Molecular Biology And Pathology Of Paediatric Cancer

Author : Catherine J. Cullinane,Susan A. Burchill,Jeremy A. Squire,John J. O'Leary,Ian J. Lewis
Publisher : OUP Oxford
Page : 360 pages
File Size : 41,8 Mb
Release : 2003-11-13
Category : Medical
ISBN : 9780191587238

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Molecular Biology and Pathology of Paediatric Cancer by Catherine J. Cullinane,Susan A. Burchill,Jeremy A. Squire,John J. O'Leary,Ian J. Lewis Pdf

There has been an explosion of knowledge and enormous progress in the fundamental understanding of the biology of cancer in recent years. This has included the realisation that cancer occurs when normal cellular functions are disturbed leading to a malignant phenotype. Much research has focussed on understanding the types of disturbances that can occur, the contribution that these abnormalities can make to the development and behaviour of particular cancers and more recently, the recognition that these cellular and genetic abnormalities can provide rational targets for new therapeutic approaches. Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers who wish to have an understanding of our current state of knowledge. A international group of editors and contributors provide guidelines on the molecular biology and pathology of paediatric oncology, aimed at clinicians and scientists working in the specialty who wish to understand current developments in molecular pathology as applied to their field. The book is a broad ranging review focusing on the impact of molecular and cytogenetic techniques on our understanding of the aetiology, clinical behaviour, diagnosis and management of paediatric cancer. The first section outlines the laboratory handling of tissue samples, theory and methodology of cytogenetic and molecular techniques and discusses predisposition syndromes. The second section highlights the application of cytogenetic and molecular methods in diagnosis and treatment of the major paediatric cancers.

Author : Larissa V. Furtado,Aliya N. Husain
Publisher : Springer
Page : 360 pages
File Size : 50,5 Mb
Release : 2018-08-01
Category : Medical
ISBN : 9783319896267

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Precision Molecular Pathology of Neoplastic Pediatric Diseases by Larissa V. Furtado,Aliya N. Husain Pdf

This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.

Author : Alexander Craig Mackinnon
Publisher : Springer Science & Business Media
Page : 273 pages
File Size : 55,8 Mb
Release : 2012-10-26
Category : Medical
ISBN : 9781627031158

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Pediatric Neoplasia by Alexander Craig Mackinnon Pdf

Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.

Author : Kathy Pritchard-Jones,Jeffrey S. Dome
Publisher : Springer
Page : 281 pages
File Size : 48,9 Mb
Release : 2015-02-04
Category : Medical
ISBN : 9783662440032

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Renal Tumors of Childhood by Kathy Pritchard-Jones,Jeffrey S. Dome Pdf

This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.

Author : Philip A. Pizzo,David G. Poplack
Publisher : Unknown
Page : 1780 pages
File Size : 54,7 Mb
Release : 2006
Category : Medical
ISBN : 0781754925

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Principles and Practice of Pediatric Oncology by Philip A. Pizzo,David G. Poplack Pdf

The definitive, most comprehensive text on pediatric oncology is now in its thoroughly updated Fifth Edition. A multidisciplinary group of the world's foremost specialists presents state-of-the-art information and guidelines on every aspect of pediatric cancer—from molecular biology and genetics to diagnosis, multimodal therapy, follow-up, and supportive care. This edition has new chapters on pathology and molecular diagnosis of leukemias and lymphomas, cellular and gene therapies, regulating patient safety in cancer treatment, non-rhabdo soft tissue sarcomas of childhood, and communicating with patients and families. Many of the previous edition's chapters have been rewritten by new contributors. Also included are up-to-date listings of resources for patients, families, and physicians.

Author : Catherine J. Cullinane,Jeremy A. Squire
Publisher : Oxford Medical Publications
Page : 360 pages
File Size : 42,8 Mb
Release : 2003
Category : Medical
ISBN : 9780192630797

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Molecular Biology and Pathology of Paediatric Cancer by Catherine J. Cullinane,Jeremy A. Squire Pdf

There has been an explosion of knowledge and enormous progress in the fundamental understanding of the biology of cancer in recent years. This has included the realisation that cancer occurs when normal cellular functions are disturbed leading to a malignant phenotype. Much research has focused on understanding the types of disturbances that can occur, the contribution that these abnormalities can make to the development and behavior of particular cancers and more recently, the recognition that these cellular and genetic abnormalities can provide rational targets for new therapeutic approaches. Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers who wish to have an understanding of our current state of knowledge. An international group of editors and contributors provide guidelines on the molecular biology and pathology of paediatric oncology, aimed at clinicians and scientists working in the specialty who wish to understand current developments in molecular pathology as applied to their field. The book is broad ranging review focusing on the impact of molecular and cytogenetic techniques on our understanding of the aetiology, clinical behaviour, diagnosis and management of paediatric cancer. The first section outlines the laboratory handling of tissue samples, theory and methodology of cytogenetic and molecular techniques and discusses predisposition syndromes. The second section highlights the application of cytogenetic and molecular methods in diagnosis and treatment of the major paediatric cancers.

