Modern Immunosuppressives

Author : H.-J. Schuurman,G. Feutren,J.-F. Bach
Publisher : Birkhäuser
Page : 218 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034883528

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Modern Immunosuppressives by H.-J. Schuurman,G. Feutren,J.-F. Bach Pdf

Expanding from the classic use of immunosuppressants in transplantation and rejection, this current overview highlights their new roles in clinical medicine. Immunosuppressants are at the forefront of new treatment modalities. Individual chapters focus on their use not only in prevention or treatment of transplant rejection, but also on their use in immune-complex and autoimmune diseases, including rheumatoid arthritis; on combination therapies to achieve synergy in immunosuppression; on new drugs, low molecular weight chemicals, the use of antibodies and gene therapy; on immunological tolerance to prevent or inhibit transplant rejection; and how data derived from transplant studies can be applied to other avenues of immunosuppression. Clinicians and researchers will appreciate the scope of the work and the presentation of new approaches in the rapidly developing field of immunosuppression.

Author : John R. Salaman
Publisher : J.P. Lippincott
Page : 280 pages
File Size : 49,7 Mb
Release : 1981
Category : Medical
ISBN : UOM:39015003252353

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Immunosuppressive Therapy by John R. Salaman Pdf

Author : Institute of Medicine,Division of Health Care Services,Committee on Medicare Coverage Extensions
Publisher : National Academies Press
Page : 410 pages
File Size : 52,5 Mb
Release : 2000-05-07
Category : Medical
ISBN : 9780309068895

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Extending Medicare Coverage for Preventive and Other Services by Institute of Medicine,Division of Health Care Services,Committee on Medicare Coverage Extensions Pdf

This report, which was developed by an expert committee of the Institute of Medicine, reviews the first three services listed above. It is intended to assist policymakers by providing syntheses of the best evidence available about the effectiveness of these services and by estimating the cost to Medicare of covering them. For each service or condition examined, the committee commissioned a review of the scientific literature that was presented and discussed at a public workshop. As requested by Congress, this report includes explicit estimates only of costs to Medicare, not costs to beneficiaries, their families, or others. It also does not include cost-effectiveness analyses. That is, the extent of the benefits relative to the costs to Medicareâ€"or to society generallyâ€"is not evaluated for the services examined. The method for estimating Medicare costs follows the generic estimation practices of the Congressional Budget Office (CBO). The objective was to provide Congress with estimates that were based on familiar procedures and could be compared readily with earlier and later CBO estimates. For each condition or service, the estimates are intended to suggest the order of magnitude of the costs to Medicare of extending coverage, but the estimates could be considerably higher or lower than what Medicare might actually spend were coverage policies changed. The estimates cover the five-year period 2000-2004. In addition to the conclusions about specific coverage issues, the report examines some broader concerns about the processes for making coverage decisions and about the research and organizational infrastructure for these decisions. It also briefly examines the limits of coverage as a means of improving health services and outcomes and the limits of evidence as a means of resolving policy and ethical questions.

Author : E. J. Corey,Barbara Czakó,László Kürti
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 51,9 Mb
Release : 2012-02-28
Category : Science
ISBN : 9781118361733

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Molecules and Medicine by E. J. Corey,Barbara Czakó,László Kürti Pdf

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

Author : Laurence S. Baskin
Publisher : Lippincott Williams & Wilkins
Page : 376 pages
File Size : 43,5 Mb
Release : 2018-04-16
Category : Medical
ISBN : 9781496367259

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Handbook of Pediatric Urology by Laurence S. Baskin Pdf

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now in full color for the first time, the third edition of the Handbook of Pediatric Urology helps you better understand the diagnosis and treatment of all major urologic disorders and conditions in infants, children, and adolescents. A new third editor, Dr. Jeffery A. Stock—Director of Pediatric Urology at Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai in New York—and over 25 contributors provide thorough, concise coverage of the entire field, making this quick-reference ideal for bedside use as well as deep-dive research.

Author : Centers for Disease Control and Prevention CDC
Publisher : Oxford University Press
Page : 672 pages
File Size : 43,7 Mb
Release : 2017-04-17
Category : Medical
ISBN : 9780190628635

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CDC Yellow Book 2018: Health Information for International Travel by Centers for Disease Control and Prevention CDC Pdf

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Author : Diana Boraschi,Giselle Penton-Rol
Publisher : Academic Press
Page : 298 pages
File Size : 55,6 Mb
Release : 2016-01-25
Category : Medical
ISBN : 9780128033364

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Immune Rebalancing by Diana Boraschi,Giselle Penton-Rol Pdf

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

Author : Jon Kobashigawa
Publisher : Springer
Page : 258 pages
File Size : 41,8 Mb
Release : 2017-03-29
Category : Medical
ISBN : 9783319437736

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Clinical Guide to Heart Transplantation by Jon Kobashigawa Pdf

