Model Systems Of Development And Aging Of The Nervous System

Author : Antonia Vernadakis,Alain M. Privat,Jean M. Lauder,Paola S. Timiras
Publisher : Springer Science & Business Media
Page : 513 pages
File Size : 40,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461320371

Get Book

Model Systems of Development and Aging of the Nervous System by Antonia Vernadakis,Alain M. Privat,Jean M. Lauder,Paola S. Timiras Pdf

The last decade has generated a multitude of studies using in vitro model systems to explore growth and differentiation of the nervous system. Although the findings have been exciting and have revealed unique properties of neural cells, considerable concern continues to be expressed regarding the significance of in vitro findings in terms of their applicability to in vivo biological events. To examine this issue further, a group of scientists pre sented and discussed their findings at a conference sponsored by the Institute of Developmental Neuroscience and Aging held in Crete, Greece, 26-29 May 1985. The conference was cosponsored by the University of Crete and was generously supported by the Ministry of Research and Technology of Greece, Tourism Organization of Greece, and also Sandoz and FIDIA. The Directors of the Institute of Developmental Neuroscience and Aging are indebted to these Institutions for their support. For the success of this conference, the Directors owe much to Drs. Eleni Fleischer-Lambropoulos and Yiannis Tsouderos, who spent countless hours in making arrangements so that the participants would have not only a scientific, but also a unique cultural, experience. Several chapters of this book focus on the complex phenomena of neurogenesis and gliogenesis, and the modulation of neuronal differentiation. The concept that neuronal differentiation has both genetic and epigenetic components is documented by elegant studies using both in vitro cultured cells and neurons transplanted in vivo.

Author : Jean Lauder
Publisher : Springer Science & Business Media
Page : 326 pages
File Size : 45,8 Mb
Release : 2013-11-21
Category : Science
ISBN : 9781475758764

Get Book

Molecular Aspects of Development and Aging of the Nervous System by Jean Lauder Pdf

The rapidly expanding fields of molecular and cellular neurobiology are the newest frontiers of neuroscience. This book represents the continuing efforts of the Institute of Developmental Neuroscience and Aging (IDNA) to disseminate the most recent advances on the developing and aging nervous system at the molecular and cellular levels. A group of neuroscientists presented and discussed their findings at a recent IDNA conference held in Athens, Greece, June 15-18, 1988. This meeting was sponsored by the National Hellenic Research Foundation, FIDIA, the Ministry of Research and Technology, the Tourism Organization of Greece, and the National Institute of Child Health and Human Development, NIH. The Directors of the IDNA are grateful to the local committee, Drs. Eleni Fleischer, Costas Sekeris, Michael Alexis, Theony Valcana, and Elias Kouvelas, for their efforts in organizing this meeting and for their successful integration of science and culture for the participants. This volume provides a comprehensive overview of the information presented at this conference, including in-depth discussions of each topic by the participants. The chapters are grouped into five general categories which correspond to the subject areas covered during the meeting. These include: Gene and Phenotypic Expression, Growth Factors and Oncogenes, Cytoskeletal and Extracellular Molecules, Neurotransmitters and Hormones, and Molecular Aspects of Aging and Alzheimer's Disease. The section on Gene and Phenotypic Expression includes discussions of transient gene expression in the nervous system (Herschman), developmental regulation of myelin-associated genes (Gordon et al.

Author : Morris Rockstein
Publisher : Elsevier
Page : 231 pages
File Size : 41,6 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323159661

Get Book

Development and Aging in the Nervous System by Morris Rockstein Pdf

Development and Aging in the Nervous System covers the proceedings of a series of symposia by the same title, held at the University of Miami Training Program in Cellular Aging on February 19-20, 1973. This book is composed of 11 chapters that specifically consider aging in its total sense, from embryonic development through senescence of a vital organ system of the body. The introductory chapters review the age changes in the neuronal microenvironment and the regulative mechanism of neuronal death in cell number control in the nervous system. The next chapters deal with the neuronal degeneration in aging mammals, the selected changes in the developing postnatal rat, and the trophic influences in the mammalian central nervous system. These topics are followed by discussions of the genesis of neuronal locus specificity, the vertebrate brain aging, and the neurochemical patterns in the developing and aging brain. The remaining chapters describe the mechanisms of enzymatic differentiation in the brain and in cultured cells and the monoamine metabolism in the aging male mouse. This book will prove useful to development and cell biologists, researchers, and advance students.

