Molecular Chaperones And Neurodegeneration

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Molecular Chaperones and Neurodegeneration

Cintia Roodveldt,Tiago F. Outeiro,Janice E. Braun
Molecular Chaperones and Neurodegeneration Book PDF

Author : Cintia Roodveldt,Tiago F. Outeiro,Janice E. Braun
Publisher : Frontiers Media SA
Page : 182 pages
File Size : 50,9 Mb
Release : 2017-12-06
Category : Electronic book
ISBN : 9782889453429

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Molecular Chaperones and Neurodegeneration by Cintia Roodveldt,Tiago F. Outeiro,Janice E. Braun Pdf

Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.

Protein Chaperones and Protection from Neurodegenerative Diseases

Stephan N. Witt
Protein Chaperones and Protection from Neurodegenerative Diseases Book PDF

Author : Stephan N. Witt
Publisher : John Wiley & Sons
Page : 516 pages
File Size : 44,5 Mb
Release : 2011-09-09
Category : Science
ISBN : 9781118063897

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Protein Chaperones and Protection from Neurodegenerative Diseases by Stephan N. Witt Pdf

How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, partly because of the potential for manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases, and partly because of the ever-aging global population. Discussing the potential to harness the power of protein chaperones, and future directions for research, discovery, and therapeutics, this book is essential reading for scientists working in the fields of biochemistry, molecular medicine, pharmacology and drug discovery, biotechnology and pharmaceutical companies, advanced students, and anyone interested in this cutting-edge topic.

Quality Control of Cellular Protein in Neurodegenerative Disorders

Uddin, Md. Sahab,Ashraf, Ghulam Md.
Quality Control of Cellular Protein in Neurodegenerative Disorders Book PDF

Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
Publisher : IGI Global
Page : 515 pages
File Size : 49,8 Mb
Release : 2020-02-14
Category : Medical
ISBN : 9781799813187

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Quality Control of Cellular Protein in Neurodegenerative Disorders by Uddin, Md. Sahab,Ashraf, Ghulam Md. Pdf

Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.

Protein Misfolding in Neurodegenerative Diseases

Robert D. E. Sewell
Protein Misfolding in Neurodegenerative Diseases Book PDF

Author : Robert D. E. Sewell
Publisher : CRC Press
Page : 592 pages
File Size : 52,6 Mb
Release : 2007-12-03
Category : Science
ISBN : 1420007149

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Protein Misfolding in Neurodegenerative Diseases by Robert D. E. Sewell Pdf

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.

Molecular Chaperones and Protein Folding As Therapeutic Targets in Parkinson's Disease and Other Synucleinopathies

Applied Research Applied Research Press
Molecular Chaperones and Protein Folding As Therapeutic Targets in Parkinson s Disease and Other Synucleinopathies Book PDF

Author : Applied Research Applied Research Press
Publisher : CreateSpace
Page : 44 pages
File Size : 51,8 Mb
Release : 2015-08-09
Category : Electronic
ISBN : 1516822471

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Molecular Chaperones and Protein Folding As Therapeutic Targets in Parkinson's Disease and Other Synucleinopathies by Applied Research Applied Research Press Pdf

Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson's disease, folding, post-translational modification and recycling of the synaptic protein alpha-synuclein are clearly altered, leading to a progressive accumulation of pathogenic protein species and the formation of intracellular inclusion bodies. Altered protein folding is one of the first steps of an increasingly understood cascade in which alpha-synuclein forms complex oligomers and finally distinct protein aggregates, termed Lewy bodies and Lewy neurites. In neurons, an elaborated network of chaperone and co-chaperone proteins is instrumental in mediating protein folding and re-folding. In addition to their direct influence on client proteins, chaperones interact with protein degradation pathways such as the ubiquitin-proteasome-system or autophagy in order to ensure the effective removal of irreversibly misfolded and potentially pathogenic proteins. Because of the vital role of proper protein folding for protein homeostasis, a growing number of studies have evaluated the contribution of chaperone proteins to neurodegeneration. We herein review our current understanding of the involvement of chaperones, co-chaperones and chaperone-mediated autophagy in synucleinopathies with a focus on the Hsp90 and Hsp70 chaperone system. We discuss genetic and pathological studies in Parkinson's disease as well as experimental studies in models of synucleinopathies that explore molecular chaperones and protein degradation pathways as a novel therapeutic target. To this end, we examine the capacity of chaperones to prevent or modulate neurodegeneration and summarize the current progress in models of Parkinson's disease and related neurodegenerative disorders.

