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Modeling For Prediction Of Radiation Induced Toxicity To Improve Therapeutic Ratio In The Modern Radiation Therapy Era Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Modeling For Prediction Of Radiation Induced Toxicity To Improve Therapeutic Ratio In The Modern Radiation Therapy Era book. This book definitely worth reading, it is an incredibly well-written.
Author : Ester Orlandi,Tiziana Rancati,Giuseppe Sanguineti,Claudio Fiorino,Riccardo Valdagni
Publisher : Frontiers Media SA
Page : 389 pages
File Size : 47,5 Mb
Release : 2021-07-27
Category : Medical
ISBN : 9782889710881
Author : Tiziana Rancati,Claudio Fiorino
Publisher : CRC Press
Page : 399 pages
File Size : 42,8 Mb
Release : 2019-06-11
Category : Science
ISBN : 9781351983105
The treatment of a patient with radiation therapy is planned to find the optimal way to treat a tumour while minimizing the dose received by the surrounding normal tissues. In order to better exploit the possibilities of this process, the availability of accurate and quantitative knowledge of the peculiar responses of the different tissues is of paramount importance. This book provides an invaluable tutorial for radiation oncologists, medical physicists, and dosimetrists involved in the planning optimization phase of treatment. It presents a practical, accessible, and comprehensive summary of the field’s current research and knowledge regarding the response of normal tissues to radiation. This is the first comprehensive attempt to do so since the publication of the QUANTEC guidelines in 2010. Features: Addresses the lack of systemization in the field, providing educational materials on predictive models, including methods, tools, and the evaluation of uncertainties Collects the combined effects of features, other than dose, in predicting the risk of toxicity in radiation therapy Edited by two leading experts in the field
Author : Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 45,9 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9783642256042
Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
Author : Issam El Naqa,Ruijiang Li,Martin J. Murphy
Publisher : Springer
Page : 336 pages
File Size : 54,5 Mb
Release : 2015-06-19
Category : Medical
ISBN : 9783319183053
This book provides a complete overview of the role of machine learning in radiation oncology and medical physics, covering basic theory, methods, and a variety of applications in medical physics and radiotherapy. An introductory section explains machine learning, reviews supervised and unsupervised learning methods, discusses performance evaluation, and summarizes potential applications in radiation oncology. Detailed individual sections are then devoted to the use of machine learning in quality assurance; computer-aided detection, including treatment planning and contouring; image-guided radiotherapy; respiratory motion management; and treatment response modeling and outcome prediction. The book will be invaluable for students and residents in medical physics and radiation oncology and will also appeal to more experienced practitioners and researchers and members of applied machine learning communities.
Author : Jeffrey Y.C. Wong,Timothy E. Schultheiss,Eric H. Radany
Publisher : Springer
Page : 271 pages
File Size : 51,6 Mb
Release : 2017-04-20
Category : Medical
ISBN : 9783319532356
This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for radiation therapy delivery have created new treatment options for patients with localized and metastatic disease, highlighting the increasingly important role of image-guided radiotherapy in treating systemic and oligometastatic disease. Further topics include the potential value of radiotherapy in enhancing immunotherapy thanks to the broader immune-stimulatory effects, how cancer stem cells and the tumor microenvironment influence response, and the application of mathematical and systems biology methods to radiotherapy.
Author : X. Allen Li
Publisher : CRC Press
Page : 426 pages
File Size : 53,5 Mb
Release : 2011-01-27
Category : Medical
ISBN : 1439816352
Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging and radiation therapy. This book provides medical physicists and radiation oncologists current and relevant information on Adaptive Radiation Therapy (ART), a state-of-the-art approach that uses a feedback process to account for patient-specific anatomic and/or biological changes, thus delivering highly individualized radiation therapy for cancer patients. The book should also benefit medical dosimetrists and radiation therapists. Adaptive Radiation Therapy describes technological and methodological advances in the field of ART, as well as initial clinical experiences using ART for selected anatomic sites. Divided into three sections (radiobiological basis, current technologies, and clinical applications), the book covers: Morphological and biological biomarkers for patient-specific planning Design and optimization of treatment plans Delivery of IMRT and IGRT intervention methodologies of ART Management of intrafraction variations, particularly with respiratory motion Quality assurance needed to ensure the safe delivery of ART ART applications in several common cancer types / anatomic sites The technology and methodology for ART have advanced significantly in the last few years and accumulated clinical data have demonstrated the need for ART in clinical settings, assisted by the wide application of intensity modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT). This book shows the real potential for supplying every patient with individualized radiation therapy that is maximally accurate and precise.