This is a concise review of up-to-date concepts and techniques in the discipline of heart transplantation. It is a review and reference for practitioners managing patients with advanced heart disease, including patients with end-stage heart failure, mechanical circulatory support or transplant recipients. Heart failure is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing heart failure is one in five. Heart failure carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. As heart transplantation remains the best treatment option for patients with end stage heart failure, this primer will provide valuable information and management strategies for physicians caring for these patients. Also, due to continued shortage in donor organs, heart transplantation is a limited resource – which further underscores the importance of appropriately evaluating patients for transplant candidacy and managing their pre, peri- and post-transplant care for maximum benefit and best outcomes.​

Author : Geoff V. Gill,Gareth Williams,John C. Pickup
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 41,9 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9780470756867

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Difficult Diabetes by Geoff V. Gill,Gareth Williams,John C. Pickup Pdf

Difficult Diabetes is intended for diabetologists and endocrinologists who want to keep abreast of the developments in this fast-changing world. It provides a distillation of clinical wisdom that is desperately required in the absence of evidence-based guidelines. This book seeks to avoid rehashing the accepted content and dogma found in the excellent textbooks of diabetes. It provides more of an in depth coverage than is possible in individual review articles. Its key objective is to provide guidance to clinicians about the most topical and controversial aspects of their practice. Provides guidance to clinicians about the most topical and controversial aspects of their practice Each chapter is written by an expert in the field who can give a balanced overview of the topic All information is as up to date as possible due to fast production of the book

Author : Pierre Cochat
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401146432

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Immunosuppression under Trial by Pierre Cochat Pdf

Immunosuppression in solid organ transplantation is currently experiencing a worldwide revival since new drugs are now available and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analysed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies.

Author : Rainer W.G. Gruessner,David E.R. Sutherland
Publisher : Springer Science & Business Media
Page : 736 pages
File Size : 49,6 Mb
Release : 2004-04-27
Category : Medical
ISBN : 0387005897

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Transplantation of the Pancreas by Rainer W.G. Gruessner,David E.R. Sutherland Pdf

Although pancreas transplants have been performed for more than 30 years, the last few years have witnessed significant growth in the options available for pancreas transplantation as well as subtantial improvements in outcome. It is therefore appropriate that a new text summarize the recent advances and put forth the standard of future care. Transplantation of the Pancreas, edited by Drs. Gruessner and Sutherland fulfills this mission by providing a state-of-the-art, definitive reference work on pancreas transplantation for transplant surgeons and physicians as well as for endocrinologists, diabetologists, nephrologists, and neurologist. The editors, from the renowned University of Minnesota Transplant Division and the Diabetes Institute, have assembled a group of renowned experts to provide an all inclusive overview of pancreas transplantation. The text features insights on the pathophysiology of diabetes mellitus and the limitations of nontransplant treatments, highlights experimental research and clinical history of pancreas transplantation, and compares and contrasts different surgical procedures. The discussions detail the broad spectrum of posttransplant complications and their treatments, which frequently require skills in general, vascular, and laparoscopic surgery, interventional radiology, critical care, and infectious disease. Chapters on immunosuppression, immunology, pathology, long-term outcome, quality of life, and cost-effectiveness focus on issues unique to pancreas recipients. Evolving areas, such as pretransplant evaluation of pancreas transplant candidates, living donation, and the current status of islet transplantation are discussed. Augmented by more than 280 illustrations, including full color line drawings created exclusively for the text, this book is the standard reference for all transplant professionals as well as all physicians caring for diabetic patients.

Author : J.A.R. Nicoll,Ian Bone,David Graham
Publisher : CRC Press
Page : 475 pages
File Size : 44,5 Mb
Release : 2006-11-24
Category : Medical
ISBN : 9780340811979

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Adams & Graham's Introduction to Neuropathology 3Ed by J.A.R. Nicoll,Ian Bone,David Graham Pdf

Introduction to Neuropathology 3Ed remains an introductory text, but more clinical material has been introduced to make it relevant to neurologists and some psychiatrists, as well as pathologists. This involves the addition of small amounts of text throughout, plus neuroimages, including functional MRI, which is in colour. In addition, the text has been updated throughout with a new team of contributing authors.

Author : Francesco M. Veronese
Publisher : Springer Science & Business Media
Page : 289 pages
File Size : 41,9 Mb
Release : 2009-12-30
Category : Medical
ISBN : 9783764386795

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PEGylated Protein Drugs: Basic Science and Clinical Applications by Francesco M. Veronese Pdf

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Author : Herbert M. Pinedo,Carolien H. Smorenburg
Publisher : Springer Science & Business Media
Page : 241 pages
File Size : 50,7 Mb
Release : 2007-06-12
Category : Medical
ISBN : 9783764374075

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Drugs Affecting Growth of Tumours by Herbert M. Pinedo,Carolien H. Smorenburg Pdf

This topical volume provides an overview of clinically relevant data on anticancer agents. It is not only intended medical doctors working with cancer patients, and for medical researchers and students. The different classes of anticancer drugs are described by international authorities on the various topics. Apart from new targets for anticancer agents, attention is also focused on improving efficacy and tolerability of existing compounds.

Author : Stephen Hanessian
Publisher : John Wiley & Sons
Page : 652 pages
File Size : 54,9 Mb
Release : 2013-12-18
Category : Medical
ISBN : 9783527676552

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Natural Products in Medicinal Chemistry by Stephen Hanessian Pdf

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer