Molecular Biology And Toxicology Of Metals

Author : Rudolfs K. Zalups,D. James Koropatnick
Publisher : CRC Press
Page : 608 pages
File Size : 42,6 Mb
Release : 2000-02-24
Category : Medical
ISBN : 0748407987

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Molecular Biology and Toxicology of Metals by Rudolfs K. Zalups,D. James Koropatnick Pdf

Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology.

Author : Philippe Collery
Publisher : John Libbey Eurotext
Page : 852 pages
File Size : 51,7 Mb
Release : 2000
Category : Medical
ISBN : 2742002944

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Metal Ions in Biology and Medicine by Philippe Collery Pdf

The objective of the 6th ISMIBM is to foster exchange of opinions between professionals and specialists working on analysis, research and applications of metal ions, trace elements and minerals in biological, biochemical, medical sciences, toxicology and environmental health. The scientific program, composed of plenary and concurrent sessions, and poster presentations is designed to promote intensive and productive dialogue among experts in these fields. A special program with short courses and mini-symposia have also been organised, featuring specialised areas including toxicology, analysis, pathology, remediation strategies, and environmental medicine. Original contributions (oral and/or poster presentations) are invited on the following themes: Metals and Environmental Health; Molecular Toxicology of Metals; Carcinogenicity of Metals; Speciation of Metals and Other Elements; Uses of Metals in Clinical Applications; Metals and Disease: Environmental and Toxicologic Pathology; Epidemiology and Occupational Health; Metals and Aging; Metals and Homeostasis; Effects of Low and High Nutritional Trace Element Status; Metals and Hormone Actions; Metals and Enzyme Activity; Metals and Chelation Therapy; Health Effects of Arsenic; Risk Assessment of Trace Element Status and Health; Advanced Methods for the Analysis of Trace Elements and Metal Ions.

Author : Mohammad Faisal,Quaiser Saquib,Abdulrahman A. Alatar,Abdulaziz A. Al-Khedhairy
Publisher : Springer Nature
Page : 451 pages
File Size : 45,5 Mb
Release : 2020-10-19
Category : Science
ISBN : 9783030459758

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Cellular and Molecular Phytotoxicity of Heavy Metals by Mohammad Faisal,Quaiser Saquib,Abdulrahman A. Alatar,Abdulaziz A. Al-Khedhairy Pdf

Plant growth and development is closely dependent on the plant environment, including the wide-spread presence of organic and inorganic xenobiotics and pollutants. Currently, heavy metals are the most common inorganic environmental pollutants and they have pronounced effects and consequences not only for plants, but also for the ecosystem in which the plants form an integral component. It has been suggested that these contaminants accumulate in agricultural crops, thus entering the food chain and posing a significant health risk. Plants growing in polluted sites exhibit altered metabolism, reduced growth, and decreased biomass production. These pollutants adhere to plant roots and exert physical or chemical toxicity and subsequently cell death in plants. Yet, plants have developed various defence mechanisms to counteract the toxicity induced by heavy metals. Only detailed study of the processes and mechanisms would allow researchers and students to understand the interactions, responses, and adaptations of plants to these pollutants; however, there are several unresolved issues and challenges regarding the interaction and biological effects of heavy metals. Therefore, this volume provides relevant, state-of-the-art findings on environmental phytotoxicity and the mechanisms of such interactions at the cellular and molecular levels. This volume consists of chapters on relevant topics contributed by different experts or group of experts so as to make available a comprehensive treatise designed to provide an in-depth analysis of heavy metals phytotoxicity. This book may serve as a reference to scientists, researchers and students in the fields of toxicology, environmental toxicology, phytotoxicology, plant biology, plant physiology, plant biochemistry and plant molecular biology, and especially those interested in heavy metals toxicology.

Author : Gaspar Banfalvi
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 47,7 Mb
Release : 2011-03-02
Category : Medical
ISBN : 9789400704282

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Cellular Effects of Heavy Metals by Gaspar Banfalvi Pdf

The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.

Author : Rudolfs K. Zalups,D. James Koropatnick
Publisher : CRC Press
Page : 442 pages
File Size : 49,6 Mb
Release : 2010-05-21
Category : Medical
ISBN : 9781420059984

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Cellular and Molecular Biology of Metals by Rudolfs K. Zalups,D. James Koropatnick Pdf

With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses

Author : Robert A. Goyer
Publisher : Elsevier
Page : 550 pages
File Size : 55,5 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483288567

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Metal Toxicology by Robert A. Goyer Pdf

Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time. Unique aspect of organ-specific orientationWritten by leading authorities in metal toxicologyChapters of special interest include Risk Assessment, Emerging Technologies, and Molecular Biological TechniquesServes as an excellent sourcebook of generalized information on metal toxicology, allowing for specific tissue-system referencing

Author : Xianglin Shi,Vince Castranova,Val Vallyathan,William G. Perry
Publisher : Springer
Page : 242 pages
File Size : 54,6 Mb
Release : 2012-12-15
Category : Science
ISBN : 1461352428

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Molecular Mechanisms of Metal Toxicity and Carcinogenesis by Xianglin Shi,Vince Castranova,Val Vallyathan,William G. Perry Pdf

These proceedings focus on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.