GeNeDis 2016

Panayiotis Vlamos
GeNeDis 2016 Book PDF

Author : Panayiotis Vlamos
Publisher : Springer
Page : 300 pages
File Size : 42,6 Mb
Release : 2017-10-01
Category : Medical
ISBN : 9783319573489

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GeNeDis 2016 by Panayiotis Vlamos Pdf

The 2nd World Congress on Genetics, Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international focum for the latest scientific discoveries, medical practices, and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation, and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2016 takes place in Sparta, Greece, 20-23 October, 2016. This volume focuses on the sessions that address geriatrics.

Molecular Biology of Neurodegenerative Diseases

David B. Teplow
Molecular Biology of Neurodegenerative Diseases Book PDF

Author : David B. Teplow
Publisher : Academic Press
Page : 499 pages
File Size : 55,9 Mb
Release : 2012-04-13
Category : Medical
ISBN : 9780123858832

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Molecular Biology of Neurodegenerative Diseases by David B. Teplow Pdf

Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson's, Alzheimer's and Huntington's disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field

Protein Quality Control in Neurodegenerative Diseases

Richard I. Morimoto,Yves Christen
Protein Quality Control in Neurodegenerative Diseases Book PDF

Author : Richard I. Morimoto,Yves Christen
Publisher : Springer Science & Business Media
Page : 145 pages
File Size : 45,9 Mb
Release : 2012-12-13
Category : Medical
ISBN : 9783642279287

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Protein Quality Control in Neurodegenerative Diseases by Richard I. Morimoto,Yves Christen Pdf

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Alexzander A.A. Asea,Ian R. Brown
Heat Shock Proteins and the Brain Implications for Neurodegenerative Diseases and Neuroprotection Book PDF

Author : Alexzander A.A. Asea,Ian R. Brown
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 44,9 Mb
Release : 2008-04-06
Category : Medical
ISBN : 9781402082313

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Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection by Alexzander A.A. Asea,Ian R. Brown Pdf

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.

Protein Misfolding in Neurodegenerative Diseases

Robert D. E. Sewell
Protein Misfolding in Neurodegenerative Diseases Book PDF

Author : Robert D. E. Sewell
Publisher : CRC Press
Page : 0 pages
File Size : 42,9 Mb
Release : 2007-12-03
Category : Science
ISBN : 0849373107

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Protein Misfolding in Neurodegenerative Diseases by Robert D. E. Sewell Pdf

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.

Heat Shock Proteins in Neuroscience

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Neuroscience Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 307 pages
File Size : 50,6 Mb
Release : 2019-10-30
Category : Science
ISBN : 9783030242855

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Heat Shock Proteins in Neuroscience by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Fundamentals of Neurodegeneration and Protein Misfolding Disorders

Martin Beckerman
Fundamentals of Neurodegeneration and Protein Misfolding Disorders Book PDF

Author : Martin Beckerman
Publisher : Springer
Page : 378 pages
File Size : 43,8 Mb
Release : 2015-11-06
Category : Medical
ISBN : 9783319221175

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Fundamentals of Neurodegeneration and Protein Misfolding Disorders by Martin Beckerman Pdf

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Pierfausto Seneci
Molecular Targets in Protein Misfolding and Neurodegenerative Disease Book PDF

Author : Pierfausto Seneci
Publisher : Academic Press
Page : 314 pages
File Size : 53,7 Mb
Release : 2014-10-07
Category : Science
ISBN : 9780128004999

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Molecular Targets in Protein Misfolding and Neurodegenerative Disease by Pierfausto Seneci Pdf

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Protein folding and misfolding: neurodegenerative diseases

Judit Ovádi,Ferenc Orosz
Protein folding and misfolding neurodegenerative diseases Book PDF

Author : Judit Ovádi,Ferenc Orosz
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 42,7 Mb
Release : 2008-12-21
Category : Medical
ISBN : 9781402094347

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Protein folding and misfolding: neurodegenerative diseases by Judit Ovádi,Ferenc Orosz Pdf

Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson’s and Alzheimer’s diseases.

Neurodegenerative Diseases

Uday Kishore
Neurodegenerative Diseases Book PDF

Author : Uday Kishore
Publisher : BoD – Books on Demand
Page : 642 pages
File Size : 45,5 Mb
Release : 2013-05-15
Category : Medical
ISBN : 9789535110880

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Neurodegenerative Diseases by Uday Kishore Pdf

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.