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 44,9 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292

Get Book

Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Author : Joy Alcedo,Thomas Flatt,Elena G. Pasyukova
Publisher : Frontiers
Page : 136 pages
File Size : 47,8 Mb
Release : 2013-08-23
Category : Electronic
ISBN : 9782889191604

Get Book

Neuronal Inputs and Outputs of Aging and Longevity by Joy Alcedo,Thomas Flatt,Elena G. Pasyukova Pdf

An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environments. This is achieved through intercellular communication not only within a single tissue but also among different tissues and organ systems. Thus, alterations in tissue-to-tissue or organ-to-organ communications, which are under genetic regulation, can affect organismal homeostasis, and consequently impact the aging process. One of the organ systems that play a major role in maintaining homeostasis is the nervous system. Considering that the nervous system includes the sensory system, which perceives the complexity of an animal’s environment, it should be no surprise that there would be a sensory influence on homeostasis and aging. To promote homeostasis, any given sensory information is transmitted through short-range signals via neural circuits and/or through long-range endocrine signals to target tissues, which may in turn be neuronal or non-neuronal in nature. At the same time, since homeostasis involves a number of feedback mechanisms, non-neuronal tissues can also modulate sensory and other neuronal functions. Several genes that regulate signaling pathways known to affect homeostasis and aging have been shown to act in neurons, in tissues that are likely downstream targets of the nervous system, or through feedback regulation of neuronal activities. These genes can have different temporal requirements: some might function early, e.g., by affecting neural development, while others may only be required later in adulthood. Some well-known examples of genes involved in the neuronal regulation of homeostasis and longevity encode components of the evolutionarily conserved nutrient-sensing insulin/insulin-like signaling pathway, the stress-sensing internal repair system, and the mitochondrial electron transport chain. Indeed, the genetic perturbation of these pathways has been found to lead to numerous diseases, many of which are age-related and involve the nervous system, such as neurodegeneration and the metabolic syndrome. Despite much progress, however, many aspects of the neuronal inputs and outputs that affect aging and longevity are poorly understood to date. For example, the precise neuronal and non-neuronal circuitries and the details of the molecular mechanisms through which genes/signaling pathways maintain homeostasis and affect aging in response to the environment remain to be elucidated. Similarly, it is presently unclear whether genes that regulate the early development of the nervous system and its consequent circuitry influence homeostasis and longevity during adulthood. At the same time, although many genes affecting aging are conserved, both the nervous system and the aging process are highly variable within populations and among taxa. Accordingly, the role of natural genetic variation in shaping the neurobiology of aging is also presently unknown. The aim of this Research Topic is therefore to highlight the genetic, developmental, and physiological aspects of the signaling networks that mediate the neuronal inputs and outputs that are required to maintain organismal homeostasis. The elucidation of the effects of these neuronal activities on homeostasis may thus provide much-needed insight into mechanisms that affect aging and longevity.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 50,5 Mb
Release : 1973
Category : Electronic
ISBN : OCLC:1414841571

Get Book

Development and Aging in the Nervous System by Anonim Pdf

Author : Parthiv Haldipur,Paula Alexandre,Sumru Bayin
Publisher : Frontiers Media SA
Page : 167 pages
File Size : 50,5 Mb
Release : 2024-06-30
Category : Science
ISBN : 9782889767076

Get Book

Model Systems to Study the Mechanisms of Neural Development and Disease by Parthiv Haldipur,Paula Alexandre,Sumru Bayin Pdf

Author : Stephen W. Scheff
Publisher : Springer Science & Business Media
Page : 228 pages
File Size : 51,6 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781461327059

Get Book

Aging and Recovery of Function in the Central Nervous System by Stephen W. Scheff Pdf

The mammalian central nervous system is a remarkable structure which has attracted many new investigators, as evidenced by the dramatic increase in scientific publications dealing with neurobiology. Every day basic scientists conduct new and exciting experiments, resulting in remarkable discoveries des tined to help mankind. Unfortunately many of these new findings are slow to be accepted by the clinical world. This is especially true in the area of brain trauma, where the present prognosis is usually very poor. We have known for quite some time that the mammalian central nervous system is capable of compensating for severe damage in many different ways, and under some circumstances behav ioral compensation can be observed. However, much is still to be learned about the various factors and events that lead to functional recovery and those condi tions that do not. It is this challenge that originally excited a number of the contributors to this volume to explore the subject of recovery from brain damage. One factor in particular that is known to change the prognosis of recovery is the age of the organism at the time of the damage. This book is an attempt to explore this important variable. Most of the literature concerning aging deals with widespread degenerative changes and paints a grim picture for the aging central nervous system in terms of recovery of function following trauma.

Author : Francesco Amenta
Publisher : CRC Press
Page : 392 pages
File Size : 52,9 Mb
Release : 1993-06-16
Category : Science
ISBN : 0849369819

Get Book

Aging of the Autonomic Nervous System by Francesco Amenta Pdf

Aging of the Autonomic Nervous System is the first book devoted to the aging of the autonomic nervous system. The book presents the most recent findings on topics such as general aspects of the autonomic nervous system, main neurotransmitter systems, age-dependent changes of neuroeffector mechanisms in target organs, and therapeutic perspectives. It also provides a comprehensive analysis of the possible consequences of these findings. Aging of the Autonomic Nervous System will be a useful volume for gerontologists and neuroscientists.