Author : Helmut Sigel
Publisher : CRC Press
Page : 416 pages
File Size : 52,6 Mb
Release : 1986-02-21
Category : Science
ISBN : 0824775406

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Metal Ions in Biological Systems by Helmut Sigel Pdf

Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 21 describes the underlying theories of nuclear magnetic resonance (NMR), promoting a wider use of NMR in studies of paramagnetic species. In six concise chapters by leading international authorities, Applications of Nuclear Magnetic Resonance to Paramagnetic Species outlines the most recent developments regarding the use of nuclear relaxation as a source for structural information ... examines studies of magnetically coupled metalloproteins and metal-porphyrin induced dipolar shifts for conformational analysis ... and evaluates the potential of paramagnetic ions as agents for enhancing NMR image contrast. With over 500 references that facilitate further research, Applications of Nuclear Magnetic Resonance to Paramagnetic Species is an essential resource for scientists and students in such disciplines as biophysics; bioinorganic, inorganic, and coordination chemistry; biochemistry; molecular biology; and enzymology. Book jacket.

Author : Markus J. Tamás,Enrico Martinoia
Publisher : Springer Science & Business Media
Page : 519 pages
File Size : 52,6 Mb
Release : 2006-07-07
Category : Science
ISBN : 9783540317197

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Molecular Biology of Metal Homeostasis and Detoxification by Markus J. Tamás,Enrico Martinoia Pdf

One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.

Author : Monica Nordberg,Gunnar F. Nordberg,Bruce A. Fowler,Lars Friberg
Publisher : Elsevier
Page : 1024 pages
File Size : 52,8 Mb
Release : 2011-04-28
Category : Science
ISBN : 9780080546100

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Handbook on the Toxicology of Metals by Monica Nordberg,Gunnar F. Nordberg,Bruce A. Fowler,Lars Friberg Pdf

Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more

Author : Gunnar F. Nordberg,Bruce A. Fowler,Monica Nordberg
Publisher : Academic Press
Page : 1544 pages
File Size : 53,6 Mb
Release : 2014-08-07
Category : Medical
ISBN : 9780123973399

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Handbook on the Toxicology of Metals by Gunnar F. Nordberg,Bruce A. Fowler,Monica Nordberg Pdf

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations and Volume II is devoted to “Specific Metals. A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals. Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Covers the toxicology of metallic nanomaterials in a new comprehensive chapter Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium

Author : Valeria Culotta,Robert A. Scott
Publisher : John Wiley & Sons
Page : 608 pages
File Size : 40,9 Mb
Release : 2016-03-16
Category : Science
ISBN : 9781118636862

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Metals in Cells by Valeria Culotta,Robert A. Scott Pdf

Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.

Author : Xianglin Shi,Vince Castranova,Val Vallyathan
Publisher : Unknown
Page : 184 pages
File Size : 55,5 Mb
Release : 2004
Category : Electronic
ISBN : OCLC:489038759

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Molecular Mechanisms of Metal Toxicity and Carcinogenesis by Xianglin Shi,Vince Castranova,Val Vallyathan Pdf

Author : Astrid Sigel,Helmut Sigel,Roland KO Sigel
Publisher : Springer Science & Business Media
Page : 590 pages
File Size : 46,7 Mb
Release : 2013-02-26
Category : Science
ISBN : 9789400751798

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Cadmium: From Toxicity to Essentiality by Astrid Sigel,Helmut Sigel,Roland KO Sigel Pdf

Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.

Author : Maria E. Ariza,Gautam N. Bijur,Marshall V. Williams
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461551539

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Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity by Maria E. Ariza,Gautam N. Bijur,Marshall V. Williams Pdf

Humans are exposed daily to low concentrations of metals that are released into the environment by both natural and industrial processes. Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity: Molecular Approaches to Determine Mechanisms of Toxicity examines concerns about the acute and/or chronic exposure of humans to concentrations of these metals that are below the threshold levels established by various federal regulatory agencies. Some of these metals are accumulated in various tissues and over time this may result in the accumulation of a significant body burden. This could increase the risk of developing a variety of diseases later in life, at a time when thresholds for such effects may already be reduced by the processes of aging. Such possibilities could only further compromise the quality of life in the elderly population and could contribute to the rising cost of health care in this country. Studies that have been conducted to determine the possible risks associated with exposure to relatively non-toxic concentrations of environmental metals have been hampered by a lack of appropriate models and a lack of funding. It has also been difficult for researchers to demonstrate a correlation between the exposure of humans or animals to low concentrations of environmental pollutants and disease. This book examines recent technological advances in the areas of molecular biology, biochemistry, and computer-enhanced image analyses that provide researchers with the tools to begin elucidating the genotoxic effects of environmental metal pollutants and the mechanisms by which these metals cause DNA damage. Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity: Molecular Approaches to Determine Mechanisms of Toxicity presents data that demonstrate that certain environmental metal pollutants are genotoxic. The authors describe the role of reactive oxygen intermediates in causing the DNA damage induced by environmental metal pollutants and discuss their possible role in human disease.