Author : Anonim
Publisher : IOS Press
Page : 126 pages
File Size : 43,6 Mb
Release : 2005
Category : Medical
ISBN : 1586035258
Since the dawn of civilization, humans have feared the unknown risks associated with the use of new natural herbs or other natural medications to cure their pain, aches and illnesses. In the ancient Indian Ayurvedic Medicine which is over 4000 years old, the Visha (poison) Tantra (wisdom) was developed as a discipline of medicine encompassing Toxicology and Preventive Medicines. Visha Tantra included the study of various toxic herbs and animals and their antidotes as well as the biomarkers of toxic effects. In the Visha Tantra and the practice of Ayurvedic medicine, there have been objective descriptions of the changes in colour and amount of urine, changes in the colour of nails, skin and eyes, breathing patterns, gastrointestinal disturbances, and precautionary measures to prevent adverse effects as biomarkers of toxicity associated with the use of herbal medicines and certain foods. The adverse effects are an inevitable outcome of the environmental and industrial chemicals and pharmaceuticals; however, efforts are ongoing to prevent unexpected life-threatening toxicities and/or irreversible organ damage.The search for non-invasive biomarkers that can be objectively linked to adverse effects associated with manmade synthetic chemicals, including pharmaceuticals and environmental pollutants, is becoming an important priority for academicians, federal agencies, pharmaceutical and industrial companies. This publication is devoted to toxicity biomarkers of target organs of toxicity and molecular epidemiology. It provides a comprehensive review of a wide spectrum of biomarkers, including molecular epidemiology biomarkers of aflatoxin and hepatitis B virus induced hepatocarcinogenesis, cytokines as the biomarkers of hepatocellular injury, drug-induced vascular injury, nephrotoxicity and reproductive toxicity biomarkers.
Author : Francesco Cellini,Nicola Silvestris,Felipe A. Calvo,Konstantinos Kamposioras,Milly Buwenge
Publisher : Frontiers Media SA
Page : 267 pages
File Size : 55,7 Mb
Release : 2022-12-01
Category : Medical
ISBN : 9782832508237
Author : W. M. Edgar,D. M. O'Mullane
Publisher : Unknown
Page : 130 pages
File Size : 46,6 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015023425047
Author : International Atomic Energy Agency
Publisher : Unknown
Page : 297 pages
File Size : 55,5 Mb
Release : 2017-04-12
Category : Technology & Engineering
ISBN : 9201008155
Accuracy requirements in radiation oncology have been defined in multiple publications; however, these have been based on differing radiation technologies. In the meantime, the uncertainties in radiation dosimetry reference standards have been reduced and more detailed patient outcome data are available. No comprehensive literature on accuracy and uncertainties in radiotherapy has been published so far. The IAEA has therefore developed a new international consensus document on accuracy requirements and uncertainties in radiation therapy, to promote safer and more effective patient treatments. This publication addresses accuracy and uncertainty issues related to the vast majority of radiotherapy departments including both external beam radiotherapy and brachytherapy. It covers clinical, radiobiological, dosimetric, technical and physical aspects.
Author : Henning Willers,Iris Eke
Publisher : Springer Nature
Page : 370 pages
File Size : 41,6 Mb
Release : 2020-08-10
Category : Medical
ISBN : 9783030497019
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
Author : William Small,Gayle E. Woloschak
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 45,8 Mb
Release : 2006
Category : Medical
ISBN : 1402080530
Radiation Toxicity: A Practical Guide brings together renowned authors from leading cancer centers. Radiation, medical and surgical oncologists, nursing professionals, and members of radiation oncology teams will find this book an important reference.
Author : Carsten Nieder,Johannes Langendijk
Publisher : Springer
Page : 364 pages
File Size : 40,6 Mb
Release : 2016-10-25
Category : Medical
ISBN : 9783319418254
This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 41,6 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Author : International Atomic Energy Agency,Eduardo Zubizarreta
Publisher : Unknown
Page : 544 pages
File Size : 49,8 Mb
Release : 2017-11-28
Category : Medical
ISBN : 920115013X
Cancer treatment is complex and calls for a diverse set of services. Radiation therapy is recognized as an essential tool in the cure and palliation of cancer. Currently, access to radiation treatment is limited in many countries and non-existent in some. This lack of radiation therapy resources exacerbates the burden of disease and underscores the continuing health care disparity among States. Closing this gap represents an essential measure in addressing this global health equity problem. This publication presents a comprehensive overview of the major topics and issues to be taken into consideration when planning a strategy to address this problem, in particular in low and middle income countries. With contributions from leaders in the field, it provides an introduction to the achievements and issues of radiation therapy as a cancer treatment modality around the world. Dedicated chapters focus on the new radiotherapy technologies, proton beams, carbon ion, intraoperative radiotherapy, radiotherapy for children, treatment of HIV-AIDS malignancies, and costing and quality management issues.