Author : James F. Willott, PhD
Publisher : Springer Publishing Company
Page : 389 pages
File Size : 49,8 Mb
Release : 1999-07-25
Category : Medical
ISBN : 9780826117175

Get Book

Neurogerontology by James F. Willott, PhD Pdf

Neurogerontology tells the story of how the aging brain affects all aspects of cognition and physical performance. It comprehensively links the principles and substance of neuroscience with gerontology and psychology. Written largely from a behavioral neuroscience perspective, Neurogerontology explores the functional relationships between the central nervous system and psychological phenomena of aging, including perception, arousal, learning, cognition, and motor behavior. Willot emphasizes healthy aging, but dementia and other pathological conditions are discussed when relevant. This evidence-based approach to the neuroscience of aging makes this a valuable reference for professionals, as well as an informative textbook for students in gerontology courses.

Author : Bill E. Beckwith,Bibie M. Chronwall,Alois Saria,Curt A. Sandman,Fleur L Strand
Publisher : Unknown
Page : 0 pages
File Size : 41,9 Mb
Release : 2000-03-15
Category : Electronic
ISBN : 0801864364

Get Book

Neuropeptides in Development and Aging by Bill E. Beckwith,Bibie M. Chronwall,Alois Saria,Curt A. Sandman,Fleur L Strand Pdf

It has become increasingly clear that the central nervous system is not a passive entity determined by either environment or heredity. Rather, the brain appears to interact with its environment throughout early and late development and thereby contributes to its own structural and functional systems. This study focuses on the role played by neuropeptides in the ontogeny of nervous systems from conception through death. The authors begin with a review of the role of neuropeptides in the pathology of aging. They then examine the family of insect neuropeptides which controls development, with special attention to the gypsy moth. Other topics include the biosynthesis and processing of neuropeptides during development; the regulation of mitogenesis, cell survival, and embryonic growth; the role of target issues; and the role of neuropeptides in the ontogeny of the brain systems involved in the stress response. The authors' findings have important implications for understanding the biological underlay of adaptation and coping mechanisms as well as for model development and treatment.

Author : James E. Birren
Publisher : Unknown
Page : 248 pages
File Size : 42,9 Mb
Release : 1959
Category : Nervous system
ISBN : UOM:39015006025350

Get Book

The Process of Aging in the Nervous System by James E. Birren Pdf

Author : Paola S. Timiras,Alain M. Privat,Ezio Giacobini,Jean M. Lauder,Antonia Vernadakis
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 41,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468480474

Get Book

Plasticity and Regeneration of the Nervous System by Paola S. Timiras,Alain M. Privat,Ezio Giacobini,Jean M. Lauder,Antonia Vernadakis Pdf

Proceedings of the Third Conference of the Institute of Developmental Neuroscience and Aging, held in Torino, Italy, April 5-7, 1990

Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publisher : Unknown
Page : 0 pages
File Size : 44,8 Mb
Release : 2013-04-25
Category : Electronic
ISBN : 1947172808

Get Book

Anatomy and Physiology by J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Pdf

Author : Hans H. Althaus,Wilfried Seifert
Publisher : Springer Science & Business Media
Page : 807 pages
File Size : 50,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783642713811

Get Book

Glial-Neuronal Communication in Development and Regeneration by Hans H. Althaus,Wilfried Seifert Pdf

This comprehensive volume is a contribution to a new se ries initiated by the NATO Panel on "Gell to Gell Signals in Plants and Animals". The book reflects the outcome of an NATO work shop and bri ngs to mi nd two im portant questions: consideri ng the mass of relevant I iteratu reavai- able, is there any necessity for a new series of books - and considering the flood of compa rable meetings - is there any point in workshops of this nature and their publication? In order to deal with such questions adequately, much more space would be needed than is available in a foreword. Thus, the answers must remain rather superficial and, of course, rather subjective. To simplify the issue, the question of publication can be narrowed down to two fac tors - the financial risk, undertaken by the publisher, and the scientific risk, borne by the editor. If the book is good (with respect to lay-out and content) it will be a success - nothing will be lost the people involved will enhance their reputation! We are left with the question of the usefulness of workshops. Without doubt, it is indeed a useful procedure for experts to come together, in an atmosphere of harmony, and freedom from external pressures and time limitations, to discuss a well-defined theme. Wether in agreement or disagreement, a fair and open forum can be expectet for a variety of contributions.