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Renal Tumors of Childhood by Kathy Pritchard-Jones,Jeffrey S. Dome Pdf
This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.
Renal Tumors of Childhood by Kathy Pritchard-Jones,Jeffrey S. Dome Pdf
This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.
Diagnosis and Surgical Management of Renal Tumors by Michael A. Gorin,Mohamad E. Allaf Pdf
Renal cell carcinoma (RCC) is the most common primary malignancy of the kidney, with an estimated 64,000 new cases diagnosed each year in the United States. Worldwide, this figure approaches 270,000 annual incident cases. At the time of initial presentation, 80% of patients with RCC will be diagnosed with a tumor localized the kidney. The majority of these lesions will be small (i.e. ≤4 cm) and potentially curable with either partial or radical nephrectomy. In recent decades, the rate of incidentally detected small renal tumors has risen substantially due the increasing use of cross-sectional imaging performed across the field of medicine. This rise in the incident number of localized renal tumors has unfortunately not resulted in a corresponding decrease in cases of metastatic RCC. This observation has led to our understanding that a significant proportion of incidentally detected renal tumors are of low malignant potential and may be safely managed with alternatives to surgery such active surveillance and thermo ablation. The use of these less invasive management approaches, however, must be balanced by the reality that upon spreading beyond the confines of the kidney, RCC is almost always incurable. Thus, when selecting a management strategy for a given patient, one must employ a risk-adapted approach that includes knowledge of a tumor’s histology and metastatic potential. In each patient, the goal of management should be to minimize the risk of progression to metastatic disease while preserving renal function and minimizing morbidity. This text provides a contemporary review of the diagnosis and surgical management of RCC. It opens with chapters on the pathology, radiology, and genetics of RCC. It then covers the risk stratification of renal tumors utilizing renal mass biopsy as well as non-invasive novel imaging-based scoring systems. Next, the surgical management of small and locally advanced renal tumors as well as the role of surgery in cases of metastatic RCC is reviewed. In addition, alternative approaches to surgery including active surveillance and ablative techniques are reviewed. Other chapters detail the emerging role of neoadjuvant and adjuvant systemic therapy in patients who are at high risk of progression to metastatic disease. Finally, the text covers the post-operative surveillance of patients with RCC as well as a summary of contemporary guidelines on the management of this disease. Diagnosis and Surgical Management of Renal Cell Carcinoma will serve as a comprehensive resource for physicians and researchers interested in RCC. All chapters will be written by experts in the field and will include the most up to date scientific and clinical information.
Handbook of Pediatric Surgery by Chandrasen K. Sinha,Mark Davenport Pdf
Although pediatric surgery is a distinct and evolving specialty, it still remains an integral part of most general surgical and paediatric medical practice. Nevertheless, surgery in children does differ from adult practice in various fundamental ways, and there are key physiological and anatomical differences that constantly need underlining. Progress and improvement in outcome has also been rapid but it is sometimes difficult for practitioners to keep themselves up-to-date with the usual surgical or paediatric text books. This book will give a concise overview of all important topics and is designed to provide information in order to recognise the common surgical conditions; namely typical symptoms and signs, investigation and then treatment management. It will also provide an anatomical and physiological background to aid understanding, in addition to emphasising logical, and where possible, evidence-based practice by the use of flow charts, tables and algorithms. Authored by an international range of leading contributors, this is the first book of its kind to offer comprehensive coverage to this topic in a quick reference, pocket-book format.
Diseases of the Abdomen and Pelvis 2018-2021 by Juerg Hodler,Rahel A. Kubik-Huch,Gustav K. von Schulthess Pdf
This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.
An Illustrated Guide to Pediatric Urology by Ahmed H. Al-Salem Pdf
This book is vital for physicians caring for young patients with urological conditions, as a quick reference book that is easy to read and well-illustrated. Pediatric urological conditions are fairly common, and infants and children are seen on daily basis with urological problems either in clinics or in hospitals. This book is useful to general surgeons, pediatricians, pediatric surgeons, fellows, residents, general physicians and family physicians, medical students and nurses. The Editor has gained experience in the diagnosis and management of various urological problems in infants and children, working in busy hospital over the last 25 years.
Nephron-Sparing Surgery by Krishna Sasidharan,Mark Soloway Pdf
Despite the rising popularity of the minimally invasive laparoscopic option, open nephron-sparing surgery is still seen by many experts as the 'gold standard' for open surgery for kidney tumors and should remain the first choice for many patients. This challenges the idea that less-invasive therapies are always more desirable than open surgery. Whi
Rare Kidney Tumors by Gabriel G. Malouf,Nizar M. Tannir Pdf
This book provides clinicians with clear guidance on treatment decision-making in patients with rare kidney cancers. After a brief review on epidemiology, pathology, and biology, each chapter focuses on the multidisciplinary management of a particular tumor subtype using the full range of available cancer therapy modalities, including surgery, radiotherapy, chemotherapy, targeted therapies, and immunotherapy. Emerging therapies and future directions in the management of each cancer subtype are also discussed. The chapters are all written by multidisciplinary teams of international experts comprising at least a urologist, a medical oncologist, and a pathologist. Rare kidney cancers represent 15% of renal cell carcinomas. In comparison with clear cell renal cell carcinomas, little is known about the biology of such cancers, and few trials have reported on the efficacy of targeted therapies in the metastatic setting. Optimal management thus poses significant challenges and often requires a multidisciplinary team. This book will be an ideal reference guide for all clinicians involved in the care of patients with these orphan tumors.