Author : David Malkin
Publisher : Springer Nature
Page : 495 pages
File Size : 47,8 Mb
Release : 2021-09-06
Category : Medical
ISBN : 9783030744489

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The Hereditary Basis of Childhood Cancer by David Malkin Pdf

This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the ‘disease-related’ chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where ‘modern’ technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.

Author : Mels Sluyser,Paul Antoine Voûte
Publisher : Ellis Horwood
Page : 140 pages
File Size : 43,9 Mb
Release : 1988
Category : Carcinogens
ISBN : UOM:39015051294877

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Molecular Biology and Genetics of Childhood Cancers by Mels Sluyser,Paul Antoine Voûte Pdf

Author : A. Julian Garvin
Publisher : S. Karger AG (Switzerland)
Page : 248 pages
File Size : 48,7 Mb
Release : 1991-01-01
Category : Medical
ISBN : 3805553773

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Pediatric Molecular Pathology by A. Julian Garvin Pdf

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 55,7 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 634 pages
File Size : 42,9 Mb
Release : 2019-11-23
Category : Medical
ISBN : 9780128132586

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Essential Concepts in Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 43,6 Mb
Release : 2000
Category : Electronic
ISBN : OCLC:64159182

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The Molecular Biology of Cancer by Anonim Pdf

Author : Philip A. Pizzo,David G. Poplack
Publisher : Lippincott Williams & Wilkins
Page : 5113 pages
File Size : 49,8 Mb
Release : 2015-06-24
Category : Medical
ISBN : 9781496318763

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Principles and Practice of Pediatric Oncology by Philip A. Pizzo,David G. Poplack Pdf

Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.

Author : Thomas James Deeley,Thomas J. Deeley
Publisher : Unknown
Page : 346 pages
File Size : 51,9 Mb
Release : 1974
Category : Medical
ISBN : UOM:39015000297740

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Central Nervous System Tumours by Thomas James Deeley,Thomas J. Deeley Pdf

Author : Hubert N. Caron,Andrea Biondi,Tom Boterberg,François Doz
Publisher : Oxford University Press
Page : 320 pages
File Size : 54,8 Mb
Release : 2020-10-08
Category : Medical
ISBN : 9780192517708

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Oxford Textbook of Cancer in Children by Hubert N. Caron,Andrea Biondi,Tom Boterberg,François Doz Pdf

The outcome for children with cancer has shown enormous improvement since the first edition of this book was published in 1975. In economically privileged countries, overall survival rates have now reached 80% at five years from diagnosis, and most of these young people will become long term survivors. The Oxford Textbook of Cancer in Children offers state-of-the-art descriptions of the approach needed for the optimal management of children with cancer, and guidance on current treatments available due to the advances made over the past decade. This seventh edition has been thoroughly revised and updated, including brand new chapters on cancer immunotherapy in children, and cancer in adolescents and young adults, plus expanded treatment of tumours of the brain and central nervous system. The book primarily provides clear and up-to-date clinical guidance for use in treatment settings whilst offering a useful background to the biology of individual tumour types and the history of the development of specific treatments. With an international and multi-disciplined authorship comprising of paediatric oncologists, surgeons, radiotherapists, imaging specialists, psychologists, nurses, and many others, the text illustrates how the paediatric oncology community works globally and collaboratively in order to drive forward new therapies, build our knowledge of these diseases, and achieve the common aim of curing childhood cancer. In this new edition, Professors Biondi and Caron have been joined by Professor François Doz, who has a distinguished international reputation, particularly in the treatment of childhood brain tumours and retinoblastoma, as well as early drug development. They have also been joined by Professor Tom Boterberg, a world renowned radio-oncologist for children with cancer. This book will be of value to paediatric oncologists, trainee paediatric oncologists, paediatric haematologists, and other professionals working in paediatric oncology: nurses, AHPs, surgeons, and clinical oncologists.