Molecular Basis Of Cardiovascular Disease

Author : Marschall S. Runge,Cam Patterson
Publisher : Springer Science & Business Media
Page : 604 pages
File Size : 53,6 Mb
Release : 2007-11-14
Category : Medical
ISBN : 9781592598786

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Principles of Molecular Cardiology by Marschall S. Runge,Cam Patterson Pdf

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

Author : Kenneth R. Chien
Publisher : Unknown
Page : 760 pages
File Size : 45,6 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015058250617

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Molecular Basis of Cardiovascular Disease by Kenneth R. Chien Pdf

The 2nd Edition of this heralded companion to Braunwald's Heart Disease explores the molecular mechanisms of cardiology and the scientific advances that are changing the practice of cardiology today. International experts discuss the role of genetics in cardiovascular disease the molecular basis of ischemic disease, thrombosis and hypertension genetic mapping approaches to inherited disorders biologically targeted agents for hypertension and heart failure and much more. Abundant figures and tables illustrate key concepts. Addresses most common cardiovascular problems from a molecular standpoint. Explores developing treatments for cardiovascular problems based on genetics. Provides references to Braunwald's Heart Disease, 6th Edition Examines today's cutting edge advances in molecular cardiology and the future of gene therapy, Examines the implications of cellular cholesterol metabolism in health and disease. . Delivers up-to-date information on understanding the origin of inherited disease.

Author : Speranza Rubattu,Massimo Volpe
Publisher : MDPI
Page : 212 pages
File Size : 47,8 Mb
Release : 2019-10-21
Category : Science
ISBN : 9783039215829

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Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides by Speranza Rubattu,Massimo Volpe Pdf

The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

Author : M. Zehender,G. Breithardt,H. Just
Publisher : Springer Science & Business Media
Page : 264 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642577246

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From Molecule to Men by M. Zehender,G. Breithardt,H. Just Pdf

From molecule to man: Medical research has indeed taken this direction, and major improvements of our understanding of the pathophysiology and epidemiology of disease have been achieved. The molecular basis of the congenital cardiovascular disorders has been extended from relatively few congenital malformations into everyday illnesses such as diabetes mellitus, hyperlipoproteinaemea, and arterial hypertension. The monogenic and, more difficult, polygenic basis for a vast majority of cardiovascular disorders are being defined more precisely from year to year. This book gives an overview of what has been achieved so far and defines the current position.

Author : Kenneth R. Chien,Eugene Braunwald
Publisher : Unknown
Page : 680 pages
File Size : 52,8 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015045649004

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Molecular Basis of Cardiovascular Disease by Kenneth R. Chien,Eugene Braunwald Pdf

Covering the molecular basis of heart disease, this text evaluates topics such as genetic mapping approaches in inherited cardiovascular disorders, and driving mechanisms in the transition from cardiac hypertrophy to heart failure.

Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Page : 339 pages
File Size : 47,9 Mb
Release : 2013-12-23
Category : Medical
ISBN : 9780124055254

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Cellular and Molecular Pathobiology of Cardiovascular Disease by Monte Willis,Jonathon W. Homeister,James R. Stone Pdf

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Author : Geert W. Schmid-Schönbein,D.Neil Granger
Publisher : Springer Science & Business Media
Page : 610 pages
File Size : 41,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9782817807614

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Molecular Basis for Microcirculatory Disorders by Geert W. Schmid-Schönbein,D.Neil Granger Pdf

A large number of cardiovascular diseases are accompanied by inflammation. This volume on the molecular basis of microcirculatory disorders gives a comprehensive summary of key steps in the inflammatory cascade. Leading investigators present a state-of-the-art analysis of the molecular determinants of leukocyte-endothelial cell adhesion, mechanotransduction in endothelial and inflammatory cells, mechanisms of cell activation, microvascular apoptosis with applications to ischemia-reperfusion in the brain, the heart and in venous disease, diabetes and hypertension. The book provides the latest thinking in these important cardiovascular problems, with the most contemporary literature and a look at the increasingly complex events during inflammation. Molecular biology tools, microvascular and modern bioengineering analysis are seamlessly integrated into the analysis of clinical problems. The book helps not only newcomers to gain entry into the interesting problems associated with microvascular disorders, but lays the foundation for the design of new therapeutic interventions.

Author : Speranza Rubattu,Massimo Volpe
Publisher : Unknown
Page : 1 pages
File Size : 54,5 Mb
Release : 2019
Category : Electronic books
ISBN : 3039215833

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Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides by Speranza Rubattu,Massimo Volpe Pdf

The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

Author : Cam Patterson,Monte S. Willis
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 50,8 Mb
Release : 2012-07-04
Category : Medical
ISBN : 9781617798917

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Translational Cardiology by Cam Patterson,Monte S. Willis Pdf

Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.

Author : Xiaoheng Liu,Youhua Tan,Bingmei M. Fu,Yang Shen
Publisher : Frontiers Media SA
Page : 165 pages
File Size : 43,6 Mb
Release : 2022-10-06
Category : Science
ISBN : 9782832501627

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New Insights Into Extracellular Vesicles in Cardiovascular Disease: Molecular Basis, Diagnosis and Therapy by Xiaoheng Liu,Youhua Tan,Bingmei M. Fu,Yang Shen Pdf

Author : Onkar N. Tripathi,Ursula Ravens,Michael C. Sanguinetti
Publisher : Springer Science & Business Media
Page : 676 pages
File Size : 45,7 Mb
Release : 2011-05-02
Category : Science
ISBN : 9783642175756

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Heart Rate and Rhythm by Onkar N. Tripathi,Ursula Ravens,Michael C. Sanguinetti Pdf

Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

Author : Jing Zhou,Jeng-Jiann Chiu,Yingxiao Wang
Publisher : Frontiers Media SA
Page : 208 pages
File Size : 40,7 Mb
Release : 2021-11-29
Category : Science
ISBN : 9782889717385

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New Insights into Cardiovascular Mechanobiology: Molecular Basis and Clinical Perspectives by Jing Zhou,Jeng-Jiann Chiu,Yingxiao Wang Pdf

Author : José Marín-García
Publisher : Springer Science & Business Media
Page : 570 pages
File Size : 51,5 Mb
Release : 2007-12-07
Category : Medical
ISBN : 9780387740720

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Aging and the Heart by José Marín-García Pdf

In this book, the genetic and molecular basis of cardiovascular aging is examined in detail and a comprehensive assessment given of the bioenergetics changes occurring in human and animal models of cardiac aging. Both current diagnostic and future therapeutic modalities are presented, giving this book a dual-pronged approach. Cardiac aging, like aging in general, is a complex process involving numerous cellular and molecular changes. This book sheds new light on the phenomenon.

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 42,8 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Author : Mary Kearns-Jonker
Publisher : Springer Science & Business Media
Page : 281 pages
File Size : 40,5 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781597450881

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Congenital Heart Disease by Mary Kearns-Jonker Pdf

Prominent researchers and clinicians describe in detail all the latest laboratory techniques currently used to define the molecular genetic basis for congenital malformations of the heart, cardiomyopathies, cardiac tumors, and arrythmias in human patients. In particular, the methods can be used to identify in clinical samples those genetic mutations responsible for such congenital abnormalities as Marfan syndrome, Williams-Beuren Syndrome, Alagille syndrome, Noonan syndrome, and Friedreich ataxia. The authors also discuss the limitations of identifying patients with congenital heart disease using these techniques during both pre- and postnatal periods.