42,9 Mb
Release : 2020-07-24
Category : Science
ISBN : 9781555819217

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Mobile DNA III by Michael Chandler,Martin Gellert,Alan M. Lambowitz,Phoebe A. Rice,Suzanne B. Sandmeyer Pdf

An exploration of the raw power of genetic material to refashion itself to any purpose... Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability. Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible presents a detailed account of the many different recombination systems that can rearrange genomes examines the tremendous impact of mobile DNA in virtually all organisms Mobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms. Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.

Author : Adam P. Roberts,Peter Mullany
Publisher : CRC Press
Page : 456 pages
File Size : 55,7 Mb
Release : 2022-03-07
Category : Science
ISBN : 9781000724707

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Bacterial Integrative Mobile Genetic Elements by Adam P. Roberts,Peter Mullany Pdf

As our understanding of mobile genetic elements continues to grow we are gaining a deeper appreciation of their importance in shaping the bacterial genome and in the properties they confer to their bacterial hosts. These include, but are by no means limited to, resistance to antibiotics, and heavy metals, toxin production and increased virulence, production of antibiotics and the ability to utilize a diverse range of metabolic substrates. We are also gaining an understanding of diversity of these elements and their interactions with each other; a property which continually complicates any attempt to classify them. We are learning more about the molecular mechanisms by which they translocate to new genomic sites both within genomes and between different bacteria. This book provides a timely, state of the art update on the properties of an important selection of different bacterial integrative mobile genetic elements and the myriad of different ways in which they move and influence the biology of the host bacterium. The chapters are all written by authors who have undertaken pioneering work in their respective fields, making this book vital reading for all who are interested in the biology of bacteria and the mobile elements they carry.

Author : Yves Bigot
Publisher : Humana Press
Page : 308 pages
File Size : 41,7 Mb
Release : 2012-02-25
Category : Medical
ISBN : 1617796042

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Mobile Genetic Elements by Yves Bigot Pdf

Transposable elements are used as genetic tools for dissecting the function of a specific gene and elaborating on mechanisms leading to genetic change and diversity, and the evolutionary impact of mobile DNA on the biology and evolution of organism. In, Mobile Genetic Elements: Protocols and Genomic Applications, Second Edition gathers a wide array of strategies and protocols for identifying transposable elements (TEs) and their evolutionary derivatives, and for studying genome structure, function, and evolution. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Through and intuitive Mobile Genetic Elements: Protocols and Genomic Applications, Second Edition aids scientists in the continuing study of in silico tools, strategies and protocols that are complementary of those described in the first volume.

Author : Tammy A. Morrish,Jose Luis García Pérez
Publisher : Frontiers Media SA
Page : 123 pages
File Size : 41,5 Mb
Release : 2018-01-16
Category : Electronic
ISBN : 9782889453894

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Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer by Tammy A. Morrish,Jose Luis García Pérez Pdf

The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS). To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.

Author : Haig H. Kazazian
Publisher : FT Press
Page : 287 pages
File Size : 42,9 Mb
Release : 2011
Category : Business planning
ISBN : 8210379456XXX

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Mobile DNA: Finding Treasure in Junk by Haig H. Kazazian Pdf

Annotation What we now know about mobile DNA--and the substantial roles it plays in humans, animals, and plants. & bull; & bull;Mobile DNA accounts for more than half of our genome: This book explains the important role it plays in shaping evolutionary change. & bull;A rich, thorough, and accessible introduction for all serious students, practitioners, and researchers in human and medical genetics, molecular biology, or evolutionary biology. & bull;By one of the field's leading researchers, Dr. Haig Kazazian. This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms--from plants and animals to humans. Highly regarded geneticist Haig Kazazian offers an accessible intellectual history of the field's research strategies and concerns, explaining how advances opened up new questions, and how new tools and capabilities have encouraged progress in the field. Kazazian introduces the key strategies and approaches taken in leading laboratories (including his own) to gain greater insight into the large proportion of our genome that derives from mobile genetic elements, including viruses, plasmids, and transposons. He also presents intriguing insights into long-term research strategies that may lead to an even deeper understanding.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 45,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Austin BURT,Robert Trivers,Austin Burt
Publisher : Harvard University Press
Page : 613 pages
File Size : 46,8 Mb
Release : 2009-06-30
Category : Science
ISBN : 9780674029118