Essentials of Surgical Pediatric Pathology by Marta C. Cohen,Irene Scheimberg Pdf
Essentials of Surgical Pediatric Pathology is a clear and practical yet comprehensive guide for trainee pediatric pathologists and non-pediatric pathologists. Each chapter corresponds to one of the main subspecialties, such as dermatopathology, head and neck pathology, and system pathology. Practical guidance is given on handling pediatric specimens and the authors highlight the ways in which common conditions present differently in adults and children. Other chapters cover conditions typical of childhood, including soft tissue tumors and blue round cell tumors. The chapters begin with a brief clinical presentation, followed by a clear macroscopical and histological description of the principal pathologies seen in children. Up-to-date genetic and immunohistochemical information is provided, and the book includes hundreds of high-quality color images. Written and edited by leading international experts in the field, this is an essential resource for trainee pediatric pathologists, as well as general pathologists who may encounter pediatric cases.
Author : Joseph Ragaz,Pierre R. Band,James H. Goldie Publisher : Springer Science & Business Media Page : 172 pages File Size : 53,8 Mb Release : 2012-12-06 Category : Medical ISBN : 9783642826719
Preoperative (Neoadjuvant) Chemotherapy by Joseph Ragaz,Pierre R. Band,James H. Goldie Pdf
Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.
Target Volume Delineation for Pediatric Cancers by Stephanie A. Terezakis,Shannon M. MacDonald Pdf
This handbook is designed to provide the radiation oncologist with clear practical guidance in the delineation of tumor volumes and/or radiation fields for a wide variety of pediatric cancers, including the most frequently encountered malignancies of childhood. This is a guide to designing treatment fields and volumes that may be utilized in the delivery of conformal therapies such as intensity-modulated radiation therapy and proton therapy, the latter being particularly relevant in children. Each chapter focuses on a specific tumor type, providing general guidelines that will assist the reader in delineating the clinical target volume for particular presentations, including patterns of spread. As the target volumes can be complex, detailed illustrations are presented of the volumes in representative cases, contoured slice by slice on the planning CT images. In addition to target volume delineation for conformal treatment, field design setup for conventional approaches is also discussed.
Kidney Cancer by Mukul K. Divatia,Ayhan Ozcan,Charles C. Guo,Jae Y. Ro Pdf
This book provides a comprehensive overview of pathology of kidney tumors along with radiological features and up to date treatment strategies that enable the readers to avail this information in day to day pathology sign-out as well as interaction with clinical colleagues of different disciplines. It also serves as a referral resource for the current medical or surgical practice while preparing for examinations or maintenance of certification. Written by experts in the field, chapters contain an updated review of important pathologic parameters mandated for diagnosis and reporting with emphasis on updated information regarding new developments in this interesting field. Numerous high-resolution color images aptly illustrate the various pathologic entities and their features as outlined in the text section along with tables that highlight the differential diagnoses and salient ancillary features. Kidney Cancer serves as a quick reference for all categories of readers alike, and provides up-to-date information on renal tumor pathology, radiology and management that are required in daily practice.
Essentials of Pediatric Radiology by Heike E. Daldrup-Link,Charles A. Gooding Pdf
Essentials of Pediatric Radiology: A Multimodality Approach provides a concise overview of both basic and complex topics encountered by pediatric radiologists in their daily practice. Written by leading pediatric radiologists from renowned children's hospitals, it focuses particularly on multimodality imaging, covering the full gamut of radiologic diagnostic techniques, including conventional radiography and ultrasound, Doppler ultrasound, up-to-date CT and MRI techniques, and PET-CT. Each chapter is generously illustrated with high quality images, as well as graphs, tables, decision flowcharts and featured cases. Chapters are arranged according to pathologies, rather than organ systems, providing the reader with clinically-oriented information when employing 'whole body' techniques or analysing scans involving multiple anatomical sites. The book is complemented by an outstanding free access website of sample cases containing questions and answers that enable readers to test their diagnostic proficiency - see http://essentials-of-pediatric-radiology.com. A key text for pediatric radiology fellows, radiology residents and general radiologists, this is also essential reading for all pediatricians.
National Academies of Sciences Engineering and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Childhood Cancers and Disability
Author : National Academies of Sciences Engineering and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Childhood Cancers and Disability Publisher : Unknown Page : 128 pages File Size : 40,5 Mb Release : 2021-09-09 Category : Electronic ISBN : 0309683491
Childhood Cancer and Functional Impacts Across the Care Continuum by National Academies of Sciences Engineering and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Childhood Cancers and Disability Pdf
Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.