Molecular Chaperones And Protein Folding As Therapeutic Targets In Parkinson S Disease And Other Synucleinopathies

Author : Applied Research Applied Research Press
Publisher : CreateSpace
Page : 44 pages
File Size : 41,5 Mb
Release : 2015-08-09
Category : Electronic
ISBN : 1516822471

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Molecular Chaperones and Protein Folding As Therapeutic Targets in Parkinson's Disease and Other Synucleinopathies by Applied Research Applied Research Press Pdf

Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson's disease, folding, post-translational modification and recycling of the synaptic protein alpha-synuclein are clearly altered, leading to a progressive accumulation of pathogenic protein species and the formation of intracellular inclusion bodies. Altered protein folding is one of the first steps of an increasingly understood cascade in which alpha-synuclein forms complex oligomers and finally distinct protein aggregates, termed Lewy bodies and Lewy neurites. In neurons, an elaborated network of chaperone and co-chaperone proteins is instrumental in mediating protein folding and re-folding. In addition to their direct influence on client proteins, chaperones interact with protein degradation pathways such as the ubiquitin-proteasome-system or autophagy in order to ensure the effective removal of irreversibly misfolded and potentially pathogenic proteins. Because of the vital role of proper protein folding for protein homeostasis, a growing number of studies have evaluated the contribution of chaperone proteins to neurodegeneration. We herein review our current understanding of the involvement of chaperones, co-chaperones and chaperone-mediated autophagy in synucleinopathies with a focus on the Hsp90 and Hsp70 chaperone system. We discuss genetic and pathological studies in Parkinson's disease as well as experimental studies in models of synucleinopathies that explore molecular chaperones and protein degradation pathways as a novel therapeutic target. To this end, we examine the capacity of chaperones to prevent or modulate neurodegeneration and summarize the current progress in models of Parkinson's disease and related neurodegenerative disorders.

Author : Chaari Ali
Publisher : LAP Lambert Academic Publishing
Page : 64 pages
File Size : 54,6 Mb
Release : 2014-01
Category : Electronic
ISBN : 3659517240

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Chaperones as a Novel Target Against Amyloids in Parkinson's Disease by Chaari Ali Pdf

Protein misfolding and amyloid formation is an underlying pathological hallmark in a number of prevalent diseases of protein aggregation, including Parkinson's disease (PD), Alzheimer's disease and Type 2 diabetes. Most importantly, the severity of these diseases appears to correlate with the degree of the deposition of amyloid aggregates. The misfolding of -synuclein, a protein involved in PD, followed by its aggregation has been shown to be highly cytotoxic and to play a key role in the death of neurons. Thus, the modulation of the aggregation process, promoting the proper folding of -synuclein, may be considered as an attractive avenue for a therapeutic intervention. Indeed, molecular chaperones have been shown to assist in the maintenance of a functional proteome in vivo and to prevent protein misfolding, aggregation and amyloid formation."

Author : Cintia Roodveldt,Tiago F. Outeiro,Janice E. Braun
Publisher : Frontiers Media SA
Page : 182 pages
File Size : 40,9 Mb
Release : 2017-12-06
Category : Electronic book
ISBN : 9782889453429

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Molecular Chaperones and Neurodegeneration by Cintia Roodveldt,Tiago F. Outeiro,Janice E. Braun Pdf

Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.

Author : Veerle Baekelandt,Evy Lobbestael
Publisher : Academic Press
Page : 324 pages
File Size : 45,8 Mb
Release : 2017-03-31
Category : Medical
ISBN : 9780128052662

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Disease-Modifying Targets in Neurodegenerative Disorders by Veerle Baekelandt,Evy Lobbestael Pdf

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress Summarizes how patients are treated today, providing a glance at future disease management Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists Written and peer reviewed by outstanding scientists in their respective fields

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 403 pages
File Size : 52,6 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319895512

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HSP70 in Human Diseases and Disorders by Alexzander A. A. Asea,Punit Kaur Pdf

The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders. Using an integrative approach to expand our current understanding of HSP70 functions, the contributors provide a synopsis of novel mechanisms by which HSP70 is involved in the regulation of human diseases and disorders. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology.

Author : Panayiotis Vlamos
Publisher : Springer
Page : 312 pages
File Size : 50,6 Mb
Release : 2017-10-01
Category : Medical
ISBN : 9783319573793

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GeNeDis 2016 by Panayiotis Vlamos Pdf

The 2nd World Congress on Genetics, Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international focum for the latest scientific discoveries, medical practices, and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation, and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2016 takes place in Sparta, Greece, 20-23 October, 2016. This volume focuses on thesessions that address neurodegenerative diseases.

Author : Ghulam Md Ashraf,Md. Sahab Uddin
Publisher : Springer Nature
Page : 621 pages
File Size : 48,7 Mb
Release : 2022-07-06
Category : Medical
ISBN : 9789811676062

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Current Thoughts on Dementia by Ghulam Md Ashraf,Md. Sahab Uddin Pdf

This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies. The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.

Author : Anonim
Publisher : Academic Press
Page : 392 pages
File Size : 45,6 Mb
Release : 2016-04-28
Category : Science
ISBN : 9780128039403

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Controversies In Diabetic Neuropathy by Anonim Pdf

This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field. Offers a comprehensive overview of state-of-the-art research on diabetic neuropathy Provides personal critiques from experts in each field Provides a running commentary by editors throughout the book Explores a range of topics including mechanisms of nerve damage, neuropathic pain, new therapies, clinical trials, and animal models of diabetic neuropathy

Author : Rodrigo Franco,Jonathan A Doorn,Jean-Christophe Rochet
Publisher : Royal Society of Chemistry
Page : 537 pages
File Size : 42,6 Mb
Release : 2017-07-25
Category : Medical
ISBN : 9781782621881

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Oxidative Stress and Redox Signalling in Parkinson’s Disease by Rodrigo Franco,Jonathan A Doorn,Jean-Christophe Rochet Pdf

Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

Author : Peter S. Harper,Max F. Perutz
Publisher : Oxford University Press, USA
Page : 352 pages
File Size : 41,6 Mb
Release : 2001
Category : Medical
ISBN : UOM:39015051307505

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Glutamine Repeats and Neurodegenerative Diseases by Peter S. Harper,Max F. Perutz Pdf

This book focuses on the discovery of a common genetic basis for a group of inherited neurological disorders, including Huntington's Disease, spino-bulbar atrophy and a series of hereditary ataxias. This shared molecular background and other similarities have led to the development of theoretical models for the pathogenesis of these diseases. It is now also clear that the mechanisms involved are likely to be of more general relevance, outside of this particular group of disorders, with implications for other neurodegenerative processes such as those involved in Alzheimer's, Parkinson's and Prion diseases. The book is an edited and updated compilation evolving from a Royal Society discussion meeting.

Author : Mark P. Mattson
Publisher : Unknown
Page : 308 pages
File Size : 44,7 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1468496441

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Pathogenesis of Neurodegenerative Disorders by Mark P. Mattson Pdf

Author : Matthias P. Mayer,Pierre Goloubinoff
Publisher : Frontiers Media SA
Page : 71 pages
File Size : 44,8 Mb
Release : 2017-03-24
Category : Electronic book
ISBN : 9782889451258

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The Hsp70 Molecular Chaperone Machines by Matthias P. Mayer,Pierre Goloubinoff Pdf

Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic reticulum form HSPA5 (BiP), and its mitochondrial form HSPA9 (Mortalin), as well as the more distantly related HSPHs (HSP110s), make up 1-2 % of the total mass of proteins in human cells. They use the energy of ATP-hydrolysis to prevent and forcefully revert the process of protein misfolding and aggregation during and following various stresses, presumably by working as unfoldases to lift aberrant conformers out of kinetic traps. As such, HSP70s, in cooperation with their J-domain co-chaperones and nucleotide exchange factors (NEFs) and co-disaggregases, form an efficient network of cellular defenses against the accumulation of cytotoxic misfolded protein conformers, which may cause degenerative diseases such as Parkinson's and Alzheimer's disease, diabetes, and aging in general. In addition to their function in repair of stress-induced damage, HSP70s fulfill many housekeeping functions, including assisting the de novo folding and maturation of proteins, driving the translocation of protein precursors across narrow membrane pores into organelles, and by controlling the oligomeric state of key regulator protein complexes involved in signal transduction and vesicular trafficking. For reasons not well understood, HSP70s are also found on the surface of some animal cells, in particular cancer cells where they may serve as specific targets for cancer immunotherapy. Here, we gathered seven mini reviews, each presenting a complementary aspect of HSP70’s structure and function in bacteria and eukaryotes, under physiological and stressful conditions. These articles highlight how, the various members of this conserved family of molecular chaperones, assisted by their various J-domain and NEF cochaperones and co-disaggregases, harness ATP hydrolysis to perform a great diversity of life-sustaining cellular functions using a similar molecular mechanism.

Author : J.W. Langston,J. Palfreman
Publisher : IOS Press
Page : 264 pages
File Size : 47,6 Mb
Release : 2013-12-02
Category : Medical
ISBN : 9781614993322

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The Case of the Frozen Addicts by J.W. Langston,J. Palfreman Pdf

In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale... It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down... it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks

Author : Colin R Martin,Victor R Preedy
Publisher : Academic Press
Page : 1548 pages
File Size : 52,9 Mb
Release : 2020-12-21
Category : Medical
ISBN : 9780128159590

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The Neuroscience of Parkinson's Disease by Colin R Martin,Victor R Preedy Pdf

The Neuroscience of Parkinson’s Disease (two volume set) provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. The book also fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease

Author : Uday Kishore
Publisher : BoD – Books on Demand
Page : 642 pages
File Size : 50,9 Mb
Release : 2013-05-15
Category : Medical
ISBN : 9789535110880

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Neurodegenerative Diseases by Uday Kishore Pdf

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.