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Genes in Conflict by Austin BURT,Robert Trivers,Austin Burt Pdf

Covering all species from yeast to humans, this is the first book to tell the story of selfish genetic elements that act narrowly to advance their own replication at the expense of the larger organism.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 49,5 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1368439880

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Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer by Anonim Pdf

The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a "copy and paste" mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS).To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.

Author : Douglas E. Berg
Publisher : Amer Society for Microbiology
Page : 972 pages
File Size : 48,6 Mb
Release : 1989-01
Category : Medical
ISBN : 1555810055

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Mobile DNA by Douglas E. Berg Pdf

Documents the remarkable mobility of DNA in procaryotic and eucaryotic genomes: the ability of various DNA segments to move to new sites, to invert, and to undergo deletion or amplification, generally without the extensive DNA sequence homology needed for classical recombination. Seventy contributors explore the mechanisms of these rearrangements, how they are regulated, their biological consequences, and their potential use as research tools. For students and researchers of molecular genetics. Annotation copyrighted by Book News, Inc., Portland, OR

Author : Hiromi Nishida,Taku Oshima
Publisher : Springer
Page : 278 pages
File Size : 41,5 Mb
Release : 2019-02-21
Category : Science
ISBN : 9789811334115

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DNA Traffic in the Environment by Hiromi Nishida,Taku Oshima Pdf

This book comprehensively discusses our current understanding of the role and biological mechanisms of horizontal transfer of genetic elements in the environment, which has been important in the evolution of prokaryotes (archaea and bacteria). Horizontal transfer of genetic elements generates variations of prokaryotes and their genomes. Comparative studies of genomes revealed that it frequently occurred during archaeal and bacterial evolution. The book introduces a variety of studies related to horizontal gene transfer, gene silencing, plasmids, phages, transposons, and the emergence of microbes that degrade man-made xenobiotics and have antimicrobial resistance. Written by leading researchers in DNA traffic, the book is a valuable guide to horizontal transfer for both young scientists and experts in the field.

Author : Christopher M. Thomas
Publisher : CRC Press
Page : 459 pages
File Size : 48,7 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203304334

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Horizontal Gene Pool by Christopher M. Thomas Pdf

Bacteria are the most ubiquitous of all organisms. Responsible for a number of diseases and for many of the chemical cycles on which life depends, they are genetically adaptable. Vital to this adaptability is the existence of autonomous genetic elements-plasmids-which promote genetic exchange and recombination. The genes carried by any particular plasmid may be found in only a few individuals of any species but can also be shared with other species and thus constitute a horizontal gene pool. This book explains the various contributions that plasmids make to this pool: the replication, stable inheritance and transfer modules, the phenotypic markers they carry, the way they evolve, the ways they contribute to their host population and the approaches that we use to study and classify them. It also looks at what we know about their activity in natural communities and the way that they interact with other mobile elements to promote bacterial evolution.

Author : Joao Carlos Setubal,Peter F. Stadler,Jens Stoye
Publisher : Humana
Page : 0 pages
File Size : 50,7 Mb
Release : 2024-06-22
Category : Science
ISBN : 1071638378

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Comparative Genomics by Joao Carlos Setubal,Peter F. Stadler,Jens Stoye Pdf

This second edition provides new and updated chapters covering computational and mathematical techniques and concepts related to the field of comparative genomics. The topics covered in the chapters range from those that address general techniques and concepts that apply to all organisms to others that are specialized and apply to specific biological systems such as viruses, bacteria, nematodes, and insects. Well-known comparative genomics web-based platforms are also covered in specific chapters. Written in the highly successful Methods in Molecular Biology series format, many chapters include introductions to their respective topics and step-by-step comparison procedures, demonstrated on actual sets of genome sequences. Authoritative and cutting-edge, Comparative Genomics: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.