Molecular Genetic Mechanisms In Development And Aging

Author : Morris Rockstein
Publisher : Elsevier
Page : 266 pages
File Size : 41,9 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323158541

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Molecular Genetic Mechanisms in Development and Aging by Morris Rockstein Pdf

Molecular Genetic Mechanisms in Development and Aging discusses the mechanisms of aging at the level of the genome. This book explores the fundamental knowledge concerning the regulation and expression of gene, which is derived from investigations on microbial organisms. Organized into nine chapters, this book starts with an overview of the molecular genetic basis for the processes of aging. This text then explores the highly complex multicellular members of the class Insecta, which provide the researcher with many distinct and unique advantages for aging studies. Other chapters discuss the mechanisms of genetic control and organization during the development and aging of eukaryotes, which pose some challenging problems in cellular and developmental biology. The final chapter deals with the limitations of previous studies, including the lack of comparability due to differences in techniques, the measuring of free amino acid titers in hemolyph only, and differing diet and environmental variations. Biologists and students interested in developmental and molecular genetics will find this book useful.

Author : Morris Rockstein
Publisher : Unknown
Page : 254 pages
File Size : 55,7 Mb
Release : 1972
Category : Electronic
ISBN : 0125915500

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Molecular genetic mechanisms in development and aging : proceedings of a symposium held in Miami, Florida, March 24-25, 1972 by Morris Rockstein Pdf

Author : Siegfried Hekimi
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783540480037

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The Molecular Genetics of Aging by Siegfried Hekimi Pdf

The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.

Author : Juan Carlos Gomez-Verjan,Nadia Alejandra Rivero-Segura
Publisher : Springer Nature
Page : 274 pages
File Size : 45,9 Mb
Release : 2020-04-13
Category : Medical
ISBN : 9783030409555

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Clinical Genetics and Genomics of Aging by Juan Carlos Gomez-Verjan,Nadia Alejandra Rivero-Segura Pdf

The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.

Author : Zhores A. Medvedev
Publisher : Springer Science & Business Media
Page : 430 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468417647

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Molecular-Genetic Mechanisms of Development by Zhores A. Medvedev Pdf

Although as part of my general plan, this book is a continua tion of my earlier monograph "Protein Biosynthesis and Problems of Ontogenesis,"* published in 1963, in all other respects it is an independent work. The earlier monograph was devoted to the analysis of many of the aspects of the problem of protein biosynthesis, and problems of inheritance and development were discussed only insofar as they are derivatives of the problems of biosynthesis. The complex act of protein biosynthesis, comprising autore production of the genetic material (DNA), formation of the templates of protein synthesis (messenger RNA), synthesis of amino acid carriers (transfer RNA), formation of ribosomes and polysomes, activation of amino acids, and so on, was examined in the previous monograph not merely from the standpoint of interaction between the components of this system, but also from that of their mani festation in actual biological systems during morphogenesis and aging of the organism. However, both morphogenesis and aging were investigated very generally, Simply as models, without any detailed analysis of their specific features and complexity. The present book is therefore a logical continuation of its prede cessor. It rests largely on a comprehensive analysis of the molecular-genetic and biochemical aspects of development and differentiation of living organisms, and questions of protein biosyn thesis are discussed briefly and generally, and only so far as is necessary for fulfillment of the primary task. • Zh. A. Medvedev. 1966. Protein Biosynthesis and Problems of Heredity. Developement.

Author : Gil Atzmon, PhD
Publisher : Springer
Page : 194 pages
File Size : 50,9 Mb
Release : 2015-04-27
Category : Medical
ISBN : 9781493924042

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Longevity Genes by Gil Atzmon, PhD Pdf

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

Author : Michael R. Rose,Caleb Finch
Publisher : Springer
Page : 328 pages
File Size : 42,5 Mb
Release : 1994-09-30
Category : Family & Relationships
ISBN : STANFORD:36105009577011

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Genetics and Evolution of Aging by Michael R. Rose,Caleb Finch Pdf

The study of aging has recently been transformed by the application of tools and ideas from genetics and evolution. This development began in 1980, and has since been gathering momentum. The present volume collects most of the principles contributing to this new direction in aging research. Additionally the book incorporates elements from both molecular genetics and evolutionary genetics, uniting two divergent strategies in the study of aging. Some of the book's articles are more molecular, and some are more evolutionary in their orientation, some contributions combine both approaches in a way that has rarely been seen. The book will thus be of broad interest through all `levels' of biology, from molecular biology to evolutionary biology. The phylogenetic diversity covered by the articles is also fairly great: from yeast to plants, nematodes to Drosophila, and rodents to man. Nonetheless, there is a unity to the treatment, with questions like mutation-accumulation, number of loci, and the possibility of postponing aging arising repeatedly throughout the discussions of particular taxonomic groups. There are few better starting places for graduate students interested in biological aging research than this volume. It is also a convenient collection for research workers in the area, who may need to track down an important idea or result. Finally, the book as a whole provides a bracing overview of biological aging.

Author : Thomas Flatt,Andreas Heyland
Publisher : OUP Oxford
Page : 506 pages
File Size : 41,9 Mb
Release : 2011-05-12
Category : Science
ISBN : 9780191621024

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Mechanisms of Life History Evolution by Thomas Flatt,Andreas Heyland Pdf

Life history theory seeks to explain the evolution of the major features of life cycles by analyzing the ecological factors that shape age-specific schedules of growth, reproduction, and survival and by investigating the trade-offs that constrain the evolution of these traits. Although life history theory has made enormous progress in explaining the diversity of life history strategies among species, it traditionally ignores the underlying proximate mechanisms. This novel book argues that many fundamental problems in life history evolution, including the nature of trade-offs, can only be fully resolved if we begin to integrate information on developmental, physiological, and genetic mechanisms into the classical life history framework. Each chapter is written by an established or up-and-coming leader in their respective field; they not only represent the state of the art but also offer fresh perspectives for future research. The text is divided into 7 sections that cover basic concepts (Part 1), the mechanisms that affect different parts of the life cycle (growth, development, and maturation; reproduction; and aging and somatic maintenance) (Parts 2-4), life history plasticity (Part 5), life history integration and trade-offs (Part 6), and concludes with a synthesis chapter written by a prominent leader in the field and an editorial postscript (Part 7).

Author : Edward L. Schneider
Publisher : Springer
Page : 448 pages
File Size : 54,5 Mb
Release : 1978-05
Category : Family & Relationships
ISBN : UOM:39015000268121

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The Genetics of Aging by Edward L. Schneider Pdf

The Genetics of Aging is divided into several sections in an attempt to provide a logical progression from the level of the genome to the realm of human genetics. The relationship between the genetic material and aging will be thoroughly explored in the initial chapters. These chapters discuss in depth the various theories that have been proposed for the mechanisms of aging at the molecular level and present data which either support or contradict these hypotheses. Subsequent chapters will deal with the genetics of aging in organisms ranging from paramecium to mammals. The largest section of this volume will be devoted to several important areas in human genetics: human genetic disorders which feature premature aging, the effect of human parental aging on the production of genetically abnor mal offspring, the genetics of human longevity, and a review of studies on aging human twins. Over the last few decades genetic technology has provided enormous insight into a number of disciplines. Therefore, in the last few chapters, several genetic approaches to the study of aging are discussed: somatic cell genetics, immunogenetics, and behavioral genetics. As the goal of this volume is to present a comprehensive examination of the genetics of aging, most chapters are oriented toward general review of their respective areas. It is my hope that this volume will encourage clinical, biological, and behavioral investigators to turn their attention to the genetic aspects of aging as well as to employ genetic technology to obtain further insight into aging processes.

Author : Pramod C. Rath
Publisher : Unknown
Page : 128 pages
File Size : 50,5 Mb
Release : 2019
Category : Aging
ISBN : 9811335869

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Models, Molecules and Mechanisms in Biogerontology by Pramod C. Rath Pdf

This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

Author : Konrad Beyreuther,Gotthard Schettler
Publisher : Springer Science & Business Media
Page : 206 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642842245

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Molecular Mechanisms of Aging by Konrad Beyreuther,Gotthard Schettler Pdf

Author : Christian Behl,Christine Ziegler
Publisher : Springer
Page : 0 pages
File Size : 48,8 Mb
Release : 2014-01-07
Category : Science
ISBN : 3642451780

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Cell Aging: Molecular Mechanisms and Implications for Disease by Christian Behl,Christine Ziegler Pdf

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Author : Olivier Toussaint
Publisher : Unknown
Page : 0 pages
File Size : 55,6 Mb
Release : 2000
Category : Aging
ISBN : 1573312711

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Molecular and Cellular Gerontology by Olivier Toussaint Pdf

This work covers a number of relevant aspects of the molecular and cellular biology of ageing, a timely general topic highlighted by the United Nations' having declared 1999 the Year of the Elderly. The papers published here represent a wide range of complementary research areas: molecular and cellular aspects; theories of ageing; molecular basis of the loss of homeostatic maintenance mechanisms; lower and higher model organisms including transgenic animal models; the genetics of human longevity; clinical and molecular aspects of age-related diseases; and integrated systems like brain and immune system aging. It is hoped that the additions to knowledge of the molecular mechanisms of ageing provided by this volume may ultimately lead to the prevention of age-related diseases.

Author : Alexey Moskalev,Alexander M. Vaiserman
Publisher : Academic Press
Page : 544 pages
File Size : 49,5 Mb
Release : 2017-11-17
Category : Medical
ISBN : 9780128110836

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Epigenetics of Aging and Longevity by Alexey Moskalev,Alexander M. Vaiserman Pdf

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Author : Bernard Strihler
Publisher : Academic Press
Page : 480 pages
File Size : 52,9 Mb
Release : 1977-01-28
Category : Science
ISBN : UCAL:B4300046

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Times, Cells, and Aging by Bernard Strihler Pdf

